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Various activities in the tourism sector, especially transportation, have a negative impact on the atmospheric complex. The paper aims to re­search tourism’s impact on global carbon dioxide emissions, the generation of photochemical smog, and noise and light pollution. Various tourism in­dustry activities have been identified, as well as tourist transport factors on which the intensity of air pollution depends. To demonstrate the harmful effects, statistical indicators and other results of modern scientific research were used, including the consequences of pollution on the living world. The paper provides current knowledge in the field, highlighting the risks of mass tourism, and the global need for more rational planning of sustainable tour­ism development.

Cardiotoxicity is one of the most important side effects of first-line chemotherapy medications. It is influenced by genetic variation, whereby the relationship between the chemotherapeutic dose and the risk of cardiotoxicity can be altered. The incidence of cardiotoxicity depends on the substance used in the therapeutic modality of cancer and can reach an incidence of 30% during a three-year follow-up. The main element of the clinical picture is systolic dysfunction of the left ventricle, with symptoms of heart failure, which can change or stop oncological therapy, along with pharmacological treatment of heart failure. These symptoms can occur during prolonged use of cancer therapies, monitoring the patient is advisable. Considering the increasing success of oncology therapy and the extension of life, as well as the improvement of the quality of life, a multidisciplinary approach, as well as the symbiosis of the work of cardiologists and oncologists, is imperative. Patient stratification concerning oncological treatment modality is imposed as part of a cardiologist's daily work from the beginning of cancer treatment.

Sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors) represent a therapeutic modality option for type 2 diabetes mellitus. This group of drugs includes dapagliflozin, empagliflozin, canagliflozin, ertugliflozin and sotagliflozin. Given their proven benefit in the scope of heart failure through clinical studies, they have also gained their place in patients with reduced, moderately reduced, or preserved systolic function of the left ventricle. Due to the effect on both the systolic and diastolic function of the left ventricle, and the neurohumoral activity itself, their range of use has been expanded in patients without a history of diabetes mellitus, and empagliflozin in a dose of 10 mg, as well as dapagliflozin in a dose of 10 mg, have been implemented in patients without diabetes mellitus. New directions for the expansion of the use of SGLT2 inhibitors have pointed towards their applicability in acute heart failure (sotagliflozin) and type 1 diabetes (sotagliflozin). Recently, clinical studies concerning the use of empagliflozin and dapagliflozin in acute coronary syndrome (ACS), appeared. The aim of this paper was to highlight the possible benefit of including SGLT2 inhibitors in patients with ACS.

Maja Arapović, Marica Mamut

Geoekološko vrednovanje reljefa Parka prirode Hutovo blato s aspekta njegove turističke i rekreacijske valorizacije provedeno je na temelju prethodne geomorfološke analize. U radu je promatran turizam i rekreacija kao sociološki elementi razvoja parka prirode Hutovo blato. Za postupak geoekološkog vrednovanja izdvojeni su reljefni oblici određenog stupnja atraktivnosti (vrhovi, padine, korita i dolinska dna, vododerine, područje oko Deranskog jezera, područje oko Svitavskog jezera i Svitavsko jezero), koji su vrednovani za sljedeće oblike rekreacije: šetnja, brdski biciklizam, rekreacijski biciklizam, promatranje ptica i krajolika te kajaking i kanuing. Stupanj pogodnosti reljefa za navedene vidove rekreacije određen je na temelju fizičke pogodnosti, estetske vrijednosti i dostupnosti. U postupku vrednovanja primijenjena je metoda relativnog vrednovanja reljefa. Provedeno vrednovanje ukazalo je na vrijedne i potencijalno vrijedne dijelove reljefa, ali i na one ograničavajuće elemente krajolika, zbog kojih pojedini dijelovi nisu do sada dovoljno turistički valorizirani. To se posebno odnosi na istočni i jugoistočni dio Parka s izraženim problemom fizičke pogodnosti i (ne)dostupnosti (udaljenost te nepostojanje ili neuređenost pješačkih staza, otežane plovnosti, nepristupačnosti obale obrasle vegetacijom). Predložene su moguće aktivnosti za povećanje geoekološke vrijednosti prostora (uređivanje infrastrukture za rekreacijski biciklizam, te obnova starih i uređenje novih edukativnih staza za šetnju i edukaciju na prostoru koji ima potencijal postati zanimljiv i atraktivan dio Parka prirode Hutovo blato).

M. Kašanin-Grubin, G. Veselinović, Nevena Antić, G. Gajica, S. Stojadinović, A. Šajnović, S. Štrbac

Soil erosion is a problem that affects the landscape at different scales and represents a serious challenge for land management and soil conservation in both natural forests and meadows. The aim of this study was to determine how the parent material and land use affect the physical and chemical properties of the soil in the area of the Fruska gora Mountain. The soils were developed on five bedrock types: serpentinite, marl, trachyte, shale, loess and two land use types: forest and meadow. Twenty-three forest soil and 24 meadow soil from a depth of 0-20 cm were sampled from the Fruska gora Mt. Following properties were determined: pH, electrical conductivity, oxidation-reduction potential, content of organic carbon, sodium adsorption ratio, aggregate size and stability. There is no statistically significant difference in pH, Eh, EC, and SAR values between the analyzed forest and meadow soils, but there is a statistically significant difference in the content of Corg. It can be conculded that both the parent matrial, and to a slightly less extent, land use have a great influence on physico-chemical properties of the soil.

Carlo Allocca, Samia Jilali, Rohit Ail, Jaehun Lee, Byungho Kim, A. Antonini, E. Motta, J. Schellong et al.

A. Luschi, Camilla Petraccone, G. Fico, L. Pecchia, E. Iadanza

The healthcare environment is made up of highly complicated interactions between many technologies, activities, and people. Ensuring a solid communication between them is vital to ease the healthcare management. Semantic ontologies are knowledge representation tools that implement abstractions to fully describe a given topic in terms of subjects and relations. This scoping review aims to identify and analyse available ontologies which can depict all the available use-cases that describe the hospital environment in relation to the European project ODIN and its future expansion. The review has been conducted on the Scopus database on January 13th, 2023 using the PRISMA extensions for scoping reviews. Two reviewers screened 3,225 documents emerged from the database search. Further filtering led to a final set of 32 articles to be analysed for the results. A set of 34 ontologies extracted by the identified articles has been analysed and discussed as well. The results of this study will lead to the implementation of a common integrated ontology which could hold information about healthcare entities as well as their semantic relationships, strengthen data exchange and interconnections among people, devices and applications in an expanded scenario which include Internet of Things, robots and Artificial Intelligence.

P. Ciambelli, L. Palma, Leone Mazzeo, Tamara Boscarino, Maria Beatrice Falasconi, S. Polvi, V. Piemonte, L. Pecchia

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