ABSTRACT Plant biostimulants are commercial products based on different chemical substances used to enhance plant growth and productivity. The effects of biostimulants, Megafol and Viva, with different dominant compositions (amino acids and humic acids) on two tomato cultivars (cv. Gravitet F1 and cv. Minaret F1) exposed to conventional and low-input macronutrient nutrition were investigated. Application of both biostimulants positively affected yield at conventional nutrition. In low-input nutrition variant, biostimulant application prevented yield loss only in cv. Minaret F1. Inter-cultivar differences were noticed in fruit characteristics (total phenol content, total flavonoids content and total antioxidative capacity) where application of biostimulants leads to opposite results in the examined cultivars. We considered the possibility of biostimulant usage as an effective nutritional addition for overcoming the problem of excessive fertilisation.

The research results referring to frequency have indicated that most of the sports injuries among athletes of both genders occur in basketball and that knee injury is the second most frequent injury during sports activities. The anterior cruciate ligament (ACL) represents one of the four most important connections for knee stability, and it is frequently prone to injury during sports activities. The aim of this paper was to determine the effects of an exercise program on the prevention of injury to the anterior cruciate ligament of the knee joint among young female basketball players. To collect existing research on the effects of the applications of prevention programs on the prevention of ACL injury in young female basketball players, the following electronic databases were searched: PubMed, SCIndeks, PEDro, J-GATE, DOAJ and Google Scholar. The analyzed studies were published between 2003 and 2018 and the participants were young female basketball players. According to the results of this study, the most frequently used training programs were neuromuscular programs, whose structure includes several types of exercises and which represented a combination of plyometric exercises, core strengthening exercises, exercises to strengthen the muscles of the lower extremities, agility exercises, flexibility exercises, and balance exercises. Finally, the application of the knee injury training program leads to an improvement in motor balance, proprioceptive abilities, balance, flexibility, as well as biomechanical abilities related to injuries of the ACL, leading to an improvement in sports performance among female basketball players.

Investigative studies of white matter (WM) brain structures using diffusion MRI (dMRI) tractography frequently require manual WM bundle segmentation, often called “virtual dissection.” Human errors and personal decisions make these manual segmentations hard to reproduce, which have not yet been quantified by the dMRI community. It is our opinion that if the field of dMRI tractography wants to be taken seriously as a widespread clinical tool, it is imperative to harmonize WM bundle segmentations and develop protocols aimed to be used in clinical settings. The EADC‐ADNI Harmonized Hippocampal Protocol achieved such standardization through a series of steps that must be reproduced for every WM bundle. This article is an observation of the problematic. A specific bundle segmentation protocol was used in order to provide a real‐life example, but the contribution of this article is to discuss the need for reproducibility and standardized protocol, as for any measurement tool. This study required the participation of 11 experts and 13 nonexperts in neuroanatomy and “virtual dissection” across various laboratories and hospitals. Intra‐rater agreement (Dice score) was approximately 0.77, while inter‐rater was approximately 0.65. The protocol provided to participants was not necessarily optimal, but its design mimics, in essence, what will be required in future protocols. Reporting tractometry results such as average fractional anisotropy, volume or streamline count of a particular bundle without a sufficient reproducibility score could make the analysis and interpretations more difficult. Coordinated efforts by the diffusion MRI tractography community are needed to quantify and account for reproducibility of WM bundle extraction protocols in this era of open and collaborative science.

