The study analyzes religious and cultural violence, focusing on the Genocide against Yazidis within the broader Kurdish socio-political framework. The ISIL genocidal intent against Yazidis includes forced relocation and practice attitudes that apply to elitism and sexual violence. It is part of the destruction of the group in terms of destruction of the spirit, will live and life itself (members) of the group. However, it should be noted that such views do not mean the legal argument for recognizing cultural genocide but an attempt to clarify the meaning of physical and biological destruction. Violence committed «in the name of religion» belongs to the dark side of religion. Violence (mostly) does not arise from the moral teachings of religions but from a perverted understanding of religion. The killing of members of a religious group is a form of physical genocide, and the threat of murder to ban religion was a way to commit cultural, that is, religious genocide. Sexual violence is different from all other weapons. The global community needs to be united to protect women and children during the war. Religion is used as an excuse for violence when the struggle is to defend the essential identity, when it is inconceivable to lose the struggle and when the struggle cannot be won. Religious support for violence causes the terrorist policy to become uncompromising. Paradoxically, just as terrorism produces fear of violence, so does the fear of terrorism produce violence

Background Providing oncology services during a pandemic can contribute to mental health challenges among healthcare workers. The present study aimed to evaluate the levels of depression, anxiety, and stress in healthcare and administrative staff in 5 oncology institutions in Bosnia and Herzegovina (BiH) in 2020 during the coronavirus disease 2019 (COVID-19) pandemic using the Depression, Anxiety and Stress Scale (DASS-21) questionnaire. Material/Methods A cross-sectional observational study enrolled 175 healthcare and administrative workers from 5 oncology institutions in BiH during December 2020. Data were collected using a questionnaire that captured general information about the participants and a DASS-21 questionnaire. Results Statistical analysis revealed a statistically significant difference in the levels of depression, anxiety, and stress (P=0.003, P=0.011, and P=0.022, respectively) among participants with comorbidities connected with increased risk of severe illness caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) compared with participants without comorbidities. There was also a statistically significant difference in the levels of stress among participants from different cities (P=0.031). Supplement intake and educational level were significantly related (P=0.012). High levels of stress and anxiety were accompanied by high levels of depression among participants (P<0.01). Conclusions The findings from the present study showed that the COVID-19 pandemic has had an effect on depression, anxiety, and stress levels in oncology staff in BiH. Monitoring these levels and providing interventions and support to oncology staff are increasingly important for their wellbeing and retention at a time of global crisis in healthcare.

ABSTRACT 1. The aim of the present study was to test the ability of an in-feed modified clinoptilolite zeolite-based mycotoxin binding substance (Minazel® Plus, Patent Co, Misicevo, Serbia; MP) to prevent gastrointestinal absorption of aflatoxin B1 (AFB1) and ochratoxin A (OTA) and its effects on health status and performance parameters of broilers. 2. A total of 375, 1 d old male broiler chickens (Cobb 500) were used for a total trial period of 42 d (from hatch to 42 d of age). Animals were randomly allocated to five treatment groups (T1-T5), in 25 pens (15 male broilers per pen, five pens per treatment). T1 was the control maize-based diet without the addition of mycotoxins, or the test product. T2 and T3 groups received contaminated maize in the diet containing 0.02 mg AFB1/kg feed and 0.1 mg OTA/kg feed, whereas T4 and T5 groups received 0.05 mg AFB1/kg feed and 0.5 mg OTA/kg feed. The MP was added to T3 (1 g/kg feed), and T5 (2 g/kg feed) groups. 3. Results showed that exposure to AFB1 and OTA at low or moderate levels, as used in this study, did not markedly affect growth performance, blood profile or organ weights. Improvements in feed conversion ratio (FCR) were observed in birds receiving MP, whereby FCR of T3 group was improved in comparison with T2 group, although there was no significant difference between T5 and T4 groups. However, average body weight gain (ABWG) was improved in the T5 group compared to T4, but not in the T3 versus T2 group comparison. 4. For serum biochemical parameters, glutamate-dehydrogenase (GLDH) was significantly improved in T5 birds in comparison with T4. The addition of MP significantly decreased residue levels of AFB1 in liver and OTA in the spleen of the treated groups. 5. The improvements in productive performance and reduction of mycotoxin residue levels in tissues demonstrated a beneficial effect of MP in cases of concurrent AFB1 and OTA ingestion by broilers.

