Globally, when accessing and driving in public transport vehicles, women have a problem with fear, experiences of sexual harassment and violence. Women's daily trips are very different from those made by men. These factors make a woman more vulnerable, as standard public transport companies do not consider these characteristics enough. The safe public transport option also helps increase the number of women in economic activities. The way of traveling determines the type of work or shift that the woman will accept. Mobility provides women with financial strength and independence, and currently access to safe public transport, both in Sarajevo Canton and throughout Bosnia and Herzegovina, and it can be said that it is not at a satisfactory level in the region, so urgent actions need to be taken. The concept for the implementation of gender equality within the Erasmus + TRAFSAF project, modeled on EU projects, is that all project partners, both those coming from the segment of higher education and NGOs, keep gender statistics and that measures to promote enrollment must be provided. female populations at all levels of study. It is also a requirement for project participants to increase the participation of women as trainers, as well as to enhance the presence of women in trainings related to traffic safety during the project. These activities should continue after the completion of the project, bearing in mind that it is necessary to integrate gender equality in the segment of traffic safety.

Abstract This paper is concerned with a recently introduced graph invariant, namely the Sombor index. Some bounds on the Sombor index are derived, and then utilized to establish additional bounds by making use of the existing results. One of the direct consequences of one of the obtained bounds is that the cycle graph Cn attains the minimum Sombor index among all connected unicyclic graphs of a fixed order n ≥ 4. Graphs having the maximum Sombor index are also characterized from the classes of all connected unicyclic, bicyclic, tricyclic, tetracyclic, and pentacyclic graphs of a fixed order, and a conjecture concerning the maximum Sombor index of graphs of higher cyclicity is stated. A structural result is derived for graphs with integer values of Sombor index. Several possible directions for future work are also indicated.

It is well known that the Golden Section plays an important role in the geometry of several polygons and polyhedra; the best known example is the length of a diagonal in the regular pentagon with unit side. In this contribution we show how the Golden Section appears as the solution of an enumerative problem connected with heptagons, more precisely, with heptagonal tilings of the hyperbolic plane. The results are then generalized by investigating whether it also appears in other types of hyperbolic tilings.

The Sombor index is a recently introduced graph-theoretical invariant of the bond-additive type. It is known that it takes integer values for bipartite semi-regular graphs whose degrees appear as two smaller elements in a Pythagorean triple. In this note, we show that it can have integer values also for graphs with more complicated structure and construct infinite families of graphs with integer Sombor indices.

Traditional drug discovery strategies are usually focused on occupancy of binding sites that directly affect functions of proteins. Hence, proteins that lack such binding sites are generally considered pharmacologically intractable. Modulators of protein activity, especially inhibitors, must be applied in appropriate dosage regimens that often lead to high systemic drug exposures in order to maintain sufficient protein inhibition in vivo. Consequently, there is a risk of undesirable off-target drug binding and side effects. Recently, PROteolysis TArgeting Chimera (PROTAC) technology has emerged as a new pharmacological modality that exploits PROTAC molecules for induced protein degradation. PROTAC molecule is a heterobifunctional structure consisting of a ligand that binds a protein of interest (POI), a ligand for recruiting an E3 ubiquitin ligase (an enzyme involved in the POI ubiquitination) and a linker that connects these two. After POI-PROTAC-E3 ubiquitin ligase ternary complex formation, the POI undergoes ubiquitination (an enzymatic post-translational modification in which ubiquitin is attached to the POI) and degradation. By merging the principles of photopharmacology and PROTAC technology, photocontrollable PROTACs for spatiotemporal control of induced protein degradation have recently emerged. The main advantage of photocontrollable over conventional PROTACs is the possible prevention of off-target toxicity thanks to local photoactivation.

Obilježavanje 170 godina od smrti Petra II Petrovića Njegoša (1813–1851) prilika je da se utvrde dosadašnji dometi njegošologije, koji svjedoče o Njegoševom nepojmljivom umotvornom potencijalu, o kompleksnosti njegovog ukupnog prosvjetiteljskog djelovanja i o njegovoj pjesničkoj poziciji, ali i da se otvore novi horizonti i mogućnosti za ispitivanje do sada nedovoljno istraženih ili neopravdano zapostavljenih kodova Njegoševog poetskog opusa.