Despite the positive effects of green infrastructure on people and the environment, it is still rarely integrated in public facilities such as schools. The main reason for this is a lack of knowledge about financing options. To fill this gap, the research project MehrGrüneSchulen (Engl.: More Green Schools) develops financing scenarios for green infrastructure in Austrian schools. This case study describes these developed scenarios, which use the principles of crowdsourcing and crowdfunding as well as the newly named principle of chain building. The idea of chain building is to motivate schools that have already successfully financed and built a low-cost greening system to present this process to another school in such a way that they are able to do the same themselves and eventually explain the process to a further school to continue this chain reaction. For the proposed funding scenarios to be effective, there is a need for innovation in education, with a focus on inter-school participation and networking. For this reason, the possible synergies of an online networking platform are discussed, which would help to connect schools and thus further improve the impact of the proposed fundraising processes.

Abstract Alpha-mannosidosis is an inherited rare disorder of mannose-containing oligosaccharides metabolism that is currently treated by enzyme replacement therapy (ERT), bone marrow transplantation (BMT), or supportive therapy (ST). However, the relative cost-effectiveness of these treatment options is yet unknown. Our study aimed to compare the cost-effectiveness of the treatment options for mild to moderate alpha-mannosidosis. The study is based on a modeling approach using a Discrete-Event Simulation model to generate and simulate the course of the disease under the influence of each of the treatment options: ERT, BMT, and ST. The model had a lifetime horizon and was made from the perspective of the Serbian Health Insurance Fund. Currently, available causal therapy of mild to moderate alpha-mannosidosis with velmanase alpha enzyme replacement is not cost-effective compared with supportive therapy (ICER = 941,587,152 RSD) or bone marrow transplantation (ICER = −398,412,755 RSD). Bone marrow transplantation can be cost-effective compared to supportive therapy (ICER = 6,032,689 RSD), but only if the willingness-to-pay threshold is increased to 9 gross domestic products (GDP) per capita per QALY gained. According to the current threshold, velmanase-alfa is not cost-effective compared to BMT or ST. To make alfa-mannosidosis therapy widely accessible to patients, criteria for assessing the cost-effectiveness of orphan drugs must include not only the absolute value of ICER but other aspects like equity weightings of QALYs, risk-sharing, reimbursement of severe forms of a disease only, or availability of dedicated funding.

What is the central question of this study? What are the biggest challenges in performing in vitro studies on isolated human umbilical arteries? What is the main finding and its importance? The protocols presented in this study indicate some potential outcomes important for interpretation of the vascular responsivities of human umbilical arteries and could be useful for planning future in vitro studies with human umbilical arteries.

Introduction The COVID-19 pandemic has had an extensive impact on public health worldwide. However, in many countries burden of disease indicators for COVID-19 have not yet been calculated or used for monitoring. The present study protocol describes an approach developed in the project “The Burden of Disease due to COVID-19. Towards a harmonization of population health metrics for the surveillance of dynamic outbreaks” (BoCO-19). The process of data collection and aggregation across 14 different countries and sub-national regions in Southern and Eastern Europe and Central Asia is described, as well as the methodological approaches used. Materials and methods The study implemented in BoCO-19 is a secondary data analysis, using information from national surveillance systems as part of mandatory reporting on notifiable diseases. A customized data collection template is used to gather aggregated data on population size as well as COVID-19 cases and deaths. Years of life lost (YLL), as one component of the number of Disability Adjusted Life Years (DALY), are calculated as described in a recently proposed COVID-19 disease model (the ‘Burden-EU’ model) for the calculation of DALY. All-cause mortality data are collected for excess mortality sensitivity analyses. For the calculation of Years lived with disability (YLD), the Burden-EU model is adapted based on recent evidence. Because Covid-19 cases vary in terms of disease severity, the possibility and suitability of applying a uniform severity distribution of cases across all countries and sub-national regions will be explored. An approach recently developed for the Global Burden of Disease Study, that considers post-acute consequences of COVID-19, is likely to be adopted. Findings will be compared to explore the quality and usability of the existing data, to identify trends across age-groups and sexes and to formulate recommendations concerning potential improvements in data availability and quality. Discussion BoCO-19 serves as a collaborative platform in order to build international capacity for the calculation of burden of disease indicators, and to support national experts in the analysis and interpretation of country-specific data, including their strengths and weaknesses. Challenges include inherent differences in data collection and reporting systems between countries, as well as assumptions that have to be made during the calculation process.

