The development of Floating Solar Photovoltaic (FPV) systems is a sign of a promising future in the Renewable Energy field. Numerous solar modules and inverters are mounted on large-scale floating platforms. It is important to design the system so that the inverter operates in its optimum range most of the time. In order to achieve this goal on the DC side, serial and parallel connections of solar modules are used. As a result, the cabling of the PV array architecture is an important issue. Modern electrical installation design requires reducing costs in cabling materials, equipment installation, and maintenance. The reduction of losses and the amount of time required to complete the design are also significant. Therefore, the main topic of this paper is DC cabling in large-scale FPV power plants (>1 MV). The serial-parallel (SP) connection scheme of solar modules and the percentage of power loss in DC cables are considered. Furthermore, a general method for determining cable lengths for FPV power plants is defined. The temperature influence on losses in DC cables is analyzed. A new method for determining the current at the maximum power point (MPP) as a function of temperature is proposed. A case study is conducted using a hypothetical 3 MW FPV power plant, and the obtained results are presented and analyzed.

The aim of the study was to develop Macedonian monosyllabic and disyllabic tests for speech audiometry, to record the speech materials, and to conduct clinical validation of the tests. The following criteria were applied: word familiarity, phonetic balance, and homogeneity of audibility. Clinical validation was conducted on a sample of 30 normal hearing subjects, aged 18 to 30 years. We developed four open-set tests for speech threshold and suprathreshold testing in quiet. The tests contain two word lists with 50 monosyllabic words and two word lists with 36 disyllabic words. Each word was introduced by a carrier phrase. Psychometric function slope from 20% to 80% correct recognition for all words was 5%/ dB. The difference between the presentation levels at which the subjects repeated all the words was ≤ 4 dB. Developed phonetically balanced word lists have relatively steep psychometric function slope and they are homogeneous in terms of the audibility.

The aim of this paper was to examine the literacy skills of deaf and hard of hearing people in electronic form writing and to compare these skills in relation to standard (“paper-pencil”) writing. The sample included 50 deaf and hard of hearing students aged from 12 to 20 years. The students were supposed to have basic literacy to be able to answer questions by writing. The Questionnaire for determining basic electronic literacy, which consisted of 15 simple questions about the student’s everyday life, was used. Variables used: correct response, vocabulary, and spelling mistakes, i.e., substitution, omission, addition, and metathesis. The test was performed at two different time intervals and in two different forms (standard and electronic forms). Data were processed by descriptive analysis and t-test. More favorable results were obtained in favor of standard writing compared to electronic writing on all variables except for vocabulary. Statistically significant differences were found for the variables vocabulary, omission, and substitution. It is important that there is also communication competence, and especially better language competence expressed in electronic form. More complex activities, such as education, studying, or doing business, require language competence for electronic expression.

OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy. ABSTRACT The antimicrobial killing mechanism of octenidine (OCT), a well-known antiseptic is poorly understood. We recently reported its interaction with Gram-negative bacteria by insertion of OCT into the outer and cytoplasmic membrane of Escherichia coli, resulting in a chaotic lipid rearrangement and rapid disruption of the cell envelope. Its action primarily disturbs the packing order of the hydrophobic moiety of a lipid, which consequently might result in a cascade of multiple effects at a cellular level. Here, we investigated OCT’s impact on two different Gram-positive bacteria, Enterococcus hirae and Bacillus subtilis, and their respective model membranes. In accordance with our previous results, OCT induced membrane disorder in all investigated model systems. Electron and fluorescence microscopy clearly demonstrated changes in cellular structure and membrane integrity. These changes were accompanied by neutralization of the surface charge in both E. hirae and B. subtilis and membrane disturbances associated with permeabilization. Similar permeabilization and disordering of the lipid bilayer was also observed in model membranes. Furthermore, experiments performed on strongly versus partly anionic membranes showed that the lipid disordering effect induced by OCT is a result of maximized hydrophobic over electrostatic forces without distinct neutralization of the surface charge or discrimination between the lipid head groups. Indeed, mutants lacking specific lipid head groups were also susceptible to OCT to a similar extent as the wild type. The observed unspecific mode of action of OCT underlines its broad antimicrobial profile and renders the development of bacterial resistance to this molecule less likely. IMPORTANCE OCT is a well-established antiseptic molecule routinely used in a large field of clinical applications. Since the spread of antimicrobial resistance has restricted the use of antibiotics worldwide, topically applied antiseptics like OCT, with a broad spectrum of antimicrobial activity and high safety profile, gain increasing importance for effective infection prevention and therapy. To eliminate a wide spectrum of disease-causing microorganisms, a compound’s antiseptic activity should be unspecific or multitarget. Our results demonstrate an unspecific mechanism of action for OCT, which remained largely unknown for years. OCT disturbs the barrier function of a bacterial cell, a function that is absolutely fundamental for survival. Because OCT does not distinguish between lipids, the building blocks of bacterial membranes, its mode of action might be attributed to all bacteria, including (multi)drug-resistant isolates. Our results underpin OCT’s potent antiseptic activity for successful patient outcome.

