Tissue ischemia means insufficient blood flow to a certain area of the body. Interruption of the arterial blood supply leads to an imbalance between metabolic supply and demand and the development of tissue hypoxia. Tissue hypoxia induces metabolic changes that result in inflammation, increased production of reactive oxygen species, and cell death. If adequate blood flow is established in the ischemic tissue, there will be an increase in cellular damage, which is referred to as ischemic-reperfusion injury. Ischemia and ischemia-reperfusion injury are at the root of numerous diseases widely present in modern society, such as myocardial infarction, cerebral insult, acute kidney injury. For now, there is no way to directly affect cellular hypoxia, but the clinical treatment of hypoxic conditions is aimed at modulating global hypoxemia and increasing the amount of oxygen dissolved in the blood. Hyperbaric oxygenation (HBO) is a treatment during which the patient breathes 100% oxygen under a pressure of at least 1.4 atmospheres. Although the use of hyperbaric therapy was recorded as early as the 17th century, today this treatment is approved for a few indications.

Cadmium (Cd) is an extremely toxic metal that is widespread in nature. Due to its favorable properties, it was widely used in the industry for the production of alkaline batteries, accumulators, pigments, and colored alloys. However, it has been shown that exposure to low concentrations of cadmium leads to damage to many organs and organ systems, and the use of this metal in industry is reduced, and it is replaced by other, less harmful materials. Today, fossil fuel combustion and cigarette consumption are important sources of cadmium exposure. Numerous studies have examined the toxic effects of cadmium and they highlight the kidneys, liver, gonads as the organs that suffer the most damage. The kidneys, as the main place of cadmium storage in the body, are mostly exposed to its toxic effects. In the proximal tubular cells of the kidney, exposure to cadmium disrupts transport processes. Although ionized cadmium (Cd 2+) is thought to be largely responsible for the damage that occurs, the role of the cadmium and metallothionein complex (Cd-MT) cannot be ignored. Peritubular exposure to ionized cadmium indirectly leads to a decrease in the activity of the Na + /L-alanine cotransporter and a decrease in the rate of slow repolarization of the luminal membrane, while the Cd-MT complex leads to both direct and indirect inhibition of this transporter. Also, the Cd-MT complex inhibits Na + /Glucosa cotransporter activity. Exposure to cadmium also leads to a decrease in the endocytic uptake of low molecular weight proteins, which is accompanied by microalbuminuria.

Introduction. The aim of this study was to evaluate the influence of the carbomer concentration (used as the gelling agent, in the range 0.5 - 2.0%) on textural and sensory characteristics of gels with 3% panthenol using sensory analysis as subjective and texture analysis as an objective assessment method. An active substance in the gels was panthenol, which also acted as a neutralizing agent of the carbomer. Participants and methods. Twenty female panelists, aged between 20 and 36, participated in the sensory study and had to fulfill a questionnaire regarding product attributes before, during and after application on the skin. Texture analysis was performed on CT3 Texture Analyzer, after each week for a month, and the following parameters were calculated: hardness cycle 1, hardness cycle 2, cohesiveness, adhesiveness, resilience and springiness. Results. The results showed that gels were stable over time and the structure of the gels was preserved regardless of compression. An increase in hardness and resilience was followed by an increase in the concentration of carbomer, while adhesiveness, cohesiveness and springiness did not differ much among different gels. The same trend was noticed when gels were compared during time. Sensory analysis confirmed findings of texture analysis and showed that with the increment of carbomer concentration, stickiness and density also enhanced, while absorption rate and spreadability decreased. Gel with 1% carbomer was chosen by the majority of panelists as favorite and as a gel they would regularly use. Conclusion. The methods of textural and sensory analysis represent valuable approaches in drug/cosmetic product design because they offer insight in the compliance of patients/consumers.

Introduction/purpose: The paper presents interesting research related to the performance analysis of the picture-wise just noticeable difference (JND) prediction model and its application in the quality assessment of images with JPEG compression. Methods: The performance analysis of the JND model was conducted in an indirect way by using the publicly available results of subject-rated image datasets with the separation of images into two classes (above and below the threshold of visible differences). In the performance analysis of the JND prediction model and image quality assessment, five image datasets were used, four of which come from the visible wavelength range, and one dataset is intended for remote sensing and surveillance with images from the infrared part of the electromagnetic spectrum. Results: The pap 86 er shows that using a picture-wise JND model, subjective image quality assessment scores can be estimated with better accuracy, leading to significant performance improvements of the traditional peak signal-to-noise ratio (PSNR). The gain achieved by introducing the picture-wise JND model in the objective assessment depends on the chosen dataset and the results of the initial simple to compute PSNR measure, and it was obtained on all five datasets. The mean linear correlation coefficient (for five datasets) between subjective and PSNR objective quality estimates increased from 74% (traditional PSNR) to 90% (picture-wise JND PSNR). Conclusion: Further improvement of the JND-based objective measure can be obtained by improving the picture-wise model of JND prediction.

