The aim of the research was to determine whether the age of the patient affects the duration of the procedure and the amount of ionizied radiation delivered when performing diagnostic coronary angiography. The research was conducted at the Clinic for Invasive Cardiology of the Public Health Institution "University Clinical Center" Tuzla in the period from December 2018. to January 2020. The research included a total sample of 240 respondents, average chronological age of 62.60 ± 9.22 years, ranging from 24 to 85 years. Out of a total of 240 respondents, in 121 respondents coronarny angiography was performed using transradial arterial approach and 119 by performing a transfemoral arterial approach. The total sample was divided into two subsamples of respondents. The first sub-sample consists of respondents up to 65 years of age, and the second sub-sample consists of respondents over 65 years of age. During each performance of coronary angiography, the duration of the procedure (in minutes and seconds) and the amount of radiation delivered during the procedure (in mGy) were measured. The research data were processed using the method of parametric and non- parametric statistics. The Mann-Whitney U test was used to verify the research objective. Based on the obtained research results, it can be concluded that in patients over 65 years of age, the duration of the coronary angiography procedure is longer, and is at the limit of statistical significance (p= 0.057). The amount of delivered radiation is higher in respondents over 65 years of age, but it is not statistically significant (p= 0.396). Keywords: Coronary angiography, coronary disease, procedure duration, age, amount of delivered radiation.

The aim of the study is to present and tune a fully automatic deep learning algorithm to segment colorectal cancers (CRC) on MR images, based on a U-Net structure. It is a multicenter study, including 3 different Italian institutions, that used 4 different MRI scanners. Two of them were used for training and tuning the systems, while the other two for the validation. The implemented algorithm consists of a pre-processing step to normalize and to highlight the tumoral area, followed by the CRC segmentation using different U-net structures. Automatic masks were compared with manual segmentations performed by three experienced radiologists, one at each center. The two best performing systems (called mdl2 and mdl3), obtained a median Dice Similarity Coefficient of 0.68(mdl2) - 0.69(mdl3), precision of 0.75(md/2) - 0.71(md/3), and recall of 0.69(mdl2) - 0.73(mdl3) on the validation set. Both systems reached high detection rates, 0.98 and 0.95, respectively, on the validation set. These encouraging results, if confirmed on larger dataset, might improve the management of patients with CRC, since it can be used as a fast and precise tool for further radiomics analyses. Clinical Relevance - To provide a reliable tool able to automatically segment CRC tumors that can be used as first step in future radiomics studies aimed at predicting response to chemotherapy and personalizing treatment.

A recently developed prototype (Laparoscopic Differential Magnetometer, in short LapDiffMag) identifies magnetic tracer accumulated inside sentinel lymph nodes (SLNs) during clinical laparoscopic procedures. The LapDiffMag relies on excitation of superparamagnetic iron oxide nanoparticles (SPIONs) and subsequent laparoscopic detection based on a nonlinear detection principle. The prototype uses an excitation coil to generate a magnetic field needed to activate SPIONs. This study reports on the process of developing a new excitation coil by describing the design choices based upon clinical requirements, by modeling delivered magnetic field using digital twin, and by comparing the magnetic fields of modeled and manufactured prototype. Digital twin technology was used to produce relevant and reliable data to demonstrate the safety and effectiveness of the excitation coil. The magnetic field originating from manufactured prototype was validated at two different heights above the excitation coil and have shown a good concordance to the data generated by its digital twin. Clinical Relevance– Current standard-of-care for a variety of tumor types consists of minimally invasive radical resection of primary tumor and regional lymph nodes (LNs). The newly introduced excitation coil will (after full validation) enable minimally invasive harvesting of sentinel LNs by means of magnetic tracer detection.

In this paper, the authors analyze the advantages and limitations of freelancing in four countries of Western Balkan. This work is based on the research with a total sample of 1031 respondents; 408 respondents from Serbia, 201 from Montenegro, 221 from North Macedonia, and 201 from Bosnia and Herzegovina. For the needs of the research, a special questionnaire was constructed and conducted by an electronic survey. The first goal of the research is to describe the functioning of freelancers in four countries, and the second is to describe the similarities and differences between countries of Western Balkan. In general, freelancers in all four countries have positive attitudes towards freelancing, although there are differences between them. Freelancers are especially satisfied with their income, and in Bosnia and Herzegovina with flexible working hours. No statistically significant differences were found among freelancers from four countries of Western Balkan in the structure of jobs they have worked in the last two years, nor in the assessment of the positive effects of new technologies on new forms of employment. They do not differ either in understanding that the work in the "Gig Economy" had less negative than positive effects on their private lives and in the fact that there are no differences in the assessment of the positive effects of freelance on the quality of life. They are no differences in terms of the proposed measures to improve the position of workers in the "Gig Economy". Unfortunately, there are also no differences in basic social rights (lack of health, disability, and pension insurance). The most significant differences have been noted between freelancers from Montenegro and freelancers from the other three countries. Freelancers from Montenegro see less positive contributions working in the "Gig Economy" than others, and they significantly more often believe that the "Gig Economy" can’t reduce unemployment and prevent brain drain abroad. The authors explain the negative attitudes of freelancers from Montenegro towards their work in the "Gig Economy" with the lower prevalence of freelancers, poorer job structure, and lower income with an unfavorable socioeconomic status.

