The paper presents the possibility of using criterion programming and neuro-fuzzy modeling in determining the value of planning technical power losses. Proposed is an optimal control in normal mode power grids which considers the value of planned technical power losses. Improved method for determining normative values of technical energy losses using the criteria programming and neuro-fuzzy modeling is presented.

Background: Borrelia burgdorferi and tick-borne encephalitis (TBE) virus are 2 types of tick-borne pathogens that can cause central nervous system infection. Routine diagnostics have so far included analysis of cerebrospinal fluid (CSF) cell numbers, CSF serology for Borrelia burgdorferi and serum serology for TBE virus. However, early diagnosis may be difficult based on antibody detection which takes time to analyze, and with the possibility of false negative results, thus delaying treatment. Cytokine analyses are becoming increasingly available in clinical routine care and may offer important information. Methods: Fifteen cytokines and chemokines were measured in the CSF from the diagnostic lumbar puncture of 37 children with TBE, 34 children with neuroborreliosis and 19 children without evidence of central nervous system infection, using Luminex technology. Results: Significantly higher levels of proinflammatory interleukin-6 were detected in the samples from TBE-infected children, when compared with neuroborreliosis or controls. In comparison, children with neuroborreliosis had significantly higher levels of interleukin-7, interleukin-8, interleukin-10, and interleukin-13 when compared with TBE infected or controls. Furthermore, the ratio between interleukin-6 and interleukin-10 was significantly different between the 2 types of tick-borne infections. Conclusions: The interleukin-6/interleukin-10 ratio can be used as a rapid diagnostic cue upon suspected tick-borne infection, enabling fast and correct treatment. Also, in serology-negative results, such information may strengthen a clinical suspicion.

Summary Background/Aim: Dental caries is the most common chronic disease affecting children worldwide today and represents a serious public health problem. Since pediatricians are the first health professionals whom children visit, they can be considered as a reliable source of information regarding the recognition of potential health problems and suggesting their solution, so they have a key role in primary health prevention. The aim of this study is to determine the position of pediatricians in the prevention of oral health of children in Montenegro through the assessment of their knowledge, attitude, and practice of primary professional preventive measures. Material and Methods: A cross-sectional survey was undertaken among the 84 pediatricians employed in Montenegro Community health services. Self-addressed reply envelope survey consisted questionnaire of 60 questions divided into 5 modules, was used as an instrument for the research. Results: Response rate was 86%, while 68,3% pediatricians think that gender is a risk factor for dental caries. Fact that cavity-causing bacteria can be transmitted from the mother was confirmed by 69% of respondents. Only 45% of them practice the current guidelines on the recommendation of the first dental examination up to 12 months of life. Conclusions: It can be concluded that pediatricians in Montenegro have positive attitudes about prevention and believe they have the responsibility to prevent caries but have shown insufficient knowledge about caries and risk factors for the oral diseases.

Introduction: Patients with hip fracture are one of the most demanding groups in the health-care system. One of the most important tasks for nurses is to assess pain and ensure the patients are pain free. Pain assessment in patients with dementia is a well-known challenge for health-care professionals due to the patients’ difficulties in verbalising pain problems. Aim: The aim of this study was to explore the experience of intensive care nurses in assessment of pain in patients with hip fracture and dementia in the postoperative setting. Methods: Data were collected through five focus group discussions using open-ended questions and qualitative content analysis. Twenty-one intensive care nurses (6 men and 15 women) participated in the focus group interviews. Results: Analysis of the data resulted in three main categories: “Communication”, “Visual assessment of pain”, and “Practical issues” including a number of subcategories. Some of the factors which influence assessment of pain in patients with dementia are the lack of information and knowledge about the patients, which causes loss of time and increased stress. The different forms of communication and ways of assessing pain in these patients were other factors mentioned by nurses as hindrances regarding assessment of the pain. Conclusion: In order to improve assessment of pain, more knowledge and information about the patients are needed and better coordination between the pre- and postoperative departments regarding these patients. In this context, different intervention studies on patient’s hip fracture and dementia are needed to increase knowledge and awareness regarding this group of patients.

Molecular strong-field approximation is applied to above-threshold detachment of homonuclear diatomic molecular negative ions. Differences between the photodetachment amplitudes for neutral diatomic molecules and diatomic anions, for both direct and rescattered electrons, are examined. Numerical results for the photoelectron spectra of $ {\rm C}_2^ - $C2− molecular anions for different intensities and wavelengths of a linearly polarized laser field and different molecular anion orientations are shown and discussed. Two-center destructive interference minima (suppression regions) in the rescattering part of the photoelectron spectra are observed. For molecules with molecular orientation defined by the angle $ {\theta _L} $θL with respect to the laser-field polarization axis, these minima manifest as two parallel straight lines in the distribution of the photoelectron yield presented in the photoelectron momentum plane. These lines make the angle $ {90^ \circ } - {\theta _L} $90∘−θL, with the momentum component parallel to the laser-field polarization axis. Focal-averaged photoelectron spectra are also presented and analyzed.

High-order harmonic generation by orthogonally polarized two-color (OTC) laser fields is analysed using strong-field approximation and quantum-orbit theory. Results for the field components frequency ratio of 2:1 and 3:1 are presented and compared. We have shown that, depending on the relative phase between the field components, the shape of the high-harmonic spectrum can be very different from that obtained by a monochromatic linearly polarized laser field. It is also shown that it is possible to generate elliptically polarized high-order harmonics with very high photon energies using OTC laser field with the frequency ratio of 3:1 and a long fundamental wavelength. An effective relative phase control of the harmonic emission is demonstrated. The obtained results are explained using the quantum-orbit theory.

