Various activities in the tourism sector, especially transportation, have a negative impact on the atmospheric complex. The paper aims to re­search tourism’s impact on global carbon dioxide emissions, the generation of photochemical smog, and noise and light pollution. Various tourism in­dustry activities have been identified, as well as tourist transport factors on which the intensity of air pollution depends. To demonstrate the harmful effects, statistical indicators and other results of modern scientific research were used, including the consequences of pollution on the living world. The paper provides current knowledge in the field, highlighting the risks of mass tourism, and the global need for more rational planning of sustainable tour­ism development.

Although there is considerable evidence suggesting a strong association of glucose, glycated hemoglobin and fatty acid levels with Type 2 diabetes mellitus (T2D), a limited number of studies have examined the association of individual fatty acids with disease progression. Acutely elevated plasma fatty acids stimulate insulin secretion while chronically elevated plasma fatty acids alter and disrupt insulin secretion. Furthermore, free fatty acids (FFA) are known to interfere with normal glucose homeostasis and affect pancreatic β-cell dysfunction. The study included 24 patients with newly diagnosed type 2 diabetes and 27 healthy controls, and analysis of the level of glucose and glycated hemoglobin was done by routine methods. The concentration of individual FFA was determined by gas chromatography with mass spectrometry detection. The results showed statistically significant differences in glucose, HbA1c, lipid profile, palmitic, linolenic, arachidonic, arachidonic, behenic acid as well as in DHA levels in all participants. In healthy subjects, no significant correlation was found between glucose and individual free fatty acids but a negative correlation was observed between DHA and glycated hemoglobin (p<0.05). Newly diagnosed diabetics showed a negative significant association between glucose and lauric acid concentrations, and also the association of glycated hemoglobin with myristic acid levels (p<0.01 and p<0.05, respectively). These data indicate the association of different types of free fatty acids with glucose levels and their control in the serum of healthy and newly diagnosed type 2 diabetics, and therefore indicate the importance of monitoring glucose levels as well as glycated hemoglobin with concentrations of individual free fatty acids in the progression of diabetes.

This study deals with the unfolded quantities based on the time intervals between successive neutron events from the aspect of the power law. Neutrons from spontaneous fission in special nuclear material induce fission in most cases. In this study, it was demonstrated that the inverse value of the number of induced neutrons decreases following a power function with the increasing radius of a plutonium metal sphere. In addition, it was considered an increase in the neutron background level with increasing altitudes. The inverse value of the mean neutron counting rate depending on altitudes can be described with a power function merely for higher elevations. A linear relationship was obtained by plotting the quantities on logarithmic axes against each other indicating generally a power law relationship for both investigated phenomena. The results of this study showed a connection between two seemingly unrelated neutron phenomena through power laws based on the distributions of time intervals between successive neutron counts. The empirical evidence implies that a connection between the observed quantities in a log-log plot is unchanged except for a multiplicative constant.

Background: Multiple sclerosis is a a complex diesase that may be presented by different neurological symptoms causing impairment of physical, psychological and cognitive functions. Objective: The aim of the study was to evaluate the influence of sociodemographic characteristics on cognitive functions in multiple sclerosis patients. Methods: This study included 60 MS patients treated at the Department of Neurology, Clinical Center University of Sarajevo. Inclusion criteria were clinically definite diagnosis of multiple sclerosis, 18 years of age or older and were able to give written informed consent. Cognitive function was evaluated by the Montreal Cognitive Assessment (MoCa) screening test. Mann-Whitney and Kruskal-Wallis test were used for comparisons between sociodemographic characteristics and MoCa test scores. Results: 76.66% were female patients. Average age of patients was 44.5 years. 70% of patients were married. 73,33% of patients had a high school degree, 20% had a college degree while only 6,66% had primary education. 38,33% of patients were employed, 33,33% were unemployed and 28,33% retired. 88.33% of patients had cognitive impairment, 68.33% having mild cognitive impairment. Executive functions (53,66%) and delayed recall (28,33%) were rated the worst. The median value of the Naming and Language MoCa domains of cognition showed statistical significant correlation with level of education (p<0.05; p<0.01).The mean value of the Language variable was statistically significantly lower in respondents aged 35 and over compared to respondents younger than 35 years (p=0,003;p<0,01), Statistically significant correlation was found between the level of education and cognitive status (rho=0,276,p<0,05), while the other variables (gender, age, marital status and employment ) did not show a statistically significant corellation. Conclusion: High perecentage of MS patients has cognitive impairment. Executive functions are rated the worst. Education is the major factor that contribute to better cognitive functioning in MS patients independent of age or employment status. The highest correlation is found between language and naming domains of cognition. Gender did not prove to be predictive factor of cognition in multiple sclerosis patients at any domain.

