AIM To investigate effects of post-sampling analysis time, a type of blood samples and collection tubes on blood gas testing. METHODS This study included 100 patients at the Clinic for Pulmonary Diseases, Clinical Centre Sarajevo. The partial pressure of oxygen (pO2) and carbon dioxide (pCO2), and the oxygen saturation level of hemoglobin (sO2) were analyzed in the arterial blood samples (ABS) and capillary blood samples (CBS) by a potentiometric method using a blood gas analyzer ABL 555 (Radiometer, Copenhagen, Denmark). Paired measurements of ABS were performed within 15 minutes and after 60 minutes from sampling and compared. The results of CBS obtained within 15 minutes were compared with matching ABS results, as well as the results obtained from CBS within 15 minutes taken into glass and plastic tubes. RESULTS pO2 and sO2 values were significantly lower after 60 minutes compared to those within 15 minutes in ABS (9.20±1.89 vs. 9.51±1.95 and 91.25±5.03 vs. 92.40±4.5; p<0.01, respectively). Values of pO2 and sO2 in CBS were significantly lower than values obtained in ABS (8.92±2.07 vs. 9.51±1.95 and 91.25±4.86 vs. 92.40±4.50; p<0.01, respectively). Obtained pO2 and sO2 values in CBS in the plastic tubes were higher than those in the glass tubes (8.50±1.98 vs. 7.89±2.0 and 89.66±11.04 vs. 88.23±11.22, p<0.01 respectively). pCO2 blood values were not influenced significantly (p>0.05). CONCLUSION The length of post-sampling analysis time, a type of blood samples and collection tubes have significant impact on blood oxygen parameters. Analysis within 15 minutes after blood sampling is considered as appropriate.

Purpose There is a critical need for population-based prospective cohort studies because they follow individuals before the onset of disease, allowing for studies that can identify biomarkers and disease-modifying effects, and thereby contributing to systems epidemiology. Participants This paper describes the design and baseline characteristics of an intensively examined subpopulation of the LifeLines cohort in the Netherlands. In this unique subcohort, LifeLines DEEP, we included 1539 participants aged 18 years and older. Findings to date We collected additional blood (n=1387), exhaled air (n=1425) and faecal samples (n=1248), and elicited responses to gastrointestinal health questionnaires (n=1176) for analysis of the genome, epigenome, transcriptome, microbiome, metabolome and other biological levels. Here, we provide an overview of the different data layers in LifeLines DEEP and present baseline characteristics of the study population including food intake and quality of life. We also describe how the LifeLines DEEP cohort allows for the detailed investigation of genetic, genomic and metabolic variation for a wide range of phenotypic outcomes. Finally, we examine the determinants of gastrointestinal health, an area of particular interest to us that can be addressed by LifeLines DEEP. Future plans We have established a cohort of which multiple data levels allow for the integrative analysis of populations for translation of this information into biomarkers for disease, and which will offer new insights into disease mechanisms and prevention.

AIM To analyse clinical, laboratory and epidemiological characteristics of brucellosis in children in Bosnia and Herzegovina. METHODS The study included 246 children aged 0-18 years, who were hospitalized in Clinics and Departments for Infectious Diseases in Tuzla, Sarajevo, Banja Luka, Zenica and Bihać in the period 2000-2013, in whom the diagnosis of brucellosis was established based on anamnestic data, clinical features and positive results from blood culture and/or positive results from one of the serological tests. RESULTS In this period, a total of 2630 patients, 246 (9.35%) of whom were children, were treated from brucellosis at the Clinics and Departments in Bosnia and Herzegovina. In the majority of cases, the children were from rural parts of the country, 226 (91.87%);214 (87.04%) cases had direct contact with sick animals, sick family member or consumption of unpasteurized dairy products from farms where brucellosis had been already established. Male children predominated, 157 (63.82%). The most frequent clinical features in affected children were fever, 194 (78.86%) and joint pain, 158 (64.22%). The average duration of antimicrobial treatment was 42.85 ± 10.67 days. A total of 228 (92.68%) children were completely cured, while relapses occurred in 18 (7.32%) children. CONCLUSION Since brucellosis is an endemic disease in Bosnia and Herzegovina, it is important that physicians in their daily practice consider brucellosis and establish proper diagnosis and therapy in children with prolonged fever, arthralgia, leukopenia and positive epidemiological data, especially in rural parts of the country.

