The aim of this study was to determine the frequencies of alleles and genotypes of the single nucleotide polymorphism of the FTO gene (rs17817449) and the intensity of physical activity in relation to the BMI of subjects in the student population. Genotyping was performed using the PCR-RFLP method. 94 subjects stated that they were not physically active, 57 subjects were moderately physically active and 52 were intensely physically active. In the total sample, the risk allele G of the investigated polymorphism rs17817449 of the FTO gene had a lower frequency (41.8%) compared to the normal allele T (58.13%). Although a higher frequency of the risk allele G was found in the group of overweight subjects compared to the group with BMI < 25, the difference was not statistically significant (p > 0.05).

Objectives: To measure and analyze the seroprevalence and risk factors of human brucellosis among clinically suspected patients in the Travnik area, Bosnia and Herzegovina in the period 2018-2023. Methods: A total of 337 samples of clinically suspected brucellosis patients in Travnik, Central Bosnia and Herzegovina were collected between 2018-2023. Rose Bengal agglutination was used for sera testing. Expressive and investigative statistics were considered. Differences between the prevalence of brucellosis according to age, sex, and the seasonal incidence rate were assessed. Results: The prevalence of brucellosis among the suspected patients was 23.30%. The highest prevalence rate 35.71%, was detected during year 2021. Higher rate of brucellosis was observed among males 63.86% than females 36.14%. Most cases were reported during month of June and October, 14.15% and 14.19% respectively. The highest prevalence, 56.76% rate was observed in age group 41–60 years old. Conclusion: Our survey found a high prevalence of human brucellosis among clinically suspected patients in Travnik area strongly indicating that clinical suspicion is a valid criterion, which requires fast laboratory detection and patient treatment. Detecting specific anti-Brucella antibodies using agglutination Rose Bengal test is a fast a reliable diagnostic procedure for clinically suspect individuals. There is a strong association between human brucellosis and age.

The auditory brainstem response (ABR) is a measure of subcortical activity in response to auditory stimuli. The wave V peak of the ABR depends on stimulus intensity level, and has been widely used for clinical hearing assessment. Conventional methods to estimate the ABR average electroencephalography (EEG) responses to short unnatural stimuli such as clicks. Recent work has moved towards more ecologically relevant continuous speech stimuli using linear deconvolution models called Temporal Response Functions (TRFs). Investigating whether the TRF waveform changes with stimulus intensity is a crucial step towards the use of natural speech stimuli for hearing assessments involving subcortical responses. Here, we develop methods to estimate level-dependent subcortical TRFs using EEG data collected from 21 participants listening to continuous speech presented at 4 different intensity levels. We find that level-dependent changes can be detected in the wave V peak of the subcortical TRF for almost all participants, and are consistent with level-dependent changes in click-ABR wave V. We also investigate the most suitable peripheral auditory model to generate predictors for level-dependent subcortical TRFs and find that simple gammatone filterbanks perform the best. Additionally, around 6 minutes of data may be sufficient for detecting level-dependent effects and wave V peaks above the noise floor for speech segments with higher intensity. Finally, we show a proof-of-concept that level dependent subcortical TRFs can be detected even for the inherent intensity fluctuations in natural continuous speech. Visual abstract Significance statement Subcortical EEG responses to sound depend on the stimulus intensity level and provide a window into the early human auditory pathway. However, current methods detect responses using unnatural transient stimuli such as clicks or chirps. We develop methods for detecting level-dependent responses to continuous speech stimuli, which is more ecologically relevant and may provide several advantages over transient stimuli. Critically, we find consistent patterns of level dependent subcortical responses to continuous speech at an individual level, that are directly comparable to those seen for conventional responses to click stimuli. Our work lays the foundation for the use of subcortical responses to natural speech stimuli in future applications such as clinical hearing assessment and hearing assistive technology.

Public budgeting and finance is a discipline that encompasses communities of research and practice. Too often, however, these communities fail to engage each other, instead choosing to operate independently. The result is that the research being conducted fails to address the questions of the day and our governments’ challenges. In this article, we come together as a community of academics and practitioners to establish an agenda for where future research should be conducted. This agenda aims to align the research being undertaken within the academic community with the needs of those working in the community of practice. After establishing ten areas where research is needed, we followed a ranked-choice voting process to establish a prioritization for them. Based on the outcome of this process, the two primary areas where research is currently needed most are the fiscal health of our governments and the implementation of social equity budgeting.  

Teaching is a process for which its plan should contain reflection onto previous experience. With that in mind, teaching situations should be continuously researched and improved in accordance with the research results. Led by this thought and the fact that students are uncritically using visualization to solve mathematical problems, we defined the aim of this research–determine the attitude of students about the visualization of mathematical content (VMC). The subject of this research are the attitudes of students towards VMC. By analyzing our research subject, we have discovered the research problem–students use visual aid to solve problems uncritically. Based on this problem, we have set the aim of our research. Our aim was to determine the students’ attitudes (and their opinions) about VMC. Based on the aim of our research, we have set four research tasks. Based on these research tasks, we have established the main (leading) research question–What is the attitude of high school students towards the application of VMC? We divided the main research question into five questions: Do high school students consider that they understand the term ‘VMC’? Who considers they use more methods of solving mathematical problems using visual aid–high school male students or female students? Students of which grades consider that they use solving problems using visual aid more? What is the attitude of high school students about the relationship between the substantiality of the picture (the amount of data it encompasses) and the difficulty of solving the problem? What is the attitude of students about the use of software to solve mathematical problems? The research has been conducted with 1,240 high school students from Sarajevo, Bosnia & Herzegovina. For the purposes of this article, we employed a survey, questionnaire-based research. The research was created as part of a larger study conducted in the context of preparing a doctoral dissertation related to VMC. It is one fundamental research. An essential aspect of this research involves students’ attitudes toward VMC. After obtaining all necessary approvals from relevant institutions and parents, students proceeded to testing and surveying in their school classrooms, under the supervision of designated individuals who facilitated the conduct of the research. The distribution of the data was not normal, so we used the Pearson Chi-square, likelihood ratio Chi-square, and linear-by-linear association test to examine the association between student attitudes and categorical variables (gender and grade). In addition, we used frequencies and percentages. It has been concluded that the students are mostly positive towards applying visualization in their process of solving mathematical problems and these should be used in the direction of improving the students’ success, their confidence and their level of contentment in their mathematics class, as well as in other life situations that encompass mathematical content. In future research, it could be examined why students expressed such attitudes about the presented situations. Additionally, it would be significant to explore why students do not consider themselves successful in applying VMC, despite claiming to understand the term. The analysis could extend to the content presented in textbooks or instructional materials students use–how visualized the content is or whether students are required to visualize it themselves. It would also be worthwhile to investigate the extent to which teachers encourage students to visualize specific tasks or do so on their behalf. Given the fluctuation in results (we observe affirmative answers–partially or completely) observed across grades–initial decrease, subsequent increase, followed by another decrease–it might be explored whether this is related to the curriculum taught in each grade (such as content, volume, number of class hours, etc.). Regarding images leading to incorrect conclusions, it would be interesting to investigate the types of images students have in mind, how frequently they encounter such situations, where they use these images, who creates them, and similar aspects. These are just some questions for future research.