Background / Aim. Asthma is a chronic inflammatory lung disorder. The effect of asthma drugs on oral health is still the subject of debate among researchers in dentistry. The aim of this study was to evaluate dental status in asthmatic children and evaluate the possible effect of drugs treating asthma on dental health. Methods. Participants were divided into two groups: the asthma (AG) and the non-asthma (NAG) group. Based on symptoms of the asthma and possibility for effective control of the disease, the asthma group was divided into two subgroups. The oral examination of the teeth was performed by the use of probe and mouth mirror under artificial light in accordance with World Health Organization recommendations. Saliva analysis was carried out by GC Saliva-Check Buffer. Results. The present study included 136 children aged from 6 to 16 years. The mean dmft/DMFT (decayed, missing, filled, teeth) of children in the AG group (6.0?4.0/3.3?4.4) was higher than in the NAG group (4.8?4.4/2.5?3.4), but significant differences were not observed between the groups. Salivary pH values were found to be similar in both groups, but a stimulated salivary flow rate was found to be significantly lower in the AG group (p<0.01). Conclusion. Although the prevalence of dental caries in the AG group was similar to the NAG group in this study, decreased stimulated salivary flow rate in the AG group may contribute to higher values of dental caries in asthmatic children in future.

Introduction. Serological testing for SARS-CoV-2 virus infection is a valuable method of estimating the extent of COVID-19 disease prevalence. The study aims to assess the seroprevalence of SARS-CoV-2 virus infection in a specific group of respondents employed in the health insurance sector, to determine the ratio of symptomatic and asymptomatic cases, as well as to examine susceptibility to COVID-19 in relation to the ABO blood group system. Methods. This research was conducted among 150 randomly selected employees from the health insurance sector of the Republic of Srpska. All respondents completed the survey, voluntary consent to participate, and had a blood sample taken. Serum samples were tested for the presence of SARS-CoV-2 specific IgG antibodies. Results. The seroprevalence of SARS-CoV-2 virus infection was 70.7%. Out of the 100 seropositive respondents, 48% had the presence of a symptom of COVID-19, while 52% had no symptoms of the disease in the period from 1 March 1 2020 until the day of testing. Examining the association between ABO blood group system and seropositivity in our study, we found that the highest seroprevalence of SARS-CoV-2 IgG antibodies among respondents was in blood group B (83.3%), followed by blood group AB (80.0%) and blood group A (75.0%), while the lowest seroprevalence was among respondents with blood group O (54.1%). Conclusion. Among employees in the health insurance sector, SARSCoV-2 seroprevalence of 70.7% was registered. Among respondents with a positive serological result on IgG, 52% were asymptomatic. The seroprevalence of SARS-CoV-2 virus infection is the lowest among subjects with blood group O.

. Background: Computer simulations can be briefly described as the use of computers to represent the dynamic responses of a tested system, by observing the behavior of another, artificial, system modeled on basis of the test system. Physical modeling has been practiced unconsciously since the beginning of the human species, that is, from the moment when the human mind began to understand all the complexity of phenomena and things that surrounded it in nature. Objective : The aim of this paper is to analyze the implementation of computer's simulation and modeling for educational agenda. Methods : This article is a review of the entire to use models, modeling and simulation by using compiters and ICT for teaching system in undergraduate, postgraduate and continuing education using published information, as well as professional papers and publications about this topic. The simulation methodology is based on computer science, statistics, numerical mathematics, operational research and artificial intelligence, but today it is sufficiently coherent and developed that it can rightly be called a separate scientific discipline. The system model represents a simplified and idealized (abstract) image of a real system. In other words, a model is a description of a real system with all its characteristics that are relevant from our point of view. Results and Discussion: Application of computer simulations in science: Different simulations are used to meet specific requirements of the scientific field and the problem such as: Numerical simulation of a differential equation, which cannot be solved analytically. This category includes theories dealing with continuous systems, such as phenomena in physical cosmology, fluid dynamics ; Stochastic simulation, used for discrete systems, where changes occur on the basis of probability, and cannot be explained by equations. These include genetic changes, and biochemical and genetic regulatory processes; Modeling of molecules and their behavior for the purpose of creating drugs; CFD–Computational Fluid Dynamics.–computers are used to perform calculations, which describe the behavior of liquids and gases; Blue Brain project; Cognitive architecture and Movement of parasites in the human body. Conclusion: This paper presents explanations and examples of the application of computer simulations in order to solve everyday problems encountered, both in medicine and all other branches of science. Conclusion: Computer simulations are an invaluable blend of nature and technology, and are one of the main sources of hope for understanding and improving the world we live in.

