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Digital technologies in the modern era are almost mandatory for the presentation of all types of cultural heritage. Virtual depictions of crafts and traditions offer the users the possibility of time travel, taking them to the past through the use of 3D reconstructions of cultural monuments and sites. However, digital resources alone are not enough to adequately present cultural heritage. Additional information on the historical context in the form of stories, virtual reconstructions, and digitized objects is needed. All of this can be implemented using a digital multimedia presentation technique called digital storytelling. Nowadays, an integral part of many museum exhibitions is interactive digital storytelling. This paper gives an overview of the techniques and discusses different means of facilitating interaction on digital storytelling applications for virtual cultural heritage presentations. We describe the ways in which natural interaction and interaction via eXtended Reality (Virtual and Augmented Reality) applications for cultural heritage are made possible. Users will find the stories told through these applications educational and entertaining at the same time. Through user-experience studies, we measure the user edutainment level and present how users react to implemented interactions.

Background Tobacco tax policy in Bosnia and Herzegovina (B&H) assumes a gradual annual increase in specific excise taxes on cigarettes. However, it is insufficient to reduce significantly consumption. This paper examines effects of the increase in cigarette prices and disposable income on cigarette demand in B&H by different income consumer groups. Methods Based on the Household Budget Surveys and microdata from 2007, 2011 and 2015, we employed logit model to estimate prevalence and Deaton’s model to estimate intensity elasticity of cigarette demand for the sample of 21 424 households (9953 are smoking households) by different income groups. We used obtained elasticities and estimated the impact of tax increase on cigarette consumption and government revenue in three tax increase scenarios. Results Ten per cent price increase would reduce the consumption of low-income households by 14%, as opposed to 9.9% for middle-income and 7% for high-income households. Low-income households would significantly increase the demand for cigarettes compared with high-income households if income increased. Increase in the specific excise tax by 25% would reduce cigarette consumption and increase government revenue, while the low-income group would experience a reduction in tax burden. Conclusions Changes in prices have different impacts on tobacco prevalence and consumption of low-income compared with middle-income and high-income socioeconomic groups. Low-income households are most responsive to changes in prices and income. Thus, the poor in B&H would benefit from an increase in tobacco excise taxes and price.

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Purpose Apocrine carcinoma of the breast (APO) expresses HER2 in 30–50% of cases. This study explored the clinicopathological features and outcome of HER2+/APO and matched HER2+/NST cohort. Methods We used the SEER database to explore the cohorts. Univariate and multivariate analyses were used to assess the survival. Based on ER and PR [steroid receptors/SR/] and HER2 status, we divided the cohorts to match the intrinsic molecular subtypes for comparisons. Results We retrieved 259 cases of HER2+/APO. Most HER2+/APO were SR negative (65%). HER2+/APO were more prevalent in the 80+ age group (24.7% vs. 15.7%, p  < 0.001). HER2+/SR−/APO had a significantly lower histological grade than the HER2+/SR−/NST ( p  < 0.001). Breast cancer-related deaths were more prevalent in HER2+/NST (7.8% vs. 3.9%, p  = 0.019). This was particularly evident between SR− subgroups (10.4% in HER2+/SR−/NST vs. 4.2% in HER2+/SR−/APO, p  = 0.008) and was reaffirmed in breast cancer-specific survival in univariate analysis ( p  = 0.03). Other than race and SR status, HER2+/APO subgroups did not differ in clinicopathological parameters. Conclusions Our study confirms the rarity of the APO and reveals that SR status in APO does not affect these patients' prognosis. HER2+/APO tumors tend to have a less aggressive phenotype and a more favorable outcome despite a markedly lower ER/PR positivity.

ABSTRACT Introduction Neuroactive peptides are peptides produced by neurons and released through controlled mechanisms that bind to specific receptors on nerve, glial, or other cell types, causing biochemical response(s) within these cells. Areas covered This article summarizes and interprets recent advancements in our knowledge of neuroactive peptides with pro- or anti-convulsant action, and about new drugs that use the molecular machinery of neuroactive peptides to suppress seizures. Expert opinion According to the results of preclinical and limited clinical investigations to date, the highest potential to become anti-epileptic drugs with marketing authorization belongs to non-peptide agonists of melanocortin receptors, thyrotropin-releasing hormone receptors, ghrelin receptors, galanin receptors, somatostatin and cortistatin receptors, oxytocin receptors, cholecystokinin receptors, and opioid kappa receptors, followed by non-peptide antagonists of the renin-angiotensin system, corticotropin-releasing hormone receptors, NK1 receptors for substance P, arginine-vasopressin receptors, and opioid delta receptors.