Man is continuously exposed to ionizing radiation because of the presence of naturally occurring radioactive materials (NORM) in the environment. Various technological processes of processing and using of materials that contain natural radionuclides generate materials of enhanced natural radioactivity (TENORM). The largest contribution to irradiance with natural sources of ionizing radiation is the exposure of the population to indoor radon. This gas originates from the radioactive decay of 226Ra and 224Ra that are present in the soil under houses and building materials. Depending on the type of building materials, indoor exposure to radon at dwellings and workplaces can be over a thousand times greater than in outdoor space. In Bosnia and Herzegovina, no valid and comprehensive radiological studies on the building materials have been performed that would guarantee for their dosimetric safety use for installation in residential and industrial buildings, highways, as well as their application for other purposes. The quantification of the radon levels that comes from building materials is a necessary and very important part of the global protection of the population from ionizing radiation. This paper presents the first results of a study on the radon activity concentrations in building materials used in Bosnia and Herzegovina. Measurements were performedwith a professional Alpha GUARD system. The mean values of the activity concentration of the exhaled radon of investigated building materials varied from 10 Bqm-3 to 101 Bqm-3, radon exhalation rate values ranged from 77.0 mBqm-2h-1 to 777.7 mBqm-2h-1. Gamma dose rate was in the range 57–112 nSv h−1.

Key Points Question Does a treat-and-extend approach with potentially less frequent anti-vascular endothelial growth factor injections and visits provide visual outcomes not worse than monthly ranibizumab injections in patients with neovascular acute macular degeneration? Findings In this randomized clinical trial of 580 patients with treatment-naive choroidal neovascularization secondary to acute macular degeneration, at month 24, visual acuity outcomes in the treat-and-extend group were not worse than those in the monthly group. This outcome occurred despite a mean of 17.6 injections and visits in the treat-and-extend group compared with 23.5 in the monthly group. Meaning These 2-year outcomes, combined with those of 1-year trials, appear to support the hypothesis that treat-and-extend regimens are not worse than monthly treatment with ranibizumab for patients with neovascular acute macular degeneration similar to patients enrolled and treated in this trial.

Introduction. Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity. The presence of polyps in the nose and sinuses is the cause of the characteristic symptoms that affect the quality of life of the patient. The study investigates the correlation between endoscopic, microbiological and radiological findings and symptom severity in patients with chronic rhinosinusitis and sinonasal polyposis. Methods. The research included 45 patients with chronic rhinosinusitis and sinonasal polyps, for whom surgery treatment was indicated after the failure of conservative therapy, and 25 healthy subjects. Intensity of symptoms in subjects was assessed by A Visual Analogue Scale. The bacteriological examination of secretion of the medial nasal corridor was carried out. Clinical and radiological assessment of the severity of the condition was done by the endoscopy and computerized tomography score (CT score). Results. A statistically significant difference was found in symptom severity between the experimental and control groups. There was a statistically significant correlation between endoscopy score and the symptom severity (r = 0.315; p = 0.035), CT-score (r = 0.720; p < 0.001) and the presence of asthma (r = 0.335; p = 0.025). Furthermore, there was a statistically significant correlation between CT score and the presence of asthma (r = 0.419; p =0.004). By binary logistic regression, a statistically significant correlation between the endoscopy score and symptom severity (OR = 1.513; p = 0.044) was found. Conclusion. In comparison with the objective clinical parameters, the severity of symptoms in patients with sinonasal polyposis is in a statistically significant correlation with the endoscopy score.

Miokarditis je ograniceno ili difuzno zapaljenje srcanog misica koje možebiti posljedica infekcije (virusi, bakterije, gljivice, rikecije, paraziti, protozoe)ili je neinfektivne prirode (sistemske bolesti, metabolicke bolesti, toksini).Postoje i miokarditisi kod kojih se etioloski faktor ne može utvrditi i svrstavajuse u grupu idiopatskih miokarditisa. Klinicka slika zavisi od intenzitetazapaljenskog procesa i topografskog rasporeda lezija pa varira od blagogoblika do teskog malignog karditisa sa razvojem srcane insuficijencije i fatalnimishodom u toku nekoliko dana. Mirovanje se preporucuje kao osnovnaterapijska mjera kod svih bolesnika sa sumnjom na miokarditis. Ukolikopostoje znaci srcane insuficijencije obavezno se uvodi antikongestivnaterapija diureticima, vazodilatatorima, digitalisom, a ako ova terapija nijeuspjesna neophodno je primijeniti inotropne lijekove (dobutamin ili inhibitorifosfodiesteraze) u intravenskoj infuziji. Poremecaji ritma kod bolesnikasa miokarditisom zahtjevaju sto hitniju terapiju odgovarajucim antiaritmicima.U lijecenju najtežih, fulminantnih, oblika miokarditisa danas se koristeimunoglubulini u visokim dozama i kortikosteroidi. Akutni perikarditisje zapaljenje perikarda koje odlikuje bol u grudima, perikardijalno trenje iserijske elektrokardiografske promjene. Svijest o ovoj bolesti se povecalazbog uvođenja neinvazivnih dijagnostickih tehnika, kao sto su ehokardiografija,CT skeniranje i kardijalna magnetna rezonanca (CMRI). Bolest možebiti teska i cak smrtonosna, posebno kod djece na imunosupresivnoj terapiji.Uzrocnik se može identifikovati iz perikardijalne tecnosti kulturom iliosjetljivijim testovima (PCR) ili iz uzoraka perikardijalne biopsije.

