The aim of this paper is to explain microclimatic indicators in the winter inside buildings for of goat housing in Bosnia and Herzegovina. Data processed in this paper were collected from ten goat farms which are deployed throughout Bosnia and Herzegovina. In the housing facilities for goats for whose were determined the microclimate status, the average temperature was in the range of optimal values. Average airflow in facilities for goats in Bosnia and Herzegovina was below the 0.2 m/s during the winter period. The average relative humidity in the goat barns in Bosnia and Herzegovina ranged permitted values. The average determined concentration of ammonia in the air barn goat farm is located above the allowable limit. On based of established levels of CO 2 in goat barns in Kozara region of Bosnia and Herzegovina could be concluded that there is above the allowable limit. Reducing the levels of harmful gases in the facilities may be required in increasing the air change in buildings either natural or artificial ventilation.

We address the problem of state estimation, attack isolation, and control of discrete-time linear time-invariant systems under (potentially unbounded) actuator and sensor false data injection attacks. Using a bank of unknown input observers, each observer leading to an exponentially stable estimation error (in the attack-free case), we propose an observer-based estimator that provides exponential estimates of the system state despite actuator and sensor attacks. Exploiting sensor and actuator redundancy, the estimation scheme is guaranteed to work if a sufficiently small subset of sensors and actuators is under attack. Using the proposed estimator, we provide tools for reconstructing and isolating actuator and sensor attacks, and a control scheme capable of stabilizing the closed-loop dynamics by switching off isolated actuators. Simulation results are presented to illustrate the performance of our tools.

Abstract 25-Hydroxyvitamin D (25-OHD) may have a prognostic value in colorectal cancer (CRC) patients. However, as 25-OHD concentration is strongly impacted by surgery, it is uncertain what is the most reliable time-point for 25-OHD assessment, pre- or post-operative. Therefore, we examined 515 CRC patients (AJCC I-III) who underwent surgery. Blood samples were collected either pre-operatively (n = 286; median = 1 day before surgery) or post-operatively (n = 229; median = 8 days). Serum 25-OHD concentration was determined by liquid chromatography–tandem mass spectrometry. Association between 25-OHD and survival was tested in the whole cohort, followed by stratified analyses in pre- and post-operatively sampled. Median 25-OHD in the cohort was 36.7 nmol/L and median follow-up time was 5.9 years. There were no differences between pre- and post-operative cohort in age, sex, 25-OHD, AJCC stage, or localization of tumor. After adjustment, higher 25-OHD (>50 nmol/L) was associated with better overall survival only in post-operative (HR = 0.53; 95% CI: 0.33–0.84; P = 0.006), but not in pre-operative cohort (HR = 1.13; 95% CI: 0.77–1.65; P = 0.53). In conclusion, higher post-operative 25-OHD levels were associated with better survival outcome in CRC patients, while no such association was found for pre-operative levels. Time-point of blood collection should be addressed carefully in future research as it might affect the prognostic value of 25-OHD in CRC.

Two-dimensional second-order topological superconductors (SOTSCs) have gapped bulk and edge states, with zero-energy Majorana bound states localized at corners. Motivated by recent advances in Majorana nanowire experiments, we propose to realize a tunable SOTSC as a two-dimensional nanowire array. We show that the coupling between the Majorana modes of adjacent wires can be controlled by phase-biasing the device, allowing to access a variety of topological phases. We characterize the system using scattering theory, which provides access to its transport properties and its topological invariants. The setup is robust against disorder, both in the nanowires themselves and in the Josephson junctions formed between adjacent wires. Further, we identify a parameter regime in which an initially trivial system is rendered topological upon adding disorder, providing an example of a second-order topological Anderson phase.

Knowing about dependencies and similarities between test cases is beneficial for prioritizing them for cost-effective test execution. This holds especially true for the time consuming, manual execution of integration test cases written in natural language. Test case dependencies are typically derived from requirements and design artifacts. However, such artifacts are not always available, and the derivation process can be very time-consuming. In this paper, we propose, apply and evaluate a novel approach that derives test cases' similarities and functional dependencies directly from the test specification documents written in natural language, without requiring any other data source. Our approach uses an implementation of Doc2Vec algorithm to detect text-semantic similarities between test cases and then groups them using two clustering algorithms HDBSCAN and FCM. The correlation between test case text-semantic similarities and their functional dependencies is evaluated in the context of an on-board train control system from Bombardier Transportation AB in Sweden. For this system, the dependencies between the test cases were previously derived and are compared to the results our approach. The results show that of the two evaluated clustering algorithms, HDBSCAN has better performance than FCM or a dummy classifier. The classification methods' results are of reasonable quality and especially useful from an industrial point of view. Finally, performing a random undersampling approach to correct the imbalanced data distribution results in an F1 Score of up to 75% when applying the HDBSCAN clustering algorithm.

