Healthcare information systems store a huge amount of patient data, so the trend of the use of data mining in healthcare is on the rise. Heart and blood vessel diseases are a leading cause of mortality both worldwide and here in Bosnia and Herzegovina, and prevention, surveillance and treatment are of great public health importance. Based on data on patients with cardiovascular disease, collected from 2011 to 2017 at Mostar Hospital, models for mortality prediction using techniques for data tree mining, neural network and logistic regression are presented. The aim of this research is to compare the effectiveness of these methods in modeling the effectiveness of predicting mortality in patients with cardiovascular disease.

Simple Summary The recognition of the role of food in the improvement and preservation of health is receiving more and more attention among consumers, especially in developed countries. Fats from red meats are considered quite unhealthy because of their high levels of cholesterol and saturated fatty acids. Healthier lipid profiles of red meats can be achieved by a proper feed composition of animals, but other factors, such as breed, sex, and live weight, are able to affect the nutritional properties of meats. This investigation aimed to evaluate the effect of breed (Bergamasca, Italian Merino, and Sopravissana) on the fatty acid composition of invisible (intramuscular) and visible (subcutaneous) fats of light lambs reared in Central Italy transhumant farms. They recently gained a Protected Geographical Indication label (European Union, Commission Implementing Regulation No. 475/2013), as ”Agnello del Centro Italia”. It is an income opportunity for local farms that passes through the nutritional valorization of lamb meat. The indices of nutritional quality of fats have showed that the meat of Italian Merino and Sopravissana lambs had better nutritional quality than the Bergamasca breed. Abstract Lamb meat is the main product of Central Italy transhumant farms, where lambs are traditionally reared with their mothers on pastures and are supplemented with concentrates and/or hay from day 20–30 until slaughter. However, few data are available on the fatty acid (FA) composition of unweaned lambs reared by extensive systems in Central Italy. The study aimed to evaluate the effect of breed (Bergamasca, Italian Merino, and Sopravissana) on the FA composition of intramuscular (longissimus lumborum, LL) and subcutaneous (SC) fats of light lambs. Statistical analysis showed that breed had effect only on some FAs in LL muscle fat (C18:0, C20:0, C14:1, C16:1, C17:1, C18:3 n-3, trans and conjugated linoleic acid isomers) and in SC adipose tissue (C21:0, C16:1, C18:1, C20:4 n-6, C20:5 n-3, C18:1 trans isomers). Gas chromatography data in combination with a chemometric approach could have some potential to discriminate among breeds. Indices of nutritional quality of the lipids suggested that the meat of Italian Merino and Sopravissana lambs might have better nutritional quality than Bergamasca; further studies, involving a greater number of animals, are needed to confirm these early results.

Previous transcriptome-wide association studies (TWAS) have identified breast cancer risk genes by integrating data from expression quantitative loci and genome-wide association studies (GWAS), but analyses of breast cancer subtype-specific associations have been limited. In this study, we conducted a TWAS using gene expression data from GTEx and summary statistics from the hitherto largest GWAS meta-analysis conducted for breast cancer overall, and by estrogen receptor subtypes (ER+ and ER−). We further compared associations with ER+ and ER− subtypes, using a case-only TWAS approach. We also conducted multigene conditional analyses in regions with multiple TWAS associations. Two genes, STXBP4 and HIST2H2BA, were specifically associated with ER+ but not with ER− breast cancer. We further identified 30 TWAS-significant genes associated with overall breast cancer risk, including four that were not identified in previous studies. Conditional analyses identified single independent breast-cancer gene in three of six regions harboring multiple TWAS-significant genes. Our study provides new information on breast cancer genetics and biology, particularly about genomic differences between ER+ and ER− breast cancer.

Istraživana je morfološka varijabilnost lista 25 populacija klena (Acer campestre L.) na području Bosne i Hercegovine. Morfometrijsko istraživanje unutarpopulacijske i međupopulacijske varijabilnosti provedeno je na temelju 19 morfoloških svojstava lista, pri čemu su korištene deskriptivne i univarijatne statističke analize. Najveću varijabilnost pokazalo je svojstvo dužina peteljke lista, dok je najmanja varijabilnost utvrđena kod izvedenog svojstva odnos maksimalne dužine plojke lista i maksimalne širine plojke lista. Izvedena svojstva lista bila su manje varijabilna od mjernih, što upućuje na manje variranje svojstava oblika u odnosu na svojstva dimenzija lista. Analiza varijance pokazala je statistički značajne razlike između populacija za sva analizirana svojstva lista. Multipla testiranja pokazala su veću međupopulacijsku nego unutarpopulacijsku varijabilnost za sva istraživana svojstva osim dva svojstva geometrijske skale podataka (kutovi žila). Za razliku od mjerenih svojstava lista, sva izvedena svojstva pokazala su veću unutarpopulacijsku nego međupopulacijsku varijabilnost. Najdivergentnija populacija, s jedne strane, bila je populacija Trebinje, s najvećim brojem minimalnih vrijednosti svojstava lista, dok je s druge strane najdivergentnija populacija Banja Luka, s najvećim brojem maksimalnih vrijednosti svojstava lista. Dobiveni rezultati mogu služiti kao temelj za dalja istraživanja u drugim dijelovima areala vrste, u svrhu determiniranja utjecaja interakcije ekoloških, geografskih, klimatskih i migracijskih čimbenika na morfološku varijabilnost populacija klena.

