While Weighted Lasso sparse regression has appealing statistical guarantees that would entail a major real-world impact in nance, genomics, and brain imaging applications, it is typically scarcely adopted due to its complex high-dimensional space composed by thousands of hyperparameters. On the other hand, the latest progress with high-dimensional hyperparameter optimization (HD-HPO) methods for black-box functions demonstrates that high-dimensional applications can indeed be eciently optimized. Despite this initial success, HD-HPO approaches are mostly applied to synthetic problems with a moderate number of dimensions, which limits its impact in scientic and engineering applications. We propose LassoBench , the rst benchmark suite tailored for Weighted Lasso regression. LassoBench consists of benchmarks for both well-controlled synthetic setups (number of samples, noise level, ambient and eective dimensionalities, and multiple delities) and real-world datasets, which enables the use of many avors of HPO algorithms to be studied and extended to the high-dimensional Lasso setting. We evaluate 6 state-of-the-art HPO methods and 3 Lasso baselines, and demonstrate that Bayesian optimization and evolutionary strategies can improve over the methods commonly used for sparse regression while highlighting limitations of these frameworks in very high-dimensional and noisy settings.

Building on an in-depth study of a manufacturing company’s shift from a product to a product-service business model, we explore how single-focus companies transition to a dual orientation. Although companies generally use highly sophisticated practices to manage a dual orientation, those that transition to one successfully start with less sophisticated practices. Early on, the use of simple tradeoff practices, which maintain the product and service logics, helps single-focus companies explore the emergent tensions that their transition to a dual orientation causes. Conversely, adopting more sophisticated practices at this early stage overwhelms them. At a later stage, these companies’ growing understanding of the tensions allows them to experiment with more comprehensive paradox practices that transcend the product and service logics. Conversely, maintaining simple practices at this stage prevents them from gaining the solution experience required to complete the transition. The evolutionary process culminates in sophisticated routinized practices that institutionalize recurrent tensions’ solution, while allowing for further experimentation to deal with new tensions. The different practices’ appropriate sequence and pacing during the evolutionary process facilitate companies’ transition to a dual orientation.

A insuficiência cardíaca (IC) é uma complexa síndrome clínica de diversas etiologias e com elevada prevalência, caracterizada por falência no suprimento adequado de sangue em relação ao retorno venoso e às necessidades metabólicas do indivíduo, cursando com intolerância ao esforço físico, consequentemente, diminuindo a capacidade funcional. O objetivo deste estudo consiste em comprovar a eficácia da mobilização precoce em pacientes com IC no leito, pelo fisioterapeuta, e ressaltar os benefícios dos exercícios físicos e a melhora na qualidade de vida. Foram realizadas pesquisas bibliográficas nas bases de dados PubMed, SciELO, ProQuest e PEDro, onde foram consultados 10 artigos publicados entre os anos 2009 a 2020. Foram utilizados os seguintes descritores para a busca: Mobilização precoce, Fisioterapia na UTI (Unidade de Terapia Intensiva), Insuficiência cardíaca, Cardiopatias, Treinamento de força e Mobilização precoce na UTI. Dos estudos analisados, os pacientes apresentaram melhora do desempenho funcional, marcha, espasticidade e também na qualidade de vida. A mobilização precoce por meio do fisioterapeuta atua diretamente na reabilitação desses pacientes promovendo ganhos significativos, contribuindo assim de forma bastante eficaz para a sua qualidade de vida.

Physically, one tends to think of non-Hermitian systems in terms of gain and loss: the decay or amplification of a mode is given by the imaginary part of its energy. Here, we introduce an alternative avenue to the realm of non-Hermitian physics, which involves neither gain nor loss. Instead, complex eigenvalues emerge from the amplitudes and phase differences of waves backscattered from the boundary of insulators. We show that for any strong topological insulator in a Wigner-Dyson class, the reflected waves are characterized by a reflection matrix exhibiting the non-Hermitian skin effect. This leads to an unconventional Goos-Hänchen effect: due to non-Hermitian topology, waves undergo a lateral shift upon reflection, even at normal incidence. Going beyond systems with gain and loss vastly expands the set of experimental platforms that can access non-Hermitian physics and show signatures associated with non-Hermitian topology.

Resistive switching (RS) devices are emerging electronic components that could have applications in multiple types of integrated circuits, including electronic memories, true random number generators, radiofrequency switches, neuromorphic vision sensors, and artificial neural networks. The main factor hindering the massive employment of RS devices in commercial circuits is related to variability and reliability issues, which are usually evaluated through switching endurance tests. However, we note that most studies that claimed high endurances >106 cycles were based on resistance versus cycle plots that contain very few data points (in many cases even <20), and which are collected in only one device. We recommend not to use such a characterization method because it is highly inaccurate and unreliable (i.e., it cannot reliably demonstrate that the device effectively switches in every cycle and it ignores cycle-to-cycle and device-to-device variability). This has created a blurry vision of the real performance of RS devices and in many cases has exaggerated their potential. This article proposes and describes a method for the correct characterization of switching endurance in RS devices; this method aims to construct endurance plots showing one data point per cycle and resistive state and combine data from multiple devices. Adopting this recommended method should result in more reliable literature in the field of RS technologies, which should accelerate their integration in commercial products.

