Identifying tumor DNA mismatch repair deficiency (dMMR) is important for precision medicine. We assessed tumor features, individually and in combination, in whole-exome sequenced (WES) colorectal cancers (CRCs) and in panel sequenced CRCs, endometrial cancers (ECs) and sebaceous skin tumors (SSTs) for their accuracy in detecting dMMR. CRCs (n=300) with WES, where MMR status was determined by immunohistochemistry, were assessed for microsatellite instability (MSMuTect, MANTIS, MSIseq, MSISensor), COSMIC tumor mutational signatures (TMS) and somatic mutation counts. A 10-fold cross-validation approach (100 repeats) evaluated the dMMR prediction accuracy for 1) individual features, 2) Lasso statistical model and 3) an additive feature combination approach. Panel sequenced tumors (29 CRCs, 22 ECs, 20 SSTs) were assessed for the top performing dMMR predicting features/models using these three approaches. For WES CRCs, 10 features provided >80% dMMR prediction accuracy, with MSMuTect, MSIseq, and MANTIS achieving [≥]99% accuracy. The Lasso model achieved 98.3%. The additive feature approach with [≥]3/6 of MSMuTect, MANTIS, MSIseq, MSISensor, INDEL count or TMS ID2+ID7 achieved 99.7% accuracy. For the panel sequenced tumors, the additive feature combination approach of [≥]3/6 achieved accuracies of 100%, 95.5% and 100%, for CRCs, ECs, and SSTs, respectively. The microsatellite instability calling tools performed well in WES CRCs, however, an approach combining tumor features may improve dMMR prediction in both WES and panel sequenced data across tissue types.

Purpose: Young people who study physical education and sport are a priori regarded as having proper body structure and body composition. It is widely presumed that young who study physical education at one of several national universities of physical education (East Sarajevo) could be characterized with proper physique and body composition. Aim of the current study was to assess and analyze the body composition of a male students Physical Education and Sport, University East Sarajevo, by bioelectric impedance analysis and determine the significance of inter correlation coefficients. Material and methods: In study the participants consist 30 male students of Faculty of Physical Education and Sport, University of East Sarajevo, the III year of study (Body Height = 182.20 ± 6.89cm; Body Weight = 80.06 ± 8.80kg; Body Mass Index= 24.03 ± 2.58kg/m²). Results: of the study showed that the body composition is within the healthy (allowed) values recommended for this population of students (Body Fat=10.90kg or 13.62%; Body Muscle= 65.74kg or 82.40%; Body Water = 61.54%; Basal metabolic rate = 2045.07kCal; Daily calorie intake = 8436.56 kCal, etc.). Inter correlation coefficients showed inverse and significantly high correlation (p=0.000) between (inter correlation coefficient Fat-Muscle = -0.945), (inter correlation coefficients Fat-Water = -0.963) while direct correlation was achieved between (inter correlation coefficient Muscle-Water = 0.986). Conclusion: The obtained results of the study defined the appropriate body composition of the students, which is a consequence of their adequate physical activity and well-designed curricula at the home faculty. In the parameters of body composition, students of physical education and sports in East Sarajevo had a higher muscle component and lower values ​​of fat component than other students as a result of their somatotype, way of studying, teaching and extracurricular physical activities.

This study aims to determine the effects of a program based on a progressive increase in the number of nage-komi repetitions (throws) on a specific judo fitness test (SJFT). The research was conducted on a total of 20 respondents. In SJFT for research purposes, 12 variables. Descriptive statistics and paired t-tests for dependent samples of initial and final testing were used for data processing. The results of the study showed significant statistical deviations in the number of throws in the first 15 seconds, with the pulse measured immediately after testing and the SJFT index (p <005). There is a noticeable need for a table to classify SJFT results for young judoists. Based on the obtained results, we can conclude that the programmed activity had positive effects on the results of the SJFT, ie that the index was statistically significantly lower in the final than in the initial testing. Taking into account the results obtained, calculated by the SPSS 22 t-test for dependent variables, the values ??of the young judoist index and the values ??of the senior index show noticeable differences. While their results can be classified into appropriate categories, the results of young judoists can be classifieclassifiedrity, under, ad and the rest as very bad. Some results could not even be ranked, so we conclude that it is necessary to make tables for classifying the results of young judoists. The obtained results can be used as guidelines for more efficient programming of the training process. Keywords: cadets, judo, juniors, SJFT test, training.

