High relationships between muscle strength and various forms of jumps are usually based on the research samples of professional athletes or students of sports and physical education. However such studies are less known in the case of recreational women. This study aimed to determine the relationship between isokinetic parameters of knee joint muscle strength with the efficiency of performing vertical jumps. The sample represents a group of 16 healthy and physically active women (age=31.04±3.71; height 168.13±8.34; weight 59.80±9.80). Knee extensors and flexors were evaluated by using an isokinetic dynamometer, while the two-foot vertical jump performance was measured using the Opto Jump System. Pearson's correlation coefficient was used to determine correlation magnitude (p<.05). The obtained results indicated high correlations of the knee extension peak torque dominant leg (KEPT D), knee extension peak torque non-dominant leg (KEPT ND) and knee flexion peak torque non-dominant leg (KFPT ND) with counter movement jump free arms (CMJFA) (r=.525; r=.511; r=.594; p<.05). High correlations was also indicated between KFPT ND with counter movement jump (CMJ) (r=.514; p<.05). Given that these are recreational women, we can assume that the countermovement free arm jump type was the most natural form of expressing their explosive potential. It is certainly important that future studies further examine the relationships between muscle strength and performance of primary and specific motor tasks in recreational women.

Este artigo objetiva analisar aspectos ligados aos estudos de metaficção historiográfica e gênero no romance Carta à rainha louca (2019), de forma a examinar, através da protagonista-escritora, uma visão feminina do Brasil do século XVIII. Apoiamo-nos nas teorias de Hutcheon (1991; 1984), Kause (2010), Scott (1995), Santos (2020), Del Priore (1994), entre outras. Como se sabe, a História foi por muito tempo narrada fundamentalmente sob uma perspectiva europeia, branca e masculina, portanto, a metaficção historiográfica, ao se voltar para a História, encara-a de modo diferente, através de perspectivas ex-cêntricas, como a de uma mulher enclausurada e tida como louca, conforme apresentado no romance em apreço.

The Beijing, 2022 Olympics will be the second Games held amid the COVID-19 pandemic. Due to the unique circumstances the 2022 Games face—the Omicron spread, high virus transmissibility in winters, and uncertainties about vaccine efficacy and future variants of concern, safety measures amid the Beijing, 2022 Games will be one of the most intricate among large international events held during the pandemic. To ensure athletes' health, safety, and ability to participate in the Games, the organizers have introduced the Olympic COVID-free “bubble” protection ecosystem, in which COVID-free athletes could stay and be protected from potential infections that could upend their Games plans, if not their career as well. However, while staying in the “bubble” is key for athletes' health and success, there is a lack of insights on factors that might prevent athletes from continuing their scheduled Olympic journey as scheduled. To shed light on the issue, based on Beijing, 2022 Olympic Playbooks and most up-to-date guidance issued, this article and its accompanying infographic were developed to illustrate factors that could influence athletes’ ability to join and stay in the “bubble”, participate in the Games, and further build their career. Furthermore, we also adapted and integrated easy-to-adopt mental health de-stress techniques recommended by the World Health Organization to help athletes better thrive amid the Beijing, 2022 Winter Olympics, in or outside of the “bubble”.

This study was to examine the response of biofertilizer formulation with the addition of consortium of microbes and biosurfactant DEA palm olein to the growth of cacao seedling. This research used randomized block design in factorial with two factors. The first factor was a biofertilizer formulation with addition of consortium of microbes consisting of seven levels: control; 2.5x107; 5x107; 7.5x107; 10x107; 12.5x107; and 15x107 CFU/mL. The second factor was the addition of biosurfactant DEA palm olein consisting of two levels, which are with and without the biosurfactant DEA palm olein. The result showed that the biofertilizer formulation with the addition of consortium of microbes was significantly affected the cacao height on 4 WAT (week after treatment), the leaf number on 6 and 12 WAT, and also in its root fresh weight parameters. The best level of the first factor was 5x107 CFU/mL. The respond of cacao height on 12 WAT and cacao root dry weight was significant to the addition of biosurfactant DEA palm olein. The best level of the second factor was with the addition of biosurfactant DEA palm olein.