Background/Aim: The aim of the research was to examine the general attitude, knoweledge and practice of pediatricians about caries in children of preschool age. Material and Methods: The research was conducted from November 2019 to the end of January 2020. The research consisted of a survey of pediatricians. The questionnaire consisted of 4 modules and 37 questions, which related to the attitude, knowledge and practice of pediatricians on the prevention of early childhood caries. Results: The majority of pediatricians (84.9%) stated that they assess the nutrition of their patients, while 32.1% of them always do oral health assessment, and half of them in the second month of the child's life; and 39.6% assess oral health only if there is a problem. The majority of pediatricians (86.8%) recommended the first dental examination, most often in the first year of the child's life (79.5%), and then every 6 months (43.5%). The majority of respondents did not required information about the dental health of their patients' mothers, fluoride toothpastes and topical application of fluoride as well (62.3-75.5%). The majority of pediatricians (79.2%) have never provided or sometimes provided educational material on caries prevention and control to the parents of their patients. The most accurate answers and the highest percentage of correct answers that the pediatricians had were about attitudes (Z=8.98, 66.63%), while the fewest correct answers and the lowest percentage of correct answers regarding the practices on the prevention of early childhood caries (Z=11.91, 58.90%). Conclusions: The research showed that pediatricians have the good attitudes and knowledge, but do not implement prevention of early childhood caries in practice. The basic deficiency of attitude, knowledge and perception of the importance of prevention is a consequence of insufficient education of pediatricians.

Background/Aim: Deep carious lesions on primary teeth usually have been causing infectious dental pulp changes. If indicated, traditional endodontic root canal treatment for these kinds of pulpal infections in primary teeth usually should involve the performing of pulpectomy methods, but often with questionable prognosis. The lesion sterilization and tissue repair (LSTR) approach is one of the good endodontic therapeutic alternatives for affected primary teeth with a poor prognosis, which could otherwise be condemned to premature extraction. Aim was to evaluate the medium-term clinical success in everyday practice of the LSTR method applied in affected primary teeth with irreversible pulpal tissue infections by observation of reduction/absence of their clinical symptoms. Material and methods: The study sample included child patients who had one or more of their affected primary molars with irreversible pulpal tissue changes of poor prognosis treated with the LSTR method. For each patient whose primary molar tooth was endodontically treated with the LSTR method a clinical evaluation of treated tooth was performed at intervals of 1 and 12 months afterwards. Results: Study sample was consisted of 40 child patients aged 4 to 9 years, with 45 primary molars included in total. It was obvious that the symptoms related to affected sample teeth have already been decreased almost immediately after initial action of triple antibiotic paste. Final outcome after 12-months follow-up period was success of applied LSTR method in 43 (95.6%) affected sample teeth in a way that initial clinical symptoms completely decreased and disappeared. Conclusions: LSTR method has been shown as successful pulpotomy technique for noninstrumental endodontic approach in non-vital pulp treatment of primary molar teeth in a 12-months follow-up period.

