Viral agents such as bovine respiratory syncytial virus (BRSV) and bovine parainfluenza virus 3 (BPIV-3) are considered primary infectious agents in bovine respiratory disease complex (BRDC). Information regarding the pathogenesis of BRDC is scarce, especially at an advanced chronicity stage, in addition to ongoing coinfection with other primary agents such as Mycoplasma bovis. Based on a retrospective review of histology slides from 104 autopsy cases, we classified cases according to type of pneumonia and chronicity. We performed immunohistochemistry (IHC) for BRSV, BPIV-3, and M. bovis as well as real-time PCR (rtPCR) for M. bovis on lung tissue of all 104 cases and correlated results with the morphologic type of pneumonia. Histomorphologically, 79 cases were classified as bronchopneumonia, 16 as bronchointerstitial pneumonia, and 9 as interstitial pneumonia. In 89 cases, at least 1 of the investigated agents was detected by IHC; 44 of these cases had a coinfection. BPIV-3 was the predominant agent present, as a single infection in 39 cases, and in coinfection with M. bovis in 39 cases. Comparing the detection methods for M. bovis, rtPCR was more specific and sensitive than IHC. The combination of both methods provided a good visual tool for assessing severity and distribution of M. bovis antigen within the tissue. Unlike BRSV, BPIV-3 and M. bovis persisted in chronic BRDC, suggesting ongoing impairment of defense mechanisms in the lung.

ABSTRACT Transitional justice and diaspora studies are interdisciplinary and expanding fields of study. Finding the right combination of mechanisms to forward transitional justice in post-conflict polities is an ongoing challenge for states and affected populations. Diasporas, as non-state actors with increased agency in homelands, host-lands, and other global locations, engage with their past from a distance, but their actions are little understood. This introductory article to a special issue develops a novel framework to study causal mechanisms and their underlying analytical rationales – emotional, cognitive, symbolic/value-based, strategic, and networks-based – linking diasporas and local actors in transitional justice. Mechanisms featured are: thin sympathetic response and chosen trauma, fear and hope, contact and framing, cooperation and coalition-building, brokerage, patronage, and connective action, among others. The contributors theorize about causal mechanisms and their sequences involving diasporas in multi-sited transitional justice processes and bring empirical evidence from various world regions.