Paraovarian cysts originate from the mesothelium and are presumed to be remnants of M?llerian or Wolffian ducts. In majority of cases they are found to be 10-80 mm in diameter and do not cause any symptoms. Paraovarian cysts can be found unexpectedly during an operation or on ultrasound examination performed for other reasons. They are most freequently discovered on ultrasound examination. However, due to the proximity of the ovary for which cystic formations are not rare, the diagnosis of these lesions can be a challenge. They are mostly asymptomatic and only large lesions (?20 cm in diameter) become symptomatic. Although these are mostly benign tumors, in rare cases they can become borderline or true malignancies. Most paraovarian cysts are found in the third and fourth decade of life. Paraovarian cyst complications include: compression of the surrounding structures of the pelvis minor and abdomen, pelvic pain, cyst torsion and rupture. Except for the already mensioned complications available literature has so far failed to show cases of uterine prolapse caused by an increase of intra-abdominal pressure due to the expansive growth of giant paraovarian cystic formation.

Cardiovascular diseases rank first on the mortality list globally or 31%. The basic measure of prevention in accordance with the recommendations of the World Health Organization is a change in risk lifestyle in terms of diet, physical activity, tobacco and alcohol consumption. Vitamin D was previously recognized as a regulator of calcium and phosphorus ratio, bone remodeling or the main controller of skeletal pathophysiology. However, vitamin D enjoys great interest in clinical and epidemiological research in terms of its possible impact on reducing the risk of cardiovascular diseases. Among other things, vitamin D deficiency is associated with an increased risk of endothelial dysfunction. Although the deficiency has been identified as a risk marker for cardiovascular diseases, the mechanism of action of vitamin D on the path from endothelial dysfunction to cardiovascular diseases has not been fully revealed. The findings in this segment of activity of vitamin D would be significant in terms of reducing morbidity and mortality from cardiovascular diseases.

Background/Aim: Orthostatic hypotension (OH) is considered to be a drop in the systolic and diastolic blood pressure (> 20 mmHg; > 10 mmHg) 3 minutes from postural changes. The objective of this study was to analyse the correlation of body mass index (BMI) and OH during the treatment with trandolapril, as a single-drug treatment of hypertension. Methods: The study involved 255 patients (average age 54.3 ± 11.7; 54.1 % men) with poorly regulated hypertension, who were given trandolapril as a single-drug treatment. The patients were divided into two groups regarding stage of hypertension: first-degree arterial hypertension (140-149 mmHg for systolic and 90-109 mmHg for diastolic blood pressure) and second-degree arterial hypertension (> 150 for systolic and > 110 mmHg for diastolic blood pressure). Incidence of OH occurrence was then analysed regarding hypertension stage and BMI during 6 months of follow-up, on 4 control examinations. Results: During 24-week period after trandolapril introduction into the treatment of hypertension, a statistically significant difference in systolic, diastolic and mean blood pressure values was observed. No statistically significant difference was observed in incidence of OH between the first and second as well as between third and fourth examination during the study. Regarding the incidence of OH in normal body weight and obese patients, there was also no statistically significant difference. Conclusion: As shown in this study, trandolapril, along with some other ACE inhibitors, has shown good balance in hypertension control and OH occurrence.

Ulcerative colitis is chronic immune-mediated disorder that affects primarily colonic mucosa. The metabolic syndrome has increasing global prevalence with a significant impact on biology of chronic diseases, such as ulcerative colitis. Today it is known that the metabolic syndrome attenuates severity of ulcerative colitis. Still, there is no evidence that different stages of metabolic syndrome alter the course of the ulcerative colitis. The aim of this study was to dissect out how progression of the metabolic syndrome impacted the biology of ulcerative colitis and severity of clinical presentation. Seventy-two patients (41 men and 31 women, 22-81 years old) were enrolled in this observational cross-sectional study. Concentrations of pro- and anti-inflammatory cytokines in serum and feces samples were measured and phenotype of colon infiltrating cells was analyzed. Patients in the terminal phase of the metabolic syndrome have clinically and pathohistologically more severe form of ulcerative colitis, which is followed by decreased concentrations of systemic galectin-1, increased values of systemic pro-inflammatory mediators and increased influx of lymphocytes in affected colon tissue. Our data suggest that reduced concentrations of galectin-1 and predomination of the pro-inflammatory mediators in patients with terminal stage of the metabolic syndrome enhance local chronic inflammatory response and subsequent tissue damage, and together point on important role of galectin-1 in immune response in ulcerative colitis patients with the metabolic syndrome.

Background/Aim. Reactive thrombocytosis, as a paraneoplastic syndrome, is often observed in cancer patients. A variety of tumor-related humoral factors and cytokines con-tribute to tumor-stimulated thrombopoiesis. However, the exact role of these cytokines in the pathogenesis of thrombocytosis remains unclear. The aim of this study was to analyze systemic values of cytokines and clinical-pathological characteristics in colorectal carcinoma (CRC) patients with and without thrombocytosis. Methods. Fifty nine CRC patients were involved in this study and divided into two groups according to the number of platelets. We recorded and analyzed the data about: age, gender, size of the cancer, localization, metastasis, vascular or lymph vessel invasion, nuclear grade, histological differentiation rate, tumor, nodus, metastasis (TNM) stage and concentration of cytokines [interleukin (IL)-1, IL-33, IL-12, IL-17 and interferon (IFN)-?] in both groups. Results. CRC patients with thrombocytosis had significantly higher nuclear grade of the cancer (p = 0.002); higher percentage of detectable metastatic lesions in the liver (p = 0.002), lung (p = 0.001), peritoneal carcinomatosis (p = 0.001), detectable invasion of blood (p = 0.012) and lymph vessels (p = 0.010). Concentrations of tumor markers [alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA) and cancer antigen 19-9 (CA19-9)] and se-rum values of IL-1 a nd I L-33 were significantly higher in CRC patients with thrombocytosis. IL-1/IL-12 (p = 0.016), IL-1/IFN-? (p = 0.007), IL-1/IL-17 (p = 0.006), IL-33/IL- 12 (p = 0.001), IL-33/IFN-? (p = 0.001), IL-33/IL-17 (p = 0.002), and IL-33/IL-1 (p = 0.006) ratios were significantly higher in CRC patients with thrombocytosis in comparison to CRC patients without thrombocytosis. Analysis of Receiver Operating Characteristic (ROC) curves showed that values of IL-1 [area under curve (AUC) = 0.718; 95% confidence interval (CI): 0.567?0.868; sensitivity 69.2%, specificity 62.9%] and IL-33 (AUC = 0.763; 95% CI: 0.614? 0.911; sensitivity 84.6%, specificity 65.7%)], could be serve as possible markers for paraneoplastic thrombocytosis in CRC patients. Conclusion. IL-1 a nd I L-33 significantly correlated to high thrombocyte number in patients with more aggressive CRC.