Uspostava SFR Jugoslavije nakon Drugog svjetskog rata označila je početak formiranja jedne nove srpske i hrvatske emigracije čiju su okosnicu predstavljali kadrovi poraženih kvislinških režima kao što su Nezavisna Država Hrvatska ili Nedićeva Srbija. Nakon vojnog poraza mnogi vojni i politički predstavnici ustaških i četničkih vlasti uspijevaju pobjeći u zapadnoevropske zemlje, Ameriku, Australiju i druge države, gdje se postepeno organiziraju i počinju nacionalno-političko djelovanje. Među tim emigrantima bili su i aktivisti za koje se nedvojbeno može tvrditi da su imali muslimanske korijene. O njihovom vlastitom nacionalnom i vjerskom izboru teško je govoriti jer u nekim konkretnim slučajevima bilježimo otklone od nacionalnih i vjerskih korijena, odnosno identitarno poistovjećivanje sa srpskom ili hrvatskom emigracijom, ovisno o ranijem političkom opredjeljenju. Časopis Bosanski pogledi, glasilo bošnjačke političke emigracije, obrađivao je različite teme koje su se pokazale izuzetno značajnim za izučavanje historije bošnjačkog naroda. U tom smislu se i polemike s pripadnicima srpske i hrvatske emigracije muslimanskih korijena na stranicama tog lista pokazuju vrijednim izvorom za razumijevanje složenosti i višeslojnosti razvojnog puta njegovog nacionalnog i religijskog identiteta.

Cardiomyopathies are diseases of the heart muscle, and present a heterogeneous group of myocardial diseases with mechanical or electrical dysfunction, characterized by ventricular hypertrophy or dilatation. They can be strictly related to the heart muscle (primary), or as part of a systemic disease (secondary), and represent a factor that leads to a reduced quality of life, the occurrence of heart failure and mortality. The primary ones are those that are genetic conditioning, the mixed ones include dilated and restrictive cardiomyopathy, and the acquired ones are caused by myocarditis, stress-induced, peripartum, tachycardia-induced and those caused by endocrine pathology (primarily in newborns of mothers with a diagnosis of diabetes mellitus). Etiologically, they can arise as a result of a genetic mutation, an inflammatory process, and they are also divided into metabolic, toxic and those caused by some other cause. The aim of the article was to present the characteristics of cardiomyopathies themselves in relation to the etiological factor, with review of the diagnostic and therapeutic modality.

The article deals with modeling and calculations of volumetric machine-building structures with complex geometry. The relevance of the work lies in the fact that its methodology and results can help design massive structural elements complex in shape, including cylinders of powerful hydraulic presses. Attention is paid to the problems of reducing the metal content of machine-building products and the safe conditions of their operation. Theoretical and applied work is based on numerical methods using analytical solutions to assess the reliability of computer calculation results. The choice of research method is because analytical solutions for massive parts of such a configuration are too complex for numerical implementation. Experimental methods are too expensive and not so universal as to sort out possible variants of shapes and sizes. For the actual model of the press, the capabilities of the finite element method implemented in the ANSYS multipurpose complex were selected and rationally used. The results of the calculations are summarized in the table and shown on the graphs of the stress distribution. Based on the performed calculations (with a reliability check based on the formulas of the theory of elasticity for simplified calculation schemes), conclusions were made to ensure a more even distribution of stresses and a reduction in the metal content of the product.

Introduction: Ascaris lumbricoides is a widely spread helminthic infection, predominantly affecting children, making them the most commonly infected population group. The objective of this study is to assess the prevalence of Ascaris lumbricoides infestation in two municipalities, Tešanj and Maglaj, and to investigate the occurrence of Ascaris lumbricoides infections in the pediatric population, focusing particularly on preschool children. Materials and Methods: The study involved the collection of 1409 fecal samples from the Tešanj and Maglaj areas, gathered over a 6-month period, spanning from September 2018 to February 2019. The processing of these samples was conducted in the Microbiology Laboratory of Tešanj General Hospital. Results: Out of the total 1409 samples, 129 (9.16%) tested positive for Ascaris lumbricoides infestation. In Tešanj, where 1198 samples were collected, 106 (8.85%) tested positive, while in Maglaj, 211 samples were collected, with 23 (10.9%) testing positive. Notably, the majority of positive cases in both Tešanj and Maglaj were preschool-age children, accounting for 88.68% and 86.96%, respectively. The study did not identify any statistically significant correlation between age and gender distribution among those with positive test results in either Tešanj or Maglaj. Conclusion: Based on the study results, which have highlighted the infestation of preschool children with Ascaris lumbricoides in two municipalities in our country, it is imperative to implement preventive measures aimed at reducing the incidence of infection.

