Sensory integration is the organization of the sense for their use. It is a neuro-biological activity that allows the reception and processing of sensory information, which in large quantity arrive to the brain, at all times. The brain's ability to successfully process tactile information allows the child to feel safe and develop a connection with those around they. Children with Down syndrome may have difficulties of sensory integration. Decreased awareness and attention to tactile stimulation is possible, which leads to a reduction in tactile discrimination and difficult manipulation of objects, or to an increased response to sensory stimuli in the form of tactile defense. The aim of the study is to examine the prevalence of sensory integration of the tactile sensory system of children with Down syndrome, and to determine the statistical significance of differences in relation to children without developmental disabilities. The total sample of respondents (N=30) consisted of two subsamples. The first subsample of respondents (N=15) consisted of children with Down syndrome, and the second subsample of respondents (N=15) consisted of children without developmental disabilities. The measurement instrument „Questionnaire for testing tactile sensory sensitivity“ with 11 variables and offered answers of possible sensory response was applied. The Mann-Whitney U test and the Wilcoxon W test at the level of statistical significance of p<0.05 were used to test the statistical significance of the differences between the subsamples of the respondents. The results of the study showed that 66.67% of children with Down syndrome have difficulties with sensory integration of the tactile sensory system. 26.67% of children are hypersensitive and 6.67% are hyposensitive. 33.33% of children with Down syndrome have a mixed type of tactile sensory response. Children with Down syndrome compared to children without developmental disabilities show better results of sensory integration of the tactile sensory system on two variables; „Walking barefoot“ and „Certain types of fabric, seams, labels, belts, cuffs, etc.“. There is a statistically significant difference at the level of p<0.05 between children with Down syndrome and children without developmental disabilities on 5 variables.

Introduction: Burnout syndrome in some European countries is recognized as an occupational disease. In the past time, it has been identified predominantly in the service sectors such as healthcare, social services, mental health and education, but later it started to be predominant in other occupations with high job requirements and time pressure. The aim of this study was to assess the presence of burnout at work among the bank employees of Sarajevo Canton, Bosnia and Herzegovina.Methods: A cross-sectional study was conducted in banks (n = 6) located in Sarajevo Canton, Bosnia and Herzegovina, between January and April 2018. Employees filled out an anonymous questionnaire, after their written informed consent had been obtained. The study included employees regardless of their job positions and job seniority.Results: The total number of surveyed employees was 260. There are not statistically significant gender differences (p = 0.854¸ p < 0.05) compared to the total Maslach Burnout Inventory (MBI) score. Statistically significant differences in relation to the total MBI score were observed in the examinees who have been working in the banking sector between 15 and 20 years (p = 0.04; p < 0.05) and examinees working temporarily <2 h/week (p = 0.016; p < 0.05), that is, more than 8 h/week (p = 0.015; p < 0.05). Mid value and standard deviation of the score in the subscale of emotional exhaustion (EE) is 26.26 ± 11.15, which shows that one third of the examinees are in high risk of EE.Conclusion: We can conclude that less than one third of examinees are in high risk of burnout syndrome.

A well-developed immune system of the organism, which, among other things, arises as a result of a healthy lifestyle, is a prerequisite for a healthy and quality life. Natural food products, primarily honey and other bee products, greatly contribute to the proper development of the body's immune response to the harmful effects of foreign substances. Honey and other bee products are a valuable and rich source of biologically active substances. They have been used for centuries in traditional medicine, due to their wide range of antibacterial, antiradical, antioxidant and anticancer effects, as well as their supportive effect in the prevention and treatment of many diseases. Consumption of honey contributes to the improvement of immunity and enriches the human diet with many valuable nutrients and bioactive substances. Bioactive substances, including polyphenols, are organic chemical compounds naturally present in honey. Polyphenols are important secondary metabolites of plants that are transferred to honey along with nectar, pollen or propolis. Several studies have confirmed the immunomodulatory role of the basic phenolic compounds present in honey. For the purpose of our research, a total of 21 samples of honey and 10 samples of alcoholic propolis extract were collected, mostly from the Federation of Bosnia and Herzegovina. Based on the obtained results, it is clear that honey itself is a rich source of antioxidants in the diet, but that the addition of propolis significantly increases its antioxidant power. The addition of propolis to honey significantly increased the antioxidant activity of all analyzed samples. After the addition of propolis, the highest antioxidant activity was again shown by a sample of forest honey from the area of Bihać, Una-Sana Canton (Š5) and its antioxidant activity is 1143.96 µmol Fe (II) / L. The lowest antioxidant activity after the addition of propolis was shown by the meadow sample of honey from Sanski Most, Una-Sana Canton, (L21), 462.71 µmol Fe (II) / L.Based on the presented results, it is clear that after the addition of propolis in the analyzed honey samples there was a significant increase in the concentration of polyphenols by an average of 11.96%.