International Physics Conference in Bosnia and Herzegovina (PHYCONBA 2020) Organizer: Physical Society in Federation of Bosnia and Herzegovina with support of the Academy of Sciences and Arts of Bosnia and Herzegovina Date: October 19, 2020 Venue: Premises of The Academy of Sciences and Arts of Bosnia and Herzegovina, 7 Bistrik street, Sarajevo, Bosnia and Herzegovina. Memebers of Organizing committee: 1. Maja Đekić (Faculty of Science, University of Sarajevo), chairwoman, 2. Mirza Hadžimehmedović (Faculty of Science, University of Tuzla), member, 3. Rifat Omerović (Faculty of Science, University of Tuzla), member, 4. Ena Žunić-Ćejvanović, member, 5. Amra Salčinović Fetić, (Faculty of Science, University of Sarajevo), Technical secretary, 6. Benjamin Fetić (Faculty of Science, University of Sarajevo), member Members of Scientific committee: 1. Dejan Milošević (Faculty of Science, University of Sarajevo, Academy of Sciences and Arts of BiH), chairman, 2. Dijana Dujak (Faculty of Electrical Engineering, University of Sarajevo), member, 3. Hedim Osmanović (Faculty of Science, University of Tuzla), member, 4. Siniša Ignjatović (Faculty of Natural Sciences and Mathematics, University of Banja Luka), member.

From the very knowledge of Industry 4.0, its implementation is carried out in all segments of society, but we still do not fully understand the breadth and speed of its implementation. We are currently witnessing major changes in all industries, so new business methods are emerging. There is a transformation of production systems, a new form of consumption, delivery, and transportation, all thanks to the implementation of new technological discoveries that cover robotics and automation, the internet of things (IoT), 3D printers, smart sensors, radio frequency identification (RFID), etc. Robotic technology is one of the most important technologies in Industry 4.0, so that the robot application in the automation of production processes with the support of information technology brings us to smart automation (i.e., smart factories). The changes are so deep that, from the perspective of human history, there has never been a time of greater promise or potential danger.

It is shown that locally asymptotically stable equilibria of planar cooperative or competitive maps have basin of attraction \begin{document}$ \mathcal{B} $\end{document} with relatively simple geometry: the boundary of each component of \begin{document}$ \mathcal{B} $\end{document} consists of the union of two unordered curves, and the components of \begin{document}$ \mathcal{B} $\end{document} are not comparable as sets. The boundary curves are Lipschitz if the map is of class \begin{document}$ C^1 $\end{document} . Further, if a periodic point is in \begin{document}$ \partial \mathcal{B} $\end{document} , then \begin{document}$ \partial\mathcal{B} $\end{document} is tangential to the line through the point with direction given by the eigenvector associated with the smaller characteristic value of the map at the point. Examples are given.

In this paper we will present the Julia set and the global behavior of a polynomial second-order difference equation of type xn+1 = axmn xx-1 + axm+1 n-1 + bxn-1 where m ? N, a > 0 and b ? 0 with non-negative initial conditions.

U ovom radu ponudit će se rodna analiza potreba i mogućih pravaca reforme izbornog zakonodavstva Bosne i Hercegovine. Fokus rada će biti na tri centralna istraživačka pitanja. Prvo, analizirat će se u kojoj mjeri i na koji način konsocijacijski politički sistemi o(ne)mogućavaju predstavljanje žena u politici. Pri tome će se u obzir uzeti različite dimenzije predstavljanja (formalno, deskriptivno, sadržajno i simbolično predstavljanje). Drugo, analizirat će se da li je Izborni zakon Bosne i Hercegovine usklađen sa Zakonom o ravnopravnosti spolova Bosne i Hercegovine. I treće, ispitivat će se u kojem pravcu se trebaju i mogu odvijati reforme izbornog zakonodavstva BiH. U tom kontekstu biće predstavljene i preporuke CEDAW komiteta i različite rodno odgovorne inicijative za reforme izbornog zakonodavstva koje dolaze kako od institucija nadležnih za rodnu ravnopravnost, tako i iz sfere civilnog društva.

This research presents the first findings on thrombopoiesis for Wistar rats. Haemopoietic cells from the femur and the sternum were analysed by light microscopy in combination with infrared and near-ultraviolet light for fine cytoplasmic structure analysis. Five main types of thrombocyte precursor cells were identified in the bone marrow samples: megakaryoblast, promegakaryocyte and megakaryocyte (basophilic, acidophilic and thrombocytogenic). More intensive thrombopoiesis and morphologically differentiated cells were found in sternum samples.