Sodium-glucose co-transporter 2 inhibitors (SGLT2 inhibitors) represent a therapeutic modality option for type 2 diabetes mellitus. This group of drugs includes dapagliflozin, empagliflozin, canagliflozin, ertugliflozin and sotagliflozin. Given their proven benefit in the scope of heart failure through clinical studies, they have also gained their place in patients with reduced, moderately reduced, or preserved systolic function of the left ventricle. Due to the effect on both the systolic and diastolic function of the left ventricle, and the neurohumoral activity itself, their range of use has been expanded in patients without a history of diabetes mellitus, and empagliflozin in a dose of 10 mg, as well as dapagliflozin in a dose of 10 mg, have been implemented in patients without diabetes mellitus. New directions for the expansion of the use of SGLT2 inhibitors have pointed towards their applicability in acute heart failure (sotagliflozin) and type 1 diabetes (sotagliflozin). Recently, clinical studies concerning the use of empagliflozin and dapagliflozin in acute coronary syndrome (ACS), appeared. The aim of this paper was to highlight the possible benefit of including SGLT2 inhibitors in patients with ACS.

Cardiotoxicity is one of the most important side effects of first-line chemotherapy medications. It is influenced by genetic variation, whereby the relationship between the chemotherapeutic dose and the risk of cardiotoxicity can be altered. The incidence of cardiotoxicity depends on the substance used in the therapeutic modality of cancer and can reach an incidence of 30% during a three-year follow-up. The main element of the clinical picture is systolic dysfunction of the left ventricle, with symptoms of heart failure, which can change or stop oncological therapy, along with pharmacological treatment of heart failure. These symptoms can occur during prolonged use of cancer therapies, monitoring the patient is advisable. Considering the increasing success of oncology therapy and the extension of life, as well as the improvement of the quality of life, a multidisciplinary approach, as well as the symbiosis of the work of cardiologists and oncologists, is imperative. Patient stratification concerning oncological treatment modality is imposed as part of a cardiologist's daily work from the beginning of cancer treatment.

Background: Correct measuring of blood and urine creatinine level is necessary for identification and tracking of chronic kidney disease (CKD). Objective: The aim of this study is a comparison of Jaffe and enzymatic methods for measuring creatinine in serum and in urine, in order to determine whether there are any statistical significant differences between them, and whether they are reflected on creatinine clearance calculation and estimated glomerular filtration rate (eGFR). Methods: Creatinine in serum and urine was measured for the group of patients (N=60; female=34, male=26) from 24 to 69 years of age by using Jaffe’s method on Dimension RxL biochemical analyzer, and enzymatic method on integrated biochemical and immunochemical analyzer Architect ci8200, and obtained levels are used for creatinine clearance calculation and eGFR. Results: The methods correlate well, both in measuring serum creatinine (r 1 = 0.990) and in measuring urine creatinine (r 2 =0.974). There are no statistically significant differences between them (p=0.57). Measuring creatinine using different methods showed no statistically significant differences in the calculated clearances (p=0.93), they significantly correlate (r=0.9722). eGFR, using the MDRD and CKD-EPI formulas, were not statistically significantly different, regardless of the used method. Conclusion: Apart from significant correlations between the used methods, the results of using the Jaffe and enzymatic methods showed no significant differences at measuring serum creatinine level, or creatinine clearance and glomerular filtration rate.