Abstract Simultaneous adsorption of heavy metals in complex multi metal system is insufficiently explored. This research gives results of key process parameters optimization for simultaneous removal of Cd(II), Co(II), Cr(III), Cu(II), Mn(II), Ni(II) and Pb(II) from aqueous solution (batch system). New lemon peel-based biomaterial was prepared and characterized by infrared spectroscopy with Fourier transformation (FTIR), scanning electron microscopy (SEM), electron dispersive spectroscopy (EDS), while the quantification of metals was made by atomic absorption spectrometry (AAS). Simultaneous removal of seven metals ions was favorable at pH 5 with 300 mg/50 mL solid-liquid phase ratio, within 60 min at room temperature with total obtained adsorption capacity of 46.77 mg g−1. Kinetic modeling showed that pseudo-second order kinetic and Weber-Morris diffusion models best describe the adsorption mechanism of all seven heavy metals onto lemon peel.

Breast cancer is one of the major causes of mortality in women worldwide. The most aggressive breast cancer subtypes are human epidermal growth factor receptor-positive (HER2+) and triple-negative breast cancers. Therapies targeting HER2 receptors have significantly improved HER2+ breast cancer patient outcomes. However, several recent studies have pointed out the deficiency of existing treatment protocols in combatting disease relapse and improving response rates to treatment. Overriding the inherent actions of the immune system to detect and annihilate cancer via the immune checkpoint pathways is one of the important hallmarks of cancer. Thus, restoration of these pathways by various means of immunomodulation has shown beneficial effects in the management of various types of cancers, including breast. We herein review the recent progress in the management of HER2+ breast cancer via HER2-targeted therapies, and its association with the programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) axis. In order to link research in the areas of medicine and mathematics and point out specific opportunities for providing efficient theoretical analysis related to HER2+ breast cancer management, we also review mathematical models pertaining to the dynamics of HER2+ breast cancer and immune checkpoint inhibitors.

Before even opening the book, Democracy by Decree: Prospects and Limits of Imposed Consociational Democracy in Bosnia and Herzegovina captures the reader’s attention with its intriguing and provocative title. But what author Adis Merdzanovic delivers in its pages is equally engaging. Merdzanovic illustrates how the consociational power-sharing arrangements in Bosnia and Herzegovina were imposed by the international community following the wars in the 1990s, rather than genuinely initiated from inside a country, and have, perhaps unsurprisingly, largely failed.

The Internet of Things (IoT) is a concept of the modern, interconnected world. Over 50 billion devices, globally-connected, make up the largest network that is stepping towards the fourth industrial revolution, and which will significantly change the system of values and business systems. In the world of heterogeneous communication technologies, choosing the optimal one is a challenge for system architects, which is not an easy task often. The paper presents a comparative analysis of widespread communication technologies in the domain of IoT, and the conclusions presented based on the performed analysis, provide a better insight into the choice of the optimal solution depending on the problem domain and therefore better quality of solutions based on the concept of IoT.

Introduction: Ramadan is the holy month of Muslims including fasting sometimes more than 20 hours. Even diabetes patients can be exempted from fasting it has been shown that almost 80% of diabetes type 2 patients intend and do fasting. To avoid acute complications during fasting, different recommendations on diabetes management are available. Considering the fact that there are more than 226 thousand diabetics in Bosnia and Herzegovina, it is important to provide structured support and healthcare service to those who are practicing fast during Ramadan. Aim: To evaluate knowledge, practice and attitudes of physicians treating diabetes (diabetologists and endocrinologists) in Bosnia and Herzegovina regarding management of diabetes in fasting patients during Ramadan. Methods: A 32 questions survey has been developed, validated and disseminated to the 27 specialists treating diabetes in Bosnia and Herzegovina through online form examining demographic characteristics, current practices and attitudes and knowledge on diabetes management during Ramadan. Results: All surveyed physicians deal with patients who are fasting during Ramadan. The majority of surveyed physicians 23 (85,2%) proactively initiate a discussion about planned fasting. More than 63,0% are following their experience and only 18,5% ADA/EASD guidelines on diabetes management during Ramadan. There are no significant differences between gender of the physicians, place of work and specialization when it comes to specific knowledge related to treatment guidelines, but some differences are observed. Conclusion: Although overall physicians` knowledge of diabetes management during Ramadan is satisfying there is opportunity in additional specialized education and measures introduction into the practice in order to improve treatment outcomes and standards of care.

Temperature-stable dissolving film eliminates cold-chain storage and successfully immunizes mice sublingually and buccally. A novel, thin-film platform that preserves live viruses, bacteria, antibodies, and enzymes without refrigeration for extended periods of time is described. Studies with recombinant adenovirus in an optimized formulation that supports recovery of live virus through 16 freeze-thaw cycles revealed that production of an amorphous solid with a glass transition above room temperature and nitrogen-hydrogen bonding between virus and film components are critical determinants of stability. Administration of live influenza virus in the optimized film by the sublingual and buccal routes induced antibody-mediated immune responses as good as or better than those achieved by intramuscular injection. This work introduces the possibility of improving global access to a variety of medicines by offering a technology capable of reducing costs of production, distribution, and supply chain maintenance.