Background Diesel engine exhaust causes adverse health effects. Meanwhile, the impact of renewable diesel exhaust, such as hydrotreated vegetable oil (HVO), on human health is less known. Nineteen healthy volunteers were exposed to HVO exhaust for 3 h in a chamber with a double-blind, randomized setup. Exposure scenarios comprised of HVO exhaust from two modern non-road vehicles with 1) no aftertreatment system (‘HVO PM+NOx ’ PM1: 93 µg m −3 , EC: 54 µg m −3 , NO: 3.4 ppm, NO 2 : 0.6 ppm), 2) an aftertreatment system containing a diesel oxidation catalyst and a diesel particulate filter (‘HVO NOx ’ PM1: ~ 1 µg m −3 , NO: 2.0 ppm, NO 2 : 0.7 ppm) and 3) filtered air (FA) as control. The exposure concentrations were in line with current EU occupational exposure limits (OELs) of NO, NO 2 , formaldehyde, polycyclic aromatic hydrocarbons (PAHs), and the future OEL (2023) of elemental carbon (EC). The effect on nasal patency, pulmonary function, and self-rated symptoms were assessed. Calculated predicted lung deposition of HVO exhaust particles was compared to data from an earlier diesel exhaust study. Results The average total respiratory tract deposition of PM1 during HVO PM+NOx was 27 µg h −1 . The estimated deposition fraction of HVO PM1 was 40–50% higher compared to diesel exhaust PM1 from an older vehicle (earlier study), due to smaller particle sizes of the HVO PM+NOx exhaust. Compared to FA, exposure to HVO PM+NOx and HVO NOx caused higher incidence of self-reported symptoms (78%, 63%, respectively, vs. 28% for FA, p  < 0.03). Especially, exposure to HVO PM+NOx showed 40–50% higher eye and throat irritation symptoms. Compared to FA, a decrement in nasal patency was found for the HVO NOx exposures (− 18.1, 95% CI: − 27.3 to − 8.8 L min −1 , p  < 0.001), and for the HVO PM+NOx (− 7.4 (− 15.6 to 0.8) L min −1 , p  = 0.08). Overall, no clinically significant change was indicated in the pulmonary function tests (spirometry, peak expiratory flow, forced oscillation technique). Conclusion Short-term exposure to HVO exhaust concentrations corresponding to EU OELs for one workday did not cause adverse pulmonary function changes in healthy subjects. However, an increase in self-rated mild irritation symptoms, and mild decrease in nasal patency after both HVO exposures, may indicate irritative effects from exposure to HVO exhaust from modern non-road vehicles, with and without aftertreatment systems.

Diesel engine exhaust causes adverse health effects. Meanwhile, the impact of renewable diesel exhaust, such as hydrotreated vegetable oil (HVO), on human health is less known. Nineteen healthy volunteers were exposed to HVO exhaust for 3 h in a chamber with a double-blind, randomized setup. Exposure scenarios comprised of HVO exhaust from two modern non-road vehicles with 1) no aftertreatment system (‘HVOPM+NOx’ PM1: 93 µg m−3, EC: 54 µg m−3, NO: 3.4 ppm, NO2: 0.6 ppm), 2) an aftertreatment system containing a diesel oxidation catalyst and a diesel particulate filter (‘HVONOx’ PM1: ~ 1 µg m−3, NO: 2.0 ppm, NO2: 0.7 ppm) and 3) filtered air (FA) as control. The exposure concentrations were in line with current EU occupational exposure limits (OELs) of NO, NO2, formaldehyde, polycyclic aromatic hydrocarbons (PAHs), and the future OEL (2023) of elemental carbon (EC). The effect on nasal patency, pulmonary function, and self-rated symptoms were assessed. Calculated predicted lung deposition of HVO exhaust particles was compared to data from an earlier diesel exhaust study. The average total respiratory tract deposition of PM1 during HVOPM+NOx was 27 µg h−1. The estimated deposition fraction of HVO PM1 was 40–50% higher compared to diesel exhaust PM1 from an older vehicle (earlier study), due to smaller particle sizes of the HVOPM+NOx exhaust. Compared to FA, exposure to HVOPM+NOx and HVONOx caused higher incidence of self-reported symptoms (78%, 63%, respectively, vs. 28% for FA, p < 0.03). Especially, exposure to HVOPM+NOx showed 40–50% higher eye and throat irritation symptoms. Compared to FA, a decrement in nasal patency was found for the HVONOx exposures (− 18.1, 95% CI: − 27.3 to − 8.8 L min−1, p < 0.001), and for the HVOPM+NOx (− 7.4 (− 15.6 to 0.8) L min−1, p = 0.08). Overall, no clinically significant change was indicated in the pulmonary function tests (spirometry, peak expiratory flow, forced oscillation technique). Short-term exposure to HVO exhaust concentrations corresponding to EU OELs for one workday did not cause adverse pulmonary function changes in healthy subjects. However, an increase in self-rated mild irritation symptoms, and mild decrease in nasal patency after both HVO exposures, may indicate irritative effects from exposure to HVO exhaust from modern non-road vehicles, with and without aftertreatment systems.