: This paper presents the results of research on energy performance related to the energy consumption for space heating of school buildings (primary and secondary schools) located in the south region of the Federation of Bosnia and Herzegovina (SR FBiH). The research was conducted by collecting data from detailed energy audit documents on a sample of 47 school buildings in the SR FBiH and is part of a broader study aimed at analyzing the energy performance of school buildings in the FBiH and determining their relationship to heating energy costs through the development of new models for faster estimation of heating energy costs. The results of the research indicate poor energy performance of existing school buildings in the SR FBiH. The analysis of the delivered energy for space heating showed that the actual consumption is 67% of the predicted and indicates an energy gap between the actual and predicted values of energy consumption for heating. Reduction of energy consumption for space heating can be achieved by applying measures to improve energy efficiency.

Introduction: The COVID-19 pandemic has been challenging time for medical care, especially in the field of infectious diseases (ID), but it has also provided an opportunity to introduce new solutions in HIV management. Here, we investigated the changes in HIV service provision across Central and Eastern European (CEE) countries before and after the COVID-19 outbreak. Methods: The Euroguidelines in Central and Eastern Europe Network Group consists of experts in the field of ID from 24 countries within the CEE region. Between 11 September and 29 September 2021, the group produced an on-line survey, consisting of 32 questions on models of care among HIV clinics before and after the SARS-CoV-2 outbreak. Results: Twenty-three HIV centers from 19 countries (79.2% of all countries invited) participated in the survey. In 69.5% of the countries, there were more than four HIV centers, in three countries there were four centers (21%), and in four countries there was only one HIV center in each country. HIV care was based in ID hospitals plus out-patient clinics (52%), was centralized in big cities (52%), and was publicly financed (96%). Integrated services were available in 21 clinics (91%) with access to specialists other than ID, including psychologists in 71.5% of the centers, psychiatrists in 43%, gynecologists in 47.5%, dermatologists in 52.5%, and social workers in 62% of all clinics. Patient-centered care was provided in 17 centers (74%), allowing consultations and tests to be planned for the same day. Telehealth tools were used in 11 centers (47%) before the COVID-19 pandemic outbreak, and in 18 (78%) after (p = 0.36), but were represented mostly by consultations over the telephone or via e-mail. After the COVID-19 outbreak, telehealth was introduced as a new medical tool in nine centers (39%). In five centers (28%), no new services or tools were introduced. Conclusions: As a consequence of the COVID-19 pandemic, tools such as telehealth have become popularized in CEE countries, challenging the traditional approach to HIV care. These implications need to be further evaluated in order to ascertain the best adaptations, especially for HIV medicine.

The continued development of robots has enabled their wider usage in human surroundings. Robots are more trusted to make increasingly important decisions with potentially critical outcomes. Therefore, it is essential to consider the ethical principles under which robots operate. In this paper we examine how contrastive and non-contrastive explanations can be used in understanding the ethics of robot action plans. We build upon an existing ethical framework to allow users to make suggestions about plans and receive automatically generated contrastive explanations. Results of a user study indicate that the generated explanations help humans to understand the ethical principles that underlie a robot’s plan.