Aim: The aim of this study is to present the first total number of tested children in the Federation of Bosnia and Herzegovina and the number of children with positive sweat test. During the study we determined the number of ill children, the median age of children with cystic fibrosis, date of initial diagnosis, an average amount of chloride in the sweat. Material and methods: The study was a retrospective, conducted at the Department of Pulmonology Pediatric Clinic of University Clinical Center of Sarajevo. Results: In the period from March 2003 to December 2014, we have tested 625 children. 351 child were from Sarajevo Canton and 272 children from other cantons. Female children were more affected then male children, in the ratio of 1: 1,105. An average age of female children was 4.19±4.26 years, and the male 2.15±3.11 years. The median concentration of chloride in the sweat measured by sweat test was for male children 103.05±21.29 mmol/L, and for the female children 96.05±28.85 mmol/L. Conclusion: Most of children in Federation of Bosnia and Herzegovina have ∆F508 gene mutation. In the post-war period we started to use a sweat test. Male children tend to live longer than female children with CF.

In this case report we describe a 49 year-old man who presented with chronic urticaria, angioedema and soft stool consistency. During diagnostic examinations Hashimoto's thyroiditis was found even though the patient never had clear symptoms of this disease. Blastocystis hominis was isolated through a stool microbiologic examination, implicating that this parasite can cause the development of Hashimoto's thyroiditis and chronic urticaria. After two-weeks treatment with metronidazole the Blastocystis hominis was eradicated, then urticaria and angioedema disappeared. During the four years of follow-up, the patient presented without any symptoms, whereas thyroid hormones were normalized and anti-thyroid antibodies declined. For the first time in the literature we show that eradication of Blastocystis hominis can prevent the development of both symptomatic Hashimoto's thyroiditis and chronic urticaria.

ACTA INFORM MED. 2015 AUG 23(4): 250-251 Received: 11 March 2015 • Accepted: 15 May 2015 © 2015 Izet Masic This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

In Prague (Czech Republic, from June 16th till June 18th 2015 was held Scientific conference “International Joint Meeting EuroMise 2015”. Scientific Conference was chaired by Pirkko Nykenen (Scientific Program Committee chair) and Scientific Symposium was chaired by Milan Tuček (Scientific Program Committee chair). Conference was held at Institute of Hygiene and Epidemiology at First Faculty of Medicine of Charles University in Prague. Symposium was held at House of Physicians in Prague. International Joint Meeting EuroMISE 2015 covered important Medical Informatics and Public Health topics methods and methodologies of collecting, capturing, processing and storing health data within the healthcare sectors at every level of Healthcare systems, especially the challenges of big data, which is today one of most important problems in Health Informatics. Conference and symposium opened many questions how to solve big data to be Figure 3. Participants of the IJM EuroMISE Course