Banija spotted pig breed was created at the end of 19th century by crossing domestic white sows with drooping ears and/or Turopolje pig sows with black Berkshire. After a period of stagnation in breeding, the population is newly recognized only few years ago and is currently in the process of breed valorisation. The aim of this study was to assess genetic diversity and structure of Banija spotted pig (BS) in comparison with geographically close populations, and to assess the differentiation level of Banija spotted pig. Based on the genotypes obtained for 24 ISAG-FAO recommended pig microsatellite markers, basic genetic diversity indicators were determined for 30 samples of BS, 20 samples of Turopolje and Crna Slavonska pig each, and 17 samples of Landrace population. Observed heterozygosity ranged from 0.36 to 0.6 and was high in BS population (0.58). Average allelic richness (range 2 – 5.2) and the rarefacted number of private alleles (range 9 to 27) were the highest in BS. Inbreeding coefficient in BS was estimated 0.06 (bootstrapping confidence interval 0.022 to 0.123). Structure analysis showed that there are five clusters in the four analysed populations, where BS are clearly distinguished from other populations and substructured. Wright’s fixation index estimates are in accordance with the clustering results. In conclusion, the population of Banija spotted pig shows great genetic diversity and is genetically different from neighbouring (geographically close) pig populations.

Background Previous studies have shown that poor family environments are related to more sleep problems; however, little is known about how family irregularity in early life affects the development of sleep problems over childhood using objective sleep measures. The current study tests the hypothesis that early family irregularity contributes to the development of sleep problems. Methods This population‐based study comprises 5,443 children from the Generation R Study. Family irregularity was measured with seven maternal‐reported questions on family routines when children were 2 and 4 years old. Mothers reported on sleep problems at child age 3, 6, and 10 years, whereas children completed questionnaires on sleep problems at age 10. Additionally, we used tri‐axial wrist accelerometers for five nights in 851 children (mean age 11.7 years) to assess sleep objectively. Results Family irregularity was associated with more mother‐ and child‐reported sleep problems at ages 3, 6, and 10 years as well as with a shorter sleep duration and later objective sleep onset, but not with sleep efficiency or waking time. The association between family irregularity and multi‐informant subjective sleep problems at age 10 years was mediated by mother‐reported child psychopathology at age 6 years. Conclusions Our findings show a long‐term robust association of preschool family irregularity with more sleep problems during childhood as well as shorter sleep duration and later sleep onset as measured objectively with actigraphy. In part, these sleep problems were associated with family irregularity by way of child psychopathology. These findings suggest that interventions improving preschool family irregularity, which are targeted to reduce child psychopathology, may also impact the development of sleep problems beneficially.

MgSO4 is used as a tocolytic agent. It is considered to be a calcium channel antagonist, but a different mechanism of its action might be involved. The aim of this study was to examine the contribution of calcium concentrations and potassium channels in the mechanism of MgSO4-mediated uterine relaxation. Isolated uteri from female Wister rats were treated with increasing MgSO4 concentrations (0.1-30 mM). MgSO4 induced dose-dependent inhibition of spontaneous activity. Addition of Ca2+ (6 mM and 12 mM) stimulated uterine contractile activity and attenuated the inhibitory activity of MgSO4. In order to analyze the role of different subtypes of potassium channels, Ca2+-stimulated uteri were pretreated with glibenclamide (Glib), a selective ATP-sensitive potassium channel inhibitor (KATP), tetraethylammonium (TEA), a non-specific inhibitor of large conductance calcium-activated potassium channels (BKCa), and 4-aminopyridine (4-AP), a voltage-sensitive potassium channel inhibitor (Kv), at concentrations that had no effect per se. Pretreatment with 4-AP had no effect on MgSO4-mediated relaxation of Ca2+-stimulated uteri. The relaxing effect of MgSO4 was potentiated by pretreatment with glibenclamide. Pretreatment with TEA attenuated the MgSO4-mediated decrease in frequency. Our results suggest that MgSO4 acts as a general calcium antagonist that influences Ca2+-mediated potassium channels. Furthermore, it seems that MgSO4 uterine relaxation activity is partially mediated by selective ATP-sensitive potassium channels, suggesting an ATP-dependent role.

Ten organic solvents (triethanolamine, diethanolamine, ethylene glycol, methyl ethyl ketone, n-hexane, triethylamine, ethylene glycol dimethyl ether, glycerol, tetrahydrofuran and dioxane) were applied as cosolvents in the CaO-catalyzed ethanolysis of sunflower oil performed in a batch stirred reactor under the following reaction conditions: temperature 70 ?C, ethanol-to-oil mole ratio 12:1, initial catalyst concentration 1.374 mol?L-1 and amount of cosolvent 20 % based on the oil amount. The main goals were to assess the effect of the used cosolvents on the synthesis of fatty acid ethyl esters (FAEE) and to select the most efficient one with respect to the final FAEE content, reaction duration and safety profile. In the absence of any cosolvent, the reaction was rather slow, providing a FAEE content of only 89.7?1.7 % after 4 h. Of the tested cosolvents, diethanolamine, triethanolamine and ethylene glycol significantly accelerated the ethanolysis reaction, whereby the last two provided a final FAEE content of 93.1?2.1 and 94.1?1.5 %, respectively, within 0.5 h. However, because of its safety profile, triethanolamine was selected as the best cosolvent for the ethanolysis of sunflower oil catalyzed by calcined CaO.