The possibility for utilization of waste heat from processes in the food industry is presented in this paper. The need for reuse of waste heat comes from the fact that energy consumption in industrial companies is uneconomical and that environmental pollution has increased. Therefore, one of the method of reuse of waste heat that is applicable in industrial processes is presented in the paper. Potential primary energy savings is presented by implementing the waste heat recovery in the food factory. The paper presents a simplified solution proposal for installation of heat exchangers with the aim of utilizing the waste heat of the refrigerant. The results showed that by the implementation of simple heat recovery significant annual fuel energy savings can be achieved as well as fuel cost savings.

Background Patients with head and neck squamous cell carcinoma (HNSCC) can develop lung squamous cell carcinoma (LuSCC), which could be the second primary tumor or HNSCC metastasis. Morphologically it is difficult to distinguish metastatic HNSCC from a second primary tumor which presents a significant diagnostic challenge. Differentiation of those two malignancies is important because the recommended treatments for metastatic HNSCC and primary LuSCC differ significantly. We investigated if the quantification of the promotor methylation status in HNSCC and LuSCC differs. Methods Primary HNSCC ( N  = 36) and LuSCC ( N  = 17) were included in this study. Methylation status in the ASC/TMS1/PYCARD (apoptosis-associated speck-like protein containing a caspase recruitment domain; 8 CpG sites) and MyD88 (Myeloid differentiation primary response protein 88; 10 CpG sites) promoters was analyzed. Bisulfite converted DNA, isolated from tumor tissue was quantified using pyrosequencing. Results of pyrosequencing analysis were expressed as a percentage for each tested CpG site. Receiver-operating characteristic (ROC) curve analysis was used for the evaluation of the diagnostic properties of selected biomarkers. Results CpG sites located in the promoters of ASC/TMS1/PYCARD_CpG8 (− 65 upstream) and MyD88_CpG4 (− 278 upstream) are significantly hypermethylated in the HNSCC when compared with LuSCC ( p  ≤ 0.0001). By performing ROC curve analysis we showed that corresponding areas under the curve (AUC) were 85–95%, indicating that selected CpG sites are useful for a distinction between primary LuSCC and primary HNSCC. Conclusions Results of the present study indicate that there is a significant difference in the methylation status of tested genes between primary HNSCC and LuSCC. However, to prove this approach as a useful tool for distinguishing second primary LuSCC from HNSCC metastasis, it would be necessary to include a larger number of samples, and most importantly, metastatic samples.

In the modern world of rapidly changing technologies, fiscal policy engagement is also needed to promote and adapt to these changes. In order to achieve economic growth, every country needs to ensure an adequate institutional environment and financial incentives for technological development. These investment incentives operate through tax system directly or indirectly. The aim of the paper is to assess the impact of Slovenia's endogenous economic growth factors on exports in the 2009–2016 period. A panel data analysis was applied to obtain empirical results. The analysis showed that a 1% real increase in government subsidies to the economy over three subsequent years increases real investment in research and development by 0.45%, and after a two-year period yields a 0.27% increase in employment of persons with higher education. The latter has a 0.14 % positive impact on the growth of exports after another three-year term. In addition to endogenous factors of economic growth in the Slovenian case, exports are also affected by the dynamics of real world trade, by the dynamics of exchange rates corrected for relative prices, and by the dynamics of wage rates.

Nowadays, the fast development of nanobiotechnology, has led to rapid diagnosis of important infectious diseases such as arboviruses-borne diseases, vector-borne infections and waterborne parasites diseases and others in order to reduce and avoid further dissemination of the infections within the general population. Furthermore, new nanomedicines based on the application of silver and gold nanoparticles which are less toxic, more effective, and that does not generate resistance could help to solve the problems of parasitic disease like leishmaniasis and chagas disease. It turns out that the combination of nanoparticles with antibiotics not only reduces the toxicity of both agents towards human cells but also enhances their ability to destroy bacteria by facilitating the binding of antibiotics to the microbes. Moreover, combining nanoparticles with antimicrobial peptides and essential oils with nanoparticles generates genuine synergy against microbial resistance.

