Healthcare systems and general surgeons are being challenged by the current pandemic. The European Association for Endoscopic Surgery (EAES) aimed to evaluate surgeons’ experiences and perspectives, to identify gaps in knowledge, to record shortcomings in resources and to register research priorities. An ad hoc web-based survey of EAES members and affiliates was developed by the EAES Research Committee. The questionnaire consisted of 69 items divided into the following sections: (Ι) demographics, (II) institutional burdens and management strategies, and (III) analysis of resource, knowledge, and evidence gaps. Descriptive statistics were summarized as frequencies, medians, ranges,, and interquartile ranges, as appropriate. The survey took place between March 25th and April 16th with a total of 550 surgeons from 79 countries. Eighty-one percent had to postpone elective cases or suspend their practice and 35% assumed roles not related to their primary expertise. One-fourth of respondents reported having encountered abdominal pathologies in COVID-19-positive patients, most frequently acute appendicitis (47% of respondents). The effect of protective measures in surgical or endoscopic procedures on infected patients, the effect of endoscopic surgery on infected patients, and the infectivity of positive patients undergoing laparoscopic surgery were prioritized as knowledge gaps and research priorities. Perspectives and priorities of EAES members in the era of the pandemic are hereto summarized. Research evidence is urgently needed to effectively respond to challenges arisen from the pandemic.

PurposeThe purpose of this paper is to investigate the determinants of innovative work behavior (IWB) by examining the moderating role of transformational leadership in the context of small and medium enterprises (SMEs).Design/methodology/approachThe study surveyed 371 employees from SMEs in Bosnia and Herzegovina by adopting convenience sampling. Hierarchical regression was used to test the hypotheses.FindingsThe findings supported the authors’ assumptions that IWB determinants such as psychological empowerment, participation in the decision-making process and organizational justice are positively related to IWB. Besides, transformational leadership moderates the relationship between organizational justice and IWB.Research limitations/implicationsThe data for this study was collected by using convenience sampling as well as a cross-sectional survey method, which limits the generalization of results.Practical implicationsTo spur the IWB among the employees in SMEs, an organization has to create an environment where psychological empowerment is high, employees have a chance to participate in the decision-making process and organizational rules and procedures are fair. In the case of organizational justice, the relationship shall be stronger if transformational leadership is present.Originality/valueIn SMEs, transformational leadership plays an important role. To the best of the authors' knowledge, this is the first study that demonstrates the moderating effect of transformational leadership on the relationship between one specific IWB determinant and IWB.

Glycogen synthase kinase 3 (GSK3) is a monomeric serine-threonine kinase discovered in 1980 in a rat skeletal muscle. It has been involved in various cellular processes including embryogenesis, immune response, inflammation, apoptosis, autophagy, wound healing, neurodegeneration, and carcinogenesis. GSK3 exists in two different isoforms, GSK3α and GSK3β, both containing seven antiparallel beta-plates, a short linking part and an alpha helix, but coded by different genes and variously expressed in human tissues. In the current review, we comprehensively appraise the current literature on the role of GSK3 in various cancers with emphasis on ovarian carcinoma. Our findings indicate that the role of GSK3 in ovarian cancer development cannot be decisively determined as the currently available data support both prooncogenic and tumor-suppressive effects. Likewise, the clinical impact of GSK3 expression on ovarian cancer patients and its potential therapeutic implications are also limited. Further studies are needed to fully elucidate the pathophysiological and clinical implications of GSK3 activity in ovarian cancer.

