Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) whose pandemic was declared on March 11 2021 (1). Spectrum of COVID-19 clinical manifestations is very wide. Most patients report to ambulance with mild or moderate symptoms, but some of them rapidly develops acute respiratory distress syndrome (ARDS), respiratory failure, acute cardiac injury, multiple organ failure and death (2). Older age, diabetes mellitus and cardiovascular disease are reported as high predictors of morbidity and mortality. Aim: To determine correlation between diabetes mellitus and severity of clinical picture in patients with COVID-19. Methods: Current study involve retrospective analysis of 1513 patients with Real Time PCR confirmed COVID-19 hospitalized in Clinic for infectious disease, University Clinical Center, Sarajevo, Bosnia and Herzegovina, in a period of June 2020 to December 2020. Results: Among them 417 had previously diagnosed of diabetes mellitus. Results show that patients with diabetes mellitus are likely to require treatment in Intensive care unit, and oxygenic support with invasive ventilation. There was no statistically significant difference in outcome of the disease. Conclusion: Even this study didn’t find increased mortality in patients with COVID-19 and diabetes mellitus, further studies should be done to determine risk for patients with DM to develop severe form of disease.                   Peer Review History: Received 23 March 2021; Revised 17 April; Accepted  5 May, Available online 15 May 2021 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:      Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Branislav Rankovic, University of Kragujevac, Serbia, rankovic@kg.ac.rs Dr. Poualeu  Kamani  Sylviane  Laure, University of Dschang, Cameroon, poualeusylviane@yahoo.fr Similar Articles: THE RISKS AND ADVANTAGES OF ANTI-DIABETES THERAPY IN THE POSITIVE COVID-19 PATIENT

To provide the quality required for its use, raw kaolin must be subjected to certain processing procedures like delamination which is applied to the layered structure materials. The aim of this research is to determine the possibility of performing delamination in the extruder and to estimate the effects of this process on the physico-chemical properties of kaolin. The results showed that delamination can be efficiently realized in the extruder by shearing densely packed layers under the influence of friction force and added Na2CO3 electrolyte. The crystal structure of the system was thus disrupted. This was confirmed by the Hinckley index (HI) decrease and by the dilatometric characteristics changes during heating. The particle size was reduced and, furthermore, new adsorption centers were formed, which led to an increase in the total cation exchange capacity (CEC). The plasticity of kaolin decreased with the increasing delamination degree, as well as the amount of water required for plastic processing, which is favorable in drying ceramic products.

Abstract Careva Cuprija (Emperor’s Bridge), located in the heart of the Old City in Sarajevo, was built in 1897. It was built as the first single-arch reinforced concrete bridge in Sarajevo with a span of 25.36 m. At that time, it was the largest structure of this type in the Austro-Hungarian monarchy. During its long life of 122 years, some rehabilitation work took place; however, the main design for its rehabilitation was done just in 2015. As the bridge is on the list of the national monuments of Bosnia and Herzegovina, ICOMOS Recommendations for the Analysis, Conservation and Structural Restoration of Architectural Heritage were followed. The current condition assessment of the bridge was used to identify the remaining service life of the bridge, the required type and level of treatments, and suitable time for applying repair and retrofitting methods. Visual inspection, nondestructive, and minor destructive tests were done with the goal to determine the mechanical characteristics of the built-in materials and define the state of the structure. The article discusses the used methods and obtained results, which were the basis for numerical model calculation and the creation of the rehabilitation design.

