Abstract This paper explores the role of knowledge visualization in facilitating decision-making in cultural heritage management. The paper addresses the issue in the specific context of stećci - the tombstones from medieval Bosnia inscribed on the UNESCO world heritage list. Grounded in the distant reading paradigm, the paper introduces a series of visualizations of spatial, temporal, architectural, iconographical, epigraphical, and impact analyses of stećci data. Together, these visualizations should enable decision-makers to gain an enhanced understanding and knowledge of this important cultural heritage. In turn, this should help them make better decisions regarding their protection and promotion.

Healthy and controlled immune response in COVID-19 is crucial for mild forms of the disease. Although CD8+ T cells play important role in this response, there is still a lack of studies showing the gene expression profiles in those cells at the beginning of the disease as potential predictors of more severe forms after the first week. We investigated a proportion of different subpopulations of CD8+ T cells and their gene expression patterns for cytotoxic proteins (perforin-1 (PRF1), granulysin (GNLY), granzyme B (GZMB), granzyme A (GZMA), granzyme K (GZMK)), cytokine interferon-γ (IFN-γ), and apoptotic protein Fas ligand (FASL) in CD8+ T cells from peripheral blood in first weeks of SARS-CoV-2 infection. Sixteen COVID-19 patients and nine healthy controls were included. The absolute counts of total lymphocytes (p = 0.007), CD3+ (p = 0.05), and CD8+ T cells (p = 0.01) in COVID-19 patients were significantly decreased compared to healthy controls. In COVID-19 patients in CD8+ T cell compartment, we observed lower frequency effector memory 1 (EM1) (p = 0.06) and effector memory 4 (EM4) (p < 0.001) CD8+ T cells. Higher mRNA expression of PRF1 (p = 0.05) and lower mRNA expression of FASL (p = 0.05) at the fifth day of the disease were found in COVID-19 patients compared to healthy controls. mRNA expression of PRF1 (p < 0.001) and IFN-γ (p < 0.001) was significantly downregulated in the first week of disease in COVID-19 patients who progressed to moderate and severe forms after the first week, compared to patients with mild symptoms during the entire disease course. GZMK (p < 0.01) and FASL (p < 0.01) mRNA expression was downregulated in all COVID-19 patients compared to healthy controls. Our results can lead to a better understanding of the inappropriate immune response of CD8+ T cells in SARS-CoV2 with the faster progression of the disease.

Background: Neurogenic stuttering is a subtype of acquired stuttering, and it is characterized by disfluencies associated with acquired brain damage. Objective: To provide an insight into pathophysiology, symptomatology, differential diagnosis, assessment, and treatment of neurogenic stuttering through a critical review of the literature. Methods: Studies published during the past and recent years were searched and analyzed on neurogenic stuttering. Results: Neurogenic stuttering is a complex disorder. The pathophysiological mechanism of neurogenic stuttering is not yet fully understood. It appears with several neurological diseases and conditions, and the use of some drugs. Differential diagnosis of neurogenic and psychogenic stuttering is a challenge for clinicians. Treatment usually requires a joint effort from speech therapists and doctors, most often neurologists Conclusion: Although research on neurogenic stuttering can be found in the literature, the complexity of this disorder still requires detailed monitoring and studying to provide the best treatment for patients.

Zbog svojih jedinstvenih i rijetkih kolekcija, Specijalne zbirke Nacionalne i univerzitetske biblioteke Bosne i Hercegovine (NUBBiH) su nezamjenjiv izvor za mnogostruke istraživačke projekte i naučne radove. Već dugi niz godina NUBBiH ulaže napor da putem svojih projekata naučnoj zajednici pobliže predstavi vrijedne kolekcije Specijalnih zbirki. Da bi se korisnicima osigurao brži i lakši pristup građi, a ujedno i zaštitili originalni dokumenti od njihovog daljeg propadanja, građa koja je obuhvaćena projektima digitalizira se i prezentira kroz Digitalne kolekcije NUBBiH. U ovom radu predstavit ćemo jedan takav projekt, a to je projekt zaštite i prezentacije Arhiva poljičkih isprava iz Zbirke Aleksandra Poljanića te ćemo prikazati dosadašnje rezultate, kao i krajnje ciljeve ovoga projekta. = The Special Collections of the National and University Library of Bosnia and Herzegovina (NULBIH) are an irreplaceable source for multiple research projects and scientific papers. For many years, NULBIH has been strengthening efforts to present values of Special Collections to the scientific community through its projects. To provide users with faster and easier access to the material, and at the same time to protect the original documents from their further deterioration, the materials covered by the projects are digitized and presented through the Digital Collections portal of the National and University Library of BIH. In this article, we will present the ongoing project “Protection and presentation of the Poljica Documents Archive from the Collection of Aleksandar Poljanić” and so far, the results and ultimate goals of this project.

