Minarets are slender and tall structures that are built from different types of materials. Modern materials are also starting to be used in such structures with the recent developments in material technology. The seismic vulnerability and dynamic behavior of minarets can vary, depending on the material characteristics. Within this study’s scope, thirteen different material types used in minarets in Türkiye were chosen as variables. A sample minaret model was chosen as an example with nine different heights to reveal how material characteristic change affects seismic and dynamic behavior. Information and mechanical characteristics were given for all the material types. Natural fundamental periods, displacements, and base shear forces were attained from structural analyses for each selected material. The empirical period formula for each material is proposed using the obtained periods, depending on the different minaret heights taken into consideration. At the same time, fundamental natural periods for the first ten modes and 13 different types of materials used in the study were estimated with the established Artificial Neural Network (ANN) model. The real periods from the experimental analyses were compared with the values estimated by the ANN using fewer parameters, and 99% of the results were successful. In addition, time history analyses were used to evaluate the seismic performance of the minaret (three different materials were considered). In this specific case, the acceleration record from the 2011 Van (Eastern Turkiye) earthquake (Mw = 7.2) was taken into consideration. Performance levels were determined for the minaret according to the results obtained for each material. It has been concluded that material characteristics significantly affect the dynamic and seismic behavior of the minarets.

BACKGROUND: Heat-not-burn (HNB) technology by the U.S. Food and Drug Administration has been classified as a modified risk tobacco product, which can be a better option for those populations who cannot give up the habit of smoking. The outlook on the effects of these products is quite controversial in the scientific world. OBJECTIVE: To present the effect of HNB tobacco products on the cardiovascular system, with reference to the existence of possible benefits of the technology. METHODS: The literature search was conducted in PubMed/Medline, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov databases, with reliance on a well-defined guiding research statement. Quality appraisal was performed using the CASP checklist for randomized controlled trials. RESULTS: The search of three databases identified 167 records, and after selection process, 25 randomized controlled trials were eligible for our study’s criteria. Twenty studies investigated the effects of HNB products on biomarkers of clinical relevance. Five studies evaluated other functional heart parameters rather than biomarkers. CONCLUSION: With HNB tobacco products, significant reductions were found in biomarkers of exposure and biological effect related to pathways involved in cardiovascular disease, including inflammation, oxidative stress, lipid metabolism, platelet function, and endothelial dysfunction.

Purpose Hospital facilities and social life, along with the global economy, have been severely challenged by COVID-19 since the World Health Organization (WHO) declared it a pandemic in March 2020. Since then, countless ordinary citizens, as well as healthcare workers, have contracted the virus by just coming into contact with infected surfaces. In order to minimise the risk of getting infected by contact with such surfaces, our study aims to design, prototype, and test a new device able to connect users, such as common citizens, doctors or paramedics, with either common-use interfaces (e.g., lift and snack machine keyboards, traffic light push-buttons) or medical-use interfaces (e.g., any medical equipment keypad) Method To this purpose, the device was designed with the help of Unified Modelling Language (UML) schemes, and was informed by a risk analysis, that highlighted some of its essential requirements and specifications. Consequently, the chosen constructive solution of the robotic system, i.e., a robotic-arm structure, was designed and manufactured using computer-aided design and 3D printing. Result The final prototype included a properly programmed micro-controller, linked via Bluetooth to a multi-platform mobile phone app, which represents the user interface. The system was then successfully tested on different physical keypads and touch screens. Better performance of the system can be foreseen by introducing improvements in the industrial production phase. Conclusion This first prototype paves the way for further research in this area, allowing for better management and preparedness of next pandemic emergencies.

Functional recovery following incomplete spinal cord injury (SCI) depends on the rewiring of motor circuits during which supraspinal connections form new contacts onto spinal relay neurons. We have recently identified a critical role of the presynaptic organizer FGF22 for the formation of new synapses in the remodeling spinal cord. Here, we now explore whether and how targeted overexpression of FGF22 can be used to mitigate the severe functional consequences of SCI. By targeting FGF22 expression to either long propriospinal neurons, excitatory interneurons, or a broader population of interneurons, we establish that FGF22 can enhance neuronal rewiring both in a circuit‐specific and comprehensive way. We can further demonstrate that the latter approach can restore functional recovery when applied either on the day of the lesion or within 24 h. Our study thus establishes viral gene transfer of FGF22 as a new synaptogenic treatment for SCI and defines a critical therapeutic window for its application.

