The excessive use of vaccines, antibiotics, and other preventive therapeutic agents in conventional broiler production has resulted in the frequent occurrence of antibiotic residues in edible tissues, posing risks to both animal and human health. These residues contribute to the global problem of antimicrobial resistance, highlighting the need for alternative approaches to poultry disease prevention. This study aimed to evaluate whether a comprehensive preventive programme encompassing biosecurity, hygiene, and an antibiotic-free prophylaxis regimen could eliminate the need for prophylactic antibiotic therapy, thereby enabling the production of broiler meat free of antibiotic residues. This approach was contrasted with the conventional production system, in which less rigorous preventive practices necessitate the prophylactic use of broad-spectrum antibiotics, ultimately resulting in detectable residues within the muscle and liver tissues of conventionally reared chickens. Ross 308 broilers were reared under field conditions. in. The control group was reared using conventional prophylactic protocols, including broad-spectrum antibiotics, vitamins, bio-stimulants, mineral supplements, and acidifiers via drinking water. The experimental group received no antibiotics; and instead were treated with hydro-soluble probiotic preparations containing vitamin C, lactose, fructose, and baker’s yeast, combined with continuous water disinfection throughout the fattening period. Microbiological analyses showed the presence of antibiotic residues in the soft tissues of conventionally reared broilers, while no residues were detected in the experimental group. Production performance indicators—mortality rate, vitality, final body weight, and overall cost—were similar to or superior to those in the antibiotic-free group, confirming that broiler meat production without antibiotics is both feasible and economically viable.

A proper diet that provides balanced nutrients according to species, breed, age, sex, and purpose is essential for achieving optimal animal growth, development, and physiological function. In relation to this statement, the aim of this study was to quantitatively assess the effects of different dietary regimens on the morphometric characteristics of the small intestine of late puerperal rats, with a emphasis on the duodenum and jejunum. The research included measurements of the height and width of intestinal villi, and the depth of crypts, in order to determine specific morphological changes associated with the influence of the diet. The experiment involved 18 adult rats divided into three groups: the first group received standard commercial rat feed (control group), the second group was fed bakery products, and the third group was given a diet consisting exclusively of meat. Over a 49-day period, body weight, organ weights, and intestinal segment lengths were measured. Histological analyses of duodenum and jejunum samples were performed, alongside detailed morphometric assessment of the intestinal mucosa. Significant alterations in intestinal villi were observed. In the duodenum, the greatest villus height and width, as well as crypt depth, were observed in rats that had meat-based diet. Similarly, in the jejunum, rats from the same group exhibited the greatest villus height and crypt depth, while the mean measure of the villus width was almost identical to mean measure in rats that were fed with commercial food. These findings suggest that diet composition profoundly influences intestinal architecture and function. Overall, the study emphasizes the critical role of balanced nutrition in maintaining gastrointestinal health, systemic homeostasis, and optimal development, not only in laboratory animals but also in a broader veterinary and biomedical context.

Multimodal emotion and sentiment recognition is commonly addressed by early fusion, which concatenates modalities before classification, or late fusion, which combines independently trained unimodal predictors. Early fusion can be accurate but monolithic, while late fusion is modular but may lose cross-modal interactions. This paper revisits XAI-guided adaptive fusion (\xgaf), a tree-based mixture of unimodal and cross-modal experts whose sample-level weights are derived from TreeSHAP attribution magnitudes. We focus on the effect of SHAP attribution reduction when experts have unequal feature dimensionalities. In this setting, mean-abs and median-abs reductions can suppress high-dimensional cross-modal experts, whereas sum-abs reduction preserves total attribution mass. On MELD 7-class emotion recognition, sum-abs \xgaf{} nearly matches early fusion across three face-sequence aggregators; the Transformer variant reaches 0.5983 \wf{}, compared with 0.6018 for early fusion and 0.4598 for probability-average late fusion. McNemar testing shows no significant difference between sum-abs \xgaf{} and early fusion on MELD ($p=1.000$), while \xgaf{} remains significantly better than late fusion ($p<0.0001$). On CMU-MOSEI 3-class sentiment recognition, sum-abs \xgaf{} reaches 0.6519 \wf{}, slightly exceeding early fusion (0.6485) and late fusion (0.5696). Ablation studies show that the main gain comes from adding cross-modal experts, especially the trimodal expert, rather than from complex per-sample routing. Diagnostics further show that mean-abs and median-abs weights are nearly uniform, while sum-abs weights concentrate on the trimodal expert. Thus, the main contribution is a transparent empirical analysis of how SHAP reduction, expert dimensionality, and cross-modal expert design affect modular multimodal fusion.

