AIM To critically evaluate the reporting quality of a random sample of clinical trials published in Endodontics against the PRIRATE 2020 checklist and to analyse the association between the quality of reported trials and a variety of parameters. METHODOLOGY Fifty randomized clinical trials relating to Endodontics were randomly selected from the PubMed database from 2015 to 2019 and evaluated by two independent reviewers. For each trial, a score of '1' was awarded when it fully reported each item in the PRIRATE guidelines whereas a score of '0' was awarded when an item was not reported; when the item was reported inadequately a score of '0.5' was awarded. For the items that were not relevant to the trial, 'Not Applicable (NA)' was given. Based on the interquartile range of the overall scores received, trials were categorized into 'Low' (0-58.4%), 'Moderate' (58.5-72.8%) and 'High' (72.9-100%) quality. The associations between characteristics and quality of clinical trials were investigated. Descriptive statistics, frequency analysis and percentage analyses were used to describe the data. To determine the significance of categorical data, the chi-square test was used. The probability value 0.05 was considered as the level of significance. RESULTS Based on the overall scores, 13 (26%), 25(50%) and 12 (24%) of the reports of clinical trials were categorized as 'High', 'Moderate' and 'Low' quality, respectively. Three items (1b, 6d, 11e) were adequately reported in all manuscripts whilst two items (5k, 5m) were scored 'NA' in all the reports. The reports published from Europe had a significantly greater percentage of 'High'-quality scores, compared to Asia, Middle East, North America and South America (P = 0.0002). The 'High'-quality reports were published significantly more often in impact factor journals (P = 0.045). Reports of clinical trials published in journals that adhered to the CONSORT guidelines had significantly more 'High' scores compared to those that did not (P = 0.008). Clinical trials with protocols registered a priori had a significantly greater percentage of 'High' scores compared to the trials that were not registered in advance (P = 0.003). No significant difference occurred between the quality of clinical trials and the number of authors, journal (Endodontic specialty vs. Non-Endodontic specialty) or year of publication. CONCLUSIONS Reports of randomized clinical trials published in the speciality of Endodontics had a substantial number of deficiencies. To create high-quality reports of clinical trials, authors should comply with the PRIRATE 2020 guidelines.

ABSTRACT Introduction: There are growing concerns among European health authorities regarding increasing prices for new cancer medicines, prices not necessarily linked to health gain and the implications for the sustainability of their healthcare systems. Areas covered: Narrative discussion principally among payers and their advisers regarding potential approaches to the pricing of new cancer medicines. Expert opinion: A number of potential pricing approaches are discussed including minimum effectiveness levels for new cancer medicines, managed entry agreements, multicriteria decision analyses (MCDAs), differential/tiered pricing, fair pricing models, amortization models as well as de-linkage models. We are likely to see a growth in alternative pricing deliberations in view of ongoing challenges. These include the considerable number of new oncology medicines in development including new gene therapies, new oncology medicines being launched with uncertainty regarding their value, and continued high prices coupled with the extent of confidential discounts for reimbursement. However, balanced against the need for new cancer medicines. This will lead to greater scrutiny over the prices of patent oncology medicines as more standard medicines lose their patent, calls for greater transparency as well as new models including amortization models. We will be monitoring these developments.

Fagus sylvatica is widely distributed across Europe thanks to its high adaptability in a wide variety of soils and climate. Microbial communities are essential for maintaining forest soil quality a...

In the teaching process, the relationship between students and university teachers is an important determinant of the quality learning and teaching process. The concepts of didactic theories provide a different approach to the didactic - methodical determination of teaching, and the position of students in the scientific - teaching process in relation to the concept of the old school and the traditional pedagogical paradigm of teaching. The student is observed and experienced as a collaborator, learning partner, authoritarian teaching styles are abandoned, democratically oriented communication and interaction are developed, with mutual respect, tolerance and respect for all participants in the teaching process. The analytical - descriptive method, comparative analysis and content analysis were used. The relationship and position of students and university teachers in the teaching process through the prism of didactic theories advocated by Christina Moller and Felix von Cube are presented. The issues of selectivity, cooperation and competitiveness as a starting point for defining the position of students in teaching, purposes and goals of learning, based on the modern pedagogical paradigmatic orientation of the “learning society”, and the analysis of the position and position of students and university teachers through the prism of cyber-information didactic theories and curriculum theories.