Institute for Physical Medicine and Rehabilitation “Dr Miroslav Zotović”, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Faculty of Health Studies, University of Sarajevo, the Federation of Bosnia and Herzegovina, Bosnia and Herzegovina. Department of Physiology, Faculty of Medicine, University of Banja Luka, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina. Medical Faculty of the Military Medical Academy, University of Defence, Belgrade, Serbia.

Introduction: Carrying a school bag is a dominant activity that a child performs during daily productive activities. The aim of the research is to examine how carrying a school bag of different weights affects the distribution of force and plantar pressure during normal walking on the flat terrain of children of varying levels of physical activity.Methods: The pilot study included 124 students aged 11-12 from Banja Luka. According to the protocol, each group of respondents was treated with an intervention-customized school bag and a comparator-school bag that the child only opted for. For the research, the Physical Activity Questionnaire for Older Children, measurement of anthropometric parameters, school bag weight, and Zebris tape (Zebris Medical GmbH, Germany) were used for gait analysis.Results: Inactive children achieved the lowest and active children’s highest walking speed during normal walking without a bag, with their customized school bag. When carrying a custom school bag: The highest maximum force is projected on the left heel 330.72 N in inactive children, and the lowest 265.93 N in moderately active children, the highest maximum pressure on the left heel is registered in inactive children, 27.60 N/cm2, and the lowest 21.85 N/cm2 in moderately active children. The maximum force-time of % of standing time on the left foot in the middle part lasted the longest in inactive children, and the shortest active children carried their school bag 40.31% and a custom school bag 39.76%.Conclusion: High physical activity and individual adjustment to distribute the burden well allow the child to adequately respond to the loads carried by the weight of the school bag.

The main objective of this quantitative study is to examine the relationship between the following independent variables: capital adequacy ratio (CAR), liquid assets to total assets (LATA) and bank size (BS) and dependent variables: return on assets (ROA), credit worthiness indicator (Zscore) and return on equity (ROE) for selected Western Balkan bank countries. This model was estimated using a panel data methodology based on the assumption of a fixed and a random effect as decided in the Hausman test. The results showed that the variable size of the bank (BS) has a positive effect on the return on assets of banks in the Western Balkans, while the variable liquid assets to total assets (LATA) and capital adequacy ratio (CAR) have a negative impact. The results also showed that the variable share of liquid assets in total assets has a positive impact on the creditworthiness indicator of banks in the Western Balkans (ZScore). The third result is the variable return on equity (ROE) and it had the strongest positive impact with the independent variable size of the bank.

Bancassurance is a term used to describe a partnership or relationship between a bank and an insurance company, where the insurance company uses a banking sales channel to sell insurance products. The implementation of banking insurance activities in the financial system contributes to the strengthening of the competitive environment, the development of new insurance products, and greater satisfaction of customer needs. The main goal of this research is to point out the importance and significance of the application of bank insurance for both financial institutions, through the analysis of financial performance indicators of both banks and insurance companies, through the aspect of income and expenses. Also, this research presents an econometric analysis that tests the impact of other income, profit/loss growth rate, as well as the cost-income ratio as independent variables and their impact on the dependent variable, i.e., return on assets of banks in Bosnia and Herzegovina. The results of the econometric analysis showed that other revenues have the greatest impact on the profitability of banks in B&H. The weakest impact on bank profitability has a cost-to-earnings ratio.

The intent to humiliate, hurt or cause harm through the use of digital technology, that is through the use of smartphones and internet is called cyberbullying. Cyberbullying can take a number of different ways and forms. Most common ways of cyberbullying are blackmailing, threats, harassment, sexual harassment, creating and using fake profiles impersonating the victim as well using their photos without permission. Within the program "Skola bez nasilja" (School without violence), in which 50 elementary (primary) schools participated, showed that 28% of students in Serbia have been involved in cyberbullying either as the victim or the bully, whilst 64% of the students stated that they have been a victim of cyberbullying in the last three months. A survey done by UNICEF showed that 1 in 3 young people have been a victim of cyberbullying. The survey was done across 30 different countries. The goal of the review paper is firstly to point out the importance of the protection of privacy and prevention of cyberbullying among minors, as well as the people that interact with kids and help in their education. To keep ourselves and our kids as safe as possible, it is necessary to inform all internet and social media users on how to protect their privacy and how to safely use digital devices in today's age. Idea behind this work is to raise awareness among young people about the possible dangers of social media which could lead to negative consequences such as anxiety, depression, isolation, suicidal thoughts and even suicide.