Plantation cultivation of grafted walnuts in Bosnia and Herzegovina did not exist until 6 years ago. Walnut seedlings (Juglans regia L) were mainly planted, which showed all the shortcomings related to the trees obtained from the seeds. In the last 5 years, there has been interest in planting grafted walnuts, so in this regard there was a need for controlled introduction of varieties suitable for this area. Research was conducted during 2020 - 2021 at four walnut tree cultivars, Chandler, Franquette, Fernor i Fernette. The aim of the research is to determine how certain varieties behave in agroecological conditions of the Majevica region and on that basis to give a proposal of the best variety for further spread in the area of this region. The research was conducted within the project number 02 / 9-712-1-5-3 / 21. The research was carried out at the Skakava Gornja site at an altitude of 192 m with a southwestern exposure (plot I) and a northeastern exposure at 172 m above sea level (plot II), with a terrain slope of 8%. The research related to vegetative growth included counting and measuring the average, then the minimum and maximum growth during two years. Yield monitoring included counting and measuring fruit number, average fruit size and calculating average yield. Generally the Chandler and Franquette varieties planted on the I plot had a stronger growth. Taking into account the vegetative growth, the number and size of fruits as well as the yield in the observed period, the Chandler and Franquette varieties are recommended for further expansion.

Abstract Aim Intra-articular non-union of fractures is an uncommon but complex problem because in general, it is characterised by marked instability, pain, strength loss and significant functional limitation. The aim of this study is to report our prospective medium-term outcomes of the treatment of intra-articular, distal humeral aseptic non-unions using open reduction and internal fixation, augmented with artificial bone. Materials and methods A retrospective case series of 16 patients with intra-articular, aseptic non-unions of the distal humerus was analysed for range of motion, pain, Mayo Elbow Performance Scores (MEPS) and Oxford Elbow Scores (OES) after 12 months. Mean age was 44 years (range, 18–84 years) and mean total follow-up was 43 months (range, 24–62 months). Results All subjective and objective scores were significantly higher 12 months after treatment with internal fixation and artificial bone augmentation; the mean improvement on the MEPS was 18 points and 17 points on the OES. All patients returned to work, most without limitations. Autografts had worse outcomes compared to allografts regarding post-operative pain and time to return to work. No adverse events related to the artificial bone augmentation were seen and all fractures consolidated. Conclusion The use of two locking plates and bone graft augmentation with autografts or allografts with artificial bone grafts is a successful treatment of intra-articular distal humeral non-unions after hardware failure or biological limitations. Clinical significance The use of artificial bone in the treatment of septic non-unions of the upper limb is safe. When no autograft is possible because of concurrent morbidity, it can be used alone or combined with an allograft to reconstruct the affected bone without leading to extra morbidity or complications. How to cite this article Rollo G, Vicenti G, Rotini R, et al. Open Reduction and Internal Fixation Using Double Plating with Biological and Artificial Bone Grafting of Aseptic Non-unions of the Distal Humerus: Clinical Results. Strategies Trauma Limb Reconstr 2021;16(3):144–151.