Bronchial asthma is a chronic disease of the airways, heterogeneous and of unknown etiology. In Brazil, decompensated bronchial asthma is the fourth leading cause of hospitalizations, with a higher incidence in the Northeast and Southeast regions, with descending mortality rates. The most common symptoms and signs are dyspnea, wheezing, retrosternal chest tightness and cough, resulting from the inflammatory process, with bronchial hyperreactivity and bronchoconstriction. This article aims to alert health professionals about the early diagnosis and treatment of exacerbated asthma in an emergency in the pandemic context of COVID-19, through this case report. Also dealing with the differential diagnosis in respiratory symptoms for COVID-19 with assessment of epidemiological risks and radiography, not very sensitive and specific for COVID-19, but widely available. This case report is about a 19-year-old Caucasian woman, single, born in Caruaru-PE, with complaints of low intensity chest discomfort, dyspnea and fatigue for three days, presenting exacerbation of symptoms in the last four hours, with previous diagnosis of asthma since childhood, currently with treatment interrupted due to fear of worsening for COVID-19 and waking up at night every day during the last month. After therapeutic conduct and clinical improvement, the patient was discharged with instructions on continuity of oral corticosteroids, return to bronchial asthma control therapy, need for follow-up in Primary Health Care (PHC) and symptoms of severity for bronchial asthma and COVID- 19 that indicate the need for emergency care.

Traffic management is a significantly difficult and demanding task. It is necessary to know the main parameters of road networks in order to adequately meet traffic management requirements. Through this paper, an integrated fuzzy model for ranking road sections based on four inputs and four outputs was developed. The goal was to determine the safety degree of the observed road sections by the methodology developed. The greatest contribution of the paper is reflected in the development of the improved fuzzy step-wise weight assessment ratio analysis (IMF SWARA) method and integration with the fuzzy measurement alternatives and ranking according to the compromise solution (fuzzy MARCOS) method. First, the data envelopment analysis (DEA) model was applied, showing that three road sections have a high traffic risk. After that, IMF SWARA was applied to determine the values of the weight coefficients of the criteria, and the fuzzy MARCOS method was used for the final ranking of the sections. The obtained results were verified through a three-phase sensitivity analysis with an emphasis on forming 40 new scenarios in which input values were simulated. The stability of the model was proven in all phases of sensitivity analysis.

Growing evidence indicates that RNAi is an effective control strategy for agronomically important fungi. To implement RNAi-based crop protection strategies, dsRNA molecules are either sprayed on foliage or generated by genetically engineered plants. Here, we summarize current knowledge of the mechanisms governing dsRNA uptake and RNAi-mediated gene silencing in fungi, as well as the factors that influence these phenomena. Of primary importance is dsRNA design, as identifying an appropriate gene for silencing and determining which region of the gene to target are critical for maximizing efficiency. Strategies for enhancing dsRNA uptake, potentially by using formulations and/or carriers that prevent dsRNA degradation by (a)biotic factors and possibly facilitate translocation, also are a key consideration. Finally, determining whether the fungal pathogen of interest contains a functional RNAi machinery is a major consideration. Integrated experimental confirmation of these important factors is necessary for the successful development of crop protection strategies against fungal pathogens.

The Southwest Asian, circum-Mediterranean, and Southern European populations (collectively, SWAMSE) together with Northern European populations form one of five "continental" groups of global populations in many analyses of population relationships. This region is of great anthropologic and forensic interest but relationships of large numbers of populations within the region have not been able to be cleanly resolved with autosomal genetic markers. To examine the genetic boundaries to the SWAMSE region and whether internal structure can be detected we have assembled data for a total of 151 separate autosomal genetic markers on populations in this region and other parts of the world for a global set of 95 populations. The markers include 83 ancestry informative SNPs as singletons and 68 microhaplotype loci defined by 204 SNPs. The 151 loci are ancestry informative on a global scale, identifying at least five biogeographic clusters. One of those clusters is a clear grouping of 37 populations containing the SWAMSE plus northern European populations to the exclusion of populations in South Central Asia and populations from farther East. A refined analysis of the 37 populations shows the northern European populations clustering separately from the SWAMSE populations. Within Southwest Asia the Samaritans and Shabaks are distinct outliers. The Yemenite Jews, Saudi, Kuwaiti, Palestinian Arabs, and Southern Tunisians cluster together loosely while the remaining populations from Northern Iraq, Mediterranean Europe, the Caucasus region, and Iran cluster in a more complex graded fashion. The majority of the SWAMSE populations from the mainland of Southwest Asia form a cluster with little internal structure reflecting a very complex history of endogamy and migrations. The set of 151 DNA polymorphisms not only distinguishes major geographical regions globally but can distinguish ancestry to a small degree within geographical regions such as SWAMSE. We discuss forensic characteristics of the polymorphisms and also identify those that rank highest by Rosenberg's In measure for the SWAMSE region populations and for the global set of populations analyzed. DATA AVAILABILITY: Genotypes on all 151 markers for all 3790 individuals typed in the Kidd Lab on the 72 Kidd lab populations have been deposited in the Zenodo archive and can be freely accessed at https://doi.org/10.5281/zenodo.4658892. Some of the data has been made public previously as supplemental files appended to publications. Data for the additional individuals included in the analyses was taken from already public datasets as indicated in the text.

