Background: Thiomersal is used as a preservative of some vaccines or as a trace from the pathogen inactivation process in vaccine production. Prophylactic use of paracetamol upon vaccination is still common, even though paracetamol decreases immune response on some vaccines. Considering the cytotoxic and genotoxic potential of thiomersal and paracetamol and possible interaction in vivo, in vitro study was performed. Methods: The genotoxic and cytotoxic effects of thiomersal and paracetamol combination were examined on human lymphocyte cultures by using two methods: analysis of chromosomal aberrations and cytokinesis-block micronucleus cytome assay. Blood samples of three healthy donors were analyzed with the following concentrations of tested substances: thiomersal 1 µg/ml and 0.5 µg/ml, paracetamol 20 µg/ml, thiomersal 0.5 µg/ml with paracetamol 20 µg/ml and thiomersal 1.0 µg/ml with paracetamol 20 µg/ml. Results: The analysis of structural chromosomal aberrations was significantly increased in all treated cultures. In cells treated with the combination of thiomersal 1 µg/ml and 20 µg/ml of paracetamol, the number of aberrations was significantly decreased. Cytokinesis-block micronucleus cytome assay analyses showed significantly increased micronucleus frequency in lymphocytes cultivated with thiomersal 1 µg/ml compared to lymphocytes cultures exposed to thiomersal 0.5 µg/ml. Conclusions: Induction of structural chromosome aberrations and micronucleus is shown as a sign of genotoxicity for the examined concentrations of thiomersal and paracetamol. The suppressing effect of paracetamol on thiomersal genotoxicity in lymphocytes culture treated with thiomersal was shown to be indicative of further examination of paracetamol use in the prevention of genotoxicity.

The influence of the ageing temperature on the hardness, electrical conductivity, thermal diffusivity and thermal conductivity of the EN AW-7075 aluminium alloy was studied in this paper. After solution treating the alloy at 480 °C for 1 h and quenching it in ice water, the investigated alloy was characterized using Differential Thermal Analysis (DTA) in order to determine the optimal temperatures for the isochronal ageing treatments. Afterwards, isochronal ageing was conducted at the temperature range of 110 °C-250 °C for 30 min The hardness, electrical conductivity, thermal diffusivity, thermal conductivity and microstructural features were investigated during the ageing treatments. Hardness had a peak value after ageing at 150 °C, while other properties gradually increased with the ageing temperature. Microstructural investigation of the aged alloy by SEM-EDS revealed the existence of precipitated phases that appear homogenously distributed in the microstructure.

Catalytic materials are the greatest challenge for the commercial application of water electrolysis (WEs) and fuel cells (FCs) as clean energy technologies. There is a need to find an alternative to expensive and unavailable platinum group metal (PGM) catalysts. This study aimed to reduce the cost of PGM materials by replacing Ru with RuO2 and lowering the amount of RuO2 by adding abundant and multifunctional ZnO. A ZnO@RuO2 composite in a 10:1 molar ratio was synthesized by microwave processing of a precipitate as a green, low-cost, and fast method, and then annealed at 300°C and 600°C to improve the catalytic properties. The physicochemical properties of the ZnO@RuO2 composites were investigated by X-ray powder diffraction (XRD), Raman and Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy (FESEM), UV-Vis diffuse reflectance spectroscopy (DRS), and photoluminescence (PL) spectroscopy. The electrochemical activity of the samples was investigated by linear sweep voltammetry in acidic and alkaline electrolytes. We observed good bifunctional catalytic activity of the ZnO@RuO2 composites toward HER and OER in both electrolytes. The improved bifunctional catalytic activity of the ZnO@RuO2 composite by annealing was discussed and attributed to the reduced number of bulk oxygen vacancies and the increased number of established heterojunctions.

