Systemic lupus erythematosus (SLE) is a disease associated with an impaired autoimmune response; the immune system attacks erroneously own tissues, which leads to inflammation, tissue damage and complement activation. The latter plays a pivotal role in SLE pathology, as complement level is suited as histological marker for disease diagnoses and management. Besides, environmentally factors have been highlighted and their significant contribution for individual genetic predisposition has been pointed out. Here complement factors, their activity and their ability to modify DNA with histone proteins are reviewed; known gene mutations involved in SLE, and new therapeutic approaches suggested for SLE are discussed and summarized, as well.

Peripartum depression (PPD) has been the focus of many studies, clinical interventions and policymaking over the past decades, yet more work is needed in order to mitigate this disorder and its negative consequences. This symposium offers an examination, through various review techniques, of five emerging understudied topics related to PPD diagnosis, treatment and policy implications. Through a scoping review, the first presentation considers how economic evaluation can inform the development of mental health policy strategies and guidelines and identify implications for preventive, screening and treatment strategies for PPD. The second presentation increases understanding of PPD disorder diagnosis through a synthesis of current literature on issues regarding PPD diagnosis in different aspects. The third presentation focuses on Paternal PPD (P-PPD) and presents a consensus report on emerging issues and questions on the prevention, diagnosis and treatment of P-PPD The fourth presentation presents, through an umbrella review of systematic reviews and meta-analyses, an overarching synthesis of the literature regarding complementary and alternative therapies (CATs) to treat PPD, while assessing the extent to which CATs are associated with depressive symptoms reduction during pregnancy or after childbirth. The fifth presentation focuses, through a systematic review, on the effectiveness of Third Wave cognitive behavioral psychological interventions in treating peripartum depression. All five presenters will discuss the major findings of their work as well as potential implications for research, clinical practice and policy. Collectively, this set of papers advances the understanding of PPD diagnosis, prevention and treatment and of implications for clinical practice, research and policy.

An atrioventricular valve insufficiency is a common form of cardiac disorder in mammals, whereas it has rarely been reported in reptiles. A two-year-old male bearded dragon (Pogona vitticeps) was presented with acute onset of lethargy, inappetence and general weakness, increased respiratory effort, dark skin color, and arched back. A gastrointestinal foreign body was suspected, but radiography showed coelomic fluid accumulation. Ultrasound heart examination revealed turbulent blood flow at the level of the atrioventricular valves. Electrocardiography by modified Einthoven lead system (lead configuration 1) as described for Squamata, did not show significant changes. A tentative diagnosis of congestive heart failure as a result of valvulopathy was made. Treatment consisted of parenteral furosemide and fluid administration and assisted feeding with appropriate food intended for adult bearded dragons. The patient was weekly evaluated and successfully recovered over the four months. Echocardiography and electrocardiography were repeated 12 months later. The prescribed treatment was successful with complete resolution of clinical signs, and long-term surveillance of the bearded dragon (Pogona vitticeps).

Background: Despite the overall success of THA, between 5 and 20% report unsatisfactory results. Several factors may cause this variable outcome. 1 of them might be ethnicity which, because of its potential social impact on living conditions, may influence quality of life too. It should be studied whether patients born and being operated in their home country Bosnia and Herzegovina (BH) had similar results as immigrants being operated in Sweden (IS). Methods: Data of 280 patients were collected prospectively from questionnaires in the BH group. Patients of the IS group were eligible if both of their parents were born outside the Nordic countries, not having Swedish as their native language. Data were gained from the Swedish Arthroplasty Registry (SAR), 449 patients were included. Outcomes were pain VAS, satisfaction VAS, EQ-VAS, and the EQ-5D. Logistic and linear regression models including age, sex, diagnosis, type of fixation, surgical incision, marital status and educational level were analysed to compare those 2 groups. Results: There were considerable differences in patient demographics between the 2 groups. Before the operation, patients in the BH group reported more problems with self-care and usual activities, even after adjustment for confounding factors (p < 0.0005). Patients in the IS group reported a higher EQ-VAS and more pain VAS (p < 0.0005), the difference in the EQ-VAS was not significant after adjustment for confounding factors (p = 0.41). After 1 year patients in the BH group reported better scores in all dimensions of the EQ-5D (p ⩽ 0.005) apart from self-care. After adjustment for confounding factors, patients in the BH group were more satisfied too (p < 0.0005). Conclusions: Immigrated patients (IS group) seemed to experience less benefit from THA 1 year after the operation despite more symptoms preoperatively. There were considerable limitations affecting the results. Nevertheless, the data are a point of concern, and it is suggested to take more multidimensional care of immigrant patients.

