Starting from the circumstance that after the death of a man, his inheritance is opened, and that his legacy can be inherited by law or on the basis of the testator's last will - testamentary, within the conducted probate procedure, the paper deals with the issue of inheritance statement characteristic and legal effect. In particular, the paper presents who can give a successor's statement, in what form, to what extent, at what time and what qualitative abilities he must have. Also, the paper explains the probate procedure through phases starting from the knowledge of the competent authority that a person has passed away until the decision on inheritance is made.

Legacy is a legal institute created in Roman law. Its significance is based on the circumstance that the testator orders the heir or some other person (debtor of the legacy) to transfer to the legatee from the inheritance some property benefit which may consist of handing over one or more certain things or rights, paying a certain amount of money, releasing a debt , some doing, not doing or suffering in favor of the legatee, etc., i.e. in all that may be the subject of any other obligation, provided that it is possible, permissible and determinable or determinable. The paper presents the concept of legacy, its development through history, regulation by modern legislation with special reference to the subject of legacies and its special types. Also, the importance of the necessary part of the heir, the inclusion of the legacy in the necessary part and the institute of the privileged heir were especially emphasized.

Deep eutectic solvents (DESs) are called 'designer solvents' due to various structural variations and the benefit of tailoring their physicochemical properties. For industrial applications of DESs it is crucial to know their physical and thermodynamic properties such as density, viscosity, and refractive index. These properties were measured for three lecithin (LEC)-based DESs with glycerol (G), triethanolamine (TEOA), and oleic acid (OLA) as functions of temperature. The viscosity was fitted by both Arrhenius-type and Vogel-Tamman-Fulcher equations. The density, viscosity, and refractive index of tested DESs decreased with the increase in temperature. The LEC:G DES exhibited the lowest density at all tested temperatures. This DES was selected as a cosolvent in the ethanolysis of cold-pressed black mustard (Brassica nigra L.) seed oil catalyzed by either calcined or non-calcined CaO. The reaction was carried out in a batch stirred reactor under the following conditions: the temperature of 70?C, the ethanol-to-oil molar ratio of 12:1, and the amount of DES and CaO of 20 and 10 wt.% (to oil), respectively. The presence of DES accelerated the reaction, while the separation of the final reaction mixture phases was faster.

Tourism is very important for the development of the country. In order to develop, every country must invest in tourism and use its resources to attract tourists. This research took into account how natural and cultural resources influence the improvement of tourism performance. On that occasion, it was observed what influence the rate of economic growth has on the relationship between natural and cultural resources and the performance of tourism. Therefore, regression analysis was used with the mediator gross social product, which represents economic growth. The results showed that three out of four tourism performances are influenced by natural and cultural resources when changing the rate of economic growth. In this way, it has been proven that natural and cultural resources influence the performance of tourism. That is why tourism must be based on the natural and cultural resources available to the country. It is necessary to invest in infrastructure, especially in road infrastructure, in order to make these resources more accessible to tourists.

Unlike most military high explosives, which are characterized by an almost plane detonation front, ammonium nitratebased commercial explosives, such as ANFO (ammonium nitrate/fuel oil mixture) and emulsion explosives, are characterized by a curved detonation front. The curvature is directly related to the rate of radial expansion of detonation products in the detonation driving zone and the rate of chemical reactions, and it is one of the characteristics of nonideal explosives. The detonation theories used to model the nonideal behaviour of explosives require both reaction rate and rate of radial expansion to be known/specified as input data. Unfortunately, neither can be measured and what is mostly used is a link between these rates and parameters which can be more easily measured. In this paper, the Wood-Kirkwood approach of determination of radial expansion through the radius of detonation front curvature and the electro-optical technique for experimental determination of detonation front curvature of ANFO explosives is applied. It was shown that an experimentally determined radius of detonation front curvature vs charge diameter, incorporated in the Wood-Kirkwood detonation theory, can satisfactorily reproduce experimental detonation velocity-charge diameter data for ANFO explosives, especially when the pressure-based reaction rate law is also calibrated (D=1.3 and k=0.06 1/(μs/GPaD)).

The traditional concept of drug discovery is based on the occupancy-driven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions. Therefore, proteins that do not have such binding sites are generally considered as pharmacologically intractable. Furthermore, drugs that act in this way must be administered in dosage regimens that often result in high systemic drug exposures in order to maintain sufficient protein inhibition. Thus, there is a risk of off-target binding and side effects onset. The landscape of drug discovery has been markedly changed since PROTAC (PROteolysis TArgeting Chimera) molecules emerged twenty years ago as a part of event-driven pharmacology model. These are bifunctional molecules that harness the ubiquitin-proteasome system, and are composed of a ligand that binds protein of interest (POI), a ligand that recruits E3 ubiquitin ligase and a linker that connects these two parts. Pharmacologically, PROTAC s bring POI and E3 ubiquitin ligase into the close proximity, which triggers the formation of a functional ternary complex POI-PROTAC -E3 ubiquitin ligase. This event drives POI polyubiquitination and subsequent degradation by the 26S proteasome. The development and exceptional properties of PROTAC molecules that brought them to clinical studies will be discussed in this paper.