As virtual worlds continue to rise in popularity, so do the expectations of users for the content of virtual scenes. Virtual worlds must be large in scope and offer enough freedom of movement to keep the audience occupied at all times. For content creators, it is difficult to keep up by manually producing the surrounding content. Therefore, the application of procedural modelling techniques is required. Virtual worlds often mimic the real world, which is composed of organized and connected outdoor and indoor layouts. It is expected that all content is present on the virtual scene and that a user can navigate streets, enter buildings, and interact with furniture within a single virtual world. While there are many procedural methods for generating different layout types, they mostly focus only on one layout type, whereas complete scene generation is greatly underrepresented. This paper aims to identify the coverage of layout types by different methods because similar issues exist for the generation of content of different layout types. When creating a new method for layout generation, it is important to know if the results of existing methods can be appended to other methods. This paper presents a survey of existing procedural modelling methods, which were organized into five categories based on the core approach: pure subdivision, grammar‐based, data‐driven, optimization, and simulation. Information about the covered layout types, the possibility of user interaction during the generation process, and the input and output shape types of the generated content is provided for each surveyed method. The input and output shape types of the generated content can be useful to identify which methods can continue the generation by using the output of other methods as their input. It was concluded that all surveyed methods work for only a few different layout types simultaneously. Moreover, only 35% of the surveyed methods offer interaction with the user after completing the initial process of space generation. Most existing approaches do not perform transformations of shape types. A significant number of methods use the irregular shape type as input and generate the same shape type as the output, which is sufficient for coverage of all layout types when generating a complete virtual world.

The nucleation kinetics of ice were investigated with four different types of aqueous solutions. The studied aqueous solutions, i.e., sucrose solution, ionic liquid (IL) solution, pyrolysis oil extract (PO) solution, and acetone‐1‐butanol‐ethanol (ABE) solution, were concentrated by batch suspension freeze crystallization. The nucleation kinetics were investigated using a temperature response method which results in data on nucleation rate per crystal. The obtained nucleation rate per crystal value can be used when dimensioning continuous crystallization processes: the nucleation rate per crystal is inversely proportional to the residence time in continuous crystallization. The subcooling degrees for different solutions were in the range of 0.33 °C to 1.89 °C. Aqueous sucrose solutions had the fastest nucleation kinetics. Ice crystallization from non‐ideal aqueous [DBNH][OAc] ionic liquid solutions required higher subcooling degrees and the nucleation rates per crystal were higher as well. Nucleation of ice formed from aqueous pyrolysis oil extract and aqueous ABE solutions occurred at a lower subcooling degree and the obtained nucleation rate per crystal values were lower.

Objectives: To conduct qualitative study with different target groups in Bosnia and Herzegovina in order to explore their views on barriers and drivers for COVID-19 vaccination, and to see if and how barriers and drivers vary between urban and rural locations, and different professional roles. Methods: The theoretical framework underpinning the study is the capability-opportunity-motivation (COM-B) behavior change framework, which has been adapted to monitor vaccine related behavior and attitudes. Data was collected from June to September 2022 through moderated discussions in focus groups. The total of 162 participants participated in 16 focus groups. Results: Among the key barriers to successful immunization identified across target groups were insufficient knowledge about vaccines, pandemic fatigue, concerns about the rapid development of the vaccine and its effectiveness, lack of confidence in the healthcare system. Some of the main drivers of vaccination against COVID-19 were confidence in science and expert recommendations. Conclusion: The COVID-19 immunization policy undergoes continuous changes, as do the pandemic prospects; we encourage further research to track the evolution of vaccine related attitudes, inform immunization policy, and create evidence-based interventions.