We consider the second-order rational difference equation xn+1=γ+δxnxn−12,\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$ {x_{n+1}=\gamma +\delta \frac{x_{n}}{x^{2}_{n-1}}}, $$\end{document} where γ, δ are positive real numbers and the initial conditions x−1\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$x_{-1}$\end{document} and x0\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$x_{0}$\end{document} are positive real numbers. Boundedness along with global attractivity and Neimark–Sacker bifurcation results are established. Furthermore, we give an asymptotic approximation of the invariant curve near the equilibrium point.

AbstractWe consider the second-order rational difference equation xn+1=γ+δxnxn−12,$$ {x_{n+1}=\gamma +\delta \frac{x_{n}}{x^{2}_{n-1}}}, $$ where γ, δ are positive real numbers and the initial conditions x−1$x_{-1}$ and x0$x_{0}$ are positive real numbers. Boundedness along with global attractivity and Neimark–Sacker bifurcation results are established. Furthermore, we give an asymptotic approximation of the invariant curve near the equilibrium point.

Introduction. Chronic rhinosinusitis with sinonasal polyposis is a chronic inflammatory process of the mucous membranes of the nasal and paranasal sinuses, clinically manifested by the appearance of polyps in the nasal cavity. The presence of polyps in the nose and sinuses is the cause of the characteristic symptoms that affect the quality of life of the patient. The study investigates the correlation between endoscopic, microbiological and radiological findings and symptom severity in patients with chronic rhinosinusitis and sinonasal polyposis. Methods. The research included 45 patients with chronic rhinosinusitis and sinonasal polyps, for whom surgery treatment was indicated after the failure of conservative therapy, and 25 healthy subjects. Intensity of symptoms in subjects was assessed by A Visual Analogue Scale. The bacteriological examination of secretion of the medial nasal corridor was carried out. Clinical and radiological assessment of the severity of the condition was done by the endoscopy and computerized tomography score (CT score). Results. A statistically significant difference was found in symptom severity between the experimental and control groups. There was a statistically significant correlation between endoscopy score and the symptom severity (r = 0.315; p = 0.035), CT-score (r = 0.720; p < 0.001) and the presence of asthma (r = 0.335; p = 0.025). Furthermore, there was a statistically significant correlation between CT score and the presence of asthma (r = 0.419; p =0.004). By binary logistic regression, a statistically significant correlation between the endoscopy score and symptom severity (OR = 1.513; p = 0.044) was found. Conclusion. In comparison with the objective clinical parameters, the severity of symptoms in patients with sinonasal polyposis is in a statistically significant correlation with the endoscopy score.

Rational drug design implies usage of molecular modeling techniques such as pharmacophore modeling, molecular dynamics, virtual screening, and molecular docking to explain the activity of biomolecules, define molecular determinants for interaction with the drug target, and design more efficient drug candidates. Kinases play an essential role in cell function and therefore are extensively studied targets in drug design and discovery. Kinase inhibitors are clinically very important and widely used antineoplastic drugs. In this review, computational methods used in rational drug design of kinase inhibitors are discussed and compared, considering some representative case studies.