This paper aims to compare the mechanical and structural properties of butt-welded properties of dissimilar aluminum alloys 2024-T351 and AA 6082-T6 obtained by MIG and TIG welding processes. Alloy AA 6082 T6 is well weldable by classic fusion welding processes (MIG and TIG), while alloy 2024-T351 is almost non-weldable. For the welding of these two different Al alloys, MIG and TIG welding procedures were used on 8 mm thick sheet metal using additional material 4043A (AlSi5) and a mixture of argon and helium as a protective gas for the MIG welding process, or pure argon for the TIG welding process. The paper compares the mechanical properties of welded joints obtained by MIG and TIG welding. The microstructural evolution of the welded joint of dissimilar aluminum alloys AA6082-T6 and AA2024-T351 is compared. The mechanical properties of welded joints of dissimilar aluminum alloys are compared based on the results of Vickers hardness tests, tensile and bending tests of welded samples.

Properties of concrete containing the ground calcined low-kaolinite clay was experimentally studied. Clay, calcined at 900 and 1000°C, was used as a partial replacement of cement at dosage of 20 % by the weight of cement. Tests performed on concrete samples include the consistency, air content, compressive strength and flexural strength. The experimental results show a moderate decrease in slump, as well as in compressive and flexural strength comparing to concrete containing only cement CEM I as a binder. Better results were obtained with concrete containing clay calcined at 1000°C. Further research is needed to determine the optimal dosage of calcined clay in concrete, as well as the optimal temperature of clay calcination.

Anemia is the most common disorder globally and one of the conditions that general practitioners most frequently encounter. The human erythrocytes are exposed to constant stress while they circulate in the blood (e.g. shear stress, osmotic stress, oxidative stress). The scope of this review was to analyze the literature data on what do the hormonal receptors do on mature red blood cells (RBC) and how they relate to the risk of anemia. We investigated the literature data in the last five years (PubMed, Google Schoolar) and analyzed the effects of hormonal receptors on four specific characteristics of mature erythrocytes: osmotic resistance; deformability/rheology, RBC hemoglobin affinity to oxygen and eryptosis. We found that the hormones have a strong impact in regulating erythrocyte survival and functionality. These receptors increase the physiological plasticity of mature erythrocytes and serve as the effective tool for deeper effects of integral regulatory mechanisms, that promote their survival and whole-body homeostasis. Additionally, these hormonal receptors are closely associated with the risk of anaemia: when the supportive function of hormones and their receptors is not effective, eryptosis increases and, consequently, the number of mature erythrocytes in the circulation decreases.

The research assessed the level of physical activity (PA) of boys and girls aged 11-14, as well as trends in PA levels. The sample included a total of 433 children aged 11-14, comprising 238 boys and 195 girls. PA was assessed using the FELS questionnaire, which included questions about the frequency of PA in sports, PA during leisure time, PA at home, and overall PA. To determine the trend in PA levels across specific domains and overall, trend analysis was applied, followed by comparisons using the LSD Post Hoc Test. Data were processed using the SPSS statistical package (p < .05). The results showed that boys had significantly higher levels of PA across all periods compared to girls. Significant changes in PA levels among boys were observed in the domain of PA in sports (Sig. = < .001) and overall PA (Sig. = .008). A significant decline in PA in sports among boys was noted between the ages of 11 and 13, as well as between 11 and 14 years, while the decline in overall PA was observed between the ages of 11 and 13. Among girls, a decline in PA in the domain of household chores was identified between the ages of 11 and 14. In the domain of overall PA, significant decreases were observed between the ages of 11 and 13, 11 and 14, 12 and 13, and 12 and 14. It was found that PA among children aged 11-14 significantly decreases around the ages of 12 and 13. Efforts should focus on promoting PA within this population group and identifying appropriate strategies to increase or at least maintain PA levels during this critical period.

Background: The scientific researchers have the role of interacting through published articles in scientific journals or presentations at scientific and professional conferences where they can affect the practices that can make achievements to society and country. or worldwide. Objective: The aim of this article was to describe bibliometric indexes and explained its importance for its evaluation and measuring quality assessment of published papers in scientific journals and advantages and disadvantages of current bibliometric portals for creating the list of universities and its academic staff by counts of deposited articles in databases and number of its citations. Methods: The author searched the most influential online databases and analyzed deposited papers by bibliometric indexes, and used a descriptive method to review important facts about bibliometrics experiences in scientific and academic practice. The author used facts deposited on the main international portals for analyzing number of citations of deposited scientific papers on Scopus and Google Scholar platform–h–Index and i10-Index and number of citations as basic data for created top list of most citated scientists in almost of all countries in the world. Results and Discussion: Bibliometric methods are used for quantitative analysis of written materials. Citation is influenced by: article quality, understanding of the article, language in which the article is written, loyalty to a group of researchers, article type, etc. Some indicators used in evaluating scientific work are Impact factor (IF); Citation of the article; Journal citations; Number and order of authors, etc. The index factor of influence depends on the quality of the journal, the language in which it was printed, the area it covers, and the journal distribution system. The portals and its platforms: Webometrics, “AD Scientific Index” and Stanford Bibliometric List are not fully relevant for measuring quality assessment of universities and its academic staff. Conclusion: Current academies and academicians can propose criteria how improve indexing scientific papers with the consultation of scientific bodies and experts at universities in one country, selected regions, or worldwide. These criteria should be necessary for quality assessment of the scientific curriculum of scientists and their published papers in scientific journals.