Thymol is one of the most important phytochemical components because of its pharmacological and bioactive potential effects. This review focuses particularly on thymol as an alternative natural antiparasitic with potential use in the pharmaceutical industry. This is in line with the preferences of the natural products for treatment being safer and without side effects. The biosynthesis pathways of thymol and carvacrol have been discussed, and mechanism of action of thymol on parasites. Studies on thymol confirmed the activity of thymol as anti-parasite against anthelmintic, Trypanosoma ssp., Toxoplasma gondii, Leishmania spp., Plasmodium falciparum, Giardia duodenalis, Eimeria ssp., Cryptosporidium baileyi and Cryptosporidium galli.

The prognostic impact of human papillomavirus (HPV) in oropharyngeal cancer is generally acknowledged, and HPV‐status is assessed routinely in clinical practice. Paradoxically, while the oral cavity seems the predilection site for productive HPV‐infections, figures on HPV‐attribution in oral cavity squamous cell carcinoma (OCSCC) differ widely, and prognostic impact is uncertain. Major obstacles are the lack of reproducible assays to detect HPV in nonoropharyngeal cancers, the relatively small cohorts studied and consequently the shortfall of convincing data. In our study, we used a validated, nucleic acid‐based workflow to assess HPV‐prevalence in a consecutive cohort of 1016 OCSCCs, and investigated its prognostic impact. In parallel, we analyzed p16‐immunohistochemistry (p16‐IHC) as surrogate marker for transforming HPV‐infection and independent prognosticator. All OCSCC‐patients diagnosed between 2008 and 2014 at two Dutch university medical centers were included (N = 1069). Formalin‐fixed, paraffin‐embedded (FFPE)‐samples of 1016 OCSCCs could be retrieved. Punch biopsies were taken from the tumor area in the FFPE‐blocks and tested for HPV. P16‐IHC was performed on 580 OCSCCs, including all HPV‐positive tumors. From 940 samples (92.5%), nucleic acids were of sufficient quality for HPV‐testing. In total, 21 (2.2%) OCSCCs were HPV DNA‐positive. All HPV DNA‐positive tumors were E6 mRNA‐positive and considered as true HPV‐positive. There was no difference in survival between HPV‐positive and HPV‐negative OCSCCs. In total, 46 of 580 (7.9%) OCSCCs were p16‐immunopositive, including all HPV‐positive tumors. Survival was comparable in p16‐positive and p16‐negative OCSCCs. To conclude, HPV‐prevalence is very low in OCSCC and neither HPV‐status nor p16‐status affects outcome. Based on these data, determining HPV‐status in OCSCC seems irrelevant for clinical management.

Decision making is constantly present in agriculture. Choosing the wrong variety carries the risk that the investment in terms of sowing does not pay off at all. Therefore, it is necessary to choose the variety that gives the best results. In order to achieve this, it is necessary to apply multi-criteria decision-making of available varieties, which is, in this paper, done on the example of hybrid varieties of rapeseed that were created by selection at the Institute of Field and Vegetable Crops in Novi Sad. By applying fuzzy logic, a novel integrated Multi-Criteria Decision-Making (MCDM) model is developed and rapeseed varieties were evaluated. For determining four main and 20 subcriteria, fuzzy PIPRECIA (PIvot Pairwise RElative Criteria Importance Assessment) method has been applied based on fuzzy Bonferroni operator, while for ranking alternatives fuzzy MABAC (Multi-Attributive Border Approximation area Comparison) method has been used. The results obtained using the novel integrated fuzzy MCDM model showed that the variety A2 – Zorica has the best results, followed by A1 - NS Ras, while the worst results were seen by the variety A5 - Zlatna. These results were confirmed using other five fuzzy MCDM methods. Sensitivity analysis—changing criteria weights showed the worst results in the variety A6 - Jovana, which took last place in the application of 18 scenarios. The presented model and the results of this research will help farmers to solve this decision problem.