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The Carpathian water buffalo represents a locally adapted but under-characterized genetic group found in Central and Eastern Europe. Genome-wide information on its genetic diversity, population structure and potential adaptive variation remains limited, particularly for Hungarian and Romanian populations. In this study, we genotyped 263 water buffalo individuals from Hungary and Romania using the GeneSeek Genomic Profiler Bovine 100K SNP array to evaluate genetic diversity, the population structure, runs of homozygosity (ROH) and candidate genomic regions showing signatures of selection. After quality control, 214 Hungarian and 33 Romanian individuals and 6605 SNPs were retained for downstream analyses. Both populations showed moderate genetic diversity, with the Romanian population displaying higher minor allele frequency, observed heterozygosity and nucleotide diversity than the Hungarian population. In contrast, the Hungarian buffalo showed a higher burden of runs of homozygosity, including a larger proportion of long ROH segments, suggesting stronger recent autozygosity or a more restricted breeding structure. Principal component analysis and neighbor-joining phylogeny separated the two populations, whereas ADMIXTURE indicated shared ancestry and a within-population substructure rather than complete population-specific differentiation. The integration of standardized FST, absolute allele-frequency differences and ROH islands identified six candidate regions under a positive signature of selection in each population. These regions harbored genes previously associated with immune response, reproduction, growth, milk production and thermotolerance in bovids. Functional enrichment was limited, with significant Gene Ontology terms detected only in the Hungarian candidate regions. Our results provide a regional genomic baseline for the future conservation and breeding management of Carpathian water buffalo. Given the use of a cross-species SNP array and unequal sample sizes, the candidate selection signals should be interpreted as hypothesis-generating and warrant validation using higher-density buffalo-specific genomic data.

Background/Objectives: Hypertrophic cardiomyopathy (HCM) is a complex myocardial disease in which structural remodeling extends beyond conventional parameters such as maximal wall thickness (MWT). This study aimed to evaluate isoperimetric analysis as a geometry-based approach for characterizing left ventricular (LV) morphology and to compare its performance with fractal analysis in distinguishing HCM from non-HCM subjects. Methods: This retrospective study included 120 subjects (60 HCM and 60 controls) who underwent clinically indicated CMR. Endocardial contours were delineated on short-axis cine images at end-diastole. The isoperimetric index (IPI), cavity-corrected IPI (CC-IPI), and fractal dimension (FD) were calculated. Group comparisons, correlations, and receiver operating characteristic analyses were performed. Results: Patients with HCM showed significantly higher IPI and CC-IPI values than controls (p < 0.001), including in sex-stratified analyses. IPI and CC-IPI correlated strongly with MWT (r = 0.867) and LV mass index (r = 0.807 and 0.803, respectively), moderately with native T1 (r = 0.567), and weakly with end-diastolic volume index (r = 0.256 and 0.253, respectively) and stroke volume (r = 0.237 and 0.229, respectively). No association was observed with late gadolinium enhancement. IPI and CC-IPI showed a strong linear correlation (R2 = 0.997), with both indices demonstrating high discriminatory performance (AUC = 1.00). Conclusions: HCM is associated with notable alterations in LV endocardial geometry beyond myocardial hypertrophy alone. IPI and CC-IPI provide simple, size-normalized, and physiologically interpretable morphologic descriptors that complement conventional CMR parameters and FD-based contour complexity analysis.

Agroecological conditions, the biological characteristics of grapevine varieties, and the application of viticultural practices significantly influence the physico-chemical properties of grapes. This study assessed the impact of agroecological conditions at two cultivation sites, Sarajevo and Trebinje, on the physico-chemical properties of Chardonnay and Cabernet Sauvignon (Vitis vinifera L.) grape varieties. The results showed that location had a statistically significant effect on several physical parameters of grape bunches and berries. Significant differences were observed in bunch and berry mass (in ‚Chardonnay‘), bunch length (in both varieties), bunch width (in ‚Cabernet Sauvignon‘), berry length (in ‚Chardonnay‘), berry width (both varieties), as well as in the mass of 100 berries, pulp and skin mass of 100 berries, and the number of seeds per 100 berries. Furthermore, the cultivation site significantly influenced the sugar and total acid content in both varieties, as well as the phenolic content in ‚Chardonnay‘ berries, and the flavonoid content and total antioxidant activity in ‚Cabernet Sauvignon‘.

