In the context of public safety, 5G offers great opportunities towards enhancing mission-critical services, by running network functions at the network edge to provide reliable and low-latency services. This demo introduces an on-demand Back Situation Awareness (BSA) application service, in a multi-domain scenario, enabling early notification for vehicles of an approaching Emergency Vehicle (EmV), indicating its Estimated Time of Arrival (ETA). The application provides the drivers ample time to create a safety corridor for the EmV to pass through unhindered in a safe manner thereby increasing the mission success. For this demo, we have developed an orchestrated MEC platform on which we have implemented the BSA service following modern cloud-native principles, based on Docker and Kubernetes.

This article addresses the issue of reliability in the Industrial Internet of Things (IIoT) in case of missing sensors measurements due to network or hardware problems. We propose to support the fault detection and classification modules, which are the two critical components of a monitoring system for IIoT, with a generative model. The latter is responsible for imputing missing sensor measurements so that the monitoring system performance is robust to missing data. In particular, we adopt generative adversarial networks (GANs) to generate missing sensor measurements and we propose to fine-tune the training of the GAN based on the impact that the generated data have on the fault detection and classification modules. We conduct a thorough evaluation of the proposed approach using the extended Tennessee Eastman Process data set. Results show that the GAN-imputed data mitigate the impact on the fault detection and classification even in the case of persistently missing measurements from sensors that are critical for the correct functioning of the monitoring system.

Significant part of Southeastern Europe (with a population of 76 million) has newborn screening (NBS) programs non-harmonized with developed European countries. Initial survey was conducted in 2013/2014 among 11 countries from the region (Albania, Bulgaria, Bosnia and Herzegovina (BIH), Croatia, Kosovo, Macedonia, Moldova, Montenegro, Romania, Serbia, and Slovenia) to assess the main characteristics of their NBS programs and their future plans. Their cumulative population at that time was ~52,5 million. At that time, none of the countries had an expanded NBS program, while phenylketonuria screening was not introduced in four and congenital hypothyroidism in three of 11 countries. We repeated the survey in 2020 inviting the same 11 countries, adding Cyprus, Greece, Hungary, and Malta (due to their geographical position in the wider region). The aims were to assess the current state, to evaluate the change in the period, and to identify the main obstacles impacting the implementation of expanded NBS and/or reaching a wider population. Responses were collected from 12 countries (BIH—Federation of BIH, BIH—Republic of Srpska, Bulgaria, Croatia, Greece, Hungary, Kosovo, North Macedonia, Malta, Montenegro, Romania, Serbia, Slovenia) with a population of 68.5 million. The results of the survey showed that the regional situation regarding NBS only modestly improved in this period. All of the surveyed countries except Kosovo screened for at least congenital hypothyroidism, while phenylketonuria was not screened in four of 12 countries. Croatia and Slovenia implemented an expanded NBS program using tandem mass spectrometry from the time of last survey. In conclusion, the current status of NBS programs in Southeastern Europe is very variable and is still underdeveloped (or even non-existent) in some of the countries. We suggest establishing an international task-force to assist with implementation and harmonization of basic NBS services where needed.

Supposed risk of malignant transformation of salivary gland pleomorphic adenoma (SGPA) is an important reason for aggressive retreatment in recurrent pleomorphic adenoma (RPA). However, although the diagnostic category ‘carcinoma ex‐pleomorphic adenoma’ suggests that malignant transformation of a pleomorphic adenoma is a regular event, this has to date not been shown to occur in sequential lesions of one patient. Here, we show the molecular events in transformation to malignancy of a pleomorphic adenoma of the parotid gland. Detailed molecular analysis revealed an LIFR/PLAG1 translocation characteristic for pleomorphic adenoma and, next to this, a PIK3R1 frameshift mutation and several allelic imbalances. In subsequent malignant recurrences, the same LIFR/PLAG1 translocation, PIK3R1 frameshift mutation, and allelic imbalances were present in addition to TP53 mutations. Thus, this case not only shows malignant transformation of SGPA, but also demonstrates that molecular analysis can be of help in recognising malignancy in the rare instance of RPA.

The status that it has today, the uniqueness and specificity of its intercultural profile, Bosnian literature owes to the centuries-old deposition of various cultural strata. How deep into the past this integral composite reaches is most visible in literary works, whose re/interpretations certify the ruthless interaction with other cultures. In the methodological key of interculturality as an area of exchange of different cultural practices, the paper (through theoretical models of German comparativists’ hermeneutics of foreign) explores the mediation of “foreign” in Bosnian literature. Certain intercultural aspects of Bosnian literature have not been sufficiently researched, and it is the ways of communicating with foreign and the connection of foreign with the experience of alienation and/or intimacy that make the life of Bosnian culture serious and portray the timeline of literary texts as a trace of longing for a universal agreement of the worlds.

This article aimed to make a theoretical review of the importance of ICT education of teachers in service of preparation for more efficient performances required by their profession in the context of general globalization changes they are exposed to. In that sense, a review of the advantages of ICT utilization and the requirements of lifelong learning which sets informatical skills as an imperative had been presented, emphasizing the role of teachers, since it requires working on self-improvement, as well as directing others towards competent, critically observed and purposeful usage of modern technological achievements. Some of the priorities for the development of higher education in B&H have been presented, where in the context of scientific research work for the 2016-2026 period, providing all of the public higher education institutions with ICT equipment is planned, which indicates that the teachers working in these institutions must possess the competencies for their utilization, especially because institutions of higher education should play the role of one of the main promoters of lifelong learning.

The ability of molecules and systems to make copies of themselves and the ability of molecules to fold into stable, well-defined three-dimensional conformations are of considerable importance in the formation and persistence of life. The question of how, during the emergence of life, oligomerization reactions become selective and channel these reactions toward a small number of specific products remains largely unanswered. Herein, we demonstrate a fully synthetic chemical system where structurally complex foldamers and self-replicating assemblies emerge spontaneously and with high selectivity from pools of oligomers as a result of forming noncovalent interactions. Whether foldamers or replicators form depends on remarkably small differences in building block structures and composition and experimental conditions. We also observed the dynamic transformation of a foldamer into a replicator. These results show that the structural requirements/design criteria for building blocks that lead to foldamers are similar to those that lead to replicators. What determines whether folding or replication takes place is not necessarily the type of noncovalent interaction, but only whether they occur intra- or intermolecularly. This work brings together, for the first time, the fields of replicator and foldamer chemistry.

In this article, we argue that within multilingual polities, whether national or transnational, multilingual parties are all-things-considered more desirable than monolingual parties operating via a lingua franca. First, we develop a taxonomy of what we believe are the main ideal-type models of “linguistic democracy,” that is, of the relationship between language and democracy in multilingual polities. Second, we argue that multilingual parties are in a better position than monolingual parties to formulate conceptions of the common good that take into account diverse linguistic and epistemic perspectives. Third, we claim that such parties can perform an educational role for their members and for citizens in general, by making them aware of the implications of linguistic diversity for democratic life. Fourth, we argue that multilingual parties can offer a linkage between citizens and government via forms of intraparty deliberation that are rendered more inclusive and democratic by the use of multiple languages.