The aim of this research is to identify the motivational structure of recreational exercisers and to investigate differences in motivation with respect to gender, ie to determine the hierarchy of motives for which they choose recreational exercise. This research shows that the strongest motivation for recreational exercise is maintaining and improving health, and certainly relaxation. After them, the most important motivation is socializing and meeting new people, and improving and maintaining physical ability. The research also showed that there are very small differences in the motives for exercise in relation to the age of the respondents, and they are reflected in good looks and fun, while relaxation and relaxation and improvement and maintenance of physical ability are equally important for all ages.

Insufficient physical activity is the fourth leading risk factor for mortality. According to the World Health Organization (WHO, 2012), people who are insufficiently physically active have a 20% to 30% increased risk of all-cause mortality compared to those who engage in at least 30 minutes of moderate-intensity physical activity each day. Previous research has confirmed that regular physical activity and well-organized leisure time improves human health and affects the prevention of a number of diseases. The purpose of this paper was to show the habits and attitudes towards the contents of sports recreation through a survey conducted on a sample of students from the University “Džemal Bijedić” in Mostar. 331 students participated in the survey. Of the total number of respondents, 81% are active as athletes and recreational athletes. It is important to emphasize that out of the total number of respondents, 27.8% decide for activities in gyms and exercises on devices.

The research was conducted on a sample of 266 respondents of preschool age, aged 4-6 years of both sexes in Preschool Institution “Zvjezdica” Banja Luka. Out of the total number of respondents, the male population consisted of 137 respondents, while female population consisted of 129 respondents. Disorders of the knee joint, X - legs, O - legs and hyperextension of the legs were used to assess the presence of lower extremity deformities. The main goal of the research was to determine the actual state of frequency and structure of lower extremity deformities in preschool subjects in relation to gender and age. The frequencies and structure of deformities of the lower extremities are shown in tabular relation to the sex and age of the subjects. The results of the research indicate a slightly higher frequency of lower extremity deformities in boys compared to girls, and the highest frequency of presence was found in subjects of both sexes aged 4 years, and slightly lower in subjects aged 5 years. It is surprising that the presence of deformities was not determined in subjects of both sexes aged 6 years. However, these results also oblige us to be careful and constantly and continuously monitor the postural status of children in order to timely identify physical disorders and take adequate activities in preventive and corrective work. The obtained results should initiate activities in order to timely diagnose, control and undertake effective programs of corrective exercise in preschool children.

This research was conducted in order to determine whether and what to extent the three-month fitness program affect changjes in body composition on a sample of 42 exercisers, recreational athletes, ages between 21 and 35. The measurement was performed using a Tanita scale, model BC-543, and the following variables were applied: body weight, muscle mass and percentage of fat. After the initial measurement, a three-month fitness exercise program was applied, and then the final measurement in order to determine the achieved effects of training. Trainings were performed three times a week and were adjusted to each recreational athlete in proportion to the age and current state of training. In the process of statistical data processing, descriptive and comparative statistics procedures were used. The basic statistical parameters for each subject were calculated individually and it was determined that there are statistically significant differences between the initial and final measurements.

Istraživanje na temu „Socijalno-ekonomski uzroci i posljedice odlaska mladih iz Bosne i Hercegovine“ je imalo za cilj locirati, analizirati i utvrditi razloge, motive i povode za napuštanjem svoje domovine i odlaskom u druge destinacije na planeti Zemlji, s težištem na socijalno-ekonomske posljedice tih odlazaka. Autori u radu težišno analiziraju i interpretiraju teorijske i empirijske spoznaje o posljedicama koje uzrokuju odlasci mladih iz Bosne i Hercegovine.Polazeći od multidimenzionalnosti problema odlaska mladih iz Bosne i Hercegovine koji iziskuje identifikaciju faktora na individualnom, porodičnom i društvenom nivou i koji doprinose ovoj pojavi, istraživanje je fokusirano na individualne, endogene i institucionalne faktore koji uzrokuju odlazak mladih iz Bosne i Hercegovine, kao i na socijalnoekonomske posljedice koje odlazak mladih nosi sa sobom.U procesu istraživanja korištene su sljedeće metode i tehnike: analiza sadržaja, upitnik, intervju, studija slučaja, anketa i statistička metoda. Za uzorak je korišten stratifikovani uzorak vodeći računa o proporcionalnoj i teritorijalnoj zastupljenosti mladih. Istraživanjem je obuhvaćeno 600 mladih osoba koje su u periodu istraživanja imale od 18 do 29 godina.Istraživanje provedeno u Bosni i Hercegovini u periodu 2019. godine i 2020. godine, pokazalo je da postoji više razloga, faktora i uzroka zašto mladi odlaze iz BiH te da su mladi ljudi, dobi od 18 do 29 godina, zastupljeni sa 69% od ukupnog broja onih koji odlaze, dok 31% pripadaju ostalim starosnim skupinama. Na temelju dobivenih rezultata založili smo se za implikaciju sagledavanja negativnih utjecaja socijalnih faktora na socijalno-ekonomske uzroke odlaska mladih iz Bosne i Hercegovine.