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Background: The rich history of pharmacy in Bosnia and Herzegovina has been sporadically dealt with systematically, except by enthusiasts and researchers. The only book on this topic was published in 1958, and after the aggression against Bosnia and Herzegovina, the history of pharmacy was treated mainly as part of the history of medicine. The lack of a culture of memory and a systematic approach to historical heritage brought together a group of experts who deal with this topic in more detail and collect available historical relevant material. Pharmacy as a highly regulated health discipline also in Bosnia and Herzegovina is a legacy of legal acts and documents that depict different periods and the development of pharmacy itself under the influence of circumstances and legislation. Objective: The aim of this paper is to show the development of legislation related to the pharmaceutical sector in Bosnia and Herzegovina through the historical periods of its development. Methods: This is retrospective research based on internet sources, archives and publications available in libraries. Results and Discussion: The available legal regulations and documents through five periods of pharmaceutical development were analysed, from which it can be concluded that the organization of the pharmaceutical industry and its development over time remained stricter. Legal regulations depict the role of pharmacy in the health system, but they also represent sources for further research in this area, and constitute important historiographical material. The analysis of legal regulations speaks volumes about the way pharmaceutical activity is organized, so it is possible to follow the appearance of the first pharmacies, pharmacists, requirements for the quality of medicines, production and the modern role of pharmacists in the health system. Pharmaceutical legislation will certainly be the subject of future negotiations on the accession of Bosnia and Herzegovina to the European Union, and harmonization with the acquis of the EU is expected in the coming period.

Optical time-domain reflectometer (OTDR) has long been and is still considered the main test tool for characterizing fiber optic links, i.e. identify and localize refractive and reflective events such as breaks, splices and connectors, and measure their insertion/return loss. Specifically, sufficient dynamic range and thus alike signal-to-noise-ratio (SNR) enable clear far-end visibility even of long fiber links. Moreover, under such conditions, the highest achievable optical bit-error-rate (BER) floor is to the large extent determined by major reflective events such as the specific trace distortion caused by connectors and splices, each with significant return loss. Realizing this has provided the opportunity window to extend the standard OTDR capabilities list by the appropriate trace postprocessing to predict the BER floor. Accordingly, considering the SNR high, and thereby the inter-symbol interference dominant error generating mechanism, we applied the time-dispersion channel model that determines the BER floor by the rms delay spread of the (fiber) channel power-delay profile. We verified the BER floor prediction in the exemplar practical test situation, by measuring the actual BER on the same fiber link, and found the obtained values well matching the OTDR based predicted ones. Furthermore, when no dominant reflective events are identified on the OTDR trace, it implies very small time dispersion allowing the OFDM symbol cyclic prefix to always prevent inter-symbol interference. This retains the CFO to solely determine the residual BER floor and vice versa, enabling indirect estimation of CFOinduced phase distortion by simple BER testing. With this regard, we abstracted CFO with the AWGN being justified by the Central Limiting Theorem to enable efficient and quite accurate short-term BER (and so CFO phase error) predictions.

In this paper, we analyze an arbitrary heterogeneous cellular network applying stochastic geometry, and propose a modified model for assessing network spectral and energy efficiency. With this regard, we recognize that, in practice, determining Signal-to-Noise-and-Interference Ratio (SINR) as the key performance indicator, requires complex field test equipment, which might not be available or affordable. Therefore, we propose here a simple model that is based on the relatively easy measurable Bit-Error Rate (BER), whose degradation caused by various impairments is considered here as if it was due to the according additive white Gaussian noise (AWGN), thus abstracting any specific non-AWGN distortion. The proposed analytical model is verified by ns3 software network simulator, whose test results are found to match the corresponding estimated values. This indicates that both spectral and energy efficiencies of small-cell networks are higher than in larger-cell networks, even more for heterogeneous two-tier networks.