Introduction/Objectives: Health authorities are facing increasing challenges to the sustainability of their healthcare systems because of the growing expenditures on medicines, including new, high-priced oncology medicines, and changes in disease prevalence in their ageing populations. Medicine prices in European countries are greatly affected by the ability to negotiate reasonable prices. Concerns have been expressed that prices of patented medicines do not fall sufficiently after the introduction of lower-cost generic oncology medicines. The objective of this study was to examine the associations over time in selected European countries between the prices of oral oncology medicines, population size, and gross domestic product (GDP) before and after the introduction of generic versions. Evidence of periodic reassessments of the price, value, and place in treatment of these medicines was also looked for. The goal of this review was to stimulate debate about possible improvements in approaches to reimbursement negotiations. Methodology: Analysis was performed of reimbursed prices of three oral oncology medicines (imatinib, erlotinib and fludarabine) between 2013 and 2017 across Europe. Correlations were explored between GDP, population size, and prices. Findings were compared with previous research regarding prices of generic oral oncology medicines. Results: The prices of imatinib, erlotinib and fludarabine varied among European countries, and there was limited price erosion over time in the absence of generics. There appeared to be no correlation between population size and price, but higher prices of on-patent oral cancer medicines were seen among countries with higher GDP per capita. Conclusion: Limited price erosion for patented medicines contributed to increases in oncology medicine budgets across the region. There was also a concerning lack of evidence re-assessments of the price, value, and place in treatment of patented oncology medicines following the loss of patent protection of standard medicines. The use of such proactive re-assessments in negotiating tactics might positively impact global expenditures for oncology medicines.

The proper application of retrosynthesis to identify possible transformations for a given target compound requires a lot of chemistry knowledge and experience. However, because the complexity of this technique scales together with the complexity of the target, efficient application on compounds with intricate molecular structures becomes almost impossible for human chemists. The idea of using computers in such situations has existed for a long time, but the accuracy was not sufficient for practical applications. Nevertheless, with the steady improvement of machine learning and artificial intelligence in recent years, computer-assisted retrosynthesis has been gaining research attention again. Because of the overall lack of chemical reaction data, the main challenge for the recent retrosynthesis methods is low exploration ability during the analysis of target and intermediate compounds. The main goal of this research is to develop a novel, template-free approach to address this issue. Only individual molecular substructures of the target are used to determine potential disconnection sites, without relying on additional information such as chemical reaction class. The model for the identification of potential disconnection sites is trained on novel molecular substructure fingerprint representations. For each of the disconnections suggested using the model, a simple structural similarity-based reactant retrieval and scoring method is applied, and the suggestions are completed. This method achieves 47.2% top-1 accuracy for the single-step retrosynthesis task on the processed United States Patent Office dataset. Furthermore, if the predicted reaction class is used to narrow down the reactant candidate search space, the performance is improved to 61.4% top-1 accuracy.

The research dealt with the identification of significant differences in the basic dimensions of personality according to the five-factor model between two groups of respondents: heroin addicts and the control group of respondents, non-consumers of psychoactive substances. Also, we wanted to determine whether the respondents - heroin addicts in relation to the non-clinical group differ significantly in personality traits given the completeness of the family environment in which they grew up, and the propensity of parents to alcoholism and violent behavior. The study included a sample of 297 subjects, of which 155 were heroin users, and 142 were non-clinical control group subjects, students of different study profiles of the University of Tuzla. The clinical and non-clinical samples were uniform in terms of characteristics important for the research. In order to test the research hypotheses, in addition to the insight into the descriptive parameters, a one-way analysis of variance was used. The results show that heroin users achieve significantly higher results in the dimensions of Agreeableness (F = 21.51; p = 0.00), Conscientiousness (F = 13.89; p = 0.00) and Neuroticism (F = 13.23; p = 0.00), while the clinical and non-clinical groups do not differ significantly in the dimensions of Openness and Extraversion. In the group of heroin consumers, respondents coming from incomplete families achieve significantly lower results on the Conscientiousness dimension (F = 4.20; p = 0.04), the tendency to consume parental alcohol proved to be a significant factor for the Neuroticism dimension (F = 4.39; p = 0, 04) and Openness (F = 15.41; p = 0.00), while parental propensity to violent behavior proved to be a significant factor for the Neuroticism dimension (F = 4.49; p = 0.04) and Openness (F = 15.41; p = 0.00). ). When it comes to the non-clinical control group, family completeness and characteristics of the family environment (parents ‘tendency to consume alcohol and parents’ tendency to violent behavior) did not prove to be significant factors for differences in personality traits.

