Background: Androgenetic alopecia (AGA) is an androgen-related condition that develops in genetically predisposed individuals. The condition is characterized by the progressive loss of terminal hairs on the scalp in a characteristic distribution. Trichoscopy represents the dermoscopy imaging of the scalp and hair. Structures which may be visualized by trichoscopy include hair shafts, hair follicle openings, perifollicular epidermis and cutaneous microvessels. Objective: The aim of this prospective study was to identify the trichoscopic features of androgenetic alopecia. Methods: Hundred-four patients with AGA and 80 healthy subjects were enrolled in this study. Data on age, gender, personal and family history, clinical type and duration of disease were collected and analyzed. Control group consisted of 80 generally healthy subjects. Trichoscopic examination was performed using either videodermatoscope or handheld dermatoskope. Trichoscopy results were obtained in frontal, occipital and both temporal areas of the scalp, including number of yellow dots and vellus hairs, number of hairs in one pilosebaceous unit and percentage of follicular ostia with perifollicular hyperpigmentation. The data were statistically evaluated. Results: The number of yellow dots, pilosebaceous units with only one hair and with perifollicular hyperpigmentation was significantly increased in androgenetic alopecia (p<0.05). The percentage of thin hairs (<0.03 mm) in AGA was significantly higher than in healthy controls (p<0.05). Conclusion: Our study has shown the significances of trichoscopy of patients with AGA. Regular clinical and trichoscopical follow-ups are very important to monitor disease activity and treatment tolerance.

By successfully solving the problem of forecasting, the processes in the work of various companies are optimized and savings are achieved. In this process, the analysis of time series data is of particular importance. Since the creation of Facebook’s Prophet, and Amazon’s DeepAR+ and CNN-QR forecasting models, algorithms have attracted a great deal of attention. The paper presents the application and comparison of the above algorithms for sales forecasting in distribution companies. A detailed comparison of the performance of algorithms over real data with different lengths of sales history was made. The results show that Prophet gives better results for items with a longer history and frequent sales, while Amazon’s algorithms show superiority for items without a long history and items that are rarely sold.

OBJECTIVE To present the characteristics of the AKT1E117K gene variant and a description of the clinical application in a patient with metastatic breast cancer. RESULTS 63 y/o woman with Stage IV Invasive lobular carcinoma at diagnosis was treated with Palbociclib and aromatase inhibitors (AI). At progression, tissue was sent for comprehensive genomic profiling to Foundation Medicine (FM) which revealed AKT1E17K mutation. In lieu of available clinical data within the patient's tumor type (HR+ HER2- breast cancer), extrapolated data from the Flatiron Health-FM (FH-FMI) Clinico-genomic Database (CGDB) was discussed at our Molecular Tumor Board (MTB). After multidisciplinary discussion, the consensus recommendation was to start treatment with the combination of mTOR inhibitor everolimus, and AI, exemestane. Patient tolerated treatment without major side effects. By the second clinical visit the patient's breast showed signs of improvement. PET/CT showed diminished left axillary uptake, decreased right paratracheal lymph node PET avidity, and stable bone disease consistent with a partial response. The most recent office visit in January 2021, breast exam revealed a normal-appearing skin with only faint erythema. All other skin lesions have resolved. Although, the role of AKT1 variant described here is not well defined and therapeutic significance of M-Tor inhibitors not established in metastatic breast cancers, comprehensive approach to this case unraveled new and successful therapeutic option in this patient. CONCLUSION This demonstrates that applying available Precision Medicine tools like MTB and real world data sets from patient populations with similar clinical and genomic profiles may provide more options for treatment.

In the present paper we consider the nonlinear superposition operator \(F\) in Banach spaces of sequences \(l_p\) \((1\le p\le \infty)\), generated by the function \(f(s, u) = d(s) + a^{ku} - 1\), with \(a > 1\) and \(k\in \mathbb{R}\setminus\{0\}\). We find out the Rhodius spectra \(\sigma_R(F)\) and the Neuberger spectra \(\sigma_N(F)\) of these operators, depending on the values of \(k\).