Purpose This study aims to propose a novel mirroring digital content marketing (MDCM) framework that extends the current consumer-based digital content marketing (DCM) framework to encompass the provider’s perspective. Relying on the stimulus–organism–response theory, the authors posit that content stimuli influence behavioural engagement responses that, respectively, mirror the motives and self-reported engagement from the consumer-based DCM. Design/methodology/approach To empirically verify the provider side of the MDCM framework, the authors used one newsletter and one matching website with corresponding 117 weekly data points. Data were drawn from three sources for six countries: newsletter content stimuli, newsletter performance indicators and Google Analytics metrics on matching website performance. OLS and panel regressions were used to analyse the data and generate results. Findings The results show that content stimuli do explain the behavioural engagement responses of consumers recorded by the provider. However, the effects of the different stimuli are inconsistent: functional stimuli have both positive and negative effects, while social stimuli positively impact the behavioural engagement response. The authors further show that the newsletter engagement response influences subsequent engagement responses across channels (e.g. via the linked news media website). Research limitations/implications Further research definitely needs to empirically verify the connection between two sides of the MDCM framework. As proposed by authors, provider-based stimuli are corresponding to the consumer-based motivations, however, which stimuli are triggering which motivations and how they can consequently be translated to both consumer- and provider-based behavioural engagement is still an open question. Different theoretical lenses could be taken in the usage of MDCM framework. Practical implications Our observations are relevant for marketers that want to use certain stimuli in their digital content, in particular a content introduced in the newsletter and the website. The authors show that stimuli are indeed related to the behavioural engagement response of consumers and that various stimuli impact engagement differently. Furthermore, the recommendations for the marketing managers of news media are to use priming across the platforms in their Web communication strategies. Originality/value This study proposes and empirically tests the provider side of the MDCM framework across two news media channels, focusing on behavioural engagement responses.

BACKGROUND: Left atrial (LA) strain analysis has emerged as a noninvasive technique for assessing LA function and early detection of myocardial deformation. Recently, its application has also shown promise in the pediatric population, spanning diverse cardiac conditions that demand accurate and sensitive diagnostic measures. OBJECTIVE: This research article endeavors to explore the role of LA strain parameters and contribute to the growing body of knowledge in pediatric cardiology, paving the way for more effective and tailored approaches to patient care. METHODS: A comprehensive literature review was conducted to gather evidence from studies using echocardiographic strain imaging techniques across pediatric populations. RESULTS: LA strain parameters exhibited greater sensitivity than conventional atrial function indicators, with early detection of diastolic dysfunction and LA remodeling in pediatric cardiomyopathy, children with multisystem inflammatory syndrome, rheumatic heart disease, as well as childhood renal insufficiency and obesity offering prognostic relevance as potential markers in these pediatric subpopulations. However, there remains a paucity of evidence concerning pediatric mitral valve pathology, justifying further exploration. CONCLUSION: LA strain analysis carries crucial clinical and prognostic implications in pediatric cardiac conditions, with reliable accuracy and sensitivity to early functional changes.

In teaching mathematics to first-year undergraduates, and thus in the appropriate calculus textbooks, the task of calculating an integral that satisfies a specific first-order or second-order recurrence relation often appears. These relations are obtained mainly by applying the method of integration by parts. Calculating such integrals is usually tedious, especially for an integer n > 2, time-consuming, and presents the possibility of making a large number of errors when computing involves multiple iterative steps. In [1], it is shown that in two cases (Theorems 2.1. and 2.3), the process of calculating integrals satisfying first-order recurrence relations can be performed quickly using easily memorised closed-form formulas for corresponding primitive functions. The question can rightly be asked whether there is a faster way to calculate other integrals of this type. In this paper, our goal is to give an affirmative answer to such a question, though without convering all situations. Since each recurrence relation is equivalent to a difference equation of the same order, the calculation of integrals mentioned above can be reduced to solving the corresponding difference equations. Since every first-order or second-order linear difference equation is solvable, it follows that for every integral which can be reduced to a first- order or second-order recurrence formula, it is possible to find corresponding primitive functions directly. Sometimes such a procedure is much faster than iterative solving of the integral. Closed-form formulas for the integrals discussed in the following sections are not unknown (see [2]). However, here our goal is to present the idea of computing indefinite integrals using difference equations. We will discuss it in more detail in Section 2. In Section 3, we discuss the application of the results obtained to calculate several improper integrals and the application of some of them in different sciences. An exciting example of such an application is the integral , which in the case n = 1 is used in the kinetic theory of gases, particularly in the Maxwell-Boltzmann distribution of gas molecules by energies (see Remark 4). Also, we compare the formulas obtained by the method of difference equations with the formulas obtained using Wolfram Alpha software (see Remark 5).