In this study, the authors analyzed the problematic use of pornographic websites and Internet sex addiction in representative samples of respondents from different age groups including 2948 respondents from Serbia and 1486 from Montenegro. A standard questionnaire of 33 questions with answers in binary form was used. In addition to epidemiological indicators, the study also included nine family risk factors and six risk factors associated with early psychosocial developmental disorders. Finally, the social profiles of Internet sex addicts in Serbia and Montenegro were described. The results of the research showed that Internet sex addicts are mostly young adults aged 20 to 30. The overall dependency rate was estimated within average limits. In general, Internet sex addiction is among the lowest of all behavioral addictions. The authors see the reason for this in the greatest potency of this addiction for the development of addictive patterns of behavior, but also in the great predictiveness of this addiction together with the gambling addiction for the emergence and development of other behavioral addictions. All examined risk factors (except for shyness and reticence) do "separate" Internet sex addicts from those who do not have the listed risk factors at zero level of significance. However, an examination of the prediction of Internet sex addiction using binary logistic regression showed that aggressive and criminal behaviors in early youth, followed by disorders in educational and emotional relations between parents and children, have the highest predictive values for Internet sex addiction. Social profiles are unclear and unstructured, and the authors explain this by the fact that biological, not sociological, and sociocultural factors play a dominant role in developing addictive patterns of behavior.

In the past three years, the COVID-19 became a global health issue and had huge impact on education. This study investigates and compares the student performances after transition from face-to-face learning environment to online learning environments as a result of the spread of the pandemic. Data is collected from a large Bosnian public university and analyzed using statistical tools. In this study student success is defined as passing the course. The results showed that there is significant difference in the performances of students, and it is dependent on learning environment. Particularly, students who attended online classes have significantly higher-grade point averages.

Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by significantly elevated levels of low-density lipoprotein (LDL) cholesterol and is usually diagnosed after the occurrence of major adverse cardiovascular event. Aim: The aim of this study was to evaluate FH existence, increase awareness of this disorder, and highlight the importance of early treatment which leads to a reduction of premature cardiovascular events and death. Methods: The research had a cross-sectional, descriptive, and analytical character, and included 6881 (n = 6881) patients who were hospitalized in the Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina, in the period from January 2019 to January 2021. LDL values were analyzed, and all patients with LDL ≥4 mmol/L were included in the study. The Dutch Lipid Score was calculated for all patients, and the findings of invasive coronary angiography were taken into account in those patients for whom it was performed. Results: From 6881 patients, 74 patients had LDL ≥4 mmol/L. Possible FH (score: 3–5) was found in 25 patients, probable FH (score: 6–8) in 2 patients, while the diagnosis of definite FH was not made in any patient. A ST-elevation myocardial infarction was an indication for hospitalization in 44.60% (n = 33), hypertension in 14.87% (n = 11), and angina pectoris in 14.87% (n = 11) of patients. Patients under the age of 65 had higher Dutch Lipid Score compared to the patients above the age of 65, regardless of male or female. Correlational analysis indicated a significant positive relationship between Dutch Lipid Score and level of cholesterol (r =0.385; P < 0.01) and LDL (r = 0.401; P < 0.001). Statistically significant predictors in the explanation of FH were age (β = −0.45; P < 0.001) and LDL (β = 0.52; P < 0.001). Conclusion: LDL values and age are the main determinants of the FH existence, and the effect on LDL values should be imperative in clinical practice.

Background: Tahyna orthobunyavirus (TAHV) is widely distributed in continental Europe. Very few studies have analyzed TAHV seroprevalence in Croatia. We analyzed the prevalence of TAHV RNA and antibodies in Croatian patients with neuroinvasive disease (NID). Methods: A total of 218 patients with unsolved NID detected during five consecutive arbovirus transmission seasons (April 2017–October 2021) were tested. Cerebrospinal fluid (CSF) and urine samples were tested for TAHV RNA using RT-PCR. In addition, CSF and serum samples were tested for TAHV antibodies using a virus neutralization test (VNT). Results: Clinical presentations in patients with NID were meningitis (141/64.7%), meningoencephalitis (56/25.7%), myelitis (8/3.7%), and ‘febrile headache’ (13/5.9%). TAHV RNA was not detected in any of the tested CSF or urine samples; however, TAHV-neutralizing (NT) antibodies were detected in 22/10.1% of patients. Detection of NT antibodies in the CSF of two patients presenting with meningitis suggested recent TAHV infection. TAHV seropositivity increased significantly with age, from 1.8% to 24.4%. There was no difference in seroprevalence between genders or areas of residence (urban, suburban/rural). The majority of seropositive patients (90.9%) resided in floodplains along the rivers in continental Croatia. Conclusions: The presented results confirm that TAHV is present in Croatia. The prevalence and clinical significance of TAHV infection in the Croatian population have yet to be determined.