This article examines women's activism and feminism in Bosnia and Herzegovina, focusing on marginalised women's groups and organisations that are often excluded from academic research and international donor interests. The theoretical section presents the main characteristics of the development of women's organisations in post-war BIH, addressing the problem of NGO-isation of activism and feminism, which marginalises groups of women and organisations that do not belong to prominent liberal feminist organisations that pursue gender mainstreaming. Qualitative research based on in-depth interviews and analysis shows that these organisations mostly focus on the local level to meet diverse, specific, and sometimes urgent needs of women (e.g., Roma women, rural women, impoverished as well as women in small local communities) facing particular challenges while doing so. Although most of them do not clearly profess a feminist identity, they are aware of the patriarchal context, especially in their local communities, and their interpretations are mostly in line with the feminist ethics of care. However, the lack of organisational capacity, sustainable funding, and a clear feminist agenda in their work undermine their critical potential to be triggers for social change.

The characters of children in Samokovlija’s stories left a distinctive and recognizable mark in the literature of Bosnia and Herzegovina. Following the postulates of Ariès, this Paper examines the phenomenon of childhood from the perspective of the changeability in the comprehension of the position of the child and childhood in various social and ideological contexts. The children's characters, according to the considerations included, are contextualized between real and literary–fictional aspects of the Sephardic heritage. Based on the selected examples of Samokovlija's stories about childhood and children, we perceive the author's most important narrative strategies. The Paper also points to how much traditional comprehension of the child and childhood in the literature of Bosnia and Herzegovina, and in the Bosnian – Sephardic literary heritage made typically and characteristically social, cultural, and historical elements of the identity be incorporated in Samokovlija's characters of children.

Experiential learning is one of the most productive ways of learning and acquiring knowledge. Through personal experience, students develop self-confidence, see more complex relationships in learning subjects, constantly have feedback on their own progress and are constantly in the circle of learning and gaining new knowledge. The paper emphasizes the role of experience in the changes that occur in an individual. Learning styles based on experience greatly influence the success of the learning process. The paper presents some of the theories that define how an individual learns when encountering new content thanks to previous experience, interests and affinities. A description of Kolb’s experiential learning theory, learning styles according to Honey and Mumford, the VARK learning model set by Fleming and Mills, as well as the criteria that experiential learning must meet in order to be efficient and purposeful.

The primary aim of the paper is to conduct research on the personality traits and pre-competition anxiety of Esports and sports players, in addition to confirming differences in personality and pre-competition anxiety between the two examined groups. The research has been conducted on 67 (N=67) subjects, 30 of whom are semi-professional or professional gamers who participate in state-level and regional-level competitions. The remaining 37 subjects are the highest-ranked athletes in Bosnia and Herzegovina. The t-test, a type of inferential statistic, has been used to determine statistical differences in disposition between the arithmetic means of the two groups, using BFI-44 (α=0.78) and CSAI-2 (α=0.60) measuring instruments. It has been anticipated that the Esports players are ranked lower at Extraversion (E) and Agreeableness (A) levels, while their Neuroticism (N) level is higher compared to the results of the athletes. The research indicates that all of the three hypotheses regarding the Big Five Model have been confirmed – on the scale of Extraversion (E) with significance levels of p=0.000 (p<0.0001); on the scale of Agreeableness (A) with significance levels of p=0.002 (p<0.01); on the scale of Neuroticism (N) with significance levels of p=0.042 (p<0.05). Furthermore, the fourth and fifth research hypotheses, proposing there is a statistically significant difference in cognitive and somatic anxiety (CSAI-2) in Esports players and athletes, were not confirmed. The sixth research hypothesis was confirmed, showing that there is a statistically significant difference between Esports players and athletes on the self-confidence dimension (CSAI-2) with p=0.030 (p<0.05). Results gathered on this sample could serve as an important part of understanding the differences between Esports players and athletes.

Paracetamol/acetaminophen (N-acetyl-p-aminophenol, APAP) overdose is one of the most important causes of drug-induced liver injury worldwide. Hepatotoxicity induced by APAP is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1. Here, we used human studies and in vitro models to demonstrate that NAPQI-derived thiomethyl metabolites identified using high-resolution mass spectrometry could serve to monitor NAPQI detoxification and elimination in patients (after intake at recommended dose or after intoxication), and to study inter-individual variability in NAPQI production. Using in vitro human models, we showed that these thiomethyl metabolites are directly linked to NAPQI detoxification since they are mainly formed after exposure to glutathione-derived conjugates via an overlooked pathway called the thiomethyl shunt. These long-term thiomethyl metabolites have great potential in future clinical studies in order to provide a more reliable history of APAP ingestion in case of acute intoxication or to study underlying causes involved in APAP-induced hepatotoxicity. One Sentence Summary Thiomethyl metabolites are new markers to monitor the elimination of the toxic N-acetyl-p-benzoquinone imine after therapeutic use or intoxication.

