We examine differences between students in physical activity levels at the University of Tuzla. Physical activity was measured using the International Physical Activity Questionnaire (IPAQ long form). Results of the Mann-Whitney U test for physical activity assessment shows that male students achieved higher levels of physical activity at a statistically significant level in four out of a total of seven variables. Keywords: students, physical activity, IPAQ

Measuring scientific impact has long become a fact of academic life. Better scholarly output is related to higher chances of being promoted and winning a research grant. There are numerous ways to measure scholarly impact, such as through the number of publications and citation analysis. The most widely used databases for assessing these metrics are Google Scholar (GS), Scopus, and Web of Science (WoS). The goal of the present paper is to provide an in-depth analysis of GS profiles and to compare GS metrics with different metric indices from Scopus and WoS. An additional goal is to do a qualitative analysis of profiles that were identified as outliers through the visual inspection of various metric indices ratios. The sample for this study consisted of 100 researchers from the University of Sarajevo with highest number of citations according to their GS profiles. The results of this study indicated a high correlation between different metric indices. Outlier analysis revealed several errors in GS profiles, some of which are attributable to GS algorithms. An in-depth analysis of outliers provided important data for identifying limitations of all metrics currently used in researcher’s evaluation. We conclude the article with several suggestions on how to improve the evaluation of individual scholar’s research output.

The aim of the study was to assess gross motor skills between boys and girls of preschool and primary school age. The study included a total sample of 83 respondents (49.3% boys) with an average chronological age of 6.14 ± 2.25 years. The Test of Gross Motor Development–3rd Edition (TGMD-3) was used to verify the set research goal. Research data were analyzed by the method of parametrical statistics. To determine the differences in gross motor skills between boys and girls, t-test was used for an independent sample of respondents. Based on the obtained research results, it can be concluded that there are no statistically significant differences between boys and girls on the locomotor and “Ball skills” subtest. Although no statistically significant differences were recorded, generally, boys achieve better results on the subtest “Ball skills” compared to girls. It is suggested that intervention programs be designed to improve girls' performance in ball skills. Key words: Children, TGMD-3, Locomotor, Ball skills, Gender.

Acta Informatica Medica journal (www.actainformmed.org), as Biomedical Informatics journal, during past 30 years of existing played important role in distribution of knowledge and experience within this scientific field, by publishing contributions of the biomedical experts from worlwide and spreading of Biomedical informatics knowledge and experiences in scientific and academic community. Acta Informatica Medica journal has been founded in the year 1993 as official journal of Bosnian-Herzegovinan Society of Medical Informatics (BHSMI). In the year 2019 Acta Informatica Medica has been accepted as official journal of the European Federation for Medical Informatics (www.efmi.org), besides 3 other journals: International Journal of Medical Informatics, Methods of Information in Medicine and European Journal of Biomedical Informatics. Journal Acta Informatica Medica is abstracted and indexed in 30 on-line data bases, including Pubmed, Pubmed Central, Scopus, Embase, Hinari, etc. The journal follows the Guidelines and recommendations of ICJME, COPE, EASE, WAME, etc. as well as the recommendations of the “Sarajevo Declaration on Integrity and Visibility of Scholarly Journals”, accepted by 17 Editors of biomedical journals at “SWEP 2018” Conference held in Sarajevo and printed in the countries in South-Eastern Europe. SCImago rank for 2021 announced the bibliometric list of the journals deposited in SCOPUS indexed database. On the list are 16 journals which are published in Bosnia and Herzegovina, and between them are 7 within biomedical sciences. Three highest are Bosnian Journal of Basic Medical Sciences - H-Index is 29, Medical Archives - H-Index is 26 and Acta Informatica Medica - H-Index is 24, etc. Acta Informatica Medical journal has Impact Score, Overall Ranking, h-index, SJR, Rating, Publisher updated on May 27, 2022: Impact Score - 1.87; h-Index - 24; Rank -12749 and SJR - 0.372.

