This paper investigates the use of conceptual metaphor as discourse pheno­menon, especially its persuasive role in political discourse. This study aims to identify conceptual metaphors that are expressed by metaphorical expressions in text corpus, to classify these metaphors by finding their source domains, to examine their conceptual structure and discourse potential. The purpose of the discussion is to describe and interpret social relations expressed by dominant metaphorical concepts that conceptualize political realm in a complex political setting and times of crisis and uprisings. Furthermore, the paper gives an insight into purposes and effects of using conceptual metaphors in this distinct political context. Text corpus consists of political speeches delivered by presi­dents of Tunis, Egypt and Libya during Arab Spring.

Ovaj rad nastoji dekonstruirati tradicionalne narative o ubiranju džizje u Osmanskom Carstvu i doprinijeti boljem poznavanju osmanske politike u nametanju spomenute dace u oblastima u kojima je sirenje islama uzelo maha kroz ispitivanje osmanske prakse nametanja džizje muslimanima na podrucju centralne Bosne. Navedeno pitanje u historiografiji je zapostavljeno te o tome postoje samo rudimentarni podaci zasnovani na vrlo ogranicenom broju osmanskih izvora. Nedostaci koji postoje u studijama kojima trenutno raspo­lažemo, u ovom radu se nastoje otkloniti analizom deftera džizje vilajeta Brod iz 1679. godine, u kojem su muslimani cinili preko 90% obveznika džizje, sto do sada nije zabilježeno ni na jednom drugom podrucju Osmanske države. Također, koristeci raznovrsnu neobjavljenu i neobrađenu građu na osmanskom jeziku, autor tumaci porijeklo i razvoj osmanske prakse ubiranja džizje od muslimanskog stanovnistva te ispituje posljedice koje je navedena pojava imala na drustvene procese koji su se odvijali u regiji, u prvom redu na proces sirenja islama. ---------------------------------------------- Muslim jizya payers in the seventeenth-century Ottoman Empire: a case study for the Vilayet of Brod This paper aims to deconstruct the traditional narratives on the Ottoman financial and political strategies towards non-Muslim and Muslim subjects in the Western Balkans by re-examining the foundation, extent and consequences of the central government’s policy of demanding a payment of jizya tax not only from non-Muslims, as stipulated in the classical Sharia law, but from the Muslim population as well. Although academic community is aware of the ex­istence of Muslim jizya payers in several regions of the Ottoman Empire, this paper argues that historiographic knowledge on the mentioned phenomenon is rather rudimentary as present studies on this topic are based on a very limited data while official financial records that contain information on Muslim jizya payers, such as the jizya registers from the Ottoman Bosnia, have still not been thoroughly analysed. Recognizing the need to include financial records into the account, the main research strategy of this paper was to identify and examine records of jizya payers which contain a significant number of Muslims in a taxpayer role as well as to compare and interpret this data with other financial, administrative and legal texts that could help us gain better insight into the phe­nomenon of Muslim jizya payers in the Ottoman practice. The main primary source for the analysis provided in this study was a register of jizya payers from the vilayet of Brod, in central parts of the Ottoman Bosnia, from the 1679, which have not been previously used in historiographic studies. On the basis of this financial register, it has been concluded that more that 90% of all jizya payers in the territory covered in the mentioned register were Muslims, which is an important and interesting fact that has still not been recorded in any other part of the Ottoman Empire. After identifying the historical background of Muslim jizya payer phenomenon in Bosnia, this case study explains its connec­tion with broader political and financial practices of the Ottoman authorities, as well as its relation with the Islamic legal tradition. Furthermore, the study uses the data from primary sources to additionally deconstruct the narrative that only Christians and Jews paid the jizya in Ottoman Empire, as well as it re-examines the validity and shortcomings of an old historiographic notion that jizya should be considered a primary reason in explaining why massive process of conversion to Islam took place in the Early Modern Ottoman Bosnia.

Ustikolina market has been mentioned since 1394 for the business of the local population, which was especially engaged in the wax trade. In addition, Du­brovnik merchants were active in Ustikolina very early on. According to some of the leading historians of the medieval period, Ustikolina could not withstand the competition of the nearby, more advanced markets, Goražde and Foča. However, from the content of sources, it is evident that the Ottoman authorities have been recorded revenues from the market tax on the Ustikolina market since the first census of 1468/1469. That means that there were trade activities before that period. In order to improve trade, in the middle of the 16th century, the local judge sent to Porte a written petition to change the weekly market in Ustikolina. It was requested that the market be held on Fridays instead of Saturdays. Local authorities wanted to rationalize and facilitate the activities of the population of Ustikolina and its surroundings and make them able to do the most important weekly tasks on the same day and attend the obligatory Friday prayer. The paper pays special attention to the analysis of the document that Porte sent to the local judge in this regard. The content of the mentioned document reveals the way in which the Ottoman state solved certain problems that were important for the local community, and the holding of the weekly market was one of those. Also, from the document, it can be established that Ustikolina had a local Muslim community, a mosque where the central weekly prayer was performed, a market, and an established market day, which were the basic preconditions for declaring a place for an urban settlement. The paper mentions similar practices from the local area, but also from the main capital of Istanbul, which is one of the indicators to what extent it was centralized the Ottoman state in the 16th century. Based on the above, can be seen the efficiency of the governing apparatus whose administrative ar­rangement in the way of functioning of large and small places was not left to chance. In the concrete example, it can be seen that the issue of establishing and changing the weekly market was resolved officially, which was defined by the state protocol.

Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women during reproductive period. It is considered a complex metabolic disorder with long-term metabolic, as well as reproductive consequences. Main pathophysiological pathways are related to the increased androgen levels and insulin resistance. Nowadays, genetic origins of PCOS are acknowledged, with numerous genes involved in the pathogenesis of hyperandrogenemia, insulin resistance, inflammation and disturbed folliculogenesis. Rotterdam diagnostic criteria are most widely accepted and four PCOS phenotypes have been recognized. Metabolic abnormalities are more common in phenotypes 1 and 2. Women with classic PCOS are more obese and typically have central type of obesity, more prevalently displaying dyslipidemia, insulin resistance and metabolic syndrome that could be associated with an increased risk of cardiovascular complications during life. Heterogeneity of phenotypes demands an individualized approach in the treatment of women with PCOS. Metabolic therapies involve a lifestyle intervention followed by the introduction of insulin sensitizers including metformin and inositols, glucagon-like peptide 1 receptor agonists (GLP-1 RA), as recently sodium glucose contransporter-2 (SGLT2) inhibitors. Addition of an insulin sensitizer to the standard infertility therapy such as CC improves ovulation and pregnancy rates. Our current review analyzes the contemporary knowledge of PCOS etiology and etiopathogenesis, its cardiometabolic risks and their outcomes, as well as therapeutic advances for women with PCOS.

The efficient, selective, and economical sorbents for the removal of Sr radionuclides are largely needed for the decontamination of effluents with high salinity. In this study, the removal of Sr was investigated using the zeolite produced from the Bayer process liquids. Based on the XRD, SEM/EDS analysis, the product was pure and highly crystalline zeolite 4A (Z4A). Removal of Sr was fast (5 min for 100% removal at 8.80 mg/L), with high maximum sorption capacity (252.5 mg/L), and independent on the initial pH in the range 3.5–9.0. Specific sorption of Sr by protonated groups on the Z4A surface was operating in addition to ion-exchange with Na ions. The selectivity of Z4A decreased in the order Sr > Ca > K > Mg > Na. 84% of Sr was separated from seawater within 5 min, at the Z4A dose of 5 g/L, while efficiency increased to 99% using the dose of 20 g/L. Desorption of radioisotope 89 Sr from seawater/Z4A solid residue was very low in deionized water (0.1–0.2%) and groundwater (0.7%) during 60 days of leaching. Z4A is a cost-effective, selective, and high-capacity medium for Sr removal, which provides high stability of retained radionuclides.

The efficient, selective, and economical sorbents for the removal of Sr radionuclides are largely needed for the decontamination of effluents with high salinity. In this study, the removal of Sr was investigated using the zeolite produced from the Bayer process liquids. Based on the XRD, SEM/EDS analysis, the product was pure and highly crystalline zeolite 4A (Z4A). Removal of Sr was fast (5 min for 100% removal at 8.80 mg/L), with high maximum sorption capacity (252.5 mg/L), and independent on the initial pH in the range 3.5–9.0. Specific sorption of Sr by protonated groups on the Z4A surface was operating in addition to ion-exchange with Na ions. The selectivity of Z4A decreased in the order Sr > Ca > K > Mg > Na. 84% of Sr was separated from seawater within 5 min, at the Z4A dose of 5 g/L, while efficiency increased to 99% using the dose of 20 g/L. Desorption of radioisotope 89Sr from seawater/Z4A solid residue was very low in deionized water (0.1–0.2%) and groundwater (0.7%) during 60 days of leaching. Z4A is a cost-effective, selective, and high-capacity medium for Sr removal, which provides high stability of retained radionuclides.