Najvažniji zahtjev vladavine prava je da ljudi na pozicijama vlasti treba da vrše svoju vlast unutar ograničavajućeg okvira dobro ustanovljenih javnih normi, umjesto na proizvoljan, ad hoc ili čisto diskrecioni način. Vladavina prava se utjelovljuje stabilnim ustavom koji se sastoji od formalnih pravila putem kojih se ograničavaju upravljačka ovlašćenja na osnovu zakonu. Pored sudova, za vladavinu prava je važno i obezbjeđenje poštovanja zakona i podsticanje izvršenja sudskih odluka od strane vladinih službenika. Upravo zbog toga, zakonodavstva u razvijenim demokratijama propisuju krivično djelo „Neizvršenje sudske odluke“ prema kojim se kažnjivim ponašanjem smatraju radnje odgovornog službenika koji odbije da izvrši pravnosnažnu presudu. Nezavisnost pravosuđa je kičma vladavine prava, dok nezavisnost sudija štiti nezavisnost pravosuđa u cjelini. Nepristrasnosti u odlučivanju sudije znači da je neophodno da sudije djeluju bez bilo kakvih ograničenja, nedoličnog uticaja, pritiska, prijetnje ili miješanja, neposrednog ili posrednog, od strane bilo kog autoriteta, uključujući autoritete unutar pravosuđa. Međutim, finansijska nezavisnost pravosuđa je još uvijek ograničena i uslovljena postupkom odobravanja budžetskih sredstava dodijeljenih pravosuđu od strane ministarstava finansija, što pravosudne organe čini zavisnim od vladajućih politika i omogućava korupciju u pravosuđu ili uticaj politike na rad pravosuđa. Reforma pravosudnog sistema moguća je samo ukoliko građani osjećaju njene benefite i pokazuju zadovoljstvo postignutim rezultatima. Sudeći prema percepciji građana, korupcija je najdominatnija u sistemu zdravstva i među političkim partijama, zbog čega Agencija za borbu protiv korupcije BiH treba pojačati svoje napore budući da je sprječavanje korupcije na visokom nivou direktno pod njenom nadležnošću. Upravo zbog toga, u namjeri da se predstavi negiranje vladavine prava u Bosni i Hercegovini, koristiće se studije slučaja koji predstavljaju sekundarnu viktimizaciju žrtava i ukazati na indikatore postojanja vladavine prava, a to su: poštovanje zakona, nezavisnost pravosuđa i odsustvo korupcije.

Supporting the expansion of best practices in Biomedical Engineering (BME) can facilitate pathway toward the providing universal health coverage and more equitable and accessible healthcare technologies, especially in low- and middle-income (LMI) settings. These best practices can act as drivers of change and may involve scientific-technological issues, human intervention during technology development, educational aspects, social performance management for improved interactions along the medical technology life cycle, methods for managing resources and approaches for the establishment of regulatory frameworks. The aim of our study was to identify weaknesses and strengths of the scientific, technological, socio-political, regulatory and educational landscape in BME in LMI resource settings. We thus analysed the current state-of-the-art through six dimensions considered fundamental for advancing quality and equity in healthcare: 1) relevant and 2) emergent technologies, 3) new paradigms in medical technology development, 4) innovative BME education, 5) regulation and standardization for novel approaches, and 6) policy making. In order to evaluate and compare their relevance, maturity and implementation challenges, they were assessed through a questionnaire to which 100 professionals from 35 countries with recognized experience in the field of BME and its application to LMI settings responded. The results are presented and discussed, highlighting the main challenges and pinpointing relevant areas where intervention, including local lobbying and international promotion of best practices is necessary. We were also able to identify areas where minimal effort is required to make big changes in global health.

Given the ongoing "arms race" in cybersecurity, the shortage of skilled professionals in this field is one of the strongest in computer science. The currently unmet staffing demand in cybersecurity is estimated at over 3 million jobs worldwide. Furthermore, the qualifications of the existing workforce are largely believed to be insufficient. We attempt to gain deeper insights into the nature of the current skill gap in cybersecurity. To this end, we correlate data from job ads and academic curricula using two kinds of skill characterizations: manual definitions from established skill frameworks as well as "skill topics" automatically derived by text mining tools. Our analysis shows a strong agreement between these two analysis techniques and reveals a substantial undersupply in several crucial skill categories, e.g., software and application security, security management, requirements engineering, compliance and certification. Based on the results of our analysis, we provide recommendations for future curricula development in cybersecurity so as to decrease the identified skill gaps.