BACKGROUND: The pulsed electromagnetic fields (PEMFs) seem effective in increasing bone mineral density and promoting osteogenesis and bone healing. OBJECTIVE: To examine the effect of two different modalities of PEMFs therapy in comparison with the recommended pharmacological treatment on experimental osteoporosis in rats. METHODS: The experimental model of estrogen-deficient osteoporosis induced by ovariectomy was used in this study. The animals were exposed to PEMFs of various frequencies (40 Hz and 25 Hzk), intensities (10 mT and 36.4 μ T), lengths of exposure, and the effects were compared with the standard treatment with pamidronate, vitamin D, and calcium supplementation. RESULTS: The application of PEMF 40Hz , significantly reduced the osteoporotic bone loss in female rats that were confirmed with biochemical, biomechanical, and histological analyses. These effects were more pronounced than in osteoporotic animals treated with pamidronate, vitamin D, and calcium supplementation. On the contrary, the exposure to PEMF 25Hz did not show restorative effects but led to further progression of osteoporosis. CONCLUSION: The exposure to PEMF 40Hz , significantly restored osteoporosis and attenuated bone fragility in comparison to the rats exposed to PEMF 25Hz or those treated with pamidronate, vitamin D, and calcium supplementation.

Climate factors have an impact on plant life cycle, yield, productivity, economy and profitability of agricultural production. There are not a lot of studies on understanding of influence of climate factors variation on maize yield in agro-ecological conditions of Serbia. The aim of this paper is analysis of variation of climatic factors over a long-time period, as well as assessment of impact of the examined climate parameters on maize yield in two localities in the Republic of Serbia. For the analysis of climatic factors (temperature, precipitation, sunshine, humidity) in the region of Central Serbia and Vojvodina, the data of meteorological stations Kragujevac and Sombor during two thirty-year periods (1961–1990 and 1991–2020) were used. In order to determine the existence and strength of the relationship between the observed climatic factors and maize yield, a correlation analysis of these indicators for the period 2005–2020 years, was performed. In the period 1991–2020, the average values of temperature were annually increased for 0.046 °C in Kragujevac and for 0.05 °C in Sombor, and in the same period the average value of sunshine on an annual level was increased for 1.3 h in Kragujevac and for 5.01 h in Sombor, 2020 in comparison to average values in period of 1961–1990. The humidity was decline annually for 1.3 in Kragujevac and for 3.4 in Sombor in period 1991–2020 in comparison to average humidity in period of 1961–1990. The results of the correlation analysis showed that the maize yield was significantly lower in the years with expressed high temperatures and precipitation deficit. Based on these studies, established effect of climate change on maize yield and that this demand developing adaptation agricultural practice through creating maize hybrids and varieties with greater adaptability and improvement of agrotechnic measure.

[This corrects the article DOI: 10.3389/fpubh.2022.795841.].

Aicardi–Goutières syndrome (AGS) is a genetically determined early-onset progressive encephalopathy caused by mutations leading to overexpression of type I interferon (IFN) and resulting in various clinical phenotypes. A gain-of-function (GOF) mutation in the IFIH1 gene is associated with robust production of type I IFN and activation of the Janus kinase (JAK) signal transducer and activator of the transcription (STAT) pathway, which can cause AGS type 7. We detail the clinical case of an infant who initially presented with Pneumocystis jirovecii pneumonia (PCP), had recurrent respiratory infections, and was later treated with a JAK inhibitor, baricitinib, because of a genetically confirmed GOF mutation in the IFIH1 gene. This spectrum of IFIH1 GOF mutations with overlapping features of hyperinflammation and severe opportunistic infection, which mimics combined immunodeficiency (CID), has not been described before. In this case, therapy with baricitinib effectively blocked IFN-α activation and reduced STAT1 signaling but had no effect on the progression of the neurological disease.

