: Complexes of general formula [ Ru(bpy) 2 (L) ]CF 3 SO 3 , where bpy = 2,2′ - bipyridine, and L = Schiff bases derived from salicylaldehyde and amino acids (glycine ( 1a), cysteine (1b), methionine (1c ) and phenylalanine ( 1d )) were synthesized. Characterization based on elemental analysis, Ru content, mass, infrared and electronic spectra confirmed RuN 5 O coordination unlike 1b where coordination occurred via azomethine nitrogen and cysteine sulfur. Cyclic voltammograms, except 1b, showed several quasi- reversible redox pairs in the positive potential range, the first located at about 0.5 V, corresponding to similar heteroleptic Ru(II) bipyridyl complexes. Biological activity was tested by interactions with DNA and BSA. DNA binding constants of order 10 3 M − 1 , suggest groove binding due to bpy ligand and hydrogen bonding of the OH and CO groups from the imine moiety. In vitro BSA protein inhibition assay performed by spectrofluorimetry showed Complex : BSA binding in 1 : 1 ratio with K b of 10 4 M − 1 order. Cytotoxicity studies by MTT assay for 72 h of drug action revealed activity of 1a and 1d against breast cancer MCF- 7 cells with IC 50 values 32 ± 8 and 26 ± 1µM, respectively.

In this paper, a novel method for the magnetic flux density estimation in the vicinity of multi-circuit overhead transmission lines is proposed. The proposed method is based on a fully connected feed-forward artificial neural network model that is trained to estimate the magnetic flux density vector components for a range of single-circuit overhead transmission lines. The proposed algorithm is able to simplify estimation process in instances when there are two or more geometrically identical circuits present in the multi-circuit overhead transmission line. In such instances, artificial neural network model is employed to estimate the magnetic flux density distribution over a considered lateral profile for only one of such circuits. The magnetic flux density estimates of the other geometrically identical circuits are derived from these results. The proposed methodology defines the resultant magnetic flux density for the multi-circuit overhead transmission line in terms of the contributions made by individual circuits. The application of the proposed magnetic flux density estimation method is demonstrated on several multi-circuit configurations of overhead transmission lines. The performance of the proposed method is compared with the Biot-Savart law based method calculation results as well as with field measurement results.

: The aim of the research was to measure the basic external characteristics of Pramenka sheep (ridge height, from the ground to the highest ridge point, lower back height, from the ground to the highest lower back point, hull lenght, chest width, chest depth, chest circumference, hull circumference, shin circumference, body weight) with the aim of comparing the measured values in order to asses the impact of breeding areas on them. Domestic kind Pramenka (Kupres strain, Vlašić strain) were used in this research. There were 36 sheeps in the experimental group, and the same number in the control group. Experimets were performed on long-term purebred herds of Pramenka on three private farms in the Una-Sana Canton, 2 municipalities of Cazin, 1 municipality of Bihać, as well as on one private farm in Central Bosnia (area of the municipality of Travnik), and one in the municipality of Kupres (Livno Canton). Based on the presented average values of the external properties of Pramenka sheep and their variations for all examined localities, we can conclude the following: that the sheep are longer in relation to their height and that the Pramenka is of medium physical development, that the differences in body measures in the examined areas are greatly influenced by the origin of certain breeds of Pramenka sheep (Kupres strain, Vlašić strain), as well as the quality of pastures and unequal access to food. By comparing our results with the results of other authors who examined the exterior of other strains of Pramenka (from region in Croatia: Rab, Lika, Pag, Istria) in our wider enviroment concluded that Vlašić Pramenka is the largest strain of Pramenka in this area.

Introduction. Lean principles have been successfully adapted to the healthcare environment, enabling hospitals and clinics to streamline their operations and focus on value as perceived by their patients. Many healthcare facilities have implemented lean principles to improve their efficiency. The subject of this paper is the lean concept, the essence of which is implementation of methods that affect the efficiency and quality of providing health services. Our aim was to point out the necessity of applying modern concepts in healthcare. Material and Methods. The primary sources of data were obtained through research on the opinions and possibility of applying the lean concept in hospitals in Bosnia and Herzegovina. We presented the results on the effectiveness of the lean concept in hospitals that apply it. Results. After implementation of the lean concept in an Italian hospital, the results showed a positive impact on the waiting time for admission, faster discharge, and faster flow of information. The results of the research in Bosnia and Herzegovina showed that there were positive attitudes towards the effects that would be achieved by implementing the lean concept. Conclusion. The implementation of the lean concept would reduce medical waste, which would positively affect the quality of health care services.

