Contemporary forms of business in tourism impose new trends conditioned by an ever-increasing number of tourists travelling in the world today. It is an undeniable fact that tourists are increasingly demanding and that it is not a simple task to satisfy all their needs and expectations. Tourist satisfaction is an important strategic weapon on which success of a tourist destination is dependent. Customer satisfaction often results in prolonged stay in a tourist place, which is certainly dependent on a fair relationship between the service user and provider, but also on the way in which that service has been delivered. Meeting the expected level of satisfaction should be a common attitude, as the emotional reaction of the visitor is based on the difference between the expected and the delivered service. A basic indicator of customer satisfaction in tourism are revisits of a tourist destination. Guests visit many destinations several times during their lifetimes, which clearly indicates that satisfaction with time spent at a certain place leads to the intention of revisiting. On the other hand, an increasingly large share of family business in tourism, especially the accommodation sector, can be directly related to the tendency of achieving tourist satisfaction through an experience based on a direct contact with service providers. Successful hosts have already realized that their guests must not be perceived merely as numbers, but need to strive towards creating a personal relationship that would generate satisfaction. The practice of renting out accommodation in private homes and households has been present in Montenegro for decades. Moreover, that form of accommodation is numerically superior to all other kinds. The goal of this paper is to explore the satisfaction of customers with services offered on tourist destinations and to establish in what way it affects the successfulness of family business based on private accommodation facilities. Research described in this paper was conducted in the coastal town of Sutomore (Bar municipality) in the Republic of Montenegro, which has been recording a significant growth of tourist visits in the recent years. The paper demonstrates the results of survey research created according to the qualitest model, conducted on a sample of 160 tourists accommodated in private accommodation premises. The results obtained will serve to propose measures for improvement the tourism offer.

Systemic lupus erythematosus (SLE) is a disease of unknown etiology in which tissues and cells are damaged by pathogenic autoantibodies and immune complexes. About ninety percent of patients with lupus are women between the ages of 20 and 40. The disease may affect only one organ system, and it also can be a multisystem and affect the skin, joints, kidneys, lungs, nervous system, and serous membrane. In the case report is presented a 38 year old patient with severe systemic lupus erythematosus, which adequately reacted to the treatment of mycophenolate mofetil. Keywords: Systemic lupus erythematosus, the effect of therapy, mycophenolate mofetil. (Scr Med 2016:47:74-75) ( ) * + , . , / 0 1 0 2 3 4 5 4 . 4 3 . 6 . , 7 . , 8 9 : ; + 7 , 7 < = . 