Abstract Quality of Experience (QoE) for mobile Web browsing is a complex and multidimensional concept. So far, the research community has addressed the influence of QoE perceptual dimensions on QoE and the impact of various influence factors on QoE perceptual dimensions for mobile Web browsing. In this study, we recognize the gap and need to analyze and gain a deeper understanding of the relationship between multiple influence factors and specific constructs of QoE perceptual dimensions. Utilizing a previously collected dataset, our goal is to fill the research gap in terms of investigating the impact of specific influence factors (loading time, aesthetics, number of taps, information quality) on various constructs comprising the user perception of usability, aesthetics, and information quality in the context of mobile Web browsing. A total of 14 research questions are raised: 7 addressing constructs comprising perceived usability (simplicity, effectiveness, quickness, efficiency, comfort, ease of use, organization), 3 addressing constructs comprising perceived aesthetics (perception of mobile Web site aesthetics, pleasance, clarity, systematicness), and 4 addressing constructs comprising perceived information quality (timeliness, clarity, conciseness, structuralism/completeness/spelling-correctness). Results of posed research questions provide indications on the strength and direction of the impact of considered QoE influence factors on the perception of studied constructs. This study contributes to the research community by being the first to address the impact of chosen QoE influence factors on individual constructs comprising QoE perceptual dimensions in the domain of mobile Web browsing, thus extending the knowledge on interplays and relations in this area. Furthermore, it contributes by revealing numerous new paradigms in the context of usability, aesthetics, and quality of information, such as: (i) beautiful and easy to reach is more simple, effective, efficient, and comfortable, (ii) easy to reach is more pleasant and clear, (iii) informative is more pleasant and clear, (iv) beautifully presented information has higher perceived quality, etc. Reported findings can be utilized by various stakeholders (mobile Web site designers, content providers, device designers, network providers) for indirect management of QoE.

An exceptional microsample from the ground layer of Leonardo da Vinci's Mona Lisa was analyzed by high-angular resolution synchrotron X-ray diffraction and micro Fourier transform infrared spectroscopy, revealing a singular mixture of strongly saponified oil with high lead content and a cerussite (PbCO3)-depleted lead white pigment. The most remarkable signature in the sample is the presence of plumbonacrite (Pb5(CO3)3O(OH)2), a rare compound that is stable only in an alkaline environment. Leonardo probably endeavored to prepare a thick paint suitable for covering the wooden panel of the Mona Lisa by treating the oil with a high load of lead II oxide, PbO. The review of Leonardo's manuscripts (original and latter translation) to track the mention of PbO gives ambiguous information. Conversely, the analysis of fragments from the Last Supper confirms that not only PbO was part of Leonardo's palette, through the detection of both litharge (α-PbO) and massicot (β-PbO) but also plumbonacrite and shannonite (Pb2OCO3), the latter phase being detected for the first time in a historical painting.

Usvajanje Smjernica generalnog sekretara Ujedinjenih nacija o Reparacijama za seksualno nasilje povezano sa sukobima (2014. godine) predstavlja dodatak dotadašnjim normativnim dešavanjima u oblasti rodno osjetljivih reparacija. Uprkos ovom progresivnom normativnom napretku i dalje postoje konceptualne praznine u pravnom i politiĉkom okviru za reparacije koje se bave seksualnim nasiljem povezanim sa sukobima i, shodno tome, tekućim izazovima u sprovođenju rodno osjetljivih reparacija. Izazovi ukljuĉuju isključenje žena iz pravnih lijekova zbog pristrasnosti u stvaranju i sprovođenju režima reparacija.Transformativne reparacije se bave neposrednim reparativnim potrebama lica koja su preživjela seksualne povrede, uz uzimanje u obzir socijalnih i ekonomskih barijera punoj ravnopravnosti žena u mnogim društvima. Te reparacije prevazilaze neposrednost seksualnog nasilja, obuhvatajući jednakost, pravdu i longitudinalne potrebe onih koji su doživjeli seksualne povrede. U tu svrhu predlažu se odgovarajući principi reparacija za seksualno nasilje povezano sa sukobima. Autori u radu poseban naglasak stavljaju na aktuelne probleme zaštite prava na zdravlje i obrazovanje ţrtava seksualnog nasilja u ratu. Takođe, predstavljeni su restitucija, rehabilitacija, reparacija i resocijalizacija žrtava seksualnog nasilja u ratu u Bosni i Hercegovini (1992–1995). Pri tome se polazi od činjenice da protek vremena nije zaliječio ratne rane, uključujući dugotrajne psihičke, fizičke, ekonomske i društvene posljedice seksualnog nasilja u ratu za preživjele i njihove porodice. Mnoge žrtve još uvijek pate od traume povezane sa ratnim seksualnim nasiljem, koja ima značajne posljedice i teško se prevazilazi. Većina preţivjelih pati i od posttraumatskog stresnog poremećaja povezanog sa razliĉitim psihiĉkim stanjima. U završnom dijelu problematizuju se neka zakonska rješenja ostvarenja reparacije za žrtve seksualnog nasilja u ratu u Bosni i Hercegovini, te izlažu konkretni prijedlozi de lege ferenda.