Background and Study Aim. The nutritional status of children can be assessed on the basis of clinical examination, laboratory procedures and anthropometric measurements. Height and body weight are most often used to determine nutrition. Children and adolescents who are at risk of being overweight often also become obese adults. Material and Methods. The research was conducted on a sample of 136 students (67 boys and 69 girls), with an average age of 11.56 years. The aim of the study was to determine the degree and differences in the degree of nutrition and body composition in boys and girls of pubertal age. Results. Based on the obtained results, T-test for small independent samples, it was determined that there are no statistically significant differences between boys and girls, both in the degree of nutrition and body composition, estimated by 10 variables using bioelectric impedance InBody 720. Also, it was found that 19.70% of boys are obese, as well as 17.40% of girls. Cumulatively with the percentage of malnourished respondents, a total of 61.50% of boys were not normally fed, as were 37.70% of girls. The obtained results indicate the need for a more extensive review of the analysed segments and a significantly larger sample of respondents, in order to act preventively in the fight against obesity, as the leading epidemiological health problem of today. Conclusion. It is obvious that physical activity based on physical education classes is not sufficient or is not sufficiently represented to meet the challenges of the modern way of life of children.

A novel ion-selective electrode with membranes based on iron(III) phosphate and silver sulfide integrated into a completely new electrode body design has been developed for the determination of iron(III) cations. The best response characteristics with linear potential change were found in the iron(III) concentration range from 3.97 × 10−5 to 10−2 mol L−1. The detection limit was found to be 2.41 × 10−5 mol L−1 with a slope of −20.53 ± 0.63 and regression coefficient of 0.9925, while the quantification limit was 3.97 × 10−5 M. The potential change per concentration decade ranged from −13.59 ± 0.54 to −20.53 ± 1.56 for Electrode Body 1 (EB1) and from −17.28 ± 1.04 to −24 ± 1.87 for Electrode Body 2 (EB2), which is presented for the first time in this work. The prepared electrode has a long lifetime and the ability to detect changes in the concentration of iron cations within 20 s. Membrane M1 showed high recoveries in the determination of iron cations in iron(III) standard solutions (98.2–101.2%) as well as in two different pharmaceuticals (98.6–106.5%). This proves that this type of sensor is applicable in the determination of ferric cations in unknown samples, and the fact that all sensor parts are completely manufactured in our laboratory proves the simplicity of the method.

The active introduction and modern technologies application in the transport market greatly affect all transport branches and the ways of their business. Availability and mass usage of the internet and web services create a new ambiance of trade through online sales respectively e-commerce. The increase in internet sales has a direct effect on the business of courier companies. The increase in the number of shipments, especially in the B2C (Business-to-consumer) segment, is putting increasing pressure on costs for companies that do pickup and delivery. Companies are trying to adapt their business to the new challenges and conditions that prevail in the transport market through different cost management models. One way to manage costs is to outsourcing costs. This paper proposes a model cost calculation in outsourcing services for pickup and delivery shipments based on the number of stops.

Abstract Language in the Balkan region of Southeastern Europe has a complex and turbulent history, acutely embodied in the tripartite and trilingual state of Bosnia and Herzegovina (BiH) in which Bosniaks, Croats, and Serbs all make claim to their own mutually-intelligible varieties of local “languages”. This study utilizes a linguistic landscape methodology to consider language use in Sarajevo, the capital of BiH, approximately 20 years after a brutal war that led to the establishment of the country. Data originate from three municipalities within the Sarajevo Canton – namely, Old Town, Center, and Ilidža – because of their representation of the region’s diversity and history. Signs were classified according to the three primary language varieties, i.e., Bosnian, Croatian, Serbian; BCS, representing a common core among the three varieties, as well as English, other languages, and mixed languages. The application of BCS uniquely positions the present research in comparison to other studies of language use in the region and allows for a more nuanced, less politically and ethnolinguistically fraught analysis of the communicative tendencies of users. More specifically, data indicate that actors in the linguistic landscape transcend the boundaries of their national, ethnic, and religious identities by tending towards the more neutral BCS, suggesting an orientation towards more translingual dispositions than previous variety-bound approaches have indicated. Thus, instead of the divisiveness of linguistic identity politics, the linguistic landscape of Sarajevo indicates a tendency toward inclusion and linguistic egalitarianism.