Abstract This study examines the incorporation of soft skills, digital competencies, and artificial intelligence (AI) tools in higher education to improve student employability in Bosnia and Herzegovina, with broader relevance for the South East Europe region, where similar transition economies face parallel challenges in aligning education with the demands of digitally transformed labor markets. The research utilizes a mixed-methods approach, integrating quantitative survey data from University of Sarajevo students with qualitative insights from industry professionals. Research indicates that the concurrent enhancement of soft skills (such as communication and critical thinking) and digital competencies, in conjunction with the utilization of AI tools, markedly enhances students’ preparedness for the contemporary labor market. The study emphasizes the essential role of autonomy in converting AI tool utilization into academic achievement and provides practical recommendations for educators, policymakers, and employers to address the skills gap in the digital economy.

Background/Objectives: The meninges, the protective membranes covering the central nervous system, undergo complex developmental processes that are critical for CNS integrity and function. Connexin 37 (Cx37) and 40 (Cx40), members of the connexin family of gap junction proteins, have been implicated in various physiological and pathological processes. They play a critical role in cell–cell communication. The aim of our study was to investigate the expression of connexins Cx37, Cx40, and Panx1 in the meninges of both human and murine models (yotari and wild type) at the 6th week/E13.5 and 8th week/E15.5 of developmental stages. Methods: Human embryonic tissues (6th–8th week, n = 4 for the 6th week and n = 4 for the 8th week) and mouse embryos (yotari Dab1−/− and wild type, E13.5–E15.5) were collected and fixed in 4% paraformaldehyde. Paraffin sections were stained for Cx37, Cx40, and Panx1 using immunofluorescence. Images were analyzed in ImageJ, and statistical comparisons were performed using one-way ANOVA with Tukey’s post hoc test (p < 0.05). Results: Cx37 was consistently expressed across all developmental stages, with the highest threshold area percentage observed at E13.5 and E15.5 in murine leptomeninges, demonstrating statistically significant differences compared to controls (p < 0.05) and notably from corresponding human stages (p < 0.001). Strong Cx37 staining intensity at E13.5 was noted in both wild-type and yot mice, while human leptomeninges displayed mild staining at the 6th week of development. In contrast, both human and murine pachymeninges exhibited moderate Cx37 expression. Additionally, the expression of Cx37 in wild-type mice surpassed that of human samples at both E13.5 and E15.5 stages (p < 0.01 and p < 0.001, respectively). For the developing dura mater, Cx37 expression peaked at E15.5 in yot mice, significantly different from both wild-type and human dura mater (p < 0.01 and p < 0.05). Cx40 expression was highest in the leptomeninges at E15.5. Panx1 was similarly expressed across stages, with the highest threshold area percent observed in wild-type leptomeninges and pachymeninges at E15.5, showing significant differences compared to yot mice and human samples (p < 0.05). Both leptomeninges and pachymeninges exhibited mild Panx1 staining at E13.5, while stronger staining was observed at E15.5 in murine samples, contrasting with mild intensity in human counterparts. Conclusions: These findings highlight the implications of Dab1 deficiency for the expression of gap junction proteins during meninges development, implicating their importance in intercellular communication that is essential for normal meningeal and neurodevelopmental processes.

Background: Antimicrobial resistance (AMR) is now a critical issue in South Africa, enhanced by considerable inappropriate prescribing of antibiotics. There is currently variable dispensing of antibiotics without a prescription. Where this occurs, it is principally for urinary tract infections (UTIs) and sexually transmitted infections (STIs). Consequently, there is a need to comprehensively evaluate antibiotic dispensing patterns and factors influencing this to reduce AMR. Methods: A previously piloted questionnaire was administered to patients exiting three different categories of community pharmacies in a rural province. The questionnaire included data on the prevalence of antibiotics dispensed, whether without a prescription, and the rationale for this. Results: A total of 465 patients leaving community pharmacies with a medicine were interviewed. 54.4% of interviewed patients were dispensed at least one antibiotic, with 78.7% dispensed these without a prescription from either independent or franchise pharmacies. Metronidazole (36.1%) and azithromycin (32.7%) were the most dispensed antibiotics. STIs were the most common infectious disease for which an antibiotic was dispensed (60.1%), with 99.6% dispensed without a prescription. Upper respiratory tract infections (URTIs) were the most common infection where antibiotics were dispensed with a prescription (60.0%), with little dispensing without a prescription (7.1%). The most frequently cited reasons for obtaining antibiotics without a prescription were prior use (56.8%), long waiting times at PHC clinics (15.6%), and financial constraints (6.0%). Conclusions: There is an urgent need to review community pharmacists’ scope of practice, including allowing them to prescribe antibiotics for infectious diseases such as UTIs, similar to other countries. Concomitantly, utilise trained community pharmacists to engage with prescribers to improve future antibiotic use, especially for URTIs.

