Background / Aim. FOLFOX (5fluorouracil, folinic acid, oxaliplatin)/CapOx (capecitabine, oxaliplatin) plus bevacizumab and FOLFIRI (5 fluorouracil, folinic acid, irinotecan) plus bevacizumab are a standard treatment options for a first line treatment of metastatic colorectal carcinoma (mCRC). The aim of this study was to compare overall response rate (ORR), progression-free survival (PFS) and overall survival (OS) in the groups of patients with mCRC who were treated in the first line with FOLFIRI/bev versus FOLFOX/bev. At the same time, it was compared the safety profile in observed groups of patients and investigated optimal treatment duration and characteristics of patients who had the best treatment outcomes. Methods. In a retrospective-prospective study, patients with mCRC were treated with a chemotherapy protocols for the first line in combination with bevacizumab (FOLFOX/bev, respectively, FOLFIRI/bev). Treatment efficacy was evaluated on the basis of overall response rate (ORR), progression-free survival (PFS) and overall survival (OS), and the safety of treatment was evaluated by monitoring adverse drug reactions. Results. ORR was 70% in the FOLFIRI/bev group and 50% in the FOLFOX/bev group. Median PFS for FOLFIRI/bev (n = 30) and for FOLFOX/bev (n = 30) was 15.6 months and 12.1 months respectively (HR, 0.85; 95% confidence interval (CI) 0.47-1.53; P = 0.5591). Median OS for FOLFIRI/bev and for FOLFOX/bev was 24.7 months and 19.9 months respectively (HR, 0.67; 95% confidence interval (CI) 0.37-1.23; P = 0.1552). In both patient groups, the patients who received more than 9 cycles of induction therapy had better treatment response in comparison with patients who received less than 9 cycles of therapy. In FOLFOX/bev group PFS was 16.9 versus 9.7 months and OS was 22.1 versus 17.6 months respectively. In FOLFIRI/bev group PFS was 9 months for patients who received less than 9 cycles of therapy versus 18.8 months for patients who received more than 9 cycles, OS was 18.0 versus 27.7 respectively. The adverse drug reactions grade 3 and 4 were 7% in the FOLFIRI/bev group versus 27% in the FOLFOX/bev group. Conclusion. Patients who received FOLFIRI/bev had better ORR (70 % versus 50 %), PFS (15.6 versus 12.1 months) and OS (24.7 versus 19.9 months). In both patient groups, better treatment response had the patients who received induction therapy for 4-6 months (more than 9 cycles of therapy).

The thiol compound 2,5-dimercapto-1,3,4-thiadiazole is a potential cathode material. The redox reactions of the mentioned thiol compound are slow at room temperature but can be enhanced using electron transfer mediators. The electrochemical oxidation of 2,5-dimercapto-1,3,4-thiadiazole on the surface of carbon electrodes modified with Ruthenium(III) Schiff base complex was studied by voltammetric methods and amperometric flow injection analysis. The electrocatalytic properties of Ruthenium(III) Schiff base complex on glassy carbon and screen printed carbon electrodes are enhanced by the addition of multi-walled carbon nanotubes and Nafion. Voltammetric studies showed that anodic oxidation of DMcT on a modified glassy carbon electrode occurs at a potential of +0.28 V vs. Ag/AgCl in Britton-Robinson buffer (pH 6.50). Flow injection amperometric measurements were performed at +0.20 V vs. Ag/AgCl in Britton-Robinson buffer solutions pH 6.50 at a 0.40 cm3 min−1 flow rate. The results of amperometric measurements for modified screen printed and glassy carbon electrodes showed that the screen printed electrode had a lower value of detection limit (0.38 mg dm−3) and quantification (1.28 mg dm−3), and a linear dynamic range from 1 to 500 mg dm−3 of 2,5-dimercapto-1,3,4-thiadiazole. Modified glassy carbon electrode provided a linear dynamic range up to 750 mg dm−3 of 2,5-dimercapto-1,3,4-thiadiazole with a detection limit of 3.90 mg dm−3 and quantification of 13.20 mg dm−3.

In recent years, the sharing economy has become a new buzzword, providing various business opportunities and challenges to conventional businesses. It is characterized by the transformation of conventional business sectors and many companies are already facing the pressure of adapting their operations to the changing conditions. Human resource management, especially when it comes to experts and knowledge workers, is among the affected business activities. In particular, due to the apparent high demand, this type of workforce has the opportunity to share services among many businesses. Therefore, human resource managers should tackle the issue of cultivating employee organizational identification to increase employee retention and achieve the desired performance. In this regard, this paper proposes a model that binds human resource management practices to employee organizational identification, innovative behaviour, knowledge sharing, and finally, employee job performance. The model is estimated using the survey method and structural equation modelling technique for data analysis. The results imply that selective recruiting, participation in decision-making, and rewarding contribute to employees' organizational identification, while training does not directly affect it. The findings, therefore, indicate that adequate human resource management practices, mainly through the simultaneous impact of the critical capabilities examined by this model, can serve as a foundation for business success in the sharing economy.