INTRODUCTION: Irritable bowel syndrome (IBS) has a major impact on emotional, social, and professional life. This study aimed to evaluate general life satisfaction, a subjective measure of well-being, in IBS patients, and to determine which factors are associated with higher life satisfaction. METHODS: IBS patients (n = 195, mean age 51.4 ± 16.5 years, 73.8% female) recruited from primary and secondary/tertiary care completed questionnaires regarding gastrointestinal symptoms, quality of life, psychological factors, and life satisfaction (Satisfaction With Life Scale, 5 items, range 5–35). A finite mixture model analysis was performed to identify latent classes. Multivariable linear regression was used to identify variables associated with life satisfaction. RESULTS: Overall, 71.3% of the patients were satisfied about their life (Satisfaction With Life Scale-score ≥21). Three latent subgroups could be identified with significantly higher life satisfaction in the subgroup with higher mental quality of life, fewer anxiety and depressive symptoms, lower gastrointestinal specific anxiety, and lower gastrointestinal symptom severity, compared with the other 2 groups. Multivariable linear regression showed that higher physical quality of life (B0.168, P < 0.001) and higher mental quality of life (B0.199, P < 0.001) were associated with higher life satisfaction. Using multivariable regression, no significant association was found between gastrointestinal symptom severity and life satisfaction. DISCUSSION: Higher physical and mental quality of life, but not gastrointestinal symptom severity, were independently associated with higher general life satisfaction in IBS. These findings reinforce the clinical need in IBS treatment to focus on the full extent of the disorder and not merely on gastrointestinal symptom improvement. ClinicalTrials.gov Identifier: NCT00775060.

Background Ikigai (meaning or purpose in life) is a concept understood by most older adults in Japan. The term has also garnered international attention, with recent academic attempts to map it to concepts in the Western well-being literature. In addition, efforts to use social and home robots to increase well-being have grown; however, they have mostly focused on hedonic well-being (eg, increasing happiness and decreasing loneliness) rather than eudaimonic well-being (eg, fostering meaning or purpose in life). Objective First, we explored how Japanese older adults experience ikigai and relate these to concepts in the Western well-being literature. Second, we investigated how a home robot meant to promote ikigai is perceived by older adults. Methods We used a mixed methods research design—including 20 interviews with older adults, a survey of 50 older adults, and 10 interviews with family caregivers. For interviews, we asked questions about older adults’ sources of ikigai, happiness, and social support, along with their perception of the robot (QT). For surveys, a number of well-being scales were used, including 2 ikigai scales—ikigai-9 and K-1—and 6 Patient-Reported Outcomes Measurement Information System scales, measuring meaning and purpose, positive affect, satisfaction with participation in social roles, satisfaction with participation in discretionary social activities, companionship, and emotional support. Questions related to the perception and desired adoption of the robot and older adults’ health status were also included. Results Our results suggest that health is older adults’ most common source of ikigai. Additionally, although self-rated health correlated moderately with ikigai and other well-being measures, reported physical limitation did not. As opposed to social roles (work and family), we found that ikigai is more strongly related to satisfaction with discretionary social activities (leisure, hobbies, and friends) for older adults. Moreover, we found that older adults’ sources of ikigai included the eudaimonic aspects of vitality, positive relations with others, contribution, accomplishment, purpose, and personal growth, with the first 3 being most common, and the hedonic aspects of positive affect, life satisfaction, and lack of negative affect, with the first 2 being most common. However, the concept of ikigai was most related to eudaimonic well-being, specifically meaning in life, along the dimension of significance. Finally, we found that Japanese older adults have high expectations of a home robot for well-being, mentioning that it should support them in a multitude of ways before they would likely adopt it. However, we report that those with the highest levels of meaning, and satisfaction with their leisure life and friendships, may be most likely to adopt it. Conclusions We outline several ways to improve the robot to increase its acceptance, such as improving its voice, adding functional features, and designing it to support multiple aspects of well-being.