The aim of our manuscript is to report of a successful perinatal outcome after treatment of acute polyhydramnios caused by duodenal atresia. A 34-year-old G3P1 was referred due to polyhydramnios in the 30th week of pregnancy. Ultrasound revealed polyhydramnios, amniotic fluid index (AFI) 28, and a double bubble sign that indicated duodenal atresia and dilatated oesophagus. In the 32nd week of gestation, the volume of amniotic fluid increases, AFI 35, along with symptoms of dyspnea and abdominal pain. Due to the clinical picture and the early gestational age, it was decided to perform an amnioreduction. In the 36th week of gestation cesarean section was performed. The baby was taken for exploratory laparotomy and found to have a simultaneous complete duodenal atresia and annular pancreas with associated dilated the first portion of the duodenum and the stomach. A side-to-side duodenoduodenostomy via single-layer hand-sewn anastomosis was performed over a transanastamotic feeding tube (TAFT). The postoperative course was uneventful. Amnioreduction is useful and safe in the treatment of acute polyhydramnios caused by duodenal atresia and thus has a significant role in prolonging gestation until fetal maturity.

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Background: For many years, pharmacy and medicine were inseparable sciences, so everything that was done in the field of medicine, that is, treatment, can be related to pharmacy. The history of pharmacy therefore also includes the history of medicine, at least until the 13th century, when pharmacy was officially separated from medicine. Objective: The aim of this study was: to describe the books and monographs that are available on the Internet, which deal with the study of the history of Pharmacy; and to show pharmaceutical history museums around the world and their unique collections of pharmaceutical artifacts. Methods: During the preparation of this paper, a descriptive method of analysis from the available literature was used. The analysis of available literature included professional books, monographs, articles and other literature available on online browsers. Results and Discussion: Today there are a large number of societies, academies, associations and foundations dealing with the history of pharmacy. Also, a lot of books, monographs and scientific papers published in on-line databases. The goal of each organization is the research of historical facts in the field of pharmacy and medicine that will be shared with professionals, but also persons who are not from the profession (doctors, librarians, archaeologists, archivists). A large number of museums have been opened for the history of pharmacy, and almost every developed country has such a museum. Such museums represent a national treasure, because they preserve the valuables of pharmacy from the territory of the country, as well as the world.

Background: The rich history of pharmacy in Bosnia and Herzegovina has been sporadically dealt with systematically, except by enthusiasts and researchers. The only book on this topic was published in 1958, and after the aggression against Bosnia and Herzegovina, the history of pharmacy was treated mainly as part of the history of medicine. The lack of a culture of memory and a systematic approach to historical heritage brought together a group of experts who deal with this topic in more detail and collect available historical relevant material. Pharmacy as a highly regulated health discipline also in Bosnia and Herzegovina is a legacy of legal acts and documents that depict different periods and the development of pharmacy itself under the influence of circumstances and legislation. Objective: The aim of this paper is to show the development of legislation related to the pharmaceutical sector in Bosnia and Herzegovina through the historical periods of its development. Methods: This is retrospective research based on internet sources, archives and publications available in libraries. Results and Discussion: The available legal regulations and documents through five periods of pharmaceutical development were analysed, from which it can be concluded that the organization of the pharmaceutical industry and its development over time remained stricter. Legal regulations depict the role of pharmacy in the health system, but they also represent sources for further research in this area, and constitute important historiographical material. The analysis of legal regulations speaks volumes about the way pharmaceutical activity is organized, so it is possible to follow the appearance of the first pharmacies, pharmacists, requirements for the quality of medicines, production and the modern role of pharmacists in the health system. Pharmaceutical legislation will certainly be the subject of future negotiations on the accession of Bosnia and Herzegovina to the European Union, and harmonization with the acquis of the EU is expected in the coming period.

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