Imuna trombocitopenija izazvana lekovima (ITIL) nastaje kao posledica destrukcije ili neadekvatne aktivacije trombocita usled dejstva imunog sistema provociranog trenutnim ili pređasnjim prisustvom leka u organizmu. Incidencija ITIL-a je oko 10 slucajeva na 1,000,000 stanovnika tokom jedne godine. Postoje cetiri osnovna mehanizma nastanka ITIL-a: (1) vezivanje antitela zavisnih od lekova za trombocite; (2) blokada vezivanja fibrinogena za glikoproteinske IIb-IIIa receptore; (3) stvaranje autoantitela protiv trombocita koja nisu zavisna od prisustva leka; i (4) stvaranje imunih kompleksa lekova sa antitelima, sto dalje dovodi do aktivacije trombocita i nastanka tromboza. Kod svih oblika imune trombocitopenije izazvane lekovima najvažnije je po utvrđivanju smanjenog broja trombocita sto pre posumnjati da je uzrocnik određeni lek. Kljucni momenat u terapiji je prekid dalje primene leka-uzrocnika, dok