Modular quantum processor architectures are envisioned as a promising solution for the scalability of quantum computing systems beyond the Noisy Intermediate Scale Quantum (NISQ) era. Based upon interconnecting tens to hundreds of quantum processors (i.e cores) via quantum coherent and classical links, this approach unravels the pressing limitations of densely qubit-packed monolithic processors, mainly by mitigating the requirements of qubit control and enhancing qubit isolation. Therefore, this new architectural design enables executing large-scale algorithms in a distributed manner. In order to assess the performance and optimize such architectures, it is crucial to analyze the quantum state transfers occurring via inter-core communication networks, referred to as inter-core qubit traffic. This would provide insights to improve the software and hardware stack for multi-core quantum computers. To this aim, we present a characterization of the spatio-temporal inter-core qubit traffic for different large-scale quantum algorithms. The programs are compiled on an all-to-all connected multi-core architecture that applies the teleportation protocol for inter-core state transfer and supports up to around 1000 qubits. We characterize the qubit traffic based on multiple performance metrics to assess the computational process and the communication overhead. Based on the showcased results, we conclude on the parallelization and scalability of presented algorithms, qualitatively evaluate the resource requirements as we scale circuit sizes, and lay the foundations of application-oriented benchmarking of large-scale multi-core architectures.

Uncontrolled acetylene release during production processes, transportation, or storage can lead to explosions and detonations endangering safety of people and material assets. This paper investigates the impact of accidental release of acetylene gas in surrounding areas. The ALOHA software has been used in this paper to modelling of acetylene release. The modelling was performed for an accidental release of 2,000 kg acetylene from direct source for one minute. F or a typical average atmospheric condition in location, this accidental acetylene release would cause a red zone of 197 m (15,000 ppm) and yellow zone of 483 m (2,500 ppm) to downwind from the source. Inadequate storage can lead to accidental situations and negative impact on people and the environment.

Self-rated health is associated with health behaviour and socio-demographic and socio-economic conditions on the way that health risks and poor socio-economic status determine poor self-rated health. The aim of the study was to determine self-rated health among students, perceive health behaviour risk and association with socio-demographic and socio-economic characteristics of students. Methods: Study is conducted as a cross-sectional study among students of health sciences in autumn semester 2022. Year. Specially designed questionnaire was constructed based on international guidelines. Anonymously filling out an on line formed questionnaire by voluntary singing on university web site. Results: More than three quarter of students perceived their health as a good and no one perceived health as a poor. Most students perceived their health as good (83,2%), mainly students with a technical background and those who are living in good socio-economic conditions (89,0%) (p0,05). The most frequent health risks among students are lack of physical activity (44,5%) and less than six hours for sleep and rest (43,8%). More than a third of students perceived fear, nervousness and tension (34,3%), a lack of time for friendship and family (33,6%) and irregular diet (31,4%). Every seventh student perceived overweight and obesity. Students who are living in poor socio-economic conditions perceived more health risks as well as those who don’t have medical background and who are employed. More students in urban area perceived mental problems than those in rural areas. Conclusion: Students are mainly perceived their health as a good and have health risks which will be reduced through health promotion in university educational programmes.

Medicinal plants play a major role in the development of human cultures. Medicinal plants are a rich source of phytochemical compounds, which have proven therapeutic efficacy throughout the ages. The therapeutic efficacy is attributed to those secondary biologically active compounds. Plants have provided the human being with all his needs of food, drink, and clothing. In addition they are an important source for the treatment of many diseases being the basis of the science of alternative medicine, In recent times, the area cultivated for these medicinal plants has increased, and scientific research has tended to study the effectiveness of these plants in treating many diseases. Most plants have an effective effect as an antioxidant, anti-hyperlipidemia, hypoglycemic, antihypertensive as well as for cardiovascular diseases and strokes. The study aims to provide important data on the extent to which some medicinal plants are used in the treatment of various diseases.

Lifestyles develop throughout the life, but adolescence and early youth are important stages in acquiring healthy lifestyles habits. This is also vulnerable period for substance misuse, worsened diet habits and sedentary lifestyles linked to academic activities and responsible for developing non communicable diseases (NCD). Goal of the article is to analyse lifestyles habits and risk factors for developing NCD among students of health sciences. Study is conducted at the University Apeiron, Faculty of Health Sciences among students from first to fourth years of study. Specially designed questionnaire was prepared and distributed on line, anonymously and voluntary fulfilled by students. Every fifth student is smokers, 5,1% consume alcohol daily, more males (12,1%) than females (2,9%) (p0,05). Majority of males (42,2%) consumed alcohol drinks in one occasion during previous month, statistically more than females (21.2%) (p0,05). More than two third of students eat fruits and vegetables daily and one third have regular meals. Moderate physical active are 42,3% of students, and physical inactive are more females than males (p0,05). Risk factors for NCD have to be prevented with supportive policies in school environment and community. Students of health sciences should be a positive model of changing risk habits for NCD and saving future quality of life.