In the period from 9 to 11 July 2015, in a luxury hotel Di-vani Palace Acropolis, in the vicinity of one of the most visited parts of Athens and Greece (Acropolis), was held scientific conference " 13 International Conference on Informatics, Management and Technology in Healthcare " (ICIMTH). This year ICIMTH represents 13 th Annual Conference in this series of scientific events, which is gathering scientists from all continents as well from the Greece from several important fields of Biomedical and Health Informatics. The Conference has a major focus on the applications of Biomedical Infor-matics starting with Clinical Informatics, Health Informatics to Public Health Informatics as well as on ICT applications in the Healthcare. Considering that, Management and Organizational Issues play an important role in the implementation phase of Biomedical Informatics into the Healthcare systems, so topics related to the above mentioned were more than welcomed. Conference covered the field of Biomed-ical Informatics in a very broad framework, including many technologies, such as Imaging, Sensors, Biomedical Equipment and Pharmacotechnology. Participants of the Conference were able to participate with presentations of full papers and posters at several scientific sessions and panels, workshops and tutorials related to the aspects of Biomedical Informatics as described in the Conference title. The major focus of the Conference was placed on the implementation of Biomedical Informatics Applications in the whole spectrum–from Clinical Informatics, Health Informatics to Public Health Infor-matics as applied in the domain of healthcare. Considering that Health management and Organization of healthcare depends of the quality of collected, processed, analyzed and in-which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Problem upotrebe zabranjenih supstanci (dopinga) u sportu je bio, jeste i bice aktuelan problem koji narusava sam duh sporta, ljepotu i zadovoljstvo, a vrlo cesto i zdravlje sportiste. Zbog toga je neophodno pristupiti rjesavanju ovoga problema, ako je moguce i trajno, mada je to nekada jednostavno neizvodljivo. U istraživanju je ucestvovalo ukupno 200 studenata Fakulteta fizickog vaspitanja i sporta, od cega 100 studenata Univerziteta u Istocnom Sarajevu (Bosna i Hercegovina) i 100 studenata AMU Aligarh PU (Indija), starosne dobi od 18-26 godina. Od ukupnog uzorka 170 (85%) su bili ispitanici muskog pola, dok je 30 (15%) ženskog pola. Osnovni cilj istraživanja je bio da se provjeri nivo znanja i utvrde stavovi studenata i utvrde njihove međusobne razlike o upotrebi zabranjenih supstanci u sportu. Za prikupljanje neophodnih informacija koriscen je anonimni anketni upitnik sa 13 jasno definisanih pitanja, (11 pitanja zatvorenog i 2 pitanja otvorenog tipa) koja su se odnosila na određena znanja, stavove o dopingu u sportu. Dobijeni su relevantni rezultati koji su globalni pokazatelj informisanosti, znanja i stavova populacije studenata fizickog vaspitanja i sporta o sve vecem problemu danasnjeg modernog sporta koga nazivamo doping. Od ukupnog uzorka, cak 85% studenata oba subuzorka su oznacili atletiku kao sport sa najvise doping afera, a zatim slijedi biciklizam (43%), bodi bilding i dizanje tegova (22%), dok su sportske igre sa (28%), Cricket (25%), Streljastvo i Sah sa (19%), kao sportovi sa najmanjim brojem doping afera.

Uprkos znacajnim teorijskim izvorima koji se odnose na lose držanje kod djece i adolescenata, a koje je izazvala promjena nacina života, saznanja o problemu abnormalne kicmene krivine treba da budu dopunjena. Može se uvidjeti sve veci broj gojazne djece i ovaj problem težine može dovesti do vece ucestalosti loseg držanja tijela. Ovaj rad ima za cilj da utvrdi ucestalost dobrog i loseg držanja tijela kod djevojcica u odnosu na njihove tjelesne težine, kao i da otkrije da li prekomjerna težina (gojaznost) daju predispoziciju za lose držanje. Istraživanje je obuhvatilo 500 djevojcica uzrasta 7-15 godina, koje žive u Szczecinu u Poljskoj. U procjeni držanja tjela, koriscena je sferosomatometrijska metoda Ivanovskog. Djevojcice sa normalnom tjelesnom težinom su predstavljale 77,7% ispitanika. U 6,7% slucajeva, identifikovana je nedovoljna tjelesna težina. 11,3% su imale  visak kilograma , dok je 4,3% djevojcica bilo gojazno - sto iznosi 15,6 % ispitanica. Nepravilno držanje tijela je identifikovano u 32,4% ispitanica. Najveci broj djevojcica sa losim držanjem tijela pronađeno je među 9-godisnjakinjama (38,6%), 13-godisnjakinjama (35.2 %) i 15-godisnjakinjama (35,1%). Prekomjerna težina i gojaznost je bila predispozicija kod ispitanica za pojavu nepravilnog držanja kicme: abnormalna kicmena krivina je pronađena u 30,8% gojaznih djevojcica i djevojcica sa prekomjernom težinom.