Big Data analytics and Artificial Intelligence (AI) technologies have become the focus of recent research due to the large amount of data. Dimensionality reduction techniques are recognized as an important step in these analyses. The multidimensional nature of Quality of Experience (QoE) is based on a set of Influence Factors (IFs) whose dimensionality is preferable to be higher due to better QoE prediction. As a consequence, dimensionality issues occur in QoE prediction models. This paper gives an overview of the used dimensionality reduction technique in QoE modeling and proposes modification and use of Active Subspaces Method (ASM) for dimensionality reduction. Proposed modified ASM (mASM) uses variance/standard deviation as a measure of function variability. A straightforward benefit of proposed modification is the possibility of its application in cases when discrete or categorical IFs are included. Application of modified ASM is not restricted to QoE modeling only. Obtained results show that QoE function is mostly flat for small variations of input IFs which is an additional motive to propose a modification of the standard version of ASM. This study proposes several metrics that can be used to compare different dimensionality reduction approaches. We prove that the percentage of function variability described by an appropriate linear combination(s) of input IFs is always greater or equal to the percentage that corresponds to the selection of input IF(s) when the reduction degree is the same. Thus, the proposed method and metrics are useful when optimizing the number of IFs for QoE prediction and a better understanding of IFs space in terms of QoE.

We aimed to assess the association of diabetes mellitus (DM) and admission hyperglycaemia (AH), respectively, and outcome in patients with acute ischaemic stroke with large vessel occlusion in the anterior circulation treated with endovascular therapy (EVT) in daily clinical practice.

Energy transition from predominantly fossil fuel driven to renewables driven system is one of the key problems human civilization is facing. Solutions for this problem come in many forms and shapes, but most of them are often one sided and limited in perspective for such a complex problem. Modelling is of great importance and provides an opportunity to better understand the problem, still it also often provides just a view of some aspects of the issue. This literature review attempts to highlight these points and provide some perspective conclusions for future effort while focusing its scope on the case of Bosnia and Herzegovina and Western Balkans, where such lack of efforts is particularly pronounced.

The ability to robustly quantify the potential for strontium precipitation and scaling in both natural surface waters and water infrastructure systems is limited. In some regions, both surface and ground water supplies contain significant concentrations of naturally occurring radionuclides, such as strontium, that can accumulate in water, soils and sediments, media, and living tissues. Methods for quantifying and predicting the potential for these occurrences are not readily available nor have they been tested and calibrated to cold region aquatic environments. Through extensive literature review, it was determined that a modified calcium carbonate precipitation potential (CCPP) model offered a scientifically credible approach to filling that knowledge gap in both the science and engineering of strontium fate and transport in water. The results from previous field and laboratory experiments were compiled to not only elucidate the fate and transport of strontium in water systems, but also to calculate the logarithmic distribution coefficient, λ, for strontium under co-precipitation conditions. Lambda (λ) is both time- and water-quality sensitive and must be measured as water mixes from source to receiving environment to determine continuous loss of Sr from the water phase. The data were collected to develop the strontium precipitation potential model that can be used in surface water quality assessment. The tool was then applied to pre-existing, publicly available, and extensive datasets for several rivers in Saskatchewan, Canada, to validate the model and produce estimates for strontium precipitation potential in those rivers.

Introduction Resource-oriented interventions can be a low-cost option to improve care for patients with severe mental illnesses in low-resource settings. From 2018 to 2021 we conducted three randomized controlled trials testing resource-oriented interventions in Bosnia and Herzegovina (B&H), i.e. befriending through volunteers, multi-family groups, and improving patient-clinician meetings using the DIALOG+ intervention. All interventions were applied over 6 months and showed significant benefits for patients’ quality of life, social functioning, and symptom levels. In this study, we explore whether patient experiences point to common processes in these interventions. Methods In-depth semi-structured interviews were conducted with 15 patients from each intervention, resulting in a total sample of 45 patients. Patients were purposively selected at the end of the interventions including patients with different levels of engagement and different outcomes. Interviews explored the experiences of patients and were audio-recorded, transcribed, and analysed using the thematic analysis framework proposed by Braun and Clark. Results Three broad themes captured the overall experiences of patients receiving resource-oriented interventions: An increased confidence and agency in the treatment process; A new and unexpected experience in treatment; Concerns about the sustainability of the interventions. Conclusions The findings suggest that the three interventions – although focusing on different relationships of the patients – lead to similar beneficial experiences. In addition to being novel in the context of the mental health care system in B&H, they empower patients to take a more active and confident role in treatment. Whilst strengthening patients’ agency in their treatment may be seen as a value in itself, it may also help to achieve significantly improved treatment outcomes. This shows promise for the implementation of these interventions in other low-resource countries with similar settings.