Modern use of drugs in the treatment of diseases of children and newborns is increasingly based on off-label use of drugs. The lack of adequate formulations for the pediatric population, the lack of appropriate therapeutic parallels for the treatment of children's diseases and the small number of clinical trials involving the pediatric population have contributed to the mass use of these drugs. The use of these drugs implies extrapolation of doses and indications registered for adults to children, although it is known that the pharmacodynamics and pharmacokinetics of children and adults differ significantly. In the past two decades, many legislative and regulatory initiatives have been taken around the world to improve the use of drugs in children. However, children are still prescribed off-label and unlicensed drugs. The aim of this study was to present a review of the literature in which off-label and unlicensed use in the pediatric population was investigated. Literature was searched through the Google Scholar and Pub Med search engines and using the keywords off label drug, pediatric medicine, use in pediatrics, in the period from May to August 2019. Selected and presented in this article are studies published in the period from 1996 to 2015, which as a subject of research had the use of off-label and unlicensed drugs in the pediatric population. Medicines prescribed for children should be registered for use in the pediatric population and used in accordance with approved indications for children, whenever possible. It is necessary to take measures for more rational use of medicines in pediatrics, which include the collaboration of health workers in order to provide medicines for children that are proven to be effective, high quality and safe to use.

In the logistics world, special attention should be given to warehousing systems, cost rationalization, and improvement of all the factors that affect efficiency and contribute to smooth functioning of logistics subsystems. In real time industrial practice, the issue of evaluating and selecting the most appropriate forklift involves a complex decision-making problem that should be formulated through an efficient analytical model. The forklifts efficiency plays a very important role in the company. The forklifts are being used on a daily basis and no logistical processes could be done without them. Therefore, it has been decided to determine their efficiency, which will contribute to the optimization of the process in this logistics subsystem. This study puts forward an integrated forklift selection model using Data Envelopment Analysis (DEA), Full Consistency Method (FUCOM) and Measurement Alternatives and Ranking According to the Compromise Solution (MARCOS) methods. Five input parameters (regular servicing costs, fuel costs, exceptional servicing costs, total number of all minor accidents and damage caused by forklifts) and one output parameter (number of operating hours) were first identified to assess efficiency of eight forklifts in a warehousing system of the Natron-Hayat company using the DEA model. This step allows sorting of efficient forklifts which are subsequently evaluated and ranked using FUCOM and MARCOS methods. A sensitivity analysis is also performed in order to check reliability and accuracy of the results. The findings of this research clearly show that the proposed decision-making model can significantly contribute to all spheres of business applications.

Introduction. Late metastases of malignant tumors in the temporal bone are very rare lesions. They can be asymptomatic for a long time, and usually manifest themselves in the form of hearing loss, dizziness, tinnitus, and paralysis of the facial nerve. Modern radiological diagnostics and explorative surgery with biopsy are essential for diagnosis. Case report. We present a rare and unusual case of a 66-year-old female patient with a facial nerve paralysis that appeared as the first sign of metastatic breast cancer in the temporal bone 10 years after treatment. A sudden hearing loss and dizziness occurred six months later and value of CA 15-3 was elevated. Scintigraphy pointed to susceptible metastatic deposits of the axial skeleton, without lesions in the temporal bone. Finally, repeated computerized tomography revealed osteolytic changes of the temporal bone six months after that. Immunohistochemical analysis of mastoid tissue samples confirmed that it was a breast cancer metastasis. One year after palliative radiotherapy and oral hormone therapy, a patient has a good general condition with better function of the facial nerve. Conclusion. A high degree of clinical suspicion sometimes requires repeated radiological diagnostics in order to detect osteolytic metastatic changes in the temporal bone, but also in other bone structures within the hematogenous dissemination of the malignant disease.

The aim of this paper is to present and discuss the influence of distributed generation on power quality. Nowadays, interest in power quality has increased since it has become a very important issue in power system delivery. One of the major problems of ensuring a certain level of power quality are harmonics. The aim of this project is to investigate an impact of photovoltaic (PV) on harmonic voltage distortion (HD) in real MV distribution network. Different scenarios will be implemented where solar power plant is going to be modelled with high variability of load and generation to see their effects on the systems power quality (PQ). Those scenarios are when PV is disconnected from the grid and PVs are connected with 2 different powers. Results presented below showed that PV improves power quality of the system, because their inverters are source of harmonics and they increase HD. However, that impact is not very significant and harmonic limits are not violated. A load flow analysis is done for the model of test system 110/35/10kV in which a distributed generator is added, that is on-grid or off-grid. The network modelling and simulation is done in DIgSILENT PowerFactory software.