Objetivo: Descrever acoes do Conselho Federal de Enfermagem atraves do Comite Gestor de Crise para o Coronavirus no pais. Metodo: descricao de atividades na modalidade de relato de experiencia que teve seus dados coletados nos arquivos, documentos e relatorio do Comite Gestor de Crise em junho de 2020. Resultados: Identificou-se dez macro acoes: criacao do Comite Gestor de Crise, Campanha “Juntos contra o Coronavirus”, Observatorio da Enfermagem, Ouvidoria e Denuncias, Equipamentos de Protecao Individual, Medidas Legais, Apoio em Saude Mental, Capacitacao Profissional e Plantao do Comite de Crise. Consideracoes Finais: as acoes desenvolvidas nesse periodo pelo Cofen contribuiram para aumentar sua interacao com os profissionais de enfermagem, bem como para promover a valorizacao destes perante as agencias de saude governamentais nacionais e internacionais, poder publico e midia nacional e internacional, destacando-se frente a outros conselhos de classe no pais. Descritores: Enfermagem; Infeccoes por Coronavirus; Pratica Profissional. Objective: To describe actions of the Federal Nursing Council through the Crisis Management Committee for Coronavirus in the country. Method: description of activities in the experience report modality that had its data collected in the files, documents and report of the Crisis Management Committee, in June 2020. Results: Ten macro actions were identified: creation of the Crisis Management Committee, “Together against Coronavirus” Campaign, Nursing Observatory, Ombudsman and Complaints, Personal Protective Equipment, Legal Measures, Mental Health Support, Professional Training and on-call the Crisis Committee.  Final Considerations : the actions developed during this period by Federal Nursing Council contributed to increase their interaction with nursing professionals, as well as to promote their valorization before national and international government health agencies, public authorities and national and international media, standing out in front to other class councils in the country. Descriptors: Nursing; Coronavirus Infections; Professional Practice. Objetivo: Describir las acciones del Consejo Federal de Enfermeria a traves del Comite de Manejo de Crisis para el Coronavirus en el pais. Metodo: descripcion de actividades en la modalidad de informe de experiencia que recolecto sus datos en los archivos, documentos e informe del Comite de Gestion de Crisis en junio de 2020. Resultados : Se identificaron diez macro acciones: creacion del Comite de Gestion de Crisis, Campana "Juntos contra el coronavirus", Observatorio de Enfermeria, Defensor del Pueblo y Quejas, Equipo de Proteccion Personal, Medidas Legales, Apoyo a la Salud Mental, Capacitacion Profesional y el Comite de Crisis de guardia. Consideraciones finales: las acciones desarrolladas durante este periodo por Cofen contribuyeron a aumentar su interaccion con los profesionales de enfermeria, asi como a promover su valorizacion ante agencias de salud gubernamentales nacionales e internacionales, autoridades publicas y medios de comunicacion nacionales e internacionales, destacandose a otros consejos de clase en el pais. Descriptores: Enfermeria; Infecciones por Coronavirus; Practica Profesional.

Introduction: Self-medication has been very popular and globally prevalent for a long time. Aim: This research aims to present pharmacists’ engagement in the process of self-medication in the Sarajevo Canton. Methods: A total of 312 respondents completed an anonymous questionnaire-based survey. The first group (165 respondents) was surveyed in the pharmacy after buying a non-prescription drug, and the second group (147 respondents) outside the pharmacy. Results: The most commonly purchased drug was paracetamol, whereas headache was dominant amongst health conditions for which treatment respondents intended to use the purchased drug. A belief that respondents could cure themselves was the most common answer when asked why they had not visited a doctor, whereas previous experience with the purchased drug prevailed as an answer when asked from whom they had gotten information about the adequacy of the purchased drug for their health problem. Respondents mostly bought drugs for themselves. Pharmacists instructed 65% of respondents on how to take the purchased drug and checked whether 55% of respondents bought an appropriate drug for their health problem. Only 25% and 29% of respondents were informed about the adverse effects and potential contraindications or interactions of the purchased drug, respectively. According to 45% of respondents, pharmacists spent up to one minute in a conversation with them about the purchased drug. Conclusion: In the Sarajevo Canton, pharmacists should be more actively involved in the process of self-medication and provide the necessary advice to patients consuming non-prescription drugs. Further research is needed to create a clearer picture.