Recently, the North American Electric Reliability Corporation (NERC) has reported that the unintended loss of solar generation occurred in Southern California over a large geographic area. One of the major reasons for this generation loss is the tripping of solar generators due to the overvoltage in a less than one cycle time frame (i.e., sub-cycle overvoltage) experienced by solar PV inverters when the grid suffers voltage drop following the transmission-level disturbances. Moreover, the sub-cycle dynamics become more complicated when solar PV inverters enter the momentary cessation operation mode in response to abnormal grid conditions. In this paper, solar PV systems with detailed inverter models that consider inverter switching dynamics and momentary cessation function are constructed for RTDS-based real-time electromagnetic simulations to explore the impact of momentary cessation on sub-cycle dynamics. It is found that undesired sub-cycle transient events not only occur when momentary cessation starts to cease energy injection but also happen when momentary cessation restart to inject energy into the system during the restoration process. Furthermore, the undesired sub-cycle transient events become more significant when increasing the number of solar PV inverters or under weak grid operating conditions. On the other hand, the severity of sub-cycle transient events can be reduced by increasing the diversity in the recovery time of solar PV inverters during the restoration process after momentary cessation.

Noise pollution is an emerging global problem therefore, it is imperative to determine noise level especially in the urban environment and its implications on human health. The objectives of this study were i) to assess the urban noise pollution and traffic density of Chiniot and Jhang and ii) to determine non-auditory health effects of noise pollution on the residents of both cities. Noise pollution was examined from 181 locations (103 from Jhang and 78 from Chiniot) and categorized into hospitals, educational, religious and recreational, residential, industrial areas, and traffic intersections. Noise levels measurements were taken using integrated sound level meter. The urban noise data showed 82% of the sites in Jhang and 95% in Chiniot exceeded the noise limits set by NEQS-Pak and WHO. Moreover, higher intensity of noise pollution (≥ 100 dB) was recorded in Chiniot (17 sites) than in Jhang (1 site). Regression analysis showed relatively strong relationship of traffic density with noise at Chiniot (R2 = 0.48) compared to Jhang (R2 = 0.31). However, spatial variability of noise with traffic density was observed at both cities. Survey study revealed that all the respondents in Jhang and Chiniot suffered from many noise related health problems such as annoyance (53 and 51%), depression (45 and 47%), dizziness (61 and 65%), headache (67 and 64%), hypertension (71 and 56%), hearing loss (53 and 56%), physiological stress (65 and 65%), sleeplessness (81 and 84%), and tinnitus (70 and 62%) due to noise, respectively. It is concluded that noise pollution is higher in Chiniot due to high traffic density resulted from higher population density and cottage industry. It is recommended that vehicles maintenance, family and urban planning could be effective measures to reduce urban noise pollution.

In this article, we study the problem of minimizing the sum of potentially nondifferentiable convex cost functions with partially overlapping dependences in an asynchronous manner, where communication in the network is not coordinated. We study the behavior of an asynchronous algorithm based on dual decomposition and block coordinate subgradient methods under assumptions weaker than those used in the literature. At the same time, we allow different agents to use local stepsizes with no global coordination. Sufficient conditions are provided for almost sure convergence to the solution of the optimization problem. Under additional assumptions, we establish a sublinear convergence rate that, in turn, can be strengthened to the linear convergence rate if the problem is strongly convex and has Lipschitz gradients. We also extend available results in the literature by allowing multiple and potentially overlapping blocks to be updated at the same time with nonuniform and potentially time-varying probabilities assigned to different blocks. A numerical example is provided to illustrate the effectiveness of the algorithm.