0 = > ? @ A B B . C B < A : + 0 1 / / / Introduction D E F G H I J K L M N M F H O E G P H I Q G R F M F S D T U V J F Q W J F H Q F H R X M Y Z [ Y R \ Y H G J R L R ] E J Y \ P J K P G J F F M H F Q Y W K H L L F Q O H W Q I Q ] H W ^ E N Q G P R ] H Y J K Q M G R Q Y G J ^ R W J H F Q Y W J I I M Y H K R I N L H _ H F ` a b J Y H G E N H O K H Y G R X L M N M F N Q G J H Y G F Q O H \ R I H Y c M F M Q L L E J Y G P H O H N O R W M K G J d H F G Q ] H R X L J X H c ^ M G K P J L W O H Y c H L W H O L E Q Y W I H Y K Q Y Q L F R ^ H K R I H J Y X H K G H W ` e D T U J F I Q Y J X H F G H W ^ E F M ^ Z f H K G J d H Q Y W K L J Y J K Q L F J ] Y F M F M Q L L E R Y G P H F [ J Y c f R J Y G F Q Y W J Y G H O Y Q L R O ] Q Y F ` g R R W [ Y R \ L H W ] H R X G P H N Q G J H Y G Q Y W G P H Q K G J d J G J H F R X P J F h P H O F J L L Y H F F Q Y W W J F H Q F H K R M O F H Q O H W H K J Z F J d H X Q K G R O F J Y G P H K P R J K H R X N P Q O I Q K R G P H O Q N E i F Q L J K E L Q G H F c b D j k l F c Q Y G J I Q L Q O J Q L F c K R O G J K R F G H O R J W F c J I I M Y R F M N N O H F Z F J d H Q ] H Y G F Q Y W I R Y R K L R Y Q L Q Y G J ^ R W J H F ` m Case report k Y n Q O K P o p p q c r s Z E H Q O Z R L W N Q G J H Y G \ Q F Q W I J G G H W G R G P H l H N Q O G I H Y G R X O P H M I Q G R L R ] E ^ H K Q M F H R X N R R O ] H Y H O Q L K R Y W J G J R Y c \ H Q [ Y H F F Q Y W N Q J Y J Y G P H f R J Y G F Q Y W I M F K L H F ` t H O I H W J K Q L P J F G R O E F P R \ H W G P Q G F P H P Q W ^ H H Y G O H Q G H W M Y W H O Q W J Q ] Y R F J F R X F H O R Y H ] Q G J d H O P H M I Q G R J W Q O G P O J G J F F J Y K H j M ] M F G o p p u Q Y W G P H G O H Q G I H Y G J Y d R L d H W L R \ Z W R F H K R O G J K R F G H O R J W F Q Y W P E W O R _ E K P L R O R v M J Y H ` w P H N Q G J H Y G W J W Y R G K P H K [ J Y X R O O H ] M L Q O K R Y G O R L F X R O Q L R Y ] H O N H O J R W R X G J I H ` w P H R ^ f H K G J d H x Y W J Y ] F F P R \ H W N Q L H F [ J Y Q Y W d J F J ^ L H I M K R M F I H I ^ O Q Y H F c \ J G P ^ M G G H O y E O Q F P R Y G P H X Q K H c N J G Z G J Y ] H W H I Q R X G P H L R \ H O L H ] Q Y W X R R G W R O F M I c Q F \ H L L Q F F E Y R d J G J F J Y G Q L R K O M O Q L f R J Y G F ` T Q ^ R O Q G R O E x Y W J Y ] F F P R \ H W F H d H O H Q Y H I J Q \ J G P G P H d Q L M H F R X H O E G P O R K E G H F p ` z { _ { p { o h L Q Y W P H I R ] L R ^ J Y z ` s ] h W L c J Y K O H Q F H W L H d H L F R X N O R G H J Y J Y G P H M O J Y H z ` s ] h o z P c W H K O H Q F H W K O H Q G J Y J Y H K L H Q O Q Y K H R X z q I L h I J Y c M O J Y Q O E N O R G H J Y N R F J G J d H S | | | V c O H W M K H W d Q L M H R X K R I N L H I H Y G K R I N R Y H Y G F c Q N R F J G J d H j b j G H F G c Q N R F J G J d H Q Y G J Z W F l b j } o p p k ~ h I L c Q Y G J Z F F l b j N R F J Z G J d H } o p p k ~ h I L ` l M O J Y ] P R F N J G Q L J  Q G J R Y c G P H N Q G J H Y G \ Q F G O H Q G H W \ J G P I H G P E L N O H W Y J F R L R Y H J Y Q W R F H R X { I ] h [ ] h W Q E c Q Y G J ^ J R G J K F Q Y W G O Q Y F X M F J R Y R X N Q K [ H W O H W ^ L R R W K H L L F ` n E K R N P H Y R L Q G H I R X H G J L J Y Q W R F H R X o p p p I ] W Q J L E \ Q F ] J d H Y R Y G P H F H d H Y G P W Q E R X P R F N J G Q L J  Q G J R Y ` l M H G R G P H L R \ d Q L M H R X O H W ^ L R R W K H L L F Q G G P H ^ H ] J Y Y J Y ] R X G O H Q G I H Y G c N M L F H G P H O Q N E \ J G P K E K L R N P R F N P Q I J W H \ Q F Y R G M F H W ` j W Z W J G J R Y Q L \ R O F H Y J Y ] R X G P H W J F H Q F H S L R \ d Q L M H J Y G P H O H W ^ L R R W K H L L F V R K K M O O H W R Y G P H G \ H Y G J H G P W Q E R X G O H Q G I H Y G ` j X