Apocrine carcinoma of the breast is a rare malignancy. According to 2019 WHO classification, apocrine cellular features and a characteristic steroid receptor profile (Estrogen receptor (ER)-negative and androgen receptor (AR)-positive) define apocrine carcinoma. Her-2/neu protein expression is reported in ∼30-50% of apocrine carcinomas, while NGS analysis showed frequent PIK3CA/PTEN/AKT and TP53 mutations Followed by deregulation in the mitogen-activated protein kinase pathway components (mutations of KRAS, NRAS, BRAF). A recent miRNA study indicates various miRNAs (downregulated hsa-miR-145-5p and upregulated 14 miRNAs such as hsa-miR-182-5p, hsa-miR-3135b, and hsa-miR-4417) may target the commonly altered pathways in apocrine carcinomas such as ERBB2/HER2 and mitogen-activated protein kinase signaling pathway. Although AR expression is a hallmark of apocrine carcinoma, little is known regarding the efficacy/resistance to antiandrogens. Success of bicalutamide, a non-steroidal anti-androgen, was reported in a case of Her2-negative apocrine carcinoma. Two recent studies, however, described presence of anti-androgen resistance biomarkers (a splice variant ARv7 and AR/NCOA2 co-amplification) in a subset of AR+ apocrine carcinomas, cautioning the use of anti-androgens in AR+ triple-negative breast carcinomas. Apocrine carcinomas rarely show biomarkers predictive of response to immune checkpoint inhibitors (PD-L1 expression, MSI-H status, and TMB-high). Therefore, a comprehensive cancer profiling of apocrine carcinomas is necessary to identify potential therapeutic targets for a truly individualized treatment approach.

Abstract The electricity supplier, having direct contact with end consumers, has significant potential for contributing to the achievement of country’s strategic goals related to increasing the share of electricity production from renewable energy sources and promoting efficient use of electricity. This paper presents the concept of conducted analyses of energy efficiency at the customers of JP Elektroprivreda BH d.d. Sarajevo for the purpose of identifying consumers where it would be useful to apply some of the energy efficiency measures and/or peak load management, all for reducing electricity costs. The results of the analysis are presented in the paper. Special attention is given to the techno-economic analysis of the application of measures used to improve the energy efficiency. The results of the analyses show that the shortest payback period is achievable by adequate waste heat recovery in compressors and refrigeration systems, reactive power compensation, control of motor drives of pumps and fans, and the replacement of motors with a higher efficiency class.

Abstract In the process of designing a system, it is necessary to identify potential threats to that system and to include appropriate countermeasures. The process that helps in finding problems in the initial phase of the system design is the threat modeling. Creating a threat model consists of several steps and there are many tools that can help in automating the procedure. This article deals with the threat analysis for an Ambient Assisted Living (AAL) system based on Wireless Sensor Network (WSN), whose main function is to provide information for carers in order to provide the best possible help to the elderly and disabled. We have identified and analysed 99 potential threats to the considered system, where Denial of Service (DoS) resulted in being the most represented class of threats. After conducting the threat assessment, the obtained results showed that the majority of threats are high-risk and justified the use of threat modeling in the design phase, since they can be utilized in further system development stages.

The increasing use of video streaming services that followed the Covid-19 pandemic has more than ever driven a rising interest among various stakeholders in service provisioning chain to understand factors influencing quality of experience (QoE). Many research activities have so far addressed different influence factors in order to understand and improve QoE when using video streaming service. However, we have recognized the requirement to address QoE as multidimensional concept, and show the relationship between QoE, perceptual dimensions, and influence factors. In this paper, we provide the multidimensional modelling and analysis of QoE for video streaming. Result analysis has shown that QoE for video streaming can be modelled by using perception of quality of video and perception of ease of use of application as predictors. The analysis of influence of individual system (i.e., resolution, coding tree unit (CTU), and constant rate factor (CRF)), context (i.e., location, lighting, and video type), and human (i.e., gender, education level, and prior experience) factors and their interactions on QoE perceptual dimensions (i.e., perception of quality and perception of ease of use) show statistically significant impacts, which means that alternations of these factors can enhance perceptual dimensions and consequently QoE for video streaming which is a final goal.

The efficient development and utilisation of magnetic nanoparticles (MNPs) for applications in enhanced biosensing relies on the use of magnetisation dynamics, which are primarily governed by the time-dependent motion of the magnetisation due to externally applied magnetic fields. An accurate description of the physics involved is complex and not yet fully understood, especially in the frequency range where Néel and Brownian relaxation processes compete. However, even though it is well known that non-zero, non-static local fields significantly influence these magnetisation dynamics, the modelling of magnetic dynamics for MNPs often uses zero-field dynamics or a static Langevin approach. In this paper, we developed an approximation to model and evaluate its performance for MNPs exposed to a magnetic field with varying amplitude and frequency. This model was initially developed to predict superparamagnetic nanoparticle behaviour in differential magnetometry applications but it can also be applied to similar techniques such as magnetic particle imaging and frequency mixing. Our model was based upon the Fokker–Planck equations for the two relaxation mechanisms. The equations were solved through numerical approximation and they were then combined, while taking into account the particle size distribution and the respective anisotropy distribution. Our model was evaluated for Synomag®-D70, Synomag®-D50 and SHP-15, which resulted in an overall good agreement between measurement and simulation.

Introduction: Prostate cancer has been the leading type of cancer to affect male population, and as such, it is a subject to efforts to furthermore diagnostic tools already in existence as well as development of new ones which will Aid early diagnostic, treatments as well as a follow up procedures and clinical trials. Bone scan index is a useful and objective biomarker used as a valuable tool for determination as to precise bone involvement in advanced cases, as well as a tool to predict the outcome in prostate cancer patients in clinical trials.Methods: This paper is a non-experimental (qualitative) research, that is, a scientific review of the literature.Results: The results we analyzed in this paper were collected from published academic journals.Conclusion: As a new imaging biomarker, bone scan index has potential to predict therapeutic effects and survival of patients with prostate cancer. Using measurable diagnostic image parameters, the bone scan index is important for determining metastatic bone changes in prostate cancer patients.