Abstract Within the span of only four years, two books on the same subject and with almost identical titles were published on two sides of Europe: Hans Prinzhorn's Artistry of the Mentally Ill (Berlin, 1922) and Pavel Ivanovich Karpov's Creativity of the Mentally Ill (Moscow, 1926). Whereas the first book was recognized as one of the key steps in the “discovery” of the psychotic art and its eventual mainstreaming, the second one quickly fell into obscurity. Its author perished in Stalinist purges of the 1930s, together with a number of his colleagues from the Russian Academy of Artistic Science (RAKhN, 1921-1931), in which he served as the head of the Commission for the Creativity of Mentally Ill. This article is the first in-depth study of Karpov's book and his theory of creativity, which he based on his extensive collection of the works of his patients (which was also lost in the purges). The article argues that his approach to psychotic art is completely independent from Prinzhorn's. Instead, it places this book in the context of the specific form of Kunstwissenschaft that was practiced in RAKhN, suggesting that this placement is of primary importance for understanding Karpov's methods and aims. More specifically, the article argues that in his research on the creativity of the mentally ill, Karpov engages in a productive dialogue with the philosopher and prominent RAKhN member Gustav Shpet's work on epistemology from the same period. The result is an original contribution to the clinical literature on art of the mentally ill patients.

BACKGROUND Since the release of the first global hepatitis elimination targets in 2016, and until the COVID-19 pandemic started in early 2020, many countries and territories were making progress toward hepatitis C virus (HCV) elimination. This study aims to evaluate HCV burden in 2020, and forecast HCV burden by 2030 given current trends. METHODS This analysis includes a literature review, Delphi process, and mathematical modelling to estimate HCV prevalence (viraemic infection, defined as HCV RNA-positive cases) and the cascade of care among people of all ages (age ≥0 years from birth) for the period between Jan 1, 2015, and Dec 31, 2030. Epidemiological data were collected from published sources and grey literature (including government reports and personal communications) and were validated among country and territory experts. A Markov model was used to forecast disease burden and cascade of care from 1950 to 2050 for countries and territories with data. Model outcomes were extracted from 2015 to 2030 to calculate population-weighted regional averages, which were used for countries or territories without data. Regional and global estimates of HCV prevalence, cascade of care, and disease burden were calculated based on 235 countries and territories. FINDINGS Models were built for 110 countries or territories: 83 were approved by local experts and 27 were based on published data alone. Using data from these models, plus population-weighted regional averages for countries and territories without models (n=125), we estimated a global prevalence of viraemic HCV infection of 0·7% (95% UI 0·7-0·9), corresponding to 56·8 million (95% UI 55·2-67·8) infections, on Jan 1, 2020. This number represents a decrease of 6·8 million viraemic infections from a 2015 (beginning of year) prevalence estimate of 63·6 million (61·8-75·8) infections (0·9% [0·8-1·0] prevalence). By the end of 2020, an estimated 12·9 million (12·5-15·4) people were living with a diagnosed viraemic infection. In 2020, an estimated 641 000 (623 000-765 000) patients initiated treatment. INTERPRETATION At the beginning of 2020, there were an estimated 56·8 million viraemic HCV infections globally. Although this number represents a decrease from 2015, our forecasts suggest we are not currently on track to achieve global elimination targets by 2030. As countries recover from COVID-19, these findings can help refocus efforts aimed at HCV elimination. FUNDING John C Martin Foundation, Gilead Sciences, AbbVie, ZeShan Foundation, and The Hepatitis Fund.

Mechanical (hardness and adhesion) and electrical (sheet resistance) characteristics of electrolytically produced copper coatings have been investigated. Morphologies of Cu coatings produced galvanostatically at two current densities from the basic sulfate electrolyte and from an electrolyte containing levelling/brightening additives without and with application of ultrasound for the electrolyte stirring were characterized by SEM and AFM techniques. Mechanical characteristics were examined by Vickers microindentation using the Chen–Gao (C–G) composite hardness model, while electrical characteristics were examined by the four-point probe method. Application of ultrasound achieved benefits on both hardness and adhesion of the Cu coatings, thereby the use of both the larger current density and additive-free electrolyte improved these mechanical characteristics. The hardness of Cu coatings calculated according to the C–G model was in the 1.1844–1.2303 GPa range for fine-grained Cu coatings obtained from the sulfate electrolyte and in the 0.8572–1.1507 GPa range for smooth Cu coatings obtained from the electrolyte with additives. Analysis of the electrical characteristics of Cu coatings after an aging period of 4 years showed differences in the sheet resistance between the top and the bottom sides of the coating, which is attributed to the formation of a thin oxide layer on the coating surface area.