G H O H F G Q ^ L J F P H W W H G H O J R O Q G J R Y J Y G P H P H I Q G R N R J H G J K F E F Z G H I c \ H W H K J W H W G R Q W I J Y J F G H O I H G P E L N O H W Y J F R L R Y H N M L F H G P H O Q N E X R O G P O H H W Q E F c Q G Q W Q J L E W R F H R X { p p p I ] N Q O H Y Z G H O Q L ` j X G H O G P H Q ^ R d H I H Y G J R Y H W c F G Q ^ J L J G E J Y O H W ^ L R R W Z L J Y H \ Q F Q K K R I N L J F P H W ` j X G H O G P H P R F N J G Q L G O H Q G I H Y G c P J ] P N O R G H J Y F d Q L M H F J Y M O J Y H r ` z ] h o z P Q Y W O H W M K H W K O H Z Q G J Y J Y H K L H Q O Q Y K H r { I L h I J Y O H I Q J Y H W ` w P H N Q G J H Y G \ Q F W J F K P Q O ] H W \ J G P O H K R I I H Y W Q G J R Y F Q ^ R M G G P H O Q N E \ J G P K R O G J K R F G H O R J W F c I E K R N P H Y R L Q G H I R X H G J L c P E W O R _ E K P L R O R Z v M J Y H c R F G H R N R O R G J K N O R G H K G J R Y Q Y W Q Y G J N L Q G H L H G G P H O Q N E ` w P H N Q G J H Y G P Q W K R I H X R O O H ] M L Q O K P H K [ M N F Q Y W Q G G P H L Q F G K R Y G O R L c J Y D H N G H I ^ H O o p { € c G P H d Q L M H R X N O R G H J Y J Y M O J Y H Q Y W K O H Q G J Y J Y H K L H Q O Q Y K H c Q F \ H L L Q F R G P H O L Q ^ R O Q G R O E N Q Z O Q I H G H O F \ H O H \ J G P J Y Y R O I Q L d Q L M H F ` Discussion w P H K Q F H R X N O H F H Y G H W N Q G J H Y G J F W J F K M F F H W J Y G H O I F R X W J Q ] Y R F J F F E F G H I J K L M N M F H O E G P H I Q G R F M F J Y Q K K R O W Q Y K H \ J G P G P H K O J G H O J Q X R O G P H W J Q ] Y R F J F Q Y W H _ G O H I H L E X Q d R O Q Z ^ L H O H F N R Y F H Q X G H O I H G P E L N O H W Y J F R L R Y H N M L F H G P H O Q N E Q Y W K R Y G J Y M R M F G P H O Q N E \ J G P I E K R N P H Y R L Q G H I R X H G J L ` D E I N Z G R I F Q Y W F J ] Y F J Y R M O K Q F H Q O H I H H G J Y ] G P H K O J G H O J Q X R O W J Q ] Y R F J F ` w P H O H Q O H  R X G P H H L H d H Y K O J G H O J Q X R O G P H K L Q F Z F J x K Q G J R Y R X F E F G H I J K L M N M F H O E G P H I Q G R F M F J Y G P H N Q G J H Y G i I Q L Q O O Q F P c Q O G P O J G J F c [ J W Y H E W J F R O W H O F c P H I Q G R L R ] J K Q L W J F R O W H O F c N R F J G J d H Q Y G J Y M K L H Q O Q Y G J ^ R W E Q Y W Q N R F J G J d H Q Y G J Z W F l b j Q Y W Q Y G J Z F F l b j Q Y G J ^ R W E ` ‚ w P H K Q F H O H N R O G J F F P R \ Y W M H G R G P H J I N R O G Q Y K H R X H Q O L E W J Q ] Y R F J F R X F E F Z G H I J K L M N M F H O E G P H I Q G R F M F c Q Y W H Q O L E Q ] ] O H F F J d H G O H Q G Z I H Y G ` Conclusion l M H G R J Y Q ^ J L J G E G R N H O X R O I [ J W Y H E ^ J R N F E c K L J Y J K Q L Z L Q ^ R Z O Q G R O E Q F F H F F I H Y G J F d H O E J I N R O G Q Y G J Y J Y W J d J W M Q L G P H O Z Q N H M G J K Q N N O R Q K P G R G P H F H N Q G J H Y G F J Y R O W H O G R Q K P J H d H L R Y ] Z G H O I O H I J F F J R Y R X G P H W J F H Q F H ` w P J F K Q F H O H N R O G N O H F H Y G H W G P H N Q G J H Y G \ P R \ Q F G O H Q G H W N O R I N G L E \ J G P Q ] Z ] O H F F J d H G P H O Q N E N M L F H W R F H F R X I H G P E L N O H W Y J F R L R Y H Q Y W P J ] P W R F H F R X I E K R N P H Y R L Q G H I R X H G J L Q Y W \ P R Q K P J H d H W K R I N L H G H L Q ^ R O Q G R O E Q Y W K L J Y J K Q L O H I J F F J R Y R X G P H W J F H Q F H ` Reference { ` t Q O J F F R Y R d Q Y Q H L Q J Y G H O Y H I H W J K J Y H ` { € ` k  W Q Y f H ` U M ] H Y H ƒ O Q Q M Y d Q