REST HTTP is the communication protocol of choice for software developers today. In IoT systems with unreliable connectivity, however, a stateless protocol like REST HTTP needs to send a request message multiple times, and it only stops the retransmissions when an acknowledgement arrives at the sender. In our previous work, we studied the usage of random linear network coding (RLNC) for REST HTTP protocol to reducing the amount of unnecessarily retransmissions. In this paper, we experimentally validate the study and analyze REST HTTP with and without RLNC in a simple testbed in dynamic IoT systems. The measurements show notable improvements in bandwidth utilization in terms of reducing the retransmissions and delay when using network-coded REST HTTP.

Brucellosis is an emergent and endemic zoonotic disease in Bosnia and Herzegovina. In this report we have diagnosed the first case of human brucellosis in Bosnia and Herzegovina, using molecular and microbiological tests, caused by live attenuated Brucella melitensis Rev.1 strain. The infection was caused through unintentional exposure to vaccination of small ruminants in Bosnia and Herzegovina and without any prior accidental self-injection of vaccine suspension.

: Medicinal nail lacquers are the most effective topical treatment of nail diseases. These formulations generally are organic solutions of the active substance as well as film-forming polymer and plasticizer, which affects the characteristics of the film formed after application and solvent evaporation. The aim of this work was to test the effects of plasticizer present in nail lacquer formulations on permeation kinetics of fluconazole through the bovine hoof membrane in a novel in vitro test. The formulations contained Eudragit RS100 dis- solved in acetone, and dibutyl-phthalate, PEG 400 or propylene glycol as plasticizers present in two different concentrations. Permeation studies were carried out during the 7-day period, and the obtained permeability pro- files analyzed using similarity and difference factors, and by model-dependent permeation kinetics. When analyzed within the same strength, the highest extent of fluconazole permeation was obtained from the formula- tion with a lower concentration of propylene glycol at 0.9% fluconazole concentration, while for formulations with 1.8% and 2.7% of fluconazole, the highest permeation was achieved from the formulation with the high- er content of PEG400. The permeation profiles showed a greater difference within one formulation of different fluconazole content than with the same plasticizer present in different concentrations, when using dibutyl- phthalate and PEG400. The permeation profiles were similar when using propylene glycol. When comparing formulations with the same concentrations of plasticizers, there were differences in formulations with the high- er fluconazole concentrations. Permeation kinetics depended on fluconazole concentration as well as the path length the active substance had to pass to reach the receptor solution.

A major research area in non-human social cognition is the investigation of cooperative problem solving, i.e. the cognition involved in situations when animals cooperate with each other. Social cognition is thought to have evolved due to the demands of social living, and is often thought to present an adaptive specialisation for living in groups. A previous analysis of social learning, another area of social cognition, has highlighted how this has consequently led to two overarching biases in the literature: firstly, a bias towards testing only social species, and secondly, an a priori assumption that social learning is qualitatively different from learning involved in non-social situations. The problem of these biases may not restricted to social learning but be present also in other areas of social cognition research. Applying an equivalent analysis to cooperative problem solving shows that here too both biases are present. Firstly, empirical studies on cooperative problem solving primarily conducted with social species and species that exhibit cooperative behaviours in the wild. Secondly, the assumption that cooperative problem solving relies on a distinctly socialcognitive ability can, at least implicitly, be observed throughout the literature. Thismay be the result of confounding different components of the cognitive process involved in cooperation: what information is required to successfully cooperate and how this information is acquired. While the former needs to involve information about another individual, there is no indication that the latter is required to differ from any known, domain-general cognitive mechanism. These two biases make it difficult to systematically test whether and how cooperation differs between species, and as such impede investigations into the evolution of cooperative problem solving.

Wide GNSS (Global Navigation Satellite System) availability has its advantages, however, in that case the system is exposed to a large number of external influences, from interference with other signals to deliberate blocking and jamming. There is also a huge increase in GNSS user number for both professional and private purposes. The technology of protection and regulation is partly behind the technological development and leaves room for undesired impacts from both natural and artificial causes. Through this paper GNSS errors are described using an android mobile application, "GNSS Analysis Tool", that allows observation of the GNSS signal characteristics.