Neuropathological studies have shown that multiple sclerosis (MS) lesions are heterogeneous in terms of myelin/axon damage and repair as well as iron content. However, it remains a challenge to identify specific chronic lesion types, especially remyelinated lesions, in vivo in patients with MS.

ABSTRACT A working memory (WM) deficit is a reliable observation in people experiencing anxiety. Whether the level of anxiety is related to the severity of WM difficulties is still an open question. In the present experiment, we investigated this aspect by testing the WM performance of people with different levels of anxiety symptoms. Participants were grouped according to self-report anxiety into a control group with low anxiety scores and an experimental group with clinically relevant anxiety. The experimental group was then divided into a high anxiety group and a severe anxiety group. Participants performed a battery of WM tasks tagging different WM processes. The results showed that, compared to participants with low anxiety, participants with clinically relevant anxiety scores had reduced accuracy in all the WM tasks. Interestingly, participants with high and severe anxiety did not present any significant difference. Anxious participants showed difficulties also in cognitive domains other than WM. Hence, these results supply reliable evidence that people with clinically relevant anxiety scores present WM difficulties, irrespective of symptoms severity. The observation that anxiety compromises performance also in cognitive domains other than WM suggests that the deficit might affect fluid cognition.

ABSTRACT In this study, 3D-printed connectors to replace the typical L-shaped joints in the construction of a chair were developed, tested and numerically analysed. Different connectors were designed and manufactured with a fused deposition modelling (FDM) 3D printer using acrylonitrile butadiene styrene (ABS) with the aim to find a simple shaped connector which could be used to build chairs and withstand standard chair loading requirements. The strength and stiffness of the joints were tested and compared with traditional beech mortise-and-tenon joints. Numerical stress and strain analyses were performed with the finite element method for an orthotropic linear-elastic model. The experimental results showed that joints with 3D-printed connectors achieved lower strength than the traditional wooden mortise-and-tenon joints with similar dimensions. The results indicate that the effect of reinforcement of the connector were not recognised due to the small thickness and inadequate geometric position and arrangement of the reinforcement ABS material. The chair assembled with 3D-printed connectors could withstand the loads for seating, but failed the backrest test according to standard EN 1728:2002. The connectors need to be optimised and reinforced to withstand standard loads.

Various devices and monitoring systems have been developed and deployed in order to monitor the power grid. Indeed, several real-world cyberattacks on power grid systems have been publicly reported. For the transmission and distribution, Phasor Measurement Units (PMUs) constitute the main sensing equipment of the overall wide area monitoring and situational awareness systems by collecting high-resolution data and sending them to Phasor Data Concentrators (PDCs). In this paper, we consider data spoofing attacks against PMU networks. The data between PMUs and PDC(s) are sent through the legacy networks, which are subject to many attack scenarios under with no, or inadequate, countermeasures in protocols, such as IEEE 37.118-2. We consider one potential attack, where an adversary may simply keep injecting a repeated measurement through a compromised PMU to disrupt the monitoring system. This attack is referred to as a Repeated Last Value (RLV) attack. We develop and evaluate countermeasures against RLV attacks using a 2D Convolutional Neural Network (CNN)-based approach, which operates in frames for each second mimicking images, in order to avoid the computational overhead of the classical sample-based classification algorithms, such as SVM. Further, we take this frame-based approach and use it with Support Vector Machine (SVM) for performance evaluation. Our preliminary results show that frame-based CNN as well as SVM provide promising results for RLV attacks while the efficacy of CNN over SVM frame becomes more pronounced as the attack intensity increases.