Introduction: The Republic of Croatia (HR) has significantly invested in monitoring the quality of inland bathing areas during the past 10 years. The aim of this paper was to analyze the results obtained during the 2014-2019 period and to compare them with the Region (non-European Union [EU] countries neighboring Croatia) and EU. Moreover, bathing water quality data at two bathing areas of Zagreb (lakes Jarun and Bundek) were processed in more detail.Methods: The quality of inland bathing areas in the HR is monitored in five rivers and five lakes in nine Croatian counties; 19 of the 35 monitored sites are located in Zagreb County. Escherichia coli (EC) was determined by EN ISO 9308-3: 1998, while intestinal enterococci (ENT) were defined by EN ISO 7899-2: 2000. Statistical processing of the results was performed using the Microsoft Excel Statistical Package (Redmond, USA) and Statistica 13.5. (Stat.Sof.Inc., Tulsa, USA); the significance level was set to p < 0.05.Results: During the study period, the worst Croatian inland water quality was recorded in 2019 (excellent quality for only 25.9% of the bathing areas), while the best quality was recorded in 2015 (excellent quality in 57.1%). On average (2014-2019), the share of bathing areas with excellent quality in Croatia was 46.3% (i.e., under the EU average of 85.3%); with no poor locations (EU average was nearly 2%). A significant positive correlation was found between fecal indicators (EC&ENT) and the amount of precipitation, while a negative correlation with water and air temperature in lakes.Conclusions: The quality of Croatian inland bathing areas is significantly lower than the European average, while EU water quality is improving. Regarding the countries bordering Croatia, Italy, Slovenia, and Hungary have achieved better results, while Montenegro, Serbia, and Bosnia and Herzegovina are still in the process of developing the monitoring of the bathing water quality.

Patient-to-image registration is currently mostly done in a semi-automated way. Fully automating this task can enhance surgical workflow and reduce human errors. Here, we present a novel solution with a nasal stent utilized to minimally invasively position spherical fiducials inside the nasopharynx and aimed for neurosurgery with electromagnetic navigation. The assembly was deployed into the pharyngeal region of a human specimen. The spherical fiducials are automatically detected in anatomy by integrated magnetic sensors while in preoperative imagery with a proposed u-net deep network. Temporal dislocation of the markers was measured interdaily after two brainstem procedures with CT imaging follow-ups. The u-net was trained to differentiate markers from other structures located in CT images. The ground-truth data was created from 22 CTs of phantoms, cadavers and swine. The dataset is split into 12, 5 and 5 for training, validation and testing, respectively. The dice coefficient was used as a similarity measure. The fiducial registration error resulted in 0.53±0.1 mm and 0.44±0.04 mm for the first and the second procedure, respectively. The fiducial positions deviated from the intraday baseline with the mean ± standard deviation 0.29±0.20 mm and 1.32±0.30 mm. The dice coefficient was 0.976, 0.878 and 0.764 during the training, validation and testing. The nasopharyngeal stent shows a potential for a stable marker fixation. The u-net can be adequately employed to segment titanium spherical fiducials.