Cigarette smoking (CS) and low physical activity levels (PAL) are known to be risk factors for cardiovascular diseases. However, few studies have examined the associations between these factors in population of university students, and, to the best of our knowledge, no study examined this issue in period after the COVID-19 pandemic, despite the detrimental social and health consequences of the pandemic. The aim of this cross-sectional study was to examine associations between sport-participation, PAL and CS among university-level students in the first year after the COVID-19 pandemic. Participants were 761 students (411 females) from three universities in Bosnia and Herzegovina and Croatia, who were tested using semi-structured anonymous questionnaires at the beginning of the 2022/2023 academic year. Questions included queries on sociodemographic characteristics, CS, PAL, and sport-participation. Differences between genders were established by Chi-square test and gender-stratified logistic regressions were calculated to evaluate the associations between sport-participation and PAL, with binomized CS (smoking vs. non-smoking). One third of participants were daily smokers. Logistic regression showed no correlation between PAL and smoking prevalence for total sample (OR = 0.88, 95%CI: 0.75-1.05), males (OR = 0.95, 95%CI: 0.41-1.45), or females (OR = 0.90, 95%CI: 0.54-1.52). In addition, sport participation was not significantly associated with smoking. Results did not prove that sport and physical exercising are a way of reducing the likelihood of smoking; this finding could be a characteristic of the studied sample of participants, but could also be related to the period that was observed (the first year after the COVID-19 pandemic). Further studies examining the associations between PAL/sport participation and other types of substance misuse are warranted.

Vine-leaved kitaibelia (Kitaibela vitifolia Willd.), also known as balkanmalva or chalice flower, is a critically endangered plant species with a high risk of extinction in the wild. A reason given for this is, among others, a low germination rate primarily caused by dormancy. The present study evaluated the seed germination and seedling growth parameters of vine-leaved kitaibelia in response to eight different pre-sowing treatments. The final germination percentage ranged from 0 % to 55 %, depending on the pre-sowing treatment. The most effective method for breaking dormancy and increasing vine-leaved kitaibelia seed germination was the treatment with seeds soaked in H2SO4 for 5 min. The mechanical scarification of vine-leaved kitaibelia seeds also improved germination as compared to control treatment, while treatments with nitric acid and gibberellic acid were not effective in enhancing seed germination. All evaluated seedling growth parameters were not affected by pre-sowing treatments. Considering that successful germination and seedling establishment are crucial for the regeneration of vine-leaved kitaibelia further studies are required in order to identify other pre-sowing treatments that could further enhance seed germination and, consequently, seedling development.

Goal: Artificial intelligence applied to medical image analysis has been extensively used to develop non-invasive diagnostic and prognostic signatures. However, these imaging biomarkers should be largely validated on multi-center datasets to prove their robustness before they can be introduced into clinical practice. The main challenge is represented by the great and unavoidable image variability which is usually addressed using different pre-processing techniques including spatial, intensity and feature normalization. The purpose of this study is to systematically summarize normalization methods and to evaluate their correlation with the radiomics model performances through meta-analyses. This review is carried out according to the PRISMA statement: 4777 papers were collected, but only 74 were included. Two meta-analyses were carried out according to two clinical aims: characterization and prediction of response. Findings of this review demonstrated that there are some commonly used normalization approaches, but not a commonly agreed pipeline that can allow to improve performance and to bridge the gap between bench and bedside.

As phasor measurement units (PMUs) become more widely used in transmission power systems, a fast state estimation (SE) algorithm that can take advantage of their high sample rates is needed. To accomplish this, we present a method that uses graph neural networks (GNNs) to learn complex bus voltage estimates from PMU voltage and current measurements. We propose an original implementation of GNNs over the power system's factor graph to simplify the integration of various types and quantities of measurements on power system buses and branches. Furthermore, we augment the factor graph to improve the robustness of GNN predictions. This model is highly efficient and scalable, as its computational complexity is linear with respect to the number of nodes in the power system. Training and test examples were generated by randomly sampling sets of power system measurements and annotated with the exact solutions of linear SE with PMUs. The numerical results demonstrate that the GNN model provides an accurate approximation of the SE solutions. Furthermore, errors caused by PMU malfunctions or communication failures that would normally make the SE problem unobservable have a local effect and do not deteriorate the results in the rest of the power system.

Glycans are an essential structural component of Immunoglobulin G (IgG) that modulate its structure and function. However, regulatory mechanisms behind this complex posttranslational modification are not well known. Previous genome-wide association studies (GWAS) identified 29 genomic regions involved in regulation of IgG glycosylation, but only a few were functionally validated. One of the key functional features of IgG glycosylation is the addition of galactose (galactosylation). We performed GWAS of IgG galactosylation (N=13,705) and identified 16 significantly associated loci, indicating that IgG galactosylation is regulated by a complex network of genes that extends beyond the galactosyltransferase enzyme that adds galactose to IgG glycans. Gene prioritization identified 37 candidate genes. Using a recently developed CRISPR/dCas9 system we manipulated gene expression of candidate genes in the in vitro IgG expression system. Up- and downregulation of three genes, EEF1A1, MANBA and TNFRSF13B, changed the IgG glycome composition, which confirmed that these three genes are involved in IgG galactosylation in this in vitro expression system.