Response assessment in the treatment of glioblastoma (GB) based on MR-imaging is still challenging, in particular for immunotherapeutic strategies. Several assessment tools have been proposed. In this post-hoc analysis we compared response assessment criteria (MacDonald, RANO, mRANO, Vol.-mRANO, iRANO) in newly diagnosed GB patients treated with tumor lysate-charged autologous dendritic cells (Audencel) and determined the differences in prediction of progression free survival (PFS) and overall survival (OS). 76 patients with newly diagnosed GB enrolled in a multicenter randomized phase II trial receiving standard of care (SOC, n= 40) or SOC + Audencel vaccine (n= 36) were included. Tumor volumes were calculated by semiautomatic segmentation. To detect differences in PFS among the assessment criteria Kruskal-Wallis-test, for correlation analysis Spearman test was used. There was a significant difference in median PFS based on the different assessments (mRANO 8.55 months [9.10-14.03], Vol.-mRANO 8.61 months [9.72-14.92] compared to MacDonald 4.04 months [5.21-8.75] and RANO 4.16 months [5.28-8.61]. For the vaccination arm only, median PFS by iRANO was 5.95 months [5.70-11.54]). There was no difference in PFS between SOC and SOC + Audencel using the different response criteria. The best correlation between PFS and OS was detected for mRANO (r= 0.65, p< 0.001) and Vol.-mRANO (r= 0.69, p< 0.001). At an 8-month landmark, the impact of progressive disease on median OS was best shown for mRANO (13.70 months [13.13-18.98], and Vol.-mRANO 12.03 months [12.51-17.94]) compared to MacDonald 17.97 months [15.45-20.92], RANO 17.97 months [15.92-20.95] and iRANO 17.34 months [14.99-22.73]. When comparing different response assessments in GB patients treated with dendritic cell-based immunotherapy the best correlation between PFS and OS was observed for mRANO and Vol.-mRANO. Overall, no difference in PFS and OS was seen between the two treatment arms. iRANO was not superior for predicting OS in patients treated with Audencel.

Introduction Although extracorporeal shock wave lithotripsy (ESWL) is minimally invasive and highly efficient for the management of kidney stones, adverse effects have been described. Available indicators of renal function exhibit insufficient sensitivity in acute renal injury (AKI). We aimed to evaluate the severity of the kidney tissue response to ESWL injury by measuring the urinary neutrophil gelatinase-associated lipocalin (uNGAL), which can indicate AKI in its early phase. Material and methods The prospective, controlled study included 62 patients with nephrolithiasis undergoing single ESWL treatment. uNGAL level was measured before the procedure, and 6 h and 12 h after. Results The median uNGAL level increased by 126.0%, 6 h after ESWL (p <0.001). The growth rate continued and 12 h after was higher by 583.7%, compared to the pre-treatment level (p <0.001). The median value of estimated glomerular filtration rate (eGFR) dropped by 15.3% 12 h after the treatment (p <0.001). It increased by 5.0% in the period 7 days to 3 months after (p <0.001) and after 3 months it was lower by 10.1% compared to pre-ESWL values (p <0.001). uNGAL level after 12 h was significantly negatively associated with eGFR, 12 h, 7 days and 3 months after the ESWL. The sensitivity of uNGAL 12 h after ESWL was 60.6%; its specificity was 75.0%, with a positive predictive value of 74.0% and negative predictive value of 61.7%. Conclusions uNGAL appears to be a useful biomarker for the assessment and prediction of AKI. It was noticed that uNGAL had the highest predictive value 12 h after the ESWL treatment.

Highlights • From 42 sampling areas (municipalities) distributed throughout the country 6 193 tick samples were collected from the ixoidae family.• I.ricinus was the most common tick species found, however with decreasing contribution to overall tick population compared to earlier studies.• Dermacentor marginatus as second most common species found had doubled its presence compared to earlier studies.• Changes is tick species distribution were discussed in light of increase of average annual temperature and rainfall, changes of land management and land use.