Background: An estimated 64.3 million people are living with heart failure worldwide. Functional MR in chronic HFrEF reflects primarily the severity of LV dysfunction and is not related to structural alterations of the mitral valvular apparatus. FMR in patients with HFrEF independently of the etiology of HFrEF and its underlying mechanisms, contributes to progression of the symptoms of HF and is independent predictor of worse clinical outcomes. Objective: The purpose of this study was to assess the severity of functional mitral regurgitation (FMR) and its clinical implications in patients with chronic heart failure with reduced ejection fraction (HFrEF). Methods: We enrolled 146 consecutive adult patients with CHF with reduced ejection fraction (HFrEF) who presented to outpatient clinics. All patients underwent clinical and physical examination. Baseline examination included medical history, detailed assessment of current medication, electrocardiogram recording, transthoracic echocardiogram and comorbidities. Heart failure with reduced ejection fraction was defined in line with the new guidelines as history of HF signs and symptoms as well as a LV ejection fraction (LVEF) below 40%. Cardiovascular risk factors were recorded according to the respective guidelines. FMR was defined and graded according to the ESC/EACTS Guidelines for the management of valvular heart disease. The extent of FMR was assessed at baseline and after a median follow-up period of 4 years in 146 consecutive HFrEF patients (left ventricular ejection fraction <40%). All of the patients received the heart failure (HF) medications in agreement with 2016 and 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Major adverse cardiac events were defined as a composite of all-cause death and the need for admission for HF. Results: A total of 146 chronic HFrEF patients (mean age of 63±11 years, 62% male, mean LVEF of 25±11%) of which 19% patients had severe FMR at baseline, with a mean EROA of 31.4±2.7 mm2 and a mean Reg Vol of 45.9±5.3 ml. There was a significant interaction between FMR and NYHA functional class in predicting death or need for hospitalization, (P < 0.0001 for the interaction term FMR NYHA III-IV). During a median follow-up period of 4.2 (IQR) 3.1-5.8) years, the primary endpoint occurred in 52 (36%) patients (21 HF admissions, and 31 deaths). There was a strong graded association between the presence and degree of FMR and risk of death or admission (P <0.0001) at 4 years follow-up period. Regarding HF therapy, 129 patients (88%) received RAAS antagonists, 17 patients (12%) received ARNI, 86 patients (59%) received beta-blockers, 75 patients (51%) were treated with MRA. 31 patients (21%) underwent cardiac resynchronization therapy (CRT) with a response rate of 64%. 24 patients (16%) underwent ICD implantation. Conclusion: Guideline-directed medical therapy is the first-line treatment for chronic HF patients who also have FMR. After this first-line approach, surgical or MitraClip transcatheter therapy can be considered in patients with persistent severe and symptomatic FMR in order to improve symptoms, quality of life and functional status.

Electronic word of mouth is a more recent form of word of mouth used by internet users who share and benefit from worldwide information. Online reviews are a very important source of information for tourists. They represent a more modern and a more reliable source of information in decision making process when compared with the content published by the foreign travel agencies. Previous research has shown that the online reviews on websites specialized for hotel ratings made a significant impact on the total number of hotel reservations. The majority of tourists find online reviews very useful and more than half of them will not make a hotel reservation if a hotel has no reviews. Since the private accommodation is quantitatively the most significant accommodation type in Croatia, the goal of this paper is to analyze the impact of electronic word of mouth on the tourist selection of private accommodation for holidays.

With the immense opportunities to make a communication network programmable, the virtualization of network functions and software defined networking are gaining momentum in both industry and research circles, being a fundamental skill-set for both electrical engineers and computer scientists. Therefore, in this article, we present and evaluate the educational framework for Service Function Chaining (SFC) practical teaching to undergraduate students aiming to prepare them for future Information and Communication Technologies (ICT) and communication networks market that will demand skillful professionals in the domain. The educational framework was designed for the Network Management course at the University of Antwerp, with the goal to bridge the gap between network programmability concepts applied in industry and those taught at the University. We evaluate the educational framework with two extensive surveys as a feedback from students that provided us with the opportunity to measure and quantify students’ experience and satisfaction with the framework. In particular, based on the challenging environment imposed by COVID-19, we identify the gaps in this educational framework and address improvements for both theoretical and practical components according to the students’ needs. Our educational framework and the thorough evaluation serve as a useful guideline on how to modernize the engineering courses and keep up with the pace of technology.

A clear margin is an important prognostic factor for most solid tumours treated by surgery. Intraoperative fluorescence imaging using exogenous tumour-specific fluorescent agents has shown particular benefit in improving complete resection of tumour tissue. However, signal processing for fluorescence imaging is complex, and fluorescence signal intensity does not always perfectly correlate with tumour location. Raman spectroscopy has the capacity to accurately differentiate between malignant and healthy tissue based on their molecular composition. In Raman spectroscopy, specificity is uniquely high, but signal intensity is weak and Raman measurements are mainly performed in a point-wise manner on microscopic tissue volumes, making whole-field assessment temporally unfeasible. In this review, we describe the state-of-the-art of both optical techniques, paying special attention to the combined intraoperative application of fluorescence imaging and Raman spectroscopy in current clinical research. We demonstrate how these techniques are complementary and address the technical challenges that have traditionally led them to be considered mutually exclusive for clinical implementation. Finally, we present a novel strategy that exploits the optimal characteristics of both modalities to facilitate resection with clear surgical margins.