Introduction/purpose: The article presents a model of a slow frequency hopping radio in the case of repeater jamming. The aim is to analyze the effectiveness of repeater jamming to a military tactical slow frequency hopping radio. Methods: It is assumed that the repeater jammer will be successful in detecting signals with slow frequency hopping at each hop and that it will perform successful partial jamming of the intercepted communication. Under partial jamming, it is considered that a certain part of the transmission time of each hop will be jammed. A theoretical analysis of the impact of a repeater jammer on a frequency hopping radio was performed based on the definition of the total probability of error. Various parameters that affect the segment of hop duration under jamming were considered. Results: The obtained results show that high effective jamming is achieved even when a short segment of hop duration is jammed. We discuss the conditions for the repeater jammer to detect the signal during each hop and emit the jamming signal with the required strength. It has been shown that increasing the frequency hopping rate can significantly reduce the effectiveness of the repeater jammer. Conclusion: Repeater jammers are highly effective against slow frequency hopping radio communication systems.

The dark-red spider mite, Tetranychus ludeni Zacher (Acari: Tetranychidae), is a highly polyphagous species and an important pest of economic plants belonging to the families Cucurbitaceae, Malvaceae, Fabaceae and Solanaceae, and growing in tropical and subtropical regions. In the Western Palaearctic, its distribution reports have recently come mostly from the Mediterranean Basin, i.e. Portugal, Spain, Italy and Israel. In a survey conducted in Serbia 2019-2021 (comprising 159 sampling locations), T. ludeni was found at 89 locations on 27 plant species of the families Rosaceae (8), Solanaceae (6), Cucurbitaceae (4), Fabaceae (2), Amaranthaceae (2), Asteraceae (2), Apiaceae (1), Convolvulaceae (1) and Poaceae (1). The dark-red spider mite was found in mixed populations with other spider mites (mostly Tetranychus urticae and T. turkestani) in around half of the sampling locations. Heavy infestation and visible symptoms of injury were observed in several locations. Three Rosaceae plant species, plum (Prunus domestica), blackthorn (Prunus spinosa) and crab apple (Malus sylvestris) were its new hosts. Serbian records of T. ludeni from locations situated at latitudes between 42?N and 46?N were the northernmost distribution records of this species in the Western Palaearctic.

The COVID-19 pandemic has changed the way people live on the planet. The global economy suffered the biggest blow. The fashion industry has been forced to implement significant changes in their value chains. The subject of the research carried out in this work is to look at the specifics of marketing logistics activities that companies operating in the fashion industry were forced to implement in order to adapt to the business conditions that arose as a result of the COVID-19 pandemic. The aim of the work is to point out the most important specifics of marketing logistics in the fashion industry in the conditions of the COVID-19 pandemic, using the example of the Zara company, which effectively and quickly implemented numerous adjustments, which enabled it to reduce the negative impact of the crisis event.

The history of Afghanistan is abundant in crises, coups, assassinations, political intrigues, as well as invasions and conquests. The last 40 years have been marked by long crises and conflicts: Soviet invasion 1979-1989, the civil war 1989-2001, the American invasion 2001-2021 with disastrous consequences for the country and the people. The invasion carried out in the name of ‘war on terrorism’, ‘bringing democracy’ and ‘freedom’, as a matter of fact, led to instability, turmoil, sectarian wars, deaths of tens of thousands of civilians and the formation of new terrorist organizations in the country, rather than peace and stability. War has become commonplace in Afghanistan. Once seen as the ‘shining star’ of Central Asia, Afghanistan is now known as the country exporting terrorism, drugs and refugees. The paper aims at showing causes and consequences of two decades long American presence in Afghanistan that left lasting imprint on Afghan society.

Agricultural production has benefited a lot from herbicides; however, the use of herbicides caused many environmental problems. Herbicide application can affect the biodiversity of an ecosystem by killing non-target organisms. Microorganisms in the soil are important factors for plant growth; they represent the biological factor of soil fertility. Herbicides can have a beneficial effect on the development of some microorganisms and a negative on others, leading to depletion of microbial diversity in soil. The objective of this work is to determine microbial activity in the soil and to isolate herbicide-resistant bacteria after the use of the "Stomp" herbicide. Agar plate method was used for the determination of microbial prevalence in the soil. The results showed an increase in the total number of bacteria, ammonifiers, fungi, and actinomycetes. Nine isolates, mostly Gram-positive spore-forming rods, showed an ability to grow in the mineral salt medium with different concentrations of "Stomp" herbicide. Isolates G1/1 and G1/2, showed high level of tolerance at the initial pendimethalin concentration of 25 mg/l. Those isolates have the potential to be used to decontaminate herbicide affected ecosystems.