BACKGROUND: Critical care medicine is a young branch of medicine, of which the development was much faster in High Income Countries (HICs) than in Low Resources Settings (LRS). Slovenia, as one of the successor states of former Yugoslavia, passed the process of transition and joined the European Union successfully. On the contrary, Bosnia and Herzegovina (B&H) went through the extremely difficult process of transition (four years of civil war), which left a deep scar to the healthcare system, including critical care medicine. OBJECTIVE: To examine the impact of HICs on the development of critical care in LRS. METHOD: This review examined the process of growing up the first modern Medical Intensive Care Unit (MICU) in the Republic of Srpska. RESULTS: The five-year process of transferring critical care knowledge from Slovenia to the health care system of Republic of Srpska has contributed to the existence of modern and state of the art MICU with tremendous social effects. CONCLUSION: The model of using the impact of HICs for improving critical care in LRS can be extrapolated to other similar settings.

The inflammatory injury of the mucous membranes lining the digestive tract, from the mouth to the anus, is called mucositis. One of the intriguing and compelling new therapeutic modalities that has emerged in recent decades due to advances in our understanding of this condition’s pathophysiology is probiotics. The purpose of this meta-analysis is to evaluate the efficiency of probiotics in the treatment of chemotherapy-induced mucositis for head and neck malignancies; a literature search was performed on PubMed, Lilacs, and Web of Science, and articles published from 2000 to 31 January 2023 were considered, according to the keywords entered. The term “Probiotics” was combined with “oral mucositis” using the Boolean connector AND; at the end of the research, 189 studies were identified from the search on the three engines. Only three were used to draw up the present systematic study and metanalysis; this meta-analysis showed that the treatment of mucositis with probiotics is an effective method, and the analysis of the results of these studies showed that the use of probiotics promoted a decrease in the severity of mucositis symptoms.

The application of Industry 4.0 (I4.0) in the field of logistics leads to the emergence and development of the concept of logistics 4.0. Many I4.0 technologies have been applied in the field of logistics. The goal of this research is to analyze the applicability of nine key I4.0 technologies in logistics centers (LC). For this purpose, an integrated MEREC (MEthod based on the Removal Effects of Criteria)—fuzzy MARCOS (Measurement of Alternatives and Ranking according to COmpromise Solution) model was developed. The applicability of nine I4.0 technologies was evaluated based on 15 subcriteria within three main groups of criteria, namely, technological, social and political, and economic and operative. Using the MEREC method, the weight values of the criteria and subcriteria were determined, while the technologies were ranked using the fuzzy MARCOS method. Based on the results obtained by applying this integrated MCDM (multicriteria decision-making) model, CC was identified as the best alternative, i.e., the technology that is most applicable in logistics centers, followed by IoT and big data. An analysis of the sensitivity of the obtained results to the change in the importance of the criteria was carried out, which shows certain changes in the ranking when the importance of the most important criterion changes.

Museums are traditionally considered learning environments and are ordinarily used for non-formal education. Physical museums, while being irreplaceable, are limited to a physical space, requiring mobility and physical presence. In addition, traditional exhibitions are not designed for interaction and physical exploration of artefacts. With the focus being shifted from museum exhibits to visitors’ experience, utilization of emerging technologies and co-creation of virtual museums not only helps in preservation of cultural heritage, but enhances the dissemination, engagement, and experience, while addressing the mobility and the plurality of voices and perspectives represented. In this work, we designed and developed the School House Virtual Museum with tangible user interfaces based on participatory, interdisciplinary, and co-creative methods with students and a larger community of researchers, artists, and practitioners working on heritage and memory. In a user study with 62 participants, usability and user experience were explored and the potential contribution of such virtual museums to learning, based on critical, cross-disciplinary, and participatory dialogue, both in cultural and educational institutions/programs has been investigated. The results have confirmed that the system has been well designed and developed, and the user experience was largely positive. The responses from educators and students confirmed that the application holds potential as a learning and education tool in either museums, schools, or when used independently.

Smart traffic lights systems (STLSs) are a promising approach to improve traffic efficiency at intersections. They rely on the information sent by vehicles via C2X communication (like in cooperative awareness messages (CAMs)) at the managed intersection. While there exists a large body of work on privacy-enhancing technologies (PETs) for cooperative Intelligent Transport Systems (cITS) in general, such PETs like changing pseudonyms often impact the performance of cITS applications. This paper analyzes the extent to which different PETs affect the performance of two types of STLSs, a phase-based and a reservation-based STLS. These are implemented in SUMO and combined with four different PETs. Through extensive simulations we then investigate the impact of those PETs on STLS performance metrics like time loss, waiting time, fuel consumption, and average velocity. Our analysis shows that the impact of PETs on performance varies greatly depending on the type of STLS. Finally, we propose a hybrid STLS which is a combination of the two STLS types as a potential solution for limiting the negative impact of PETs on performance.