We discuss neutrino magnetic moments as a way of constraining physics beyond the Standard Model. In fact, new physics at the TeV scale can easily generate observable neutrino magnetic moments, and there exists a multitude of ways of probing them. We highlight in particular direct dark matter detection experiments (which are sensitive to neutrino magnetic moments because of the predicted modifications to the solar neutrino scattering rate), stellar cooling, and cosmological constraints.

Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent respiratory syncytial virus (RSV) which causes severe outcomes in infants. We applied complementary approaches with primary pediatric LR-MSCs and a state-of-the-art model of human RSV infection in lamb. Remarkably, RSV-infection of pediatric LR-MSCs led to a robust activation, characterized by a strong antiviral and pro-inflammatory phenotype combined with mediators related to T cell function. In line with this, following in vivo infection, RSV invades and activates LR-MSCs, resulting in the expansion of the pulmonary MSC pool. Moreover, the global transcriptional response of LR-MSCs appears to follow RSV disease, switching from an early antiviral signature to repair mechanisms including differentiation, tissue remodeling, and angiogenesis. These findings demonstrate the involvement of LR-MSCs during virus-mediated acute lung injury and may have therapeutic implications. AUTHOR SUMMARY This work identifies a novel function of lung-resident MSCs during virus-induced acute lung injury. These findings contribute to the understanding of host response and lung repair mechanisms during a highly prevalent clinical situation and may have therapeutic implications.

Abstract Pomelo peel and sugar beet in their native forms were proposed as novel biosorbents. They were investigated as 1%, 3% and 5% (w/v) loadings for dry purification of biodiesel samples synthesized from animal fat and vegetable oil using a conventional method. The effects of biosorbents were examined by determining the following biodiesel quality parameters: acid value (AV), peroxide value (PV), density, viscosity, flash point (FP), soap and free glycerol (FG) content. Dry washing was compared to the water washing technique. Biosorbents characterization was performed by FTIR and SEM analysis. The 5% loadings of both biosorbents reduced the soap content to below 36 ppm. In contrast, the soap content after water washing was 172.6 ppm in biodiesel from vegetable oil and 256 ppm in biodiesel from lard. The FG removal efficiency was in a linear correlation with the biosorbents’ loadings. The lowest FG values in biodiesel from vegetable oil (0.25 ppm) and from lard (0.23 ppm) were found upon purification with 5% pomelos peel and 5% sugar beet, respectively. Best results were achieved using 5% pomelo peel, closely followed by 3% pomelo peel. Such adsorption capacity can be explained by the porous structure and the functional groups present in pomelo peel.

Freshwater ecosystems are among the most threatened in the world, while providing numerous essential ecosystem services (ES) to humans. Despite their importance, research on freshwater ecosystem services is limited. Here, we examine how freshwater studies could help to advance ES research and vice versa. We summarize major knowledge gaps and suggest solutions focusing on science and policy in Europe. We found several features that are unique to freshwater ecosystems, but often disregarded in ES assessments. Insufficient transfer of knowledge towards stakeholders is also problematic. Knowledge transfer and implementation seems to be less effective towards South-east Europe. Focusing on the strengths of freshwater research regarding connectivity, across borders, involving multiple actors can help to improve ES research towards a more dynamic, landscape-level approach, which we believe can boost the implementation of the ES concept in freshwater policies. Bridging these gaps can contribute to achieve the ambitious targets of the EU’s Green Deal.