ABSTRACT Flaviviruses such as the dengue (DENV) and the Zika virus (ZIKV) are important human pathogens causing around 100 million symptomatic infections each year. During infection, small subgenomic flavivirus RNAs (sfRNAs) are formed inside the infected host cell as a result of incomplete degradation of the viral RNA genome by cellular exoribonuclease XRN1. Although the full extent of sfRNA functions is to be revealed, these non-coding RNAs are key virulence factors and their detrimental effects on multiple cellular processes seem to consistently involve molecular interactions with RNA-binding proteins (RBPs). Discovery of such sfRNA-binding host-factors has followed established biochemical pull-down approaches skewed towards highly abundant proteins hampering proteome-wide coverage. Yeast three-hybrid (Y3H) systems represent an attractive alternative approach. To facilitate proteome-wide screens for RBP, we revisited and improved existing RNA-Y3H methodology by (1) implementing full-length ORF libraries in combination with (2) efficient yeast mating to increase screening depth and sensitivity, and (3) stringent negative controls to eliminate over-representation of non-specific RNA-binders. These improvements were validated employing the well-characterized interaction between DDX6 (DEAD-box helicase 6) and sfRNA of DENV as paradigm. Our advanced Y3H system was used to screen for human proteins binding to DENV and ZIKV sfRNA, resulting in a list of 69 putative sfRNA-binders, including several previously reported as well as numerous novel RBP host factors. Our methodology requiring no sophisticated infrastructure or analytic pipeline may be employed for the discovery of meaningful RNA–protein interactions at large scale in other fields.

Background Classical ST‐T waveform changes on standard 12‐lead ECG have limited sensitivity in detecting acute coronary syndrome (ACS) in the emergency department. Numerous novel ECG features have been previously proposed to augment clinicians' decision during patient evaluation, yet their clinical utility remains unclear. Methods and Results This was an observational study of consecutive patients evaluated for suspected ACS (Cohort 1 n=745, age 59±17, 42% female, 15% ACS; Cohort 2 n=499, age 59±16, 49% female, 18% ACS). Out of 554 temporal‐spatial ECG waveform features, we used domain knowledge to select a subset of 65 physiology‐driven features that are mechanistically linked to myocardial ischemia and compared their performance to a subset of 229 data‐driven features selected by multiple machine learning algorithms. We then used random forest to select a final subset of 73 most important ECG features that had both data‐ and physiology‐driven basis to ACS prediction and compared their performance to clinical experts. On testing set, a regularized logistic regression classifier based on the 73 hybrid features yielded a stable model that outperformed clinical experts in predicting ACS, with 10% to 29% of cases reclassified correctly. Metrics of nondipolar electrical dispersion (ie, circumferential ischemia), ventricular activation time (ie, transmural conduction delays), QRS and T axes and angles (ie, global remodeling), and principal component analysis ratio of ECG waveforms (ie, regional heterogeneity) played an important role in the improved reclassification performance. Conclusions We identified a subset of novel ECG features predictive of ACS with a fully interpretable model highly adaptable to clinical decision support applications. Registration URL: https://www.clinicaltrials.gov; Unique Identifier: NCT04237688.

Este é um estudo prospectivo, transversal, descritivo com abordagem quantitativa, desenvolvido de 2017 a 2018, numa unidade municipal de saúde de Belém-PA; e que tem como objetivo avaliar o conhecimento de comunicantes de hanseníase antes e após uma ação educativa, acerca dos sinais e sintomas da doença, os riscos de adoecimento e as formas de prevenção. Fizeram parte da pesquisa 93 comunicantes, das quais 48% acreditava que a doença era transmitida por utensílios, assim como 54% afirmava ser uma patologia letal. Existiam lacunas significativas de conhecimento sobre a hanseníase por parte dos contatos intradomiciliares contatados. Identificou-se impacto positivo da ação educativa, com aumento do nível de conhecimento sobre a hanseníase entre os comunicantes. 

Abstract Seven spider mite species were recorded for the first time in Serbia: Bryobia macedonica Hatzinikolis & Panou, 1996 and Bryobia querci Hatzinikolis & Panou, 1997 from Bryobiinae, and Eutetranychus orientalis Klein, 1936; Oligonychus bicolor Banks, 1894; Oligonychus platani McGregor, 1950 Tetranychus canadensis McGregor, 1950 and Tetranychus ludeni Zacher, 1913 from Tetranychinae. Together with previously reported data, these findings raise the number of known tetranychid species in Serbia to 44, the second highest number of spider mite species recorded in the Balkan countries. The records of O. bicolor and T. canadensis are also the first ones on the Balkan Peninsula. The most frequent species were T. ludeni and E. orientalis, found in 24 and 13 out of 57 sampling locations. Spider mites were recorded on host plants in four basic habitat types, but predominantly in cultivated habitats and woodlands. A total of 27 plant species from nine families were recorded as hosts for newly recorded spider mites, including 12 plant species as new hosts for four tetranychids, and three plant species as new hosts for the family Tetranychidae. Plant family Rosaceae had the highest number of new hosts (7) and harbored the highest number of spider mite species (5). Tetranychus ludeni had the highest number of host plants (11) with two plant species as its new hosts. Oligonychus bicolor was found on eight host plants including five new hosts for this species and one new host for the family Tetranychidae. The other two new hosts for the family Tetranychidae harbored O. platani and B. querci, respectively. Symptoms of heavy infestations by E. orientalis and T. ludeni were recorded on host plants in several locations.