In the last few decades, bark beetle outbreaks have increased in European forests, triggered by extreme weather events, such as drought and windstorms. A core element of integrated pest management to control outbreaks are salvage logging and sanitation felling, i.e., the timely removal or treatment of potential brood material and already infested trees after disturbance events. Associated with these management operations as well as with regular, planned thinning and cutting, felling residues, such as treetops, branches and stumps that remain in the forest provide potentially suitable breeding material for bark beetles and may trigger further outbreak events. Although felling residue management is part of regular forest management in most of Europe, no overview exists on its use throughout the continent. To fill this gap, we gathered forest health experts from 20 European countries and used a questionnaire to provide information on felling residue management in the context of forest protection in managed forests. Relevant legislation in these countries was reviewed for regulations concerning this topic. We found that most countries have felling residue management in their legislation and/or perform it in practice. In 12 of the 20 countries, felling residue management is being applied to manage bark beetles, particularly in areas that have experienced large-scale outbreaks in the last few decades. Felling residues are mainly managed in forests dominated by Norway spruce (Picea abies L. Karst) and pines (Pinus spp.) (in 19 and 17 of the countries, respectively). The most frequently used management methods on a European level were piling or mulching of felling residues. These methods were used in 14 and 16 of the countries, respectively. Besides bark beetle management, use of residues for bioenergy (4 countries) and biodiversity conservation (6 countries) was reported. The diversity of felling residue management practices across Europe may reflect differences in forest policies and climatic gradients that are affecting bark beetle outbreak risks. This overview presents the variety of felling residue management applied across 20 European countries, highlighting the reasons for and implications of its use, as well as further research needs.

Rad analizira usklađenost Zakona o zaštiti ličnih podataka iz 2025. (ZZLP) s Općom uredbom o zaštiti podataka (GDPR), kao i njegov odnos prema općim pravilima odštetnog prava sadržanim u Zakonu o obligacionim odnosima (ZOO). Iako ZZLP kao lex specialis i lex posterior ima prednost u primjeni, ispitano je da li određene nedorečenosti ili kolizije između ova dva zakona podrivaju temeljni cilj GDPR-a – osiguranje djelotvornih, odvraćajućih i razmjernih pravnih sredstava. Utvrđen je visok stepen normativne usklađenosti ZZLP-a s GDPR-om, naročito u pogledu administrativnih i krivičnih sankcija. Međutim, značajna odstupanja uočena su u oblasti naknade štete. Sudska praksa Suda Evropske unije potvrđuje da ne postoji pravilo de minimis, da šteta mora biti stvarna i dokaziva, te da naknada ima isključivo kompenzacijski karakter. Budući da je BiH kandidat za članstvo u EU, ovi standardi su relevantni i za domaće sudove. Ključni problem identificiran je u pitanju uzročnosti i štete, koju ZZLP ne uređuje detaljno, pa se primjenjuju pravila ZOO. Dokazivanje uzročnosti može otežati ostvarivanje zaštite, zbog čega se razmatra mogućnost kvalifikacije obrade podataka kao opasne djelatnosti, čime bi se teret dokazivanja prebacio na obrađivača. Posebno su analizirana pitanja materijalne i nematerijalne štete. Kod materijalne štete, mali iznosi mogu obeshrabriti oštećene, pa se razmatra potencijalna uloga nominalne ili kaznene štete, uprkos restriktivnom stavu Suda EU. Najveći nesklad između ZZLP/GDPR i ZOO odnosi se na nematerijalnu štetu. Dok GDPR i ZZLP dopuštaju naknadu neovisno o intenzitetu i trajanju povrede, ZOO polazi od subjektivnog koncepta koji zahtijeva određeni prag bola ili straha. Stoga se predlaže de lege ferenda prelazak na objektivnu koncepciju nematerijalne štete, prema kojoj sama povreda ličnih prava predstavlja štetu, dok bi intenzitet bola i straha služio samo za određivanje visine naknade. Također su kritizirane procesne manjkavosti, uključujući izostanak alternativne mjesne nadležnosti i nedostatak odredbi o kolektivnoj zaštiti prava. Ključne riječi: zaštita osobnih podataka, GDPR, naknada štete za povredu osobnih podataka, nematerijalna šteta, kolektivna zaštita.