Introduction: Having in mind the importance of providing continuous pediatric dental services during the COVID-19 pandemic and the fact that children have similar viral loads to adults, the potential to spread the virus to others, and with variable clinical presentation of COVID-19 infection, this study aimed to analyze the impact of COVID-19 outbreak on pediatric dentistry service provision, risks, and preventive measures before and during dental treatment. Method: Structured and closed epidemiological cross-sectional survey involved seven Southeastern European countries. The questionnaire was developed using the modified Delphi method, pretested, and tested in North Italy during April 2020. The sample consisted of licensed dental professionals reached via national dental chambers and social media using the best strategies according to the national setting. Results: A total of 3227 dentists participated in the survey, and we included 643 specialists in this study—among them, 164 were pediatric dentists. Most pediatric dentists worked in the public sector (61.0%) and provided emergency (64.6%) and routine dental treatment (18.3%) during the outbreak. One-third of pediatric dentists were COVID-19 tested, statistically significantly more than other specialties, and 3.0% tested COVID-19 positive. In addition, significantly more pediatric dentists (13.4%) reported the presence of at least one symptom related to COVID-19 compared to other specialists (6.1%). None of the pediatric dentists reported PPE shortage. However, 26.2% of all specialists stated that they lacked clear step by step professional guidance in a national language. Similarly, in both groups, around 10% of specialists attended education on coronavirus. Conclusions: Considering that most pediatric dentists provided dental treatment during lockdown in their countries in public health centers and that they will continue to work during pandemic, our results suggest that pediatric dentists might be at higher risk of COVID-19 infection. Further research should focus on finding better ways to promote and adapt preventive, protective measures and PPE in the pediatric dental setting to be behaviorally acceptable. Moreover, additional efforts should be invested in dental education regarding COVID-19 in the mother tongue.

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2021;54(5):712-735. SOURCE OF FUNDING Information not available. TYPE OF STUDY/DESIGN Systematic review with meta-analysis.

UDK: 630*232:582.475(497.6) It is well known that mechanical damage to trees, caused by felling and removal of timber from the forest, has multiple negative effects on the quality of the stock and the health of the forests as well as the volume increment. In Bosnia and Herzegovina there were no significant analises of volume increment loss due to bark damage of the trees. In this paper, a direct relationship between the significant damage to the bark of the stem and the size of the volume increment of individual trees was determined. Original data recorded during the Second National Forest Inventory in Bosnia and Herzegovina (2006-2009), within the accesible high economical forests was used. These forests cover a total area of 1.329.500 ha. Data on measured trees was taken from every fourth sample plot (one from cluster). 18.546 trees were selected, on which the 10-year increment of brest diameter (DBH) was measured and significant mechanical damage was recorded (LOJO et al., 2008). Of the total number of selected trees, 2.635 or 14.21% were mechanically damaged. The results of the study showed that the volume increment of trees, with significant bark damage of all tree species and thickness, was lower from 4,9% to 19,4% in average, compared to undamaged trees. Based on registered damage the bark of the stem, during second NFI BiH and determined the average losses increment on individual trees, it was estimated how much these losses are on an annual basis in, productive high forests in Bosnia and Herzegovina. The volume increment of mechanically damaged trees is statistically significantly lower compare to the increment of undamaged trees, resulting in a total loss of about 200.000 m3 / year / 1.329.500 ha.

UDK: 630*232:582.475(497.6) Provenance experiments with forest trees provide valuable information about the growth and adaptability of population, often transferred from remote geographical regions and various climate conditions. This study researches the growth of nine provenances of silver fir from the area of its natural distribution in Bosnia and Herzegovina. The experiment was established in the year 1991 in the form of a random block system with 5 repetitions. For planting, we used five-year-old seedlings (2/3), and planting spacing was 2x2 m. Each Silver fir provenance was included with 320 plants. Measurement results in the 28th year of age show the existence of variations between silver fir provenances in characteristics; mean height, mean diameter and average tree volume. Silver fir provenance from Bosanski Petrovac showed the best results. The mean height of this Silver fir provenance at the age of 28 was 9.1 m, while the mean diameter was 11.9 cm. Provenances that show the lowest growth (8.1 m) were from Pale, Olovo-Klis and Konjic. Silver fir provenance from Konjic has the lowest mean diameter (10.7 cm). In all provenances, we have had a culmination of height increment in age between 20 and 25 years. Variation between tested silver fir provenances for examined characteristic “mean height” was larger (four groups of population) compared to examined characteristic “mean diameter” (two groups of population). Volume of mean tree (0.062m3) and assortment (111.33 m3/ha) in Bosanski Petrovac provenance was larger than spreadsheet values for the first yield class for Central Europe conditions. The trial shows that silver fir in Bosnia and Herzegovina is variable on the local level due to specific micro-habitual conditions in which it grows.

The limited sensitivity of existing analysis techniques at the nanometer scale makes it challenging to systematically examine the complex interactions in redox-based resistive random access memory (ReRAM) devices. To test models of oxygen movement in ReRAM devices beyond what has previously been possible, we present a new nanoscale analysis method. Harnessing the power of secondary ion mass spectrometry, the most sensitive surface analysis technique, for the first time, we observe the movement of 16 O across electrically biased SiO x ReRAM stacks. We can therefore measure bulk concentration changes in a continuous profile with unprecedented sensitivity. This reveals the nanoscale details of the reversible field-driven exchange of oxygen across the ReRAM stack. Both the reservoir-like behavior of a Mo electrode and the injection of oxygen into the surface of SiO x from the ambient are observed within one profile. The injection of oxygen is controllable through changing the porosity of the SiO x layer. Modeling of the electric fields in the ReRAM stacks is carried out which, for the first time, uses real measurements of both the interface roughness and electrode porosity. This supports our findings helping to explain how and where oxygen from ambient moisture enters devices during operation.