Wind Farm Podveležje is located on the plateau Podveležje, about 10 km east of the city of Mostar, in the center of the Herzegovina-Neretva Canton. The Wind Farm consists of 15 wind turbines, each with a power of 3.2 MW, making a total capacity of 48 MW. The geological structure of the surrounding area on the Podveležje plateau is very complex due to its intricate tectonic complex, ranging from layered to thinly layered Upper Cretaceous limestone with Turonian-aged radiolites as the bedrock. Cracks are often highly prominent, filled with rock weathering products, terra rosa and clay material. During geological and geotechnical investigations at foundation locations, caverns were identified in certain places. The program of additional works (destructive boreholes and TV logging) was carried out to delineate the cavern locations on WT-3, WT-4, WT-8, WT-12, WT-15, and WT-16 plateaus. The aim of the paper is to describe the cavern rehabilitation at locations of wind turbine foundation including substrate preparation, filling procedures, mixture composition, and performing destructive boreholes to verify rock mass compactness.

In the current study, we assessed the prevalence and molecular features of HER2-low phenotype in the apocrine carcinomas of the breast (ApoCa) and its relationship with tumor-infiltrating lymphocytes (TILs). A cohort of 64 well-characterized therapy-naïve ApoCa was used. The TIL distribution was assessed using the hematoxylin and eosin whole slide/scanned images following the international TILs working group recommendations. Next-generation sequencing (NGS) was performed in a subset of HER2-low ApoCa. All patients were women, with a mean age of 62 years. Forty-three carcinomas were pure apocrine carcinoma (PAC; ER−/AR+), and the remaining 21 were classified as apocrine-like carcinomas (ALCs; ER+/−, AR+/−). HER2/neu was positive (score 3+ by IHC and/or amplified by FISH) in 20/43 (47%) PAC and 4/21 (19%) ALC. The prevalence of HER2-low expression (scores 1+ or 2+ without HER2 amplification) in ApoCa was 39% without significant differences between PAC and ALC (P ═ 0.14); however, the HER2-low phenotype was more prevalent in triple-negative PAC than in ALC (P < 0.001). Levels of TILs were low (≤10%) in 74% of ApoCa (median: 5%, range 0%–50%). TIL levels were significantly higher in ALC than in PAC (P ═ 0.02). HER2 status had no impact on TIL distribution (P ═ 0.45). The genomic profile of HER2-low ApoCa was similar to other subtypes of ApoCa. ApoCa has predominantly low TIL, particularly PAC. The prevalence of the HER2-low phenotype in ApoCa is high, which should have therapeutic and clinical implications given the recently approved therapies with antibody–drug conjugates (ADCs) for HER2-low breast cancers.

Abstract Reimagine Resilience (2023), designed and established at Teachers College, Columbia University, is an innovative program that builds awareness and understanding among educators and educational personnel in the U.S. on the precursors and causes of educational displacement in students, supporting educators in promoting belonging, connectedness, and resilience to prevent educational displacement, extremism, and radicalization among students in their schools and classrooms. The study demonstrates the effectiveness of the Reimagine Resilience Program in producing attitudinal shifts in participating education personnel as they cultivate an awareness of their own biased speech and conduct. Further, this study spotlights the Program’s efficacy in identifying ways to actively prevent educational displacement as educators gain new knowledge of protective and risk factors for radicalization and targeted violence. This study underscores the importance of innovation in pedagogy, practice, assessment, and professional training for educators and educational staff to effectively engage educators in extremism and violence prevention.

Abstract This study presents findings on the indicators of educational displacement as an early risk factor for radicalization in school settings in the U.S. We collected and analyzed data from 301 students living in 43 U.S. states to inform the creation of Reimagine Resilience, an innovative violence prevention training program for educators and educational staff developed at Teachers College, Columbia University, and to measure early indications of educational displacement as a risk factor for radicalization. The study shows that poor teacher-student relations and multiple experiences of biased speech and behavior are significant early predictors of the students’ educational displacement. Educational displacement, in this study, is measured as a lack of social belonging in schools.