Regular exercise improves health, modulating the immune system and impacting inflammatory status. Immunoglobulin G (IgG) N-glycosylation reflects changes in inflammatory status; thus, we investigated the impact of regular exercise on overall inflammatory status by monitoring IgG N-glycosylation in a previously inactive, middle-aged, overweight and obese population (50.30 ± 9.23 years, BMI 30.57 ± 4.81). Study participants (N = 397) underwent one of three different exercise programs lasting three months with blood samples collected at baseline and at the end of intervention. After chromatographically profiling IgG N-glycans, linear mixed models with age and sex adjustment were used to investigate exercise effects on IgG glycosylation. Exercise intervention induced significant changes in IgG N-glycome composition. We observed an increase in agalactosylated, monogalctosylated, asialylated and core-fucosylated N-glycans (padj = 1.00 × 10−4, 2.41 × 10−25, 1.51 × 10−21 and 3.38 × 10−30, respectively) and a decrease in digalactosylated, mono- and di-sialylated N-glycans (padj = 4.93 × 10−12, 7.61 × 10−9 and 1.09 × 10−28, respectively). We also observed a significant increase in GP9 (glycan structure FA2[3]G1, β = 0.126, padj = 2.05 × 10−16), previously reported to have a protective cardiovascular role in women, highlighting the importance of regular exercise for cardiovascular health. Other alterations in IgG N-glycosylation reflect an increased pro-inflammatory IgG potential, expected in a previously inactive and overweight population, where metabolic remodeling is in the early stages due to exercise introduction.

Naphtho-triazoles and thienobenzo-triazoles have so far proven to be very potent inhibitors of the enzyme butyrylcholinesterase (BChE). Based on these results, in this work, new thienobenzo-thiazoles were designed and synthesized, and their potential inhibitory activity was tested and compared with their analogs, naphtho-oxazoles. The synthesis was carried out by photochemical cyclization of thieno-thiazolostilbenes obtained in the first reaction step. Several thienobenzo-thiazoles and naphtho-oxazoles have shown significant potential as BChE inhibitors, together with the phenolic thiazolostilbene being the most active of all tested compounds. These results are significant as BChE has been attracting growing attention due to its positive role in the treatment of Alzheimer’s disease. Computational examination based on the DFT approach enabled the characterization of the geometry and electronic structure of the studied molecules. Furthermore, the molecular docking study, accompanied by additional optimization of complexes ligand-active site, offered insight into the structure and stabilizing interactions in the complexes of studied molecules and BChE.

At the end of 2018, Gazi Husrev-bey library in Sarajevo and the renowned institution for historical research in the Republic of Turkey, Türk Tarih Kurumu, signed a protocol on cooperation on the project of preparing and publishing the regesta of the voluminous manuscript Tārīẖ-i Enveri, History of Muhamed Enveri Kadić. For the next four years, both of these institutions, which kept the first copies of the History, undertook a series of activities in order to realize the signed project. On January 13, 2023, the Gazi Husrev-bey library marked its 486th anniversary by promoting the planned and completed part of the work. The fact that the name and work of this special archivist, copyist, poet, epigrapher and bibliophile was known in detail by a limited number of people outside the fields of Orientalism, Ottoman studies and history, imposes the need to present, in a concise form, his character, work and visions.

In our study, we investigated the chemical composition and cytotoxic activity of essential oils isolated from Dalmatian sage (Salvia officinalis L.) collected along the Adriatic coast of Croatia. Scanning electron microscopy (SEM) was used to examine the morphology of the stem and leaf surfaces. Essential oil excretory glands were detected on both the leaves and stem surfaces. The essential oils were isolated by hydrodistillation, and their chemical composition was determined by gas chromatography and mass spectrometry (GC-MS). Sage essential oils were mixtures of terpene compounds, among which the most common were: α- and β-thujone, camphor, and 1,8-cineol. Cytotoxic activity was tested using MTS assay on multiple cell lines: normal and immortalized fibroblasts (HF77FA and HDF-Tert), immortalized lung line (BEAS-2B), and breast adenocarcinoma (MDA-MB-231). The growth of treated cells was determined relative to control conditions without treatment. The immortalized lung line was the least resistant to the activity of the essential oils, whereas immortalized fibroblasts were the most resistant. Statistical analysis has connected the cytotoxic effect and chemical composition of the studied essential oils. To the best of our knowledge, this work is the first testing of the cytotoxic activity of S. officinalis EO’s on the BEAS-2B, HF77FA, and HDF-Tert cell lines. The presented data on essential oil chemical composition and cytotoxic effect on 4 types of human cells supports pharmacotherapeutic potential this plant is known to have.