Background: Invasive lobular carcinoma (ILC) comprises 10-15% of breast tumors and is the second most common histological type after invasive ductal carcinoma (IDC). Patients with ILC are often diagnosed at an older age and more advanced stage than those with IDC. Late recurrences and worse long-term survival suggest the need for improved approaches to treatment optimization and exploration of molecular pathways unique to ILC. Although previous reports have described comprehensive transcriptomic profiling of ILC, these were limited by small sample sizes. Furthermore, differential gene expression between ILC and IDC within genomic risk groups and molecular subtypes has yet to be explored. Here we characterize differential gene expression between ILC and IDC in a large, age-matched patient subset categorized by 70-gene signature/MammaPrint (MP) risk and 80-gene signature/BluePrint (BP) subtype. Methods: The prospective FLEX Registry (NCT03053193) includes stage I-III primary invasive breast cancer patients who receive MP/BP testing and consent to full transcriptome and clinical data collection. This sub-analysis included 450 ILC patients enrolled from 2017 to present. Compared with a random selection of IDC patients (n=450, mean age, 60 years), ILC patients were older (mean, 63 years, p ± 1.0 were considered significant. Results: ILC represented 13% of FLEX cases (n=450/3562), and were 81% lymph node-negative, 99% ER+, 94% HER2-negative, and 68% MP Low Risk (LR). By BP, ILC were 99% Luminal, 1% HER2, and Conclusions: Here we report differential clinical and molecular characteristics between ILC and IDC in a large, age-matched patient subset. Regardless of MP risk, expression of CDH1 was lower in ILC compared with IDC. Approximately one-third of ILCs were MP HR, and we report a greater number and diversity of DEGs between HR ILC and HR IDC compared with LR tumors, in particular genes related to TGFβ signaling. TGFβ pathway genes play a variety of roles in the tumor microenvironment, including induction of angiogenesis, fibroblast growth factor stimulation, and inhibition and/or exclusion of an immune response. These results suggest that therapeutic strategies targeting the TGFβ pathway may be future avenues of exploration in ILC, although further studies are warranted to characterize underlying molecular mechanisms. Citation Format: Beth-Ann Lesnikoski, Jennifer A. Crozier, Gordan Srkalovic, Patricia Robinson, Clodia Osipo, Kaylan Banda, Heather M. Kling, Josien Haan, William Audeh, FLEX Investigators Group. Differential gene expression in luminal-type invasive lobular carcinoma and invasive ductal carcinoma by MammaPrint risk stratification [abstract]. In: Proceedings of the 2020 San Antonio Breast Cancer Virtual Symposium; 2020 Dec 8-11; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2021;81(4 Suppl):Abstract nr PS18-03.

Increasing the incidence of caesarean section is not in line with professional and deontological guidelines. Elective cesarean section prevents primordial prevention of chronic cardiovascular, gastrointestinal, imunological, endocrinologicalmorbidity by peripartal programming. Elective non-medical indicated caesarean section is not a procedure that respects deontological, clinical etics, scientific and professional principles. It is like an unacceptable surgery outside the scope of medical ethics. Clientelism in high-risk clinical obstetric medicine is not a professional and deontologically correct category: a physician shouldnotbeaprovider on request of healthypregnant women with the potential to have a medically incorrect procedure and complications associated with it and to put a healthy pregnant/maternity and child status in the patient's status. Thefinancial, social, political and cultural components must not outweigh good clinical practice and themoral principles ofmedicine.

Violent video game playing is a consistent risk factor for aggression, but research on its psychopathology and trait underpinnings are primarily based on community or university student samples, thus the ecological validity to adjudicated and juvenile justice system-involved youth lacks clarity. This is an important void in the literature because relative to youth in the general population, adjudicated and detained youth evince greater psychopathology, more severe delinquency and violence histories, and clinical psychopathic features. Negative binomial regression models using data from 252 youth in residential placements found that several psychopathic features are significantly associated with violent video gaming. The role of psychopathy operated differently across gender and arrest chronicity, and across models remorselessness emerged as an important correlate. Given the desensitization that can occur with violent video game play, it is of particular concern among delinquent youth with psychopathic personality features.

The American College of Rheumatology guidance for management of pediatric patients with multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2 have been recently published. The guidance was prepared by the multidisciplinary Task Force and provide a very rational approach to management of this condition. There is, however, one area in which we are in disagreement.

Let S be a symmetric linear relation in the Pontyagin space (K, [., .]) and let Π = (H,Γ0,Γ1) be the corresponding boundary triple. We prove that the corresponding Weyl function Q satisfies Q ∈ Nκ(H). Conversely, for regular Q ∈ Nκ(H), we find linear relation S ( A, where A is representing self-adjoint linear relation of Q, and we prove that Q is the Weyl function of the relation S. We also prove  = kerΓ1, where  is the representing relation of the Q̂ := −Q−1. In addition, if we assume that the derivative at infinity Q ′ (∞) := lim z→∞ zQ(z) is a boundedly invertible operator then we are able to decompose A,  and S in terms of S, i.e. we express relation matrices of A,  and S in terms of S, which is a bounded operator in this case.