Background: The Renal Registry of Bosnia and Herzegovina systematically collects national data on kidney replacement therapy for patients with end-stage kidney disease (ESKD). This report summarizes 2 decades of registry data (2002-2022), showing trends in incidence, prevalence, modality distribution, and patient outcomes. Methods: Data were obtained annually from 30 dialysis centers across the country. Incidence, prevalence, and survival rates for hemodialysis (HD), peritoneal dialysis (PD), and kidney transplantation were calculated per million population (pmp). Descriptive statistics and Kaplan–Meier survival analyses were performed using SPSS 25. Results: Between 2002 and 2022, the number of dialysis centers increased from 18 to 30, and the total treated population rose by 43.5% (from 1687 to 2421 patients). Hemodialysis remained the predominant modality (80.4%), while PD accounted for only 3.0% of all dialysis patients. The incidence rate in 2022 was 118.9 pmp, and the prevalence reached 685.6 pmp. The leading causes of ESKD were diabetic nephropathy (29.5%) and hypertensive nephropathy (13.1%). The crude mortality rate among dialysis patients in 2022 was 13.2%, primarily due to cardiovascular disease. By the end of 2022, a total of 402 patients lived with a functioning kidney graft. Conclusion: Over the past 2 decades, Bosnia and Herzegovina has experienced steady growth in its dialysis population and gradual improvements in registry coverage. However, the country continues to face challenges, including low utilization of PD and limited transplantation activity. Strengthening early chronic kidney disease detection and expanding organ donation programs remain key national priorities.   Cite this article as: Resić H, Rebić D, Turković AM. The renal registry of Bosnia and Herzegovina. Turk J Nephrol. Published online May 11, 2026. doi: 10.10.5152/turkjnephrol.2026.25988.

Background/Objectives: Pharmacists play a key role in managing urinary tract infection (UTI) symptoms by providing medications, self-care advice, and over-the-counter treatments, while referring patients to a doctor when necessary. This study aimed to examine the practices of community pharmacists in managing UTI symptoms and to gain insight into their attitudes toward antibiotic use for this condition. Methods: A cross-sectional study was conducted among community pharmacists in Serbia using a previously validated online questionnaire, assessed for content and face validity and pilot-tested among pharmacists. Results: A total of 430 community pharmacists participated in the study. Patients more often consulted pharmacists before visiting a doctor than after (median 5 vs. 3 per week; p < 0.001). For uncomplicated UTIs, pharmacists primarily recommended increased fluid intake (92.8%), herbal teas (94.7%), and food supplements (85.6%), whereas for complicated UTIs, most referred patients to a doctor (95.4%). Attitudes, perceived competence, and support for over-the-counter antibiotic availability were significantly associated with gender, years of experience, and specialization. Pharmacists who agreed that antibiotics are the most effective treatment for uncomplicated urinary tract infections were more likely to refer patients to a doctor (p < 0.01). Conclusions: Pharmacists are frequently consulted for UTI management and emphasize non-antibiotic approaches for uncomplicated cases. Their attitudes influence counseling practices, highlighting the need for standardized UTI counseling services, antimicrobial stewardship education, and structured communication training to support appropriate antibiotic use.

Rhegmatogenous retinal detachment (RRD) is a vision-threatening retinal disorder in which successful anatomical reattachment does not always result in satisfactory functional visual recovery. Optical coherence tomography (OCT) has become an essential non-invasive imaging modality for evaluating retinal microstructure and identifying biomarkers associated with postoperative visual outcomes. This narrative review summarizes and critically evaluates current evidence regarding the prognostic significance of OCT biomarkers following RRD repair. Available studies indicate that primary outer retinal biomarkers, particularly the integrity of the ellipsoid zone (EZ) and external limiting membrane (ELM), are the most reliable predictors of postoperative best-corrected visual acuity. Preservation of these structures reflects photoreceptor viability and is strongly associated with improved visual recovery. Secondary biomarkers, including hyperreflective foci, intraretinal cystic changes, retinal folds, persistent subretinal fluid, and preretinal hyperreflective dots, provide complementary information regarding inflammatory activity, retinal remodeling, and postoperative complications such as epiretinal membrane formation. Although these biomarkers have considerable clinical value for prognostication, patient counseling, and postoperative monitoring, their interpretation is limited by heterogeneity among studies, differences in imaging protocols, and the lack of standardized assessment criteria. Future large-scale prospective studies are needed to validate OCT biomarkers and establish standardized approaches for their integration into routine clinical practice.