L W S H G Q L V Z ƒ H R ] O Q W i ƒ Q O W „ x Y … ƒ Q Y Z f Q T M [ Q i † R I Q Y R d o p p z ‡ Y f J ] Q o ` r { { i { q o o o ` D K P M O ˆ t ` ‰ \ H O d J H d R X K L J Y J K Q L I Q Y J X H F G Q G J R Y F R X G P H F E F G H I J K L M N M F H O J G H I Q G R W M F J Y Q W M L G F ` l R F G M N Y R Y Q \ \ \ ` M N G R W Q G H ` K R I ` r ` j M F G J Y t j c ƒ Q L R \ Š U i b Q G M O Q L P J F G R O E Q Y W G O H Q G Z I H Y G R X L M N M F Y H N P O J G J F ` D H I J Y b H N P O R L { q i o c { q q q ` ˆ n J W i q q € o o u  z ` U ] Y H O ‹ ` w P H M F H L Q ^ R O Q G R O E G H F G H F J Y G P H W J Q ] Y R F J F R X D U T ` Š Œ L J Y ˆ Q G P R L o p p p … € r i z o z Z r o `  Ž Ž  + 2 2 (  . ( ) * . ) 5 ‘ 2 , . , , ’ 7 2 “ ”  . 0 ’ . 7 . 8 = 8 • – * ( + , — , , 1 — — • – > * ( + • – > , 1 ’ , = ’ Odgovor na terapiju mikofenolat mofetilom kod pacijentice sa teškim oblikom sistemskog eritemskog lupusa SAŽETAK Sistemski eritemski lupus (SEL) je bolest nepoznate etiologije u kojoj su tkiva i ćelije oštećeni patogenim autoantitijelima i imunskim kompleksima. 90% oboljelih su žene, a starosna dob u kojoj najčešće oboljevaju je između 20. i 40. godine života. Bolest može zahvatiti samo jedan organski sistem, a može biti i višesistemska i zahvatiti kožu, zglobove, bubrege, pluća, nervni sistem i serozne membrane. U radu je prikazan slučaj 38-ogodišnje pacijentice sa teškim oblikom sistemskog eritemskog lupusa, koji je adekvatno odreagovao na terapiju mikofenolat mofetilom. Ključne riječi: Sistemski eritemski lupus, efekat terapije, mikofenolat mofetil 75 LJ. BOŽIĆ-MAJSTOROVIĆ, B. GAŠIĆ, D. JOVIĆ, M. VUKČEVIĆ, J. AĆIMOVIĆ

Background: Advanced paternal and/or maternal age is a classic risk factor for Down syndrome. The aim of the study was to investigate the frequency of Down syndrome types in children and its association with maternal and paternal age in Bosnia and Herzegovina. Subjects and Methods: The cross sectional, observational study included 127 children, 49 girls and 78 boys, aged 1-180 months suspected to have Down syndrome, admitted to the Centre for Genetics, Faculty of Medicine University of Sarajevo, for cytogenetic analysis and differential diagnosis of Down syndrome during the period from January 2010 to May 2015. Standard method of 72 hours cultivation of peripheral blood lymphocytes has been applied. The accepted level of statistical significance was p<0.05. Study Results: The most common type of Down syndrome was standard trisomy (86.6%), comparing to translocation and mosaicism (7.1%; 6.3%, respectively). The highest frequency of Down syndrome cases was in mother and father’s group from 30-39 years old (57; 57 children, respectively) compared to mother and father’s groups with younger than 30 (44; 29, respectively) and 40 and older (26; 41, respectively). The significant difference was found in maternal age between translocation and mosaicism groups (p=0.036). Difference between parental years and type of Down syndrome was significant when Standard trisomy 21 and translocation (p=0.045), as well as mosaicism and translocation (p=0.036), were compared. Conclusion: The most common type of Down syndrome was standard trisomy 21, with highest occurrence in parents from 30 to 39 years old. Parents were the youngest in translocation group. Obtained results suggest that multidisciplinary approach to identifying the trigger for trisomy appearance and the influence of maternal age is required.