Since December 2019, the COVID-19 pandemic, which originated in Wuhan, China, has resulted in over six million deaths worldwide. Millions of people who survived this SARS-CoV-2 infection show a number of post-COVID complications. Although, the comorbid conditions and post-COVID complexities are to some extent well reviewed and known, the impact of COVID-19 on pre-existing congenital anomalies and genetic diseases are only documented in isolated case reports and case series, so far. In the present review, we analyzed the PubMed indexed literature published between December 2019 and January 2022 to understand this relationship from various points of view, such as susceptibility, severity and heritability. Based on our knowledge, this is the first comprehensive review on COVID-19 and its associations with various congenital anomalies and genetic diseases. According to reported studies, some congenital disorders present high-risk for developing severe COVID-19 since these disorders already include some comorbidities related to the structure and function of the respiratory and cardiovascular systems, leading to severe pneumonia. Other congenital disorders rather cause psychological burdens to patients and are not considered high-risk for the development of severe COVID-19 infection.

The prevalence of English as a global language has been mirrored in various domains of life. The latest testimony to its pervasive influence on other languages is finely portrayed through the case of coronavirus that blindsided the world recently. The disease has led to certain English words being used so often that they have become an integral part of everyday vocabulary in many languages and thus in the Bosnian language. The present quantitative research paper considers the frequency of usage and knowledge of the original form and meaning of English words related to the current pandemic used as Anglicisms in the Bosnian language. Respondents of different demographic backgrounds have reported infrequent use of these Anglicisms during and before the pandemic. Moreover, it has been reported that their knowledge of the English written form of these Anglicisms is more significant than their knowledge of their Bosnian translations/synonyms. The results indicated that Covid-19-related Anglicisms are characteristic of speakers of all ages, genders, and English-proficiency backgrounds.

Background We aimed to determine the diagnostic yield of transthoracic (TTE) and transesophageal echocardiography (TEE) in patients with ischemic stroke and transient ischemic attack with established indications for direct oral anticoagulants before the index event. Methods and Results This was a retrospective cohort study of consecutive patients with preceding established indications for long‐term therapeutic direct oral anticoagulants presenting to a single comprehensive stroke center with ischemic stroke or transient ischemic attack. Choice of echocardiography modality was based on expert recommendations. The primary outcome was a composite of prespecified management‐relevant high‐risk findings adjudicated by an expert panel, based on TTE and TEE reports according to evidence‐based recommendations. Explorative analyses were performed to identify biomarkers associated with the primary outcome. Of 424 patients included (median [interquartile range] age, 78 [70–84] years; 175 [41%] women; National Institutes of Health Stroke Scale, 4 [1–12]; 67% atrial fibrillation), 292 (69%) underwent echocardiography, while 132 (31%) did not. Modality was TTE in 191 (45%) and TEE in 101 (24%). Median time from index event to echocardiography was 2 (1–3) days. TTE identified 26 of 191 (14%) patients with 35 management‐relevant pathologies. TEE identified 16 of 101(16%) patients with 20 management‐relevant pathologies. Most management‐relevant findings represented indicated coronary artery disease and valvular pathologies. In a further 3 of 191 (2%) patients with TTE and 4 of 101 (4%) patients with TEE, other relevant findings were identified. Variables associated with management‐relevant high‐risk pathologies included more severe stroke, diabetes, and laboratory biomarkers (NT‐proBNP [N‐terminal pro‐B‐type natriuretic peptide], C‐reactive protein, d‐dimer, and troponin levels). Conclusions In patients with established indications for long‐term direct oral anticoagulant therapy and stroke who received echocardiography, both TTE and TEE identified a relevant and similar proportion of management‐relevant high‐risk pathologies and predictive biomarkers could help to guide diagnostic workup in such patients.

c-kit is a classical proto-oncogene that encodes a receptor tyrosine kinase (RTK) that responds to stem cell factor (SCF). C-KIT signaling is a critical regulator of cell proliferation, survival, and migration and is implicated in several physiological processes, including pigmentation, hematopoiesis, and gut movement. Accumulating evidence suggests that dysregulated c-KIT function, caused by either overexpression or mutations in c-kit, promotes tumor development and progression in various human cancers. In this review, we discuss the most important structural and biological features of c-KIT, as well as insights into the activation of intracellular signaling pathways following SCF binding to this RTK. We then illustrate how different c-kit alterations are associated with specific human cancers and describe recent studies that highlight the contribution of c-KIT to cancer stemness, epithelial-mesenchymal transition and progression to metastatic disease in different experimental models. The impact of tyrosine kinase inhibitors in treating c-KIT-positive tumors and limitations due to their propensity to develop drug resistance are summarized. Finally, we appraise the potential of novel therapeutic approaches targeting c-KIT more selectively while minimizing toxicity to normal tissue.