Restricting movement for the population and the impact of preventative measures due to the COVID-19 pandemic have spurred research interests in analyzing the healthy lifestyle of the student population. The aim of the study was to examine gender differences between students in physical activity, and the perceptions of physical fitness and well-being during lock-down due to COVID-19. The sample consisted of male (n=268; 25.9%; age 22.56±2.12) and female students (n=768; 74.1%; age 22.12±1.73) at the University of Sarajevo (UNSA). The questionnaire included questions and scales constructed to measure: physical activity, physical fitness, and the acute effects on well-being. χ² independence test were used to determine gender differences (p<0.05). Prior to the declaration of the COVID-19, there was a significant difference in the level of regular physical activity between male and female students at UNSA (p<.01). The data indicated that at that time 65% of male students were regularly physically active, while 45% of female students had regular physical activity. During the lock-down measures at UNSA: 46% of male and 40% of female students reported being regularly physically active and no significant differences were found in relation to gender (p>.05); 65% of male and 58% of female students reported a decline in physical fitness and significant gender differences were found (p<.05). After exercising male students reported better concentration and mood, more energy and motivation, and less nervousness in the range of 62–79%, while female students reported better concentration and mood, more energy and motivation, and less nervousness in the range of 62-81%. No significant differences were found in the physical activity acute effects on students' well-being in relation to gender (p>.05). Although gender differences in physical activity disappeared during the early phase of COVID-19 and lockdown measures, a more pronounced decrease in physical fitness was present in female students. The reported physical activity had equally positive acute effects on students' well-being.

BACKGROUND Digital video recordings are increasingly used across various medical and surgical disciplines with advances in computer hardware and software technologies. The creation of high-quality surgical video footage requires a basic understanding of key technical considerations, together with creativity and sound aesthetic judgment. Online operative videos have become a core resource within neurosurgical education. OBJECTIVE To provide a step-by-step description for making operative videos using a video from a real case as an example. METHODS We recorded an operative video of the microsurgical resection of a right lateral ventricle subependymoma performed by an anterior interhemispheric transcallosal approach. The patient consented to surgical resection of the subependymoma and to publication of this operative video. With the video, we explain the step-by-step process the authors used for developing the raw video into a publishable surgical video. RESULTS The patient depicted in our video tolerated the surgery well and made a complete recovery. The final video produced from the surgery illustrated elements that Operative Neurosurgery, Neurosurgery, and other journals require in surgical videos. CONCLUSION Although more than 1200 peer-reviewed (PubMed) neurosurgical operative videos have been published so far, there has not been a single publication that describes the step-by-step process of producing an operative video. To the best of our knowledge, this is the first published detailed description of editing of an educational operative video in neurosurgery and the first video case report of a microsurgical resection of subependymoma of the lateral ventricle in the peer-reviewed English literature.

The 87Sr/86Sr isotope ratio can, in principle, be used for provenancing of cement. However, while commercial cements consist of multiple components, no detailed investigation into their individual 87Sr/86Sr isotope ratios or their influence on the integral 87Sr/86Sr isotope ratio of the resulting cement was conducted previously. Therefore, the present study aimed at determining and comparing the conventional 87Sr/86Sr isotope ratios of a diverse set of Portland cements and their corresponding Portland clinkers, the major component of these cements. Two approaches to remove the additives from the cements, i.e. to measure the conventional 87Sr/86Sr isotopic fingerprint of the clinker only, were tested, namely, treatment with a potassium hydroxide/sucrose solution and sieving on a 11-µm sieve. Dissolution in concentrated hydrochloric acid/nitric acid and in diluted nitric acid was employed to determine the 87Sr/86Sr isotope ratios of the cements and the individual clinkers. The aim was to find the most appropriate sample preparation procedure for cement provenancing, and the selection was realised by comparing the 87Sr/86Sr isotope ratios of differently treated cements with those of the corresponding clinkers. None of the methods to separate the clinkers from the cements proved to be satisfactory. However, it was found that the 87Sr/86Sr isotope ratios of clinker and cement generally corresponded, meaning that the latter can be used as a proxy for the clinker 87Sr/86Sr isotope ratio. Finally, the concentrated hydrochloric acid/nitric acid dissolution method was found to be the most suitable sample preparation method for the cements; it is thus recommended for 87Sr/86Sr isotope analyses for cement provenancing.