Muesli bars is a generic term that refers to baked or cold-formed cereal-based snack bars, and may contain other ingredients such as fruit, nuts, seeds, chocolate, yoghurt, and a variety of other fillings and/or toppings. By changing the ingredients nutritional value of muesli bar can be modified. In this research, protein-rich and energy-high muesli bars have been produced, because they contain a higher amount of fat, proteins and sugar. However, fats and sugars were not added but come from specific ingredients (hazelnuts, walnuts, chia seeds, sesame, sunflower and pumpkin seeds, oat flakes, etc.). Four muesli bar formulations were developed, two with hazelnuts and two with walnuts, added in the amount of 25% and 50%, respectively. The other ingredients were added in the same amount. The product was dried at 80°C for several hours. The composition, polyphenolic compounds and antioxidant capacity were determined in the products before and after drying. Also, muesli bars were sensory evaluated.

This paper presents the study that would allow a revision of the currently valid diagnostic reference level in intraoral dental X-ray radiography in Bosnia and Herzegovina. The study was conducted for six procedures that are used to capture incisor, premolar and molar teeth, of both maxilla and mandible, in adults. Measurements were performed on 41 intraoral X-ray devices, 20 of which were systems with digital image receptor and 21 film-based X-ray systems. In this study, incident air kerma (Ki) and air kerma-area product (PKA) were used as patient dose descriptors. The third quartile (Q3) of the measured incident air-kerma values was used to compare with the current national diagnostic reference level (DRL) for intraoral dental procedures. The obtained results of Q3 for both types of devices, with film-based and digital image receptors, have shown that the third quartile values are lower (3.5 and 1.2 mGy, respectively) than the current national DRL (7.0 mGy). Hence, new data can be used to re-establish the diagnostic reference levels in intraoral dental X-ray examinations in Bosnia and Herzegovina.

Abstract. Current global mitigation ambition up to 2030 under the Paris Agreement, reflected in the National Determined Contributions (NDCs), is insufficient to achieve the agreement's 1.5  ∘ C long-term temperature limit. As governments are preparing new and updated NDCs for 2020, the question as to how much collective improvement is achieved is a pivotal one for the credibility of the international climate regime. The recent Special Report on Global Warming of 1.5  ∘ C by the Intergovernmental Panel on Climate Change has assessed a wide range of scenarios that achieve the 1.5  ∘ C limit. Those pathways are characterised by a substantial increase in near-term action and total greenhouse gas (GHG) emission levels about 50 % lower than what is implied by current NDCs. Here we assess the outcomes of different scenarios of NDC updating that fall short of achieving this 1.5  ∘ C benchmark. We find that incremental improvements in reduction targets, even if achieved globally, are insufficient to align collective ambition with the goals of the Paris Agreement. We provide estimates for global mean temperature increase by 2100 for different incremental NDC update scenarios and illustrate climate impacts under those median scenarios for extreme temperature, long-term sea-level rise and economic damages for the most vulnerable countries. Under the assumption of maintaining ambition as reflected in current NDCs up to 2100 and beyond, we project a reduction in the gross domestic product (GDP) in tropical countries of around 60 % compared to a no-climate-change scenario and median long-term sea-level rise of close to 2 m in 2300. About half of these impacts can be avoided by limiting warming to 1.5  ∘ C or below. Scenarios of more incremental NDC improvements do not lead to comparable reductions in climate impacts. An increase in aggregated NDC ambition of big emitters by 33 % in 2030 does not reduce presented climate impacts by more than about half compared to limiting warming to 1.5  ∘ C. Our results underscore that a transformational increase in 2030 ambition is required to achieve the goals of the Paris Agreement and avoid the worst impacts of climate change.

Interval recognition is an important part of ear training—the key aspect of music education. Once trained, the musician can identify pitches, melodies, chords, and rhythms by listening to music segments. In a conventional setting, the tutor would teach a trainee the intervals using a musical instrument, typically a piano. However, this is expensive, time consuming, and nonengaging for either party. With the emergence of new technologies, including virtual reality (VR) and areas such as edutainment, this and similar trainings can be transformed into more engaging, more accessible, customizable (virtual) environments, with the addition of new cues and bespoke progression settings. In this work, we designed and implemented a VR ear training system for interval recognition. The usability, user experience, and the effect of multimodal integration through the addition of a perceptual cue, spatial audio, was investigated in two experiments with 46 participants. The results show that the system is highly acceptable and provides a very good experience for users. Furthermore, we show that the added spatial auditory cues provided in the VR application give users significantly more information for judging the musical intervals, something that is not possible in a non-VR environment.

Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this fact, we recently reported the prevalence of both HPVs and EBV in cervical and breast cancers. We herein explore for the first time the co-prevalence of high-risk HPVs and EBV in 98 head and neck (HN) squamous cell carcinoma (SCC) tissues from Bosnian patients using polymerase chain reaction (PCR) and immunohistochemistry (IHC) analysis, as well as tissue microarray methodology. The majority of these cancer tissue cases were from the oral cavity (68%). We found that high-risk HPVs and EBV are co-present in 34.7% of the SCC samples; with a significant correlation between the various HPV types and EBV co-incidence (p = 0.03). Our data showed that 30.8% of oral SCCs are positive for E6 oncoprotein of high-risk HPVs and 44.6% are positive for LMP1 of EBV. The most commonly expressed HPVs in our HNSCC samples include HPV types 16, 18, 45 and 58. Additionally, 37.5% of oral SCCs are positive for both HPVs and EBV, with statistically significant association between high-risk HPV types and EBV (p < 0.05). More importantly, our data revealed that the co-presence of HPV and EBV is strongly correlated with advanced tumor stage (p = 0.035). In this study we show that HPV and EBV oncoviruses are co-present in HNSCC, particularly in oral cancer, where they can cooperate in the initiation and/or progression of this cancer. Thus, further studies are necessary to elucidate the mechanism of this cooperation.

Background Human papillomaviruses (HPVs) and Epstein–Barr virus (EBV), known oncoviruses, can be co-present and cooperate in the initiation and/or progression of human carcinomas, including head and neck. Based on this fact, we recently reported the prevalence of both HPVs and EBV in cervical and breast cancers. Methods We herein explore for the first time the co-prevalence of high-risk HPVs and EBV in 98 head and neck (HN) squamous cell carcinoma (SCC) tissues from Bosnian patients using polymerase chain reaction (PCR) and immunohistochemistry (IHC) analysis, as well as tissue microarray methodology. Results The majority of these cancer tissue cases were from the oral cavity (68%). We found that high-risk HPVs and EBV are co-present in 34.7% of the SCC samples; with a significant correlation between the various HPV types and EBV co-incidence (p = 0.03). Our data showed that 30.8% of oral SCCs are positive for E6 oncoprotein of high-risk HPVs and 44.6% are positive for LMP1 of EBV. The most commonly expressed HPVs in our HNSCC samples include HPV types 16, 18, 45 and 58. Additionally, 37.5% of oral SCCs are positive for both HPVs and EBV, with statistically significant association between high-risk HPV types and EBV (p < 0.05). More importantly, our data revealed that the co-presence of HPV and EBV is strongly correlated with advanced tumor stage (p = 0.035). Conclusion In this study we show that HPV and EBV oncoviruses are co-present in HNSCC, particularly in oral cancer, where they can cooperate in the initiation and/or progression of this cancer. Thus, further studies are necessary to elucidate the mechanism of this cooperation.

The concentrations of 16 polycyclic aromatic hydrocarbons (PAH) in smoked dry sausage Hercegovacka kobasica were investigated. The sausages were stuffed in two different casings (collagen and natural) and smoked in traditional and industrial smokehouses. The highest concentration of PAH 16 were detected in sausages in natural casings smoked in the traditional manner. The samples smoked in the industrial chamber stuffed in collagen casing showed the lowest PAH 16 content. The content of PAH 4 in sausage smoked in the traditional way and stuffed in natural casing averaged 24.46 µg/kg, which is more the double of maximum prescribed concentration of 12 µg/kg. The concentration of cancerogenic benzo[a]pyrene averaged 7.79 µg/kg in sausage stuffed in natural casing and smoked in the traditional way, which is almost four times the legislative prescribed values (2 µg/kg). Sausage smoked in the traditional manner and stuffed in collagen casing showed lower values for PAH 4 (13.88 µg/kg) and benzo[a]pyrene (4.97 µg/kg), but these values were also above the legislative prescribed values.