Cultural and event tourism plays a key role in the global tourism industry, contributing significantly to national, regional, and cross-border development strategies. It attracts visitors interested in cultural heritage, artistic events, and local traditions, supporting the preservation and promotion of local identity. Assessing cultural tourist flows become essential to understand their economic and social impact, and this article proposes an integrated methodology, combining quantitative and qualitative approaches, including data collection on cultural events, participant estimation, economic analysis, satisfaction assessment, data visualization, reporting, and continuous monitoring. The proposed model ensures a comprehensive evaluation of cultural tourist flows and supports the sustainable development of cultural tourism. Its relevance is both theoretical and applied: it offers a conceptual and analytical framework for studying this complex phenomenon, but also, it provides useful insights for decision-makers and stakeholders involved in tourism development, helping to design effective policies and strategies for promoting and managing cultural tourism. The novelty of the research lies in the proposal of a detailed and integrated methodology tailored to the specific challenges of evaluating cultural tourism, aiming to improve data accuracy, strategic planning, and long-term sustainability.

Background: Refractory atrioventricular nodal reentrant tachycardia (AVNRT) is a rare condition, but poses a clinical challenge after failed standard ablation. Very high-power, short-duration (vHPSD) radiofrequency (RF) ablation has not yet been explored in slow pathway ablation/modification. Case Summary: A 61-year-old woman with recurrent AVNRT despite two prior ablations and multiple antiarrhythmics underwent successful slow pathway ablation using a 90-watt, 4-s vHPSD protocol. CARTO-guided mapping localized the presumed slow pathway, followed by several 90 W applications. Transient second-degree AV block (Wenckebach type) occurred and resolved spontaneously. The patient remained arrhythmia-free at 6-month follow-up. Conclusions: This is the first reported clinical use of 90 W/4 s RF energy for AVNRT. The vHPSD approach may offer an effective alternative for patients with refractory AVNRT.

U radu je predstavljeno do sada neobrađeno djelo pod naslovom Kašf al–ʼasrār bi ḥaqāʼiq al–kitāb wa daqāʼiq al–ṭahāra (Otkrivanje tajni o značenjima riječi knjiga i osobitostima riječi čistoća), koje je u drugoj polovini XVIII stoljeća napisao Muhamed Sin Mustafin Čajničanin (Muḥammad Ibn Muṣṭafā al–Čāyničawī). Ovaj se autor u literaturi spominje kao muderis, sarajevski muftija i autor jednog poznatijeg djela iz logike. Djelo koje je predmet ovog rada, iako registrirano, ranije nije bilo predmet tekstološke analize niti analize sadržaja. U radu su korištena dva rukopisna primjerka ovog djela, od kojih se jedan čuva u rukopisnoj zbirci Gazi Husrev–begove biblioteke u Sarajevu, a drugi u zbirci rukopisa na orijentalnim jezicima Univerzitetske biblioteke „Svetozar Marković“ u Beogradu. Istraživanje obuhvata opis i tekstološku analizu dvaju dostupnih rukopisa, kritičku obradu djela, prijevod i analizu sadržaja s fokusom na analizu genitivne veze kitāb al–ṭahāra, te oblika i značenja njenih članova.

Attributive relative clauses introduced by adverbial relativizers are rarely used in Modern Standard Arabic, and are completely absent in its syntactic description. The intriguing aspect of this type of relative clause lies in the fact that their attributive function is opposed to the main purpose of the use of adverbial relativizers, namely the formation of adverbial clauses. The main task of this paper is the analysis of examples of attributive relative clauses introduced by the adverbial relativizers ḥayṯu, ḥīna, ʻindamā, kamā and munḏu found in works belonging to Modern Standard Arabic. The analysis is based on the analytical–descriptive method and the typological–functional approach, which allow examining of attributive relative clauses introduced by adverbial relativizers from different perspectives. Although the analysis will include exploring syntactic functions of head nouns in main and relative clauses, whereby the relative clause formation strategy using the relative word to encode the syntactic function of head noun in the relative clause is illustrated, this is not the only goal of the paper. The paper also aims to demonstrate that attributive relative clauses introduced by adverbial relativizers, although formally functioning as attributive modifiers, tend to convey diverse semantic content. Moreover, this type of Arabic relative clause is not only an embodiment of the law of linguistic economy but it also represents an exceptionally effective means of stylistic choice.