Polyhydramnios is a condition related to an excessive accumulation of amniotic fluid in the third trimester of pregnancy and it can be acute and chronic depending on the duration. Published data suggest that during muscle development, in the stage of late histochemical differentiation decreased mechanical loading cause decreased expression of myosin heavy chain (MHC) type 1 leading to slow-to-fast transition. In the case of chronic polyhydramnios, histochemical muscle differentiation could be affected as a consequence of permanent decreased physical loading. Most affected would be muscles which are the most active i.e., spine extensor muscles and muscles of legs. Long-lasting decreased mechanical loading on muscle should cause decreased expression of MHC type 1 leading to slow-to-fast transition, decreased number of muscle fiber type I especially in extensor muscles of spine and legs. Additionally, because MHC type 1 is present in all skeletal muscles it could lead to various degrees of hypotrophy depending on constituting a percentage of MHC type 1 in affected muscles. These changes in the case of preexisting muscle disorders have the potential to deteriorate the muscle condition additionally. Given these facts, idiopathic chronic polyhydramnios is a rare opportunity to study the influence of reduced physical loading on muscle development in the human fetus. Also, it could be a medical entity to examine the influence of micro- and hypogravity conditions on the development of the fetal muscular system during the last trimester of gestation.

Aim: The aim of this study is to assess the knowledge of sexually transmitted infections (STIs), sexual habits, and behavior among students of medical and nonmedical students in Serbia. Methodology: The cross-sectional study of 1,273 university students of four undergraduate institutions in Serbia, two of medical and two of nonmedical orientation. A standardized questionnaire, prepared in line with the questionnaire of the European health research—the second wave (European Health Interview Survey—EHIS wave 2), according to defined internationally accepted indicators, was used as a survey instrument. Results: Statistically significant difference (p < 0.001) between medical and nonmedical student groups was determined for the following parameters: naming four of five STIs (29.1 vs. 13.4%), knowledge about vaccines against some STIs (26.0 vs. 17.0%), relationship between HPV infection and cervical malignancy (48.2 vs. 16.7%) engaged in the sexual relations (87.9 vs. 76.4%), never used a condom (15.2 vs. 10.4%), underwent gynecological or urological examination (66.7 vs. 44.1%), and tested to one of STIs (10.5 vs. 4.9%). Conclusion: Both student groups have limited knowledge on possible consequences that risky sexual behavior has for reproductive health. Promotion of knowledge about STIs, awareness of all complications, and consequences of these infections certainly affect the reduction of risky behavior.

This paper investigates the impact of foreign direct investment on economic growth, on a sample of three groups of countries, classified according to the criterion of economic development. The research problem that seeks to be solved is defined by the question: Do foreign direct investment affect the economic growth of targeted countries and in what way? The objectives of the research are to explain the mechanism of functioning of foreign direct investment and the implications for macroeconomic growth parameters, ceteris paribus. The results of the research show the existence of correlation and determination of the dependent variable with the variations of the independent variable. In this way, the main hypothesis of the paper was confirmed, that foreign direct investment has a stimulating effect on economic growth and the effect of investment is a priori determined by the defined economic policy and the appropriate institutional and legislative framework of the countries, ceteris paribus. The methods used in this paper are regression analysis, i.e. simple linear regression, and analysis and synthesis of previous research and theoretical findings, in order to draw conclusions by induction. The analysis of the data confirms that foreign direct investments have an impact on the economic growth of each group of countries individually, but that in certain groups this connection is present. Thus, the results of the research showed the existence of a relation between FDI and economic growth, i.e. they emphasized FDI as a significant predictor of economic growth in the targeted groups of countries ceteris paribus. The paper represents the author's contribution to economic theory and practice, and to the general public, but also to decision-makers in developing countries. Further research should be directed towards whether it is possible to influence the increase of GDP by "copying" a certain country in terms of attracting foreigners.