Posmatrajući historiju razvoja maloljetniĉkog prijestupništva, vidljivo je da se ono javlja u svim zemljama bez obzira na društvena ureĊenja. Razlika, meĊutim, postoji u nizu faktora koji opredjeljuju borbu protiv maloljetniĉkog prijestupništva, od kojih je jedan od znaĉajnijih utjecaj pojedinih subjekata maloljetniĉkog pravosuĊa na odabir, trajanje i proces izvršenja reakcije, mjere ili sankcije prema maloljetnom poĉiniocu kriviĉnog djela. Sud kao poseban autoritet ima i veoma znaĉajnu ulogu pri primjeni i izvršenju kriviĉnih sankcija,mnaroĉito kriviĉnih sankcija institucionalnog tretmana. Svojim odlukama mijenja “sudbinu” i tok izvršenja izreĉenih sankcija, a samim tim i samog maloljetnika. Autorice se u ovom radu bave ulogama suda pri izvršenju sankcija institucionalnog tretmana, posebno se osvrćući na meritornu ulogu suda pri izvršenju kriviĉne sankcije - upućivanje u odgojni centar. Izvršenje ove odgojne mjere, prava i duţnosti subjekata u tom procesu te uloge sudija za maloljetnike pri individualizaciji odgojnih mjera maloljetniku, sudska individualizacija, bit će prikazani kroz konkretne primjere, analizirajući pritom studij sluĉaj iz prakse KJU „Odgojni centar Kantona Sarajevo“. Treba se naglasiti da pri sudskoj individualizaciji sankcioniranje ima kao cilj resocijalizaciju maloljetnika, što podrazumijeva multidisciplinarni pristup te adekvatnu primjenu pravnog, pedagoškog, psihološkog i socijalnog pristupa u radu sa maloljetnim prijestupnicima.

Anksioznost je neizbjeţna u svakodnevnom ţivotu te predstavlja automatski odgovor ĉovjeka na doţivljaj opasnosti. TakoĊer, problemi i simptomi vezani uz anksioznost sastavni su dio sazrijevanja te predstavljaju adaptivne odgovore koji ĉuvaju od opasnih situacija i djeluju motivacijski. Anksioznost postaje problem za osobu onda kada prestane djelovati motivirajuće i zaštitniĉki. Cilj rada je ispitati prisustvo aksioznosti kod uĉenika zavšnih razreda osnovne škole. U radu se pošlo od pretpostavke da je aknsioznost prisutna kod uĉenika završnih razreda u razliĉitim podruĉjima. Uzorak ispitanika ĉinilo je 120 uĉenika završnih razreda osnovne škole na podruĉju Tuzlanskog kantona. Istraţivanje je sprovedeno u februaru 2023. godine. Mjerni instrument korišten u istraţivanju je Skala djeĉje anksioznosti autorice Purić (1992; prema Zaić, 2005) namijenjena je ispitivanju anksioznosti djece školske dobi. Podaci su obraĊeni metodama deskriptivne statistike. Rezultati istraţivanja upućuju na prisustvo anksioznosti na tri podruĉja: ispitnu, socijalnu i opštu aksioznost u razliĉitom intenzitetu. Najveći intenzitet je zabiljeţen u podruĉju ispitne anksioznosti.