Small intestinal bacterial overgrowth (SIBO) is a major yet underrecognized driver of gastrointestinal morbidity in systemic sclerosis (SSc). Disordered motility, fibrosis, and dysbiosis promote microbial stasis, malabsorption, and malnutrition, contributing substantially to impaired quality of life and survival. Diagnostic accuracy remains limited: jejunal aspirate culture is invasive, whereas breath testing offers only moderate sensitivity and specificity. Empirical antibiotic therapy yields transient symptom relief, but recurrence is common, and evidence guiding optimal eradication strategies is sparse. Adjunctive measures, including probiotics, prokinetics, and dietary interventions, remain variably applied, with heterogeneous outcomes across studies. Novel microbiome-targeted, neuromodulatory, and antifibrotic therapies are emerging as promising mechanism-based options. Bearing this in mind, this narrative review aims to consolidate current knowledge on SIBO eradication in SSc. We first outline the pathophysiological rationale and clinical relevance of bacterial overgrowth. We then synthesize available evidence for treatment strategies, appraise barriers to durable remission, and discuss implications for multidisciplinary management. Finally, we highlight emerging approaches, including microbiome-directed therapies, novel prokinetics, and antifibrotic interventions, and define priorities for future clinical research.

Introduction: Post-traumatic embitterment syndrome is a pathological reaction to drastic life events and doesnot have the tendency to end. This syndrome also occurs relatively frequently in patients with post-traumatic stress disorder (PTSD).Aim: To investigate post-traumatic embitterment syndrome in patients with post-traumatic stress disorder.Subjects and methods: A cross-sectional study was conducted on a sample of 200 subjects who were participants in the past war. The research group consists of 100 subjects who participated in the war and have a diagnosis of PTSD, and the control group consists of 100 healthy volunteers who were in the war but were not previously diagnosed with PTSD.The study used a sociodemographic questionnaire, a self-assessment questionnaire for post-traumatic embitterment syndrome, and a clinical questionnaire for post-traumatic stress disorder.Results: Subjects with PTSD show a statistically significantly higher level of post-traumatic embitterment syndrome compared to subjects without PTSD. There were no statistically significant differences between the groups that actively and passively participated in the war, between genders, and between the groups with current PTSD and lifetime PTSD.Conclusion: Subjects with PTSD show a statistically significantly higher level of post-traumatic embitterment syndrome compared to subjects without PTSD.

This document presents strategic guidelines and a development framework aimed at enhancing higher education programs in biotechnology within Bosnia and Herzegovina. It emphasizes the importance of aligning academic curricula, research capacities, and innovation ecosystems with global sustainable development goals (SDGs) and emerging scientific trends. Drawing on insights from the 2025 scientific-expert symposium "Next-Generation Biotechnologists – Skills of Future Educators," this work outlines key recommendations for modernizing educational approaches, strengthening interdisciplinary collaboration, and fostering the next generation of biotechnologists equipped to meet societal and technological challenges. The framework is intended for academic institutions, policymakers, and stakeholders committed to advancing biotechnology education and innovation in the region.