ABSTRACT Background The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. Results The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in KT rate varied widely across European countries. An East–West gradient was observed for DD-KT rate, with Western European countries performing more KTs. In addition, most countries performed fewer LD-KTs. In 2018, Spain had the highest DD-KT rate (64.6 p.m.p.) and Turkey the highest LD-KT rate (37.0 p.m.p.). Conclusions The total KT rate increased due to a rise in the KT rate from DDs and to a lesser extent from LDs, with large differences between individual European countries.

The purpose of the study is to scientifically substantiate the positive influence of football on the physical and intellectual development of athletes. Material and methods. When conducting experimental research, a student questionnaire was first conducted to identify the success of studies and the specific interests of students who play football, play other sports, and students who do not play sports at all. 82 fifth-grade students of schools No. 38, 49 took part in the survey. The formative experiment was conducted on the basis of Kindergarten No. 38, in the fifth grades. It was found that the largest percentage of the total number of students are those engaged in other sports (58.5%). A large number are students who do not play any sports (34.10% of the total number of students). The smallest percentage was found among students who play football (7.3% of the total number of students). Results. It has been established that among the students who play football, there are absolutely no students who study at the first level of competence (in the final grades there are grades of 1-3 points on a 12-point scale), 33.3% are those whose academic success is level 2 competence (among the final grades there are grades of 4-6 points), and the largest percentage are students studying at the third level of competence (66.7%) (among the final grades there are no grades below 7 points). Among the students who are engaged in other sports, there are also absolutely no students who study at the first level of competence. Among students who do not play sports, the largest number of those who study are dissatisfied and satisfied. This shows that playing sports, both football and other sports, provide conditions for improving academic performance Conclusions. The obtained data indicate that the practice of sectional work on football provides conditions for the combined physical, intellectual and artistic development of children, about the possibility of a comprehensive all-round influence on the process of child development through the use of effective means of comprehensive development of children.

The economic and technical requirements of current changes in the distribution system are reflected in the use of all available resources and the activation of mechanisms for local use of flexibility. Local flexibility markets are evolving and face numerous obstacles for which appropriate solutions must be found. The local flexibility market will be complemented by the development of a local flexibility register, which will contain all relevant information about the flexibility assets necessary for the efficient operation of the local flexibility market. In this paper, interpretation and quantification of the flexibility sources location on the flexibility service in the distribution grid is given. The information is derived from power flow simulation results and finally written down in the form of line coefficients, which are determined by applying the least squares method to the power flow results. We have developed a Python-based simulator to perform the methodology to determine the information and test it on a realistic medium voltage distribution grid in Bosnia and Herzegovina. This paper confirms the approximate linearity of the active power changes on the demand side to the line load and to the voltage at the nodes for a given operating condition of the distribution grid.

We compute the first gravimetric geoid model for Bosnia and Herzegovina (BHG2022) based upon the KTH method and additive corrections. The BHG2022 is computed with the help of 34,820 terrestrial gravity points and a digital elevation model produced by the Shuttle Radar Topography Mission. The gravity data is gridded onto a 0.02 arc-degree resolution via the nearest neighbour interpolation method. ITU_GGC16 and ITG-Grace2010 models are utilised to provide long wavelengths of gravity field up to 280 and 180 maximum degree/order in the geoid computation, respectively. On the basis of an external evaluation by 609 Global Navigation Satellite System (GNSS)-levelling points homogeneously distributed over the country, the accuracy of the BHG2022 is estimated to be 5.65 cm absolutely. This is the most precise geoid model ever seen in this territory. The result highlights the significant effect of all gravity data obtained from various sources on the accuracy of the geoid model.

The presence of plastic waste in large quantities in the environment is a major problem and therefore a challenge for many researchers to examine the most effective methods of their disposal. In this paper, the source of microplastic and its hazardous effect on human health and interactions of plastics with plants were studied. Due to the specific physical-chemical features of micro- and nano-plastics, they are ideal candidates for the adsorption of organic pollutants, pathogens and heavy metals. The uptake and accumulation of nanoplastics by plants, adsorption studies, and bioaccumulation are shown here. In addition, recent research on the interaction of polystyrene micro- and nanoplastics with plants has been discussed. Many studies have shown that the most affected part of the plant was the roots, followed by leaves, shoots, and then the stem. Nanoplastics are found to be more harmful than microplastics due to permeation through the biological membranes of plants, while microplastics adhere to leaves.