We define a set of pseudo-observables characterizing the properties of Higgs decays in generic extensions of the Standard Model with no new particles below the Higgs mass. The pseudo-observables can be determined from experimental data, providing a systematic generalization of the “κ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\kappa $$\end{document}-framework” so far adopted by the LHC experiments. The pseudo-observables are defined from on-shell decay amplitudes, allow for a systematic inclusion of higher-order QED and QCD corrections, and can be computed in any Effective Field Theory (EFT) approach to Higgs physics. We analyze the reduction of the number of independent pseudo-observables following from the hypotheses of lepton universality, CP invariance, custodial symmetry, and linearly realized electroweak symmetry breaking. We outline the importance of kinematical studies of h→4ℓ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$h\rightarrow 4\ell $$\end{document} decays for the extraction of such parameters and present their predictions in the linear EFT framework.

Secondary angiosarcoma of the breast is a rare, but well-described complication of radiation therapy for primary breast carcinoma. Currently, it appears refractory to most systemic chemotherapy though rare responses to taxanes exist (1,2). Overall, patient prognosis is poor (3). A 78-year-old female underwent left breast conservation and axillary node dissection in 1999 for invasive ductal carcinoma followed by whole breast radiation therapy. Eleven years later, she noted multiple small nodules in the medial aspect of the left breast. Biopsy of the nodules revealed angiosarcoma of the breast. A metastatic follow-up showed no evidence of distant disease and a modified radical mastectomy performed. Histopathology confirmed the presence of angiosarcoma with all margins negative. The patient completed a course of postmastectomy irradiation with dose limitation by previous radiation for her original breast conserving procedure. This was administered concurrently with adjuvant chemotherapy (Taxol and Adriamycin). The patient did not tolerate the chemotherapy but finished the course of radiation therapy. Ten months later, angiosarcoma nodules recurred along the mastectomy scar. Chemotherapy with single agent carboplatinum was ineffective. Six months later, she underwent a wide resection of the skin and soft tissue of the left chest wall with multiple cutaneous nodules and positive deep margin (the pectoral muscle/ribs) was noted. In the interim, she underwent a split thickness skin graft to cover the large defect. Within 6 months, recurrent disease appeared in the graft and surrounding soft tissue. With no documented distant metastases, the patient again underwent a resection of recurrent tumors, chest wall and two ribs requiring TRAM flap coverage. A Caris profile was requested. She remained free of local recurrence for only 4 months, when multiple and rapidly growing subcutaneous nodules became evident about the chest wall and flap (Fig. 1A). The Caris gene expression assay performed earlier demonstrated a potential therapeutic benefit of sunitinib due to the upregulation of VEGFR2. Sunitinib was then

Abstract Background: Competition in the banking industry has been an important topic in the scientific literature as researchers tried to assess the level of competition in the banking sector. Objectives: This paper has an aim to investigate the market structure and a long term equilibrium of the banking market in Bosnia and Herzegovina nationwide as well as on its constitutional entities as well as to evaluate the monopoly power of banks during the years 2008-2012. Methods/Approach: The paper is examining the market structure using the most frequently applied measures of concentration k-bank concentration ratio (CRk) and Herfindahl-Hirschman Index (HHI) as well as evaluating the monopoly power of banks by employing Panzar-Rosse “H-statistic”. Results: The empirical results using CRk and HHI show that Bosnia and Herzegovina banking market has a moderately concentrated market with a concentration decreasing trend. The Panzar-Rosse “H-statistic” suggests that banks in Bosnia and Herzegovina operate under monopoly or monopolistic competition depending on the market segment. Conclusions: Banks operating on the banking market in Bosnia and Herzegovina seem to be earning their total and interest revenues under monopoly or perfectly collusive oligopoly.

Dear Editor, With the number of percutaneous coronary interventions (PCIs) on the rise, it is expected that there will be a corresponding growth in population of patients with prior PCI referred to coronary artery bypass grafting (CABG) as a result of long-term PCI failure, incomplete revascularization, or coronary artery disease progression. The prevalent position of the interventional cardiologists of: ‘‘subsequent CABG may be successfully performed in any patient with a history of previous PCI’’ is now being seriously challenged. Furthermore, results of several studies that investigated the impact of previous PCI on subsequent CABG were found to be conflicting. For this reason, we read with great interest the article by Niclauss et al. regarding the influence of prior PCI on subsequent CABG. There are only a few studies reporting onmidor long-term results following surgical revascularization in patients with prior PCI, and from that point of view the article by Niclauss et al. is indeed a very fine contribution. This study produced another very important conclusion—there is no difference in terms of mortality depending on prior PCI status. However, a cautionary warning was identified in that particular study: the proportion of patients who underwent isolated percutaneous transluminal angioplasty (PTCA)—20% in PCI prior CABG group—looks to be far too big for contemporary clinical practice in our view. Having in mind different pathophysiological mechanisms responsible for PTCA and PCI failure, we believe that such a large number of patientsmight, in fact, skew the results of the study. We, therefore, think that excluding the subgroup of patients would yield results that would be more representative of a contemporary practice. In Table 1, it is indicated that a proportion of patients with prior myocardial infarction (MI) is very similar between the groups (40% vs. 44%, p1⁄4 0.07). Does this mean that the patients with MI were not treated with PCI in large number? The report did not appear to indicate the number of patients having previous MI treated with PCI that were subsequently referred to CABG. For the purpose of analysis, it would be useful to see in what percentage was the artery, already treated with stent, revascularized surgically. Another factor worthy of attention is the number of multiple PCIs and its influence on CABG. Based on our clinical practice, we know that cardiologists are likely to be very persistent in their attempts to percutaneously revascularize the artery. Table 2 of Niclauss et al. paper counts 22.3% (89) prior-PCI patients taking clopidogrel which seems quite low. We seek explanation about how long the patients took the drug following PCI. Again, 77.7% of patients with previous PCI were merged with those not submitted to PCI when the impact of active double anti-platelet therapy was investigated. We believe that conclusions would be more accurate (meaningful) if only the original groups were considered. Careful decision-making in the setting of multivessel disease is mandatory. Obviously, many risk factors (patient related, procedure related, drug related, coronary artery anatomy, and pathology) may influence the success or failure of specific procedures, thus emphasizing the need for adequate patient selection according to corresponding procedure type. In order to gain meaningful insight about the relation between PCI and subsequent CABG, more contemporary studies including a larger proportion of patients treated with drug eluting stents and/or biodegradable stents are highly warranted. Conflict of interest: The authors acknowledge no conflict of interest in the submission.