This is the second volume of the official magazine of the European Federation for MedicalInformatics (EFMI) named as “EFMI Inside”, which was established as Newspaper in Lyon in August 2019, during “MEDINFO 2019” Conference and EFMI Council meeting. Idea for founding EFMI Inside was born by Catherine Chronaki, current President of EFMI and Izet Masic, Honorary Fellow of EFMI and Editor-in-Chief of the official journal of EFMI Acta Informatica Medica. EFMI Council members discussed and concluded to start with magazine in which we can record important and prompt facts and information about past of EFMI, with current and future activities of European Federation for Medical Informatics). After the first issue published in 2020 a lot of medical informaticians expressed their positive comments about usufull and informative magazine within medical informatics field worldwide. This publication became an important and useful resource of EFMI activities for everybody who wants to be familiar with Medical informatics development and achievements in all areas of this academic and scientific discipline in European countries, but also, worldwide. The second issue covered facts about 31st MIE 2021 Conference organized in Athens in May 2021, but also contains important facta about other EFMI activities and intreview with a pinoneer of Medica informatics, academician Gjuro Dezelic from Croatia, and finaly, obituaries of the three influential Medical informatics experts: Francis Roger France, Ragnar Nordberg and Peter Pharow. Some of chairs of Working Groups contributed with their reports in the past year who were actively involved in the development of Medical informatics in their countries, but also worldwide.

A perfect dielectric model was incorporated into the OpenFOAM? software and used for investigation and, possibly, improvements of electrohydrodynamic calculations. Two different sets of numerical simulations were analyzed, in which two different fluids were present. The first set was one-dimensional, while in the second, a drop of one fluid was surrounded by the other fluid. It is shown that oscillations and possible artificial generation of a curl of the electric field strength can be observed at applying certain expressions or calculation strategies, which can be thus abandoned. Usage of dynamic meshes, at least those present in the used software, and of limiters for the gradient of the electric field strength can lead to large numerical errors. It is also shown that usage of certain cell face values could improve the results. An electric Courant number was derived by dimensional analysis, and it could be suggested for future calculations. Conclusions made in this paper are expected to be transferable to other more complicated models.

Development of solid self-nanoemulsifying drug delivery systems (s-SNEDDS) for oral delivery of lysozyme Merima Sirbubalo, Tamás Sovány, Katalin Kristó, Géza Regdon jr, Edina Vranić 1 University of Sarajevo, Faculty of Pharmacy, Department of Pharmaceutical Technology, Sarajevo, Bosnia and Herzegovina 2 University of Szeged, Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, Szeged, Hungary

This paper presents a comprehensive treatment of the complex motion control systems in the the Sliding Mode Control (SMC) framework. The single and multi degrees of freedom (DOF) plants and applications to haptics and functionally related systems are discussed. The paper concentrates on presenting the designs that are easy to apply and tune. The proposed algorithms are based on the application of the equivalent control observer and the convergence term that guaranty stability of the closed loop in a Lyapunov sense and enforces the sliding mode on selected manifolds. Presented SMC design leads to a solution that easily could be modified to include majority of the algorithms presented in the literature.

Recently, nanotechnology is widely used in agriculture with the aim of achieving high agricultural yields. Due to the unique surface and physicochemical properties, nanomaterials can be used to deliver nutrients to plants via nanoparticles, for the synthesis of nanopesticides, nanofungicides, and to design nanosensors for the detection of very low concentrations of pesticides and other contaminants. Excessive use of pesticides and fertilizers causes the loss of soil biodiversity and the development of resistance to pathogens. Nenoencapsulation of fertilizers, pesticides and herbicides is used for slow and specific dosed release of nutrients as well as agrochemicals. This paper discusses the applications of nanotechnology and their positive effect in agriculture in relation to the common methods used so far.

This review mainly focuses on nanoparticle-based drug delivery systems fabricated from plants (starch, cellulose, pectin), animals (chitosan, gelatin) and microorganisms (dextran). Herein, the focus is on the physical-chemical properties of biopolymers and its derivatives and the mechanism of action in the treatments of cancer. Nanoparticle-based drug delivery systems improved efficacy by: increasing half-life of vulnerable drugs and proteins, improving the solubility of hydrophobic drugs, and allowing controlled and targeted release of drugs in diseased site. Of all the mentioned biopolymers, only dextran and pure pectin are problematic. Some clinical studies have shown unexpected side effects caused by dextran such as thrombocytopenia and hepatotoxicity and, pure pectin-based materials, undesirable swelling and corrosion properties. Doxorubicin has been used in combination with almost all of these biopolymers because it is widely used as an effective chemotherapeutic agent in the treatment of many types of solid tumors of the breast, lung, colon, ovary, prostate and bladder.