Introduction: Glaucoma is the second leading cause of blindness in the world and represents a significant social and health problem. Early detection of glaucoma enables early initiation of treatment and may delay disease progression. The aim of this work is to determine whether it is possible to detect glaucoma in early stages. Methods: A public awareness campaign was carried out in University Clinic Center (UCC) in Tuzla, Bosnia and Herzegovina (B&H) during 2012, 2013, 2014 and 2015 Glaucoma Week, with one-day, free of charge screening of individuals. This screening program was composed of getting brief medical history, slit-lamp examination including intraocular pressure and anterior chamber dept evaluation and non-mydriatic fundus exam with evaluation of the cup/disk ration. Results: A total of 682 individuals were screened, 277 were male and 405 were female. The youngest individual was 8 years old and the oldest individual was 84 years old. The mean age was 57.6 years. Intraocular pressure higher then 21,9 mmHg was found in 83 patients. Conclusion: Glaucoma is a disease that affects visual acuity and gradually leads to blindness. It occurs in all age groups in both sexes and in all races. Early detection of disease and proper treatment can prevent permanent loss of vision. Detection and early treatment of glaucoma must become one of the leading public health programs in B&H.

Objectives: The association of inflammatory reactions with almost all types of cancer supports the concept that inflammation is a critical component of tumor progression. The present study aimed to evaluate the relationship of serum markers of chronic inflammation with the stage of and histopathological size of colorectal carcinoma (CRC). Methods: This cross-sectional study included 90 patients of both sexes, mean age 66.2 (range 47-78) years, with clinically and histologically confirmed CRC, who were admitted to the Clinic for abdominal surgery UCCS for surgical treatment of CRC. The patients according to the stage of disease were divided into three groups (stage II–IV). The control group consisted of 30 subjects with no signs of malignancy and acute inflammatory diseases. Staging of CRC was done according to the TNM classification. In each patient, the preoperative blood samples were taken for determination of the parameters of inflammation: the erythrocyte sedimentation rate, white blood cells, C-reactive protein (CRP), fibrinogen and alpha 2 globulins. Results: It was confirmed that increasing markers of inflammation followed increasing stages of colorectal cancer, depth of tumor invasion and the occurrence of metastatic disease. CRP is a biomarker that consistently and significantly increases from the second to the fourth stage of colorectal cancer (7.2 (2.3-14.6) mg/L vs. 21.85 (12.3-41) mg/L vs. 38.6 (21.5-79) mg/L; p<0.01) and significantly correlates positively with the stage of CRC (r= 0.783, p<0.001), and the tumor size (r=0.249, p<0.05). Conclusion: The study results point to an increase in the degree of chronic inflammation throughout the progression of colorectal cancer. The most consistent marker of chronic inflammation that accompanies the progression of colorectal carcinoma is CRP.