Objective. The aim of this study was to compare mortality of patients after colorectal cancer surgery between hospitals in Serbia, which performed organized colorectal cancer screening and those which did not. Methods. The database included all patients who underwent surgery for colorectal cancer after the introduction of organized colorectal cancer screening Program in Serbia, in 2014-2015. The target group were patients 50-74 years old in the colorectal screening program, and the data was compared to the age-matched group from hospitals which did not perform the program logistic regression. Results. The was used to determine the significance of the differences in the observed variables, and the predictors of mortality after colorectal cancer surgery. Results. The 3631 patients were included in this study. The majority of them were operated due to the rectal cancer 2111 (58%), while 1062 (29.2%) were operated due to the colon cancer. Postoperative survival was significantly better in the target group in organized screening program (p<0.001; OR=0.46; 95%CI 0.33-0.62). There was a significant difference between patients who underwent surgery for colorectal cancer localized in the left colon, compared to the patients with localization in the right colon (p<0.001). The mortality after the surgery of colorectal cancer (4.7%) was followed by high comorbidity of cardiovascular diseases (24%). Conclusion. Patients included in the organized colorectal cancer screening have lower postoperative mortality than these not included. This indicates the necessity for further work on organized colorectal cancer screening, in order to reduce postoperative and overall mortality.

Introduction/Objective. The aim of the study was to examine the progression of diabetic nephropathy (DN) in a prospective three-year period as well as to establish the risk factors for DN progression. Methods. The study involved 45 patients with type 2 diabetes and DN (26 males, aged 18?62 years) followed up for three years. All the patients underwent physical examination and laboratory analysis at each visit. Laboratory analyses included complete blood count, serum glucose, urea, creatinine, protein, lipid concentration, glycosylated hemoglobin (HbA1c) and urine protein, albumin and creatinine concentration. Glomerular filtration rate (GFR) was calculated using Modification of Diet in Renal Disease formula. Kidney length and parenchymal thickness were measured by ultrasound. Results. Fasting serum glucose concentration (12.0 ? 2.79 vs. 9.50 ? 2.22, p < 0.001) and HbA1c (7.99 ? 1.43 vs. 7.49 ? 1.29, p < 0.031) were decreased over the three years. Albuminuria increased (43.75 ? 10.83 vs. 144.44 ? 52.70 mg/l, p < 0.001) and GFR (63 vs. 58.3 ml/min/1.73 m2) decreased significantly during the study, but serum lipid concentration remained unchanged. Mean kidney length and parenchymal thickness decreased during the three years. Linear regression analysis found systolic blood pressure, fasting glycemia, HbA1c as positive and kidney length and parenchymal thickness as negative predictors of proteinuria increase, but proteinuria as negative and serum iron and albumin concentrations as positive predictors of annual change in GFR. Conclusion High blood pressure and high HbA1c are selected as significant risk factors for increasing proteinuria, which is a significant predictor of GFR decreasing in patients with DN.

Genetic and environmental factors play an important role in the development of type 2 diabetes mellitus (DM2) and its complications. Diabetic nephropathy (DN) is one of the most common microangiopathic chronic complications of diabetes. Oxidative stress occurs under condition of increased production of free radicals and/or decreased activity of antioxidant defense mechanisms and it is an important link in the complex mechanism of diabetic vascular changes. Glutathione transferases (GST) are enzymes involved in xenobiotic metabolism and they are part of complex antioxidant defense mechanisms. Numerous studies have found an association of GST gene polymorphism to a predisposition to various diseases, including diabetes and diabetic nephropathy. Our and other authors' results suggest that genetic variations in enzymes involved in free radical metabolism are associated with the development of end-stage kidney disease in patients with diabetes, which could become the basis for the development of preventive and early therapeutic strategies in high risk people.