A generalized (6DOF) model for evaluating fragment trajectory elements is defined, which incorporates a novel model for estimating the projected surface of the body and novel model for estimating aerodynamic force and moment. This 6DOF model is developed on the basis of differential equations of the center of mass motion and movement around the center of mass (currently no known model incorporates movement of the body around its center of mass), and can model the parameters that play an essential role in movement of the bodies with irregular shape through the atmosphere. In our model the basic parameters (i.e. body dimensions) can be arbitrarily changed in the initial part of the analysis, and based on their values and values of initial kinematic parameters (initial velocity, position, orientation), trajectories can be determined (as well as other parameters: velocities, orientation) in a relatively short amount of time. The calculation of the complete trajectory of the fragments can be used in a number of applications: the analysis of the effects of the fragments (i.e. the safety analysis of the location of the ammunition depots, due to the potential explosion of the projectile) or in the estimation of a danger zones when demining larger quantities of the munition. Also, from the point of view of the parameters of the lethal zone of HE projectiles, it is generally important to estimate the trajectory of the fragments in the range up to 50m, so this model can be used to model such a scenario also. This model could also be potentially used wherever there is a need to calculate flight mechanics parameters of irregularly shaped bodies. Generalized (6DOF) model for estimation of an irregularly shaped body trajectory is implemented in a computer program, written in MatLab. Based on the model, the trajectory calculations were performed for the complete trajectory and for shorter distances to the center of the explosion, with varied geometric-inertial parameters and initial kinematic conditions for the given fragment.

A review of internal blast loads on structures modeling methods is presented in the paper. Also, numerical simulations of the internal explosion were done in software Ansys Autodyn. Critical areas of confined spaces were identified for this type of explosion event. Recommendations were given regarding the use of numerical simulations in blast wave parameter prediction, as well as suggestions for further research.

Lubarda, B. & Topalić-Trivunović, Lj.: Alien flora of the city of Banja Luka (Bosnia and Herzegovina). Nat. Croat., Vol. 29, No. 2, 217-226, 2020, Zagreb. In the urban area of Banja Luka, 77 species of alien plants have been found, most of them neophytes (64.94%) while a smaller percentage are archeophytes (35.06%). Most of the plants originate from America (34), and Asiatic species rank second (17). Most of the alien plants belong to the Compositae family, in terms of life form are therophytes, and intention has been involved in their arrival in this area.The anthropogenic change indicator values have been shown to have a significant anthropogenic impact on the overall flora.

Abstract Background The European Leadership Forum (ELF) of the European Society of Plastic, Reconstructive and Aesthetic Surgery (ESPRAS) previously identified the need for harmonisation of breast reconstruction standards in Europe, in order to strengthen the role of plastic surgeons. This study aims to survey the status, current trends and potential regional differences in the practice of breast reconstruction in Europe, with emphasis on equity and access. Materials and Methods A largescale web-based questionnaire was sent to consultant plastic and reconstructive surgeons, who are experienced in breast reconstruction and with understanding of the national situation in their country. Suitable participants were identified via the Executive Committee (ExCo) of ESPRAS and national delegates of ESPRAS. The results were evaluated and related to evidence-based literature. Results A total of 33 participants from 29 European countries participated in this study. Overall, the incidence of breast reconstruction was reported to be relatively low across Europe, comparable to other large geographic regions, such as North America. Equity of provision and access to breast reconstruction was distributed evenly within Europe, with geographic regions potentially affecting the type of reconstruction offered. Standard practices with regard to radiotherapy differed between countries and a clear demand for European guidelines on breast reconstruction was reported. Conclusion This study identified distinct lack of consistency in international practice patterns across European countries and a strong demand for consistent European guidance. Large-scale and multi-centre European clinical trials are required to further elucidate the presented areas of interest and to define European standard operating procedures.

To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (SSc) patients in the international juvenile SSc inception cohort, and to compare these characteristics between the classically defined juvenile diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) subtypes and among those with overlap features.

Edmundas Kazimieras Zavadskas, Irena Đalić, Željko Stević Institute of Sustainable Construction, Vilnius Gediminas Technical University, LT 10223 Vilnius, Lithuania. Faculty of Economics, University of Banja Luka, Majke Jugovića 4, Banja Luka 78000, Bosnia and Herzegovina. Faculty of Transport and Traffic Engineering, University of East Sarajevo, Vojvode Mišića 52, Doboj 74000, Bosnia and Herzegovina.

Nutrients are chemical substances obtained from food. They have different roles in body.  Some are used as energy source, some as structural materials, and regulating agents. Nutrients may reduce the risks of some diseases. There are some recommendations about dietary intake of these nutrients for optimal health. This study aimed to estimate average calcium and magnesium content in day meal in a sample of students from Faculty of Medicine of Sarajevo University. A cross-sectional study was conducted during academic 2015/16 year at Faculty of Medicine of Sarajevo University. The survey covered 44 students. The research instrument was a self-administered questionnaire, by which 3-Day Diet Record was provided. The average intakes of calcium and magnesium were estimated using Nutritional analysis computer program (Nutrics Professional Nutrition Analysis Software). On daily level average intake of calcium was 718.39±311.14 mg in total sample and average intake of magnesium was 292.57±310.10 mg in total sample. Average Ca/Mg ratio was 2.45. In our sample cheese was top source of calcium with Ca/Mg ratio of 32.5, and bread was top source of magnesium with Ca/Mg ratio of 3.1. These results emphasize the importance of monitoring the food nutrition facts in order to achieve adequate nutrients intake.