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Background: Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disorder and involves multiple organs, intellectual disability and epilepsy. Mutations in TSC1 and TSC2 genes are responsible for the molecular disease mechanism. Objective: The aim is to determine molecular background of a patient with a suspicion of TSC. Case presentation: In this case report, we describe a seven year old patient with the clinical manifestation of TSC that includes supratentorial changes, subependymal hamartomas and angifibromas in the facial area. Besides the brain and skin changes, no other TSC characteristics were observed. The patient was referred to molecular genetic testing using Next Generation Sequencing (NGS). Results: Clinical exome sequencing revealed intronic TSC2 c.4849+2T>G variant. The variant was confirmed using Sanger sequencing on the subject. However, the variant was not detected in the parents, which indicated that it arose de-novo. The RegSNP-intron, Mutation Taster and Human Splicing Finder were used as a bioinformatic tools to predict the possible effect on protein. Using bioinformatic tools, it was determined that the variant is possibly damaging to protein. Conclusion: This data suggest that observed splicing intronic variant could be the cause of TSC in this pediatric patient.

Background: Tranexamic acid can prevent death from bleeding after trauma and postpartum hemorrhage. Objective: The aim of the paper was to assess whether tranexamic acid reduces hematoma expansion and improves outcome in adults with stroke caused by intracerebral hemorrhage. Case presentation: Administration of Tranexamic acid in a patient after a diagnosis of intracerebral hematoma, which occurred after coronary stent implantation. Intracerebral hematoma, or neurological deficit, occurs one day after cardiac surgery in the patient. The case report will present the radiological resolution of the intracerebral hematoma, as well as the improvement of the clinical picture, neurological deficit, in the patient during a one-month follow-up, after the administration of Tranexamic acid. Conclusion: Tranexemic acid is affordable, easy to administer, appears to be safe, and is widely available, so even a modest treatment effect can have an important global impact, and it is necessary to consider its more frequent use, as well as to initiate larger randomized trials.

The research was conducted in the area of Northern Serbia. The lowland hygrophilous forests of Gornji Srem where pedunculate oak is the dominant tree species were studied. In the paper was investigated the content of essential and non-essential heavy metals (Cu, Zn, As, Mn, Co, Pb, Ni, Cd) on two different soil types: hydromorphic (fluvisol) and automorphic (chernozem). Three experimental plots were analyzed on each soil type. Soil loading with heavy metals was studied by soil horizons. Based on the obtained results, it was established that the concentrations of all elements are within the allowed concentrations, except for nickel (Ni), whose values on some experimental plots and horizons exceed the maximum allowed concentrations. Content of all investigated elements are higher on fluvisol, except for As, whose amount is similar on both soil types. The obtained results indicate that the loading of heavy metals in both soil types is within the allowed limits and there is no significant negative impact on the development and production characteristics of the forest ecosystems located in researched area.

Background: MitoWizz is an advanced bioinformatics tool designed for the analysis of the human mitochondrial genome, offering precise and efficient data interpretation. It enables comparisons of sequencing results obtained from various instrumental methods with the reference Andersen genome (rCRS), aiding in the identification of alterations. This capability is particularly valuable in forensic and clinical mitochondrial DNA analysis. Objective: The primary goal of developing MitoWizz is to automate and streamline mitochondrial DNA analysis, providing researchers and forensic experts with a fast, reliable, and comprehensive tool for sequence comparison, variation detection, and data validation. Methods: MitoWizz compares query sequences in opposed to the reference genome and allows direct comparison of two sequences to identify genetic variations. To ensure accuracy, the results are validated through the Clustal Omega W by aligning sequences with the human mitochondrial DNA reference from GenBank (NC_012920.1). Results: The software detected genetic variations and generated a visual report, as demonstrated in an analysis where 11 mutations were identified in various genes, with an 88% sequence identity to the reference genome. The accuracy of the detected alterations was further validated using the Omega Clustal W program. Conslusion: MitoWizz significantly reduces analysis time and enhances result reliability by integrating multiple analytical steps into a single platform. By automating mtDNA comparisons and validation, it provides forensic and research laboratories with a high-throughput, efficient solution for precise mitochondrial genome analysis.

Proper nutrition is important for the healthy growth and development of preschool children. During this period, they undergo rapid physical, cognitive, and emotional changes, making it essential to provide both the necessary nutrients to support their overall development and hygienically safe foods. Maintaining high sanitary and hygienic standards in preschool food facilities requires a comprehensive approach that integrates regulatory compliance, facility design, staff training, and effective sanitation practices. By prioritizing these standards, preschools can provide a safe and healthy environment that supports the well-being and development of preschool children. Regulatory requirements form the backbone of sanitation standards in preschools. These guidelines are often established by public health authorities and childcare regulators, setting out minimum standards for cleanliness, food handling, and facility maintenance. Adherence to these regulations ensures that preschools provide a safe and healthy environment for children. Essential components include proper kitchen design, adequate ventilation, pest control measures, and accessible handwashing facilities. Assessing the effectiveness of hygiene practices in preschools involves a multi-pronged approach, including regular inspections, health monitoring, feedback collection, staff training assessments, and incident analysis. By continuously evaluating and improving hygiene practices, preschools can provide a safe and healthy environment for children.

This paper aimed to examine specific factors that influence and have prognostic power on the profitability of selected insurance companies in the Republic of Serbia. Panel data were used for four insurance companies operating in the Republic of Serbia from 2013 to 2022, to estimate a linear model between the determinants that are theoretically expected to affect the performance and profitability of insurance companies. The findings of the paper revealed that company size according to all three methods (method of least squares, method of fully modified least squares, and robust method of least squares) has a significantly positive influence on the profitability of insurance companies. Also, the growth rate of the premium according to the fully modified least squares method has a positive (significant) impact on the profitability indicator, i.e. ROA. Seen from the other side, the weakest i.e., negative (significant) impact on the profitability of insurance companies in the Republic of Serbia was achieved by the independent variable expense ratio.