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Summary Background The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes a respiratory illness named coronavirus disease 2019 (COVID-19), which is one of the main global health problems since 2019. Glycans attached to the Fc portion of immunoglobulin G (IgG) are important modulators of IgG effector functions. Fc region binds to different receptors on the surface of various immune cells, dictating the type of immune response. Here, we performed a large longitudinal study to determine whether the severity and duration of COVID-19 are associated with altered IgG glycosylation. Methods Using ultra-high-performance liquid chromatography analysis of released glycans, we analysed the composition of the total IgG N-glycome longitudinally during COVID-19 from four independent cohorts. We analysed 77 severe COVID-19 cases from the HR1 cohort (74% males, median age 72, age IQR 25-80); 31 severe cases in the HR2 cohort (77% males, median age 64, age IQR 41-86), 18 mild COVID-19 cases from the UK cohort (17% males, median age 50, age IQR 26-71) and 28 mild cases from the BiH cohort (71% males, median age 60, age IQR 12-78). Findings Multiple statistically significant changes in IgG glycome composition were observed during severe COVID-19. The most statistically significant changes included increased agalactosylation of IgG (meta-analysis 95% CI [0.03, 0.07], adjusted meta-analysis P= <0.0001), which regulates proinflammatory actions of IgG via complement system activation and indirectly as a lack of sialylation and decreased presence of bisecting N-acetylglucosamine on IgG (meta-analysis 95% CI [-0.11, -0.08], adjusted meta-analysis P= <0.0001), which indirectly affects antibody-dependent cell-mediated cytotoxicity. On the contrary, no statistically significant changes in IgG glycome composition were observed in patients with mild COVID-19. Interpretation The IgG glycome in severe COVID-19 patients is statistically significantly altered in a way that it indicates decreased immunosuppressive action of circulating immunoglobulins. The magnitude of observed changes is associated with the severity of the disease, indicating that aberrant IgG glycome composition or changes in IgG glycosylation may be an important molecular mechanism in COVID-19. Funding This work has been supported in part by Croatian Science Foundation under the project IP-CORONA-2020-04-2052 and Croatian National Centre of Competence in Molecular Diagnostics (The European Structural and Investment Funds grant #KK.01.2.2.03.0006), by the UKRI/MRC (Cov-0331 - MR/V027883/1) and by the National Institutes for Health Research Nottingham Biomedical Research Centre and by Ministry Of Science, Higher Education and Youth Of Canton Sarajevo, grant number 27-02-11-4375-10/21.

Simple Summary Recently, the interactions between microbiota and the host have been reported to induce the onset and progression of human cancer via epithelial–mesenchymal transition (EMT). In contrast, some microorganisms can protect against cancer growth, indicating an anticancer therapeutic action of such microbiota. In the review, we summarize findings from the literature, exploring the underlying mechanisms by which pathogenic microorganisms induce EMT. We also highlight the potential of exploiting these complex interactions for developing new biological therapies. Abstract Advancement in the development of molecular sequencing platforms has identified infectious bacteria or viruses that trigger the dysregulation of a set of genes inducing the epithelial–mesenchymal transition (EMT) event. EMT is essential for embryogenesis, wound repair, and organ development; meanwhile, during carcinogenesis, initiation of the EMT can promote cancer progression and metastasis. Recent studies have reported that interactions between the host and dysbiotic microbiota in different tissues and organs, such as the oral and nasal cavities, esophagus, stomach, gut, skin, and the reproductive tract, may provoke EMT. On the other hand, it is revealed that certain microorganisms display a protective role against cancer growth, indicative of possible therapeutic function. In this review, we summarize recent findings elucidating the underlying mechanisms of pathogenic microorganisms, especially the microbiota, in eliciting crucial regulator genes that induce EMT. Such an approach may help explain cancer progression and pave the way for developing novel preventive and therapeutic strategies.

Rapid population growth requires more intense production of food industry, with two major consequences: significant amount of food processing residues and more sewage sludge originating from biological wastewater treatment plant. Sludge is a big concern for the disposal for wastewater treatment plant. The European Union makes an effort regarding the reduction of organic fractions disposed at a landfill. Composting is a cost-effective and ecological-friendly alternative for managing biodegradable organic fractions. Experiments of co-composting of sewage sludge, green waste and food waste, at carbon/nitrogen ratios 8.75, 18.00 and 24.90, were performed during three months by monitoring temperature, pH, moisture, carbon and nitrogen proportion, carbon/nitrogen ratio, and germination index. The results showed that co-composting of sewage sludge, green waste, and food waste is effective and results in the production of quality compost.

Introduction: Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these oncoviruses and their crosstalk in breast cancer is still unclear. Methods: We explored the co-presence of high-risk HPVs, EBV, and MMTV-like virus in 74 breast cancer samples from Qatar using PCR. Results: We found the presence of HPV and EBV in 65% and 49% of our cancer sample cohorts; 47% of the samples are positive for both oncoviruses. The MMTV-like virus alone was detected in 15% of the samples with no significant association with clinicopathological features. The three oncoviruses were co-present in 14% of the cases; no significant association was noted between the co-presence of these viruses and the clinicopathological features. Conclusion: Despite the presence of the oncoviruses, additional studies are necessary to understand their interactions in human breast carcinogenesis.

Pathological gambling and alcoholism are addictions with many common characteristics. Unfortunately, this suggests that a person who is prone to developing an addiction very often develops another addiction, or addictive behavior, over time. In this way, a person with a gambling problem can very often develop an addiction to alcohol, just as an alcoholic can develop a pathological gambling problem over time. Factors influencing the development of addiction, alcoholism in gamblers or gambling in alcoholics, are not only characteristics of an individual prone to addiction, but also external, social factors; gambling sites most often include bars while many bars have gambling machines. In this case report, we present one such example, through all stages of its development to treatment, and this includes diagnosis, treatment and post-hospital follow-up. The treatment for these addictions differs, because alcoholism also requires detoxification. However, when realistic and achievable goals are set, as well as triggers identified and the person's awareness is enhanced, alongside educating and engagement of the individual through functional and adequate behaviors, treatment can be very successful. The probability of relapse exists in both forms of addiction, however, it increases significantly if a person has both addictions.