Anti-aging cosmetics are often sought after in order to slow down the aging process. Free radicals are one of the main causes of skin aging, and therefore antioxidants are used in anti-aging cosmetics. The aim of this study was to investigate which method is the most suitable for determining the antioxidant capacity of these products. Having samples extracted, the antioxidant capacity of the extracts obtained was determined by the following spectrophotometric methods: DPPH, Folin-Ciocalteu, FRAP, the ABTS method and the ferroion chelation method with ferrosine. The antioxidant capacity of the samples varied depending on the extract type and the method used. DPPH and ferroion chelation measurements with ferrosine were carried out in the part of the spectrum where plant pigments absorb. These pigments are often found in anti-aging products affecting these methods measurement results. The Folin-Ciocalteu method is suitable for researching the antioxidant capacity of hydrophilic extracts, but not lipophilic ones, where turbidity and the formation of a gelled ring occur. The FRAP method revealed similar results for all the samples and proved to be less sensitive than the others. The ABTS method for both types of extracts has proven to be the most suitable and sensitive method for determining the antioxidant capacity of anti-aging products.

This paper presents the results of a preliminary study, which utilizes a hashtag-based approach and mixed-method procedures to describe the nexus between commemoration practices and visual social media. It mainly focuses on Instagram hashtags for the Day of the Republic of Srpska, a disputed and controversial public holiday celebrated on the 9th of January in the Republic of Srpska, to track how commemoration practices related to national memories are shaped through the process of digital (re)mediation.

The aim of the study was to test two assumptions about the lateralization of the processing of emotional facial expressions: the assumption of right hemisphere dominance and the valence assumption and to egsamine the influence of gender of the presented stimulus (chimera) and depression as an emotional state of participants. The sample consisted of 83 female students, with an average age of 20 years. Participants solved the Task of Recognizing Emotional Facial Expressions on a computer and then completed the DASS-21, Depression subscale. The results of the study partially confirmed the assumption of valence for the dependent variable - the accuracy of the response. Participants were recognizing more accurately the emotion of sadness than happiness when it is presented on the left side of the face, which is consistent with the valence hypothesis, according to which the right hemisphere is responsible for recognizing negative emotions. However, when it comes to the right side of the face, participants were equally accurately recognizing the emotion of sadness and happiness, which is not consistent with the valence hypothesis. The main effect of the gender of the chimera was statistically significant for the accuracy of the response, the recognition accuracy was higher for the male chimeras compared to the female. A statistically significant negative correlation was obtained between the variable sides of the face (left and right) with the achieved result on the depression subscale for the dependent variable - reaction time. The higher the score on the depressive subscale, the slower (longer) is reaction time to the presented chimera, both on the left and on the right.

This review paper offers a definition and explanation of the self-care concept as one of the basic ways of developing and nurturing professional and personal capacities and maintaining healthy boundaries between the professional and personal life of helpers. The paper also emphasizes the ethical components of self-care as an imperative of helpers to take care of their own mental and physical health. Challenges for the development and maintenance of skills and conditions for the sustainability of self-care in the helping professions are described and analyzed from the perspective of personal responsibility and the institution’s obligation to ensure healthy working conditions and professional growth and development. Introduction to the self-care concept and comparative analysis is presented through the presentation of various, mostly foreign studies that have monitored the effects of self-care on the overall health of helpers and their professional effects. The paper also describes the adverse consequences of the lack of self-care skills and activities that encourage it. It also emphasizes the negative effects on the health of the helpers and their work potential. In conclusion, guidelines are defined for the development and maintenance of the helper's self-care, important both for his satisfaction in personal life and especially in professional success and self-actualization.

Uncertainty, unfolding in the most extreme forms in the period of one of the greatest global challenges – a threat to the health and wellbeing of people, caused by the pandemic, is gaining a form difficult to conceive in temporal and conceptual terms. In the perception of students, the young people on the brink of the first employment, the uncertainty primarily reflects in the estimate of possibilities of finding a job and opportunities to construct a professional identity. This paper examines the potential role of personal branding in the improvement of student opportunities to find the desired job, as well as the importance of higher education institutions as strategic partners in the process. This paper, among others, also emphasizes the importance of empowering students towards the recognition of the role of their knowledge and competencies acquired during the studies; the role which does not correspond to banal, oversimplified reduction of the role of education as means to meet the labour market needs.

In Bosnia and Herzegovina, there is a large number of non-sanitary landfills and landfills where pharmaceutical waste from households is being disposed, as well as the medical waste from different health institutions. Expired pharmaceuticals are mostly being disposed there, because there is very little attention paid on waste sorting at the place of its origin. Now days, there are thousands of different medicine, and mainly, along with the other household waste, expired antibiotics are disposed of too. Degradation of expired pharmaceuticals in the environment very often leads to formation of products with completely different properties in regards to the original compound, but also it is not uncommon for those newly formed products to be more toxic than the original ones. This paper analyses the impact of rainwater infiltration on the body of the landfill where expired pharmaceuticals are being disposed of, as well as other medical waste at municipal landfills in Bosnia and Herzegovina. Field studies on the size of the rainwater infiltration as a function of different parameters have been conducted, and also degradation analysis of different expired drugs that are being disposed of in landfills has been performed.