Cultural and event tourism plays a key role in the global tourism industry, contributing significantly to national, regional, and cross-border development strategies. It attracts visitors interested in cultural heritage, artistic events, and local traditions, supporting the preservation and promotion of local identity. Assessing cultural tourist flows become essential to understand their economic and social impact, and this article proposes an integrated methodology, combining quantitative and qualitative approaches, including data collection on cultural events, participant estimation, economic analysis, satisfaction assessment, data visualization, reporting, and continuous monitoring. The proposed model ensures a comprehensive evaluation of cultural tourist flows and supports the sustainable development of cultural tourism. Its relevance is both theoretical and applied: it offers a conceptual and analytical framework for studying this complex phenomenon, but also, it provides useful insights for decision-makers and stakeholders involved in tourism development, helping to design effective policies and strategies for promoting and managing cultural tourism. The novelty of the research lies in the proposal of a detailed and integrated methodology tailored to the specific challenges of evaluating cultural tourism, aiming to improve data accuracy, strategic planning, and long-term sustainability.

Background: Peritoneal lymphangiomatosis is a rare benign lymphatic disorder with diagnostic and therapeutic challenges. It may mimic peritoneal carcinomatosis or mesothelioma, often requiring histological confirmation. Management options are limited, and long-term data on targeted therapies, including sirolimus, remain scarce. Case Presentation: We present the case of a 45-year-old woman with a history of surgically corrected atrial septal defect, who developed progressive abdominal distension and dysuria in May 2014. Abdominal ultrasound (US) and contrast-enhanced abdominal computed tomography (CT) revealed diffuse ascites, peritoneal thickening, and cystic changes. Diagnostic uncertainty led to an exploratory laparotomy in May 2015, where histopathology confirmed peritoneal lymphangiomatosis. After failed conservative management including dietary modification, diuretic therapy, and repeated paracenteses, she was started on sirolimus 2 mg/day in August 2016. Her serum trough levels were maintained between 5–15 ng/mL. She achieved a Karnofsky Performance Score of 100% (indicating full functional capacity) within two months and has remained in complete clinical and radiologic remission for over 8 years. Diabetes mellitus type 2 was diagnosed during follow-up and is well controlled with insulin therapy. Conclusion: This case underscores the difficulty of diagnosing peritoneal lymphangiomatosis and highlights the transformative potential of sirolimus therapy. To our knowledge, this is one of the longest documented remissions of peritoneal lymphangiomatosis under mechanistic target of rapamycin (mTOR) inhibition. Keywords: peritoneal lymphangiomatosis, sirolimus, mTOR inhibitor, rare disease, ascites, lymphatic malformation, case report, remission, Karnofsky score, targeted therapy.

The primary objective of external fixation is to stabilize bone fractures, with the mechanical characteristics of the fixation system playing a critical role in shaping the biomechanical environment of the fracture and, consequently, the healing process. This study presents an experimental investigation of the stability of eight unilateral external fixation configurations applied to an open tibial fracture. The stiffness of each configuration was evaluated under axial compression, anterior–posterior (AP) bending, medial–lateral (ML) bending, and torsional loading. In addition, the effects of structural parameters—such as the number of half-pins, planarity of the configuration, and interfragmentary distance—on fixator stiffness and generated stresses were examined. The results revealed a linear relationship between applied load and both bone segment displacement and principal stresses. Biomechanical tests demonstrated that biplanar configurations provide sufficient stability for open tibial fractures, while simultaneously offering an optimal structural design for the fixation system. Moreover, the number of half-pins was identified as a statistically significant factor influencing configuration stiffness under axial loading and torsion, with biplanar configurations proving particularly effective in torsional scenarios. However, in AP and ML bending tests, neither configuration type nor any individual parameter produced statistically significant differences in bending stiffness. Interestingly, interfragmentary distance did not exert a statistically significant effect on configuration stiffness under any loading condition. Furthermore, neither configuration type nor the analyzed parameters had a notable influence on the principal stresses measured at the control points.

In this research, the impact of applications on improving urban logistics was examined using the example of the company EX, with an emphasis on the sustainability of its business. To conduct this research, expert decision-making was used. The model used ten criteria and eight applications. To incorporate uncertainty into this research, an intuitionistic fuzzy approach was used. Based on the obtained CC values, the criteria weights were determined using the SiWeC (Simple Weight Calculation) method, while the WASPAS (Weighted Aggregated Sum Product Assessment) method ranked the applications. The results showed that “Security and data protection” and “System reliability and stability” were the most important criteria, while Application 1 achieved the best results. These results were confirmed by the consistency analysis of the WASPAS method and the sensitivity analysis, which considered 30 scenarios.

OBJECTIVE To report two additional cases of glycogen-rich clear cell carcinoma (GRCC) of the breast - detailing their clinicopathologic features, immunophenotypes, and follow-up - and to provide an updated literature review since 2020. CASE REPORTS Two patients (66 and 52 years old) had GRCC confirmed morphologically and histochemically. Case 1 was ER-positive/HER2- positive (luminal B/HER2-positive) and was managed with surgery, followed by adjuvant chemotherapy, endocrine therapy, and anti-HER2 therapy (trastuzumab). Case 2 was triple-negative and received neoadjuvant chemoimmunotherapy (pembrolizumab- based) with marked pathologic tumor regression at resection. Both patients were disease-free at one and 12 months, respectively. CONCLUSIONS GRCC is heterogeneous and should not be regarded as a single clinicopathologic entity within invasive breast carcinoma of no special type or assumed to have a uniform prognosis. Management should be biomarker-guided, as illustrated by these cases. The role of targeted and immune therapies in GRCC warrants multi-institutional studies.

Efficient and consistent string processing is critical in the exponentially growing genomic data era. Locally Consistent Parsing (LCP) addresses this need by partitioning an input genome string into short, exactly matching substrings (e.g.,"cores"), ensuring consistency across partitions. Labeling the cores of an input string consistently not only provides a compact representation of the input but also enables the reapplication of LCP to refine the cores over multiple iterations, providing a progressively longer and more informative set of substrings for downstream analyses. We present the first iterative implementation of LCP with Lcptools and demonstrate its effectiveness in identifying cores with minimal collisions. Experimental results show that the number of cores at the i^th iteration is O(n/c^i) for c ~ 2.34, while the average length and the average distance between consecutive cores are O(c^i). Compared to the popular sketching techniques, LCP produces significantly fewer cores, enabling a more compact representation and faster analyses. To demonstrate the advantages of LCP in genomic string processing in terms of computation and memory efficiency, we also introduce LCPan, an efficient variation graph constructor. We show that LCPan generates variation graphs>10x faster than vg, while using>13x less memory.

We study strong-field ionization by quantum lights with emphasis on high-order above-threshold ionization and the intensity-dependent enhancements in the photoelectron spectra. We find that the length of the plateau in the photoelectron energy spectrum generated by such quantum lights can be extended by an order of magnitude in comparison with that generated by the classical coherent laser light and that within this plateau resonantly enhanced groups of sharp peaks appear at energies which are integer multiple of the photon energy. We relate the observed intensity-dependent enhancements to the channel closing effect. Our results are particularly interesting in the context of the recent interplay and merging of quantum optics with strong-field physics and attoscience.

Fennel (Foeniculum vulgare), a culinary and folk medicinal plant used worldwide in infantile colic, bloating, and indigestion, has scarce scientific evidence.