Este artigo discute a producao das culturas infantis a partir das experiencias de meninos e meninas, de 3 a 5 anos de idade, com a linguagem das historias em quadrinhos (HQs), tendo como foco as relacoes de genero. Reconhece as HQs como uma das producoes midiaticas que interfere nos modos de viver das criancas, muitas vezes reforcando estereotipos fundados nas diferencas sexuais. Assim, em uma interlocucao com a filosofia, sociologia, sociologia da infância, pedagogia da infância e arte, problematiza como as criancas se apropriam dos quadrinhos, o que deles reproduzem, inventam ou reinventam. Trata-se de um estudo de caso realizado em uma pre-escola municipal localizada na regiao do Grande ABC Paulista, que teve como procedimentos metodologicos: a observacao e registro de campo, os relatos orais das criancas, a analise dos documentos oficiais da Rede Municipal de Educacao e da pre-escola, entrevista com quadrinhista e a analise das HQs produzidas pelas criancas. Defende que meninos e meninas participam de maneira ativa na sociedade da qual fazem parte, portanto, nao so reproduzem a cultura do mundo adulto, mas ao se apropriarem coletiva e criativamente desta produzem as culturas infantis. Demonstra serem as HQs parte da cultura material da infância, que se constituem em suportes para aspectos simbolicos das culturas infantis, que as criancas compartilham entre si e com os adultos e as adultas, onde se observam padroes e valores identitarios sendo negociados; isso revela que elas nao so reproduzem estereotipos da cultura heteronormativa, mas transgridem as fronteiras de genero. Nesse sentido, aponta para o desafio de trazer as criancas para o debate acerca da relacao “infâncias, midia e genero”, na perspectiva de (re)conhecer como elas fruem, produzem e vao alem das imagens midiaticas. “Girls don´t draw cars… but there are girls who do it”: child cultures, gender and comics Abstract This article discusses child culture-oriented productions based on the experience of boys and girls aged 3-5 with the language found in comics, focusing on gender relations. The article views comics as one of the media products which can be related to child behavior, from the perspective of sexual differentiated stereotypes. It also examines an association with philosophy, sociology, sociology of childhood, early childhood pedagogy and art, in a sense which casts light on how children interact with comics.  It shows a case study conducted at kindergarten, in the Greater ABC region, which had methodological procedures: the field observation and recordings; the oral reports of children; analysis of the official documents of the Municipal Administration of Education and the documents of preschool; an interview with a comic artist, and analysis of comics produced by children.  It supports that boys and girls actively take part in their societies. In fact, not only do they reproduce the adult world culture, but also produce child cultures. It demonstrates that comics are part and parcel of childhood as a symbolic resource to be shared among adults and children. It points out that identity patterns and values are in the spotlight, suggesting that gender boundaries are to be redrawn. In sum, the article prompts further reflections on childhood, the media and gender. Keywords : Childhood. Gender. Media. “Las ninas no dibujan coches… pero hay ninas que los dibujan”: culturas infantiles, relaciones de genero e historietas Resumen Este articulo discute la produccion de las culturas infantiles a partir de las experiencias de ninos y ninas de 3 a 5 anos de edad con el lenguaje de las historietas (comics), teniendo como foco las relaciones de genero. Reconoce las historietas como una de las producciones mediaticas que interfiere en la manera de vivir de los ninos, muchas veces reforzando estereotipos fundados en las diferencias sexuales. De esta manera, en una interlocucion con la filosofia, sociologia, sociologia de la infancia, pedagogia de la infancia y el arte, problematiza como los ninos, se apropian de las historietas, lo que de ellas reproducen, inventan o reinventan. Se trata de un estudio de caso realizado en un kindergarten municipal ubicado en la region del Grande ABC Paulista, que tenian los procedimientos metodologicos: la observacion y el campo de registro; los informes orales de los ninos; el analisis de los documentos oficiales de la Red de Educacion Municipal y preescolar; entrevista con el comic; y el analisis de los comics producidos por los ninos. Defiende que los ninos y ninas participan de manera activa en la sociedad de la cual hacen parte, por lo tanto no solo reproducen la cultura del mundo adulto, pero al apropiarse colectiva e individualmente de esta producen las culturas infantiles. Demuestra que las historietas son parte de la cultura material de la infancia, que se constituye en soportes para aspectos simbolicos de las culturas infantiles, que los ninos comparten entre si y con los adultos, donde se observan patrones y valores de identidad siendo negociados; eso revela que ellas no solo reproducen estereotipos de la cultura normativa heterosexual, pero infringen las fronteras de genero. En ese sentido, apunta para el desafio de traer los ninos para el debate acerca de la relacion “infancias, media y genero”, en la perspectiva de (re)conocer como ellas disfrutan, producen y van mas alla de las imagenes mediaticas. Palabras claves: Infancia. Relaciones de Genero. Media.

M. Oruč, University of Zenica, Zenica, B and H; J. Duraković, S. Muhamedagić, University of Zenica, Faculty of Metallurgy and Materials Science, Zenica, B and H; B. Fakić, M. Rimac, University of Zenica, Metallurgical Institute „Kemal Kapetanović“, Zenica, B and H In this paper is given the research conducted at the specified quality screws which had different mechanical properties after completion of the same heat treatment. Results of chemical and metallographic analysis and hardness tests indicated the deficiencies that can be corrected in the course of production and thermal processing of finished products screws.