Understanding the impacts of climate on tourism has evolved since the late 20th century, shifting from one-dimensional and partial approaches to more comprehensive and multifaceted ones. To more accurately assess the climatic suitability of destinations for recreational tourism, the Holiday Climate Index (HCI) has been developed in recent years. The HCI's variable rating scale and component weighting system are based on insights into tourists' climatic preferences. Since different types of destinations have distinct climatic requirements, the HCI is designed with specifications for two major tourism segments—urban and beach. The HCI: Urban focuses on urban tourism, where the city and its attractions serve as the primary destination and point of interest. This study analyzes the HCI: Urban for Sarajevo, the most significant tourism destination in Bosnia and Herzegovina. The monthly probability is calculated by determining the frequency of daily index scores within ideal and unacceptable categories. Ideal climatic conditions for urban tourism are defined as days with scores between 90 and 100, while unacceptable conditions are those with scores below 40. Of all tourists visiting Bosnia and Herzegovina in 2023, 41% visited the Sarajevo Canton, which makes it a significant case study. This paper analyzes the HCI: Urban index for Sarajevo in relation to tourist visits throughout the year, and the obtained ratings reflect tourists' climatic preferences for urban destinations. Holiday Climate Index (HCI): Urban was analyzed for the Sarajevo area, the capital of Bosnia and Herzegovina, in order to more accurately assess the climatic suitability of this destination for tourism. The word “holiday” was chosen to better reflect what the index was designed for (i.e. recreational tourism), since tourism is much broader in definition. This paper analyzes the HCI: Urban index for Sarajevo in relation to tourist visits during the year, and the obtained scores reflect tourists' climate preferences for the city destination. Considering that tourists in Sarajevo stay only for a short time (average length of stay 2.1 days), determinants that affect tourist satisfaction and elements of the destination that need to be improved in order to increase the length of stay have been identified. Analysis of average daily values of climatic parameters of a particular destination and monitoring their trend plays an important role in the organization of tourist trips. This research is the first of its kind related to Sarajevo, and understanding local climatic conditions is crucial for developing tourism strategies, planning, and organizing tourism events in the capital of Bosnia and Herzegovina, which is the most visited tourist city in the entire country.

<p>This study explores the use of natural plant extracts as a sustainable method to enhance the quality and safety of long-life sausages by incorporating them into natural edible casings. Ethanol (E) and aqueous (A) extracts of blackthorn (BT) and red cherry (RC), as well as their ethanol and water-based solutions, were prepared and analysed for their antioxidant and antimicrobial properties. The analyses included the quantification of total phenols, non-flavonoids, flavonoids, flavonols, and anthocyanins, along with antioxidant activity assessments using FRAP, DPPH, and ABTS assays. Antimicrobial efficacy was tested against Gram-positive and Gram-negative bacteria (<em>Staphylococcus aureus</em>, <em>Bacillus cereus</em>, <em>Escherichia coli</em>, and <em>Salmonella enterica</em>) and mold <em>Penicillium expansum</em> via agar dilution methods to determine MIC and MBC/MFC.</p> <p>Results showed that ethanol extracts had higher antioxidant activity than aqueous ones (p&lt;0.05), with the ethanol extract of blackthorn (EBT) containing the highest levels of phenolics (54.11 mg GAE/g d.e.) and exhibiting the strongest antioxidant, antimicrobial, and antifungal activities. Casings treated with EBTE (ethanol BT extract dissolved in ethanol) demonstrated significant antibacterial properties, particularly against Gram-negative bacteria. This study confirms that plant-extract-enriched natural casings can protect against oxidation and microbial spoilage, thereby enhancing the overall quality and safety of dry-cured sausages.&nbsp;</p>

Many cyberattacks succeed because they exploit flaws at the human level. To address this problem, organizations rely on security awareness programs, which aim to make employees more resilient against social engineering. While some works have suggested that such programs should account for contextual relevance, the common praxis in research is to adopt a"general"viewpoint. For instance, instead of focusing on department-specific issues, prior user studies sought to provide organization-wide conclusions. Such a protocol may lead to overlooking vulnerabilities that affect only specific subsets of an organization. In this paper, we tackle such an oversight. First, through a systematic literature review, we provide evidence that prior literature poorly accounted for department-specific needs. Then, we carry out a multi-company and mixed-methods study focusing on two pivotal departments: human resources (HR) and accounting. We explore three dimensions: threats faced by these departments; topics covered in the security-awareness campaigns delivered to these departments; and delivery methods that maximize the effectiveness of such campaigns. We begin by interviewing 16 employees of a multinational enterprise, and then use these results as a scaffold to design a structured survey through which we collect the responses of over 90 HR/accounting members of 9 organizations. We find that HR is targeted through job applications containing malware and executive impersonation, while accounting is exposed to invoice fraud, credential theft, and ransomware. Current training is often viewed as too generic, with employees preferring shorter, scenario-based formats like videos and simulations. These preferences contradict the common industry practice of annual sessions. Based on these insights, we propose recommendations for designing awareness programs tailored to departmental needs and workflows.