In order to promote traffic safety, and specifically in the prevention of accidents on the roads, modern standards and procedures require the construction, constant monitoring and updating the database of geospatial data of importance for the spatial and temporal distribution, an analysis of the traffic accidents causes and consequences and the creation of an appropriate response to the traffic risk arising from road’s factor as a geospatial entity. One of the possibilities for meeting the said requirements is the use of GPS technology. Constant monitoring and topographic inventory of changes in the domain of exploitation and technical roads features on the digital geotopographic materials in some of the GIS environment is one of the requirements, standards and procedures for the traffic risk management, but also for creation of a part of the national infrastructure of geospatial data on the principle of interoperability. This paper presents the characteristics of GPS device GeoExplorer® 2008, produced by U.S. Company Trimble, which integrates GPS receiver and a portable computer with the Windows Mobile operating system, and thus represents a functional, light, portable and durable device for field work, with the range of applications for geospatial data mapping and updating in a various and primarily in mobile GIS applications. GIS is a set of software tools, which enable the analysis of different types of data associated with geographic maps. Data on current road conditions and technical traffic control collected by mentioned device shall form the basis for filling in a database in dedicated, stationary GIS applications as a support system part for the traffic safety management.

This paper is occupied with the improvement of three main functions of the preview of information from database in a table form: storage of changes or new entry in the table, delete of records from the table and sorting of information by clicking on the heading of column in the table information review. These improvements were obtained by occurrence coding connected t DBGrid. The accomplishment of these functions is regulated by the way that users of Windows applications accepted it as usual in that businesses, so the regulations of these applications which are programmed in Delphi improved its quality. Very important attribute of this paper is that the coding of algorithms have been done for using its procedures without a change, what creates the modularity of the source code.

IntroductionWe hypothesised that breast cancer risk for relatives of women with early-onset breast cancer could be predicted by tumour morphological features.MethodsWe studied female first-degree relatives of a population-based sample of 452 index cases with a first primary invasive breast cancer diagnosed before the age of 40 years. For the index cases, a standardised tumour morphology review had been conducted for all; estrogen (ER) and progesterone receptor (PR) status was available for 401 (89%), and 77 (17%) had a high-risk mutation in a breast cancer susceptibility gene or methylation of the BRCA1 promoter region in peripheral blood DNA. We calculated standardised incidence ratios (SIR) by comparing the number of mothers and sisters with breast cancer with the number expected based on Australian incidence rates specific for age and year of birth.ResultsUsing Cox proportional hazards modelling, absence of extensive sclerosis, extensive intraductal carcinoma, absence of acinar and glandular growth patterns, and the presence of trabecular and lobular growth patterns were independent predictors with between a 1.8- and 3.1-fold increased risk for relatives (all P <0.02). Excluding index cases with known genetic predisposition or BRCA1 promoter methylation, absence of extensive sclerosis, circumscribed growth, extensive intraductal carcinoma and lobular growth pattern were independent predictors with between a 2.0- and 3.3-fold increased risk for relatives (all P <0.02). Relatives of the 128 (34%) index cases with none of these four features were at population risk (SIR = 1.03, 95% CI = 0.57 to 1.85) while relatives of the 37 (10%) index cases with two or more features were at high risk (SIR = 5.18, 95% CI = 3.22 to 8.33).ConclusionsThis wide variation in risks for relatives based on tumour characteristics could be of clinical value, help discover new breast cancer susceptibility genes and be an advance on the current clinical practice of using ER and PR as pathology-based predictors of familial and possibly genetic risks.

A male patient, aged 33, was treated at the Clinicfor Oncology, Hematology and Radiotherapy atthe University Clinical Center, Tuzla, with thediagnosis of diffuse large B-cell lymphoma. Conformalradiotherapy was conducted on the regionof the epipharynx, oropharynx and lymphnodes of the neck on both sides (1).