In recent times the chiral semimetal cobalt monosilicide (CoSi) has emerged as a prototypical, nearly ideal topological conductor hosting giant, topologically protected Fermi arcs. Exotic topological quantum properties have already been identified in CoSi bulk single crystals. However, CoSi is also known for being prone to intrinsic disorder and inhomogeneities, which, despite topological protection, risk jeopardizing its topological transport features. Alternatively, topology may be stabilized by disorder, suggesting the tantalizing possibility of an amorphous variant of a topological metal, yet to be discovered. In this respect, understanding how microstructure and stoichiometry affect magnetotransport properties is of pivotal importance, particularly in case of low-dimensional CoSi thin films and devices. Here we comprehensively investigate the magnetotransport and magnetic properties of ≈25 nm Co1–xSix thin films grown on a MgO substrate with controlled film microstructure (amorphous vs textured) and chemical composition (0.40 < x < 0.60). The resistivity of Co1–xSix thin films is nearly insensitive to the film microstructure and displays a progressive evolution from metallic-like (dρxx/dT > 0) to semiconducting-like (dρxx/dT < 0) regimes of conduction upon increasing the silicon content. A variety of anomalies in the magnetotransport properties, comprising for instance signatures consistent with quantum localization and electron–electron interactions, anomalous Hall and Kondo effects, and the occurrence of magnetic exchange interactions, are attributable to the prominent influence of intrinsic structural and chemical disorder. Our systematic survey brings to attention the complexity and the challenges involved in the prospective exploitation of the topological chiral semimetal CoSi in nanoscale thin films and devices.

Given the growing number of devices and their need for internet access, researchers are focusing on integrating various network technologies. Concerning indoor wireless services, a promising approach in this regard is to combine light fidelity (LiFi) and wireless fidelity (WiFi) technologies into a hybrid LiFi and WiFi network (HLWNet). Such a network benefits from LiFi’s distinct capability for high-speed data transmission and from the wide radio coverage offered by WiFi technologies. In this paper, we describe the framework for the HWLNet architecture, providing an overview of the handover methods used in HLWNets and presenting the basic architecture of hybrid LiFi/WiFi networks, optimization of cell deployment, relevant modulation schemes, illumination constraints, and backhaul device design. The survey also reviews the performance and recent achievements of HLWNets compared to legacy networks with an emphasis on signal to noise and interference ratio (SINR), spectral and power efficiency, and quality of service (QoS). In addition, user behaviour is discussed, considering interference in a LiFi channel is due to user movement, handover frequency, and load balancing. Furthermore, recent advances in indoor positioning and the security of hybrid networks are presented, and finally, directions of the hybrid network’s evolution in the foreseeable future are discussed.

The relationship between firms’ exports and increases in productivity is generally regarded as positive. While the causal effects of process innovation are straightforward and positive, the effect of product innovation on productivity is ambiguous. However, there is a lack of empirical evidence on a joint effect that innovation and exports have on firms’ productivity. In our attempt to fill this gap, we explore individual and joint effects of innovation and exports on productivity by employing cross-sectional firm-level data. We use the sixth wave of the Business Environment and Enterprise Performance Survey (BEEPS VI: 2018–2020) conducted by the EBRD and the World Bank. Using a stratified random sampling, the data was collected from interviews with representatives of randomly chosen firms from 32 countries. The overall results suggest that exporting firms are more productive than non-exporters, while the impact of innovation is more heterogeneous. Whereas EU and high-income countries reap the productivity benefits, this effect is absent in other regions and countries with medium and low-income levels. Finally, our results indicate the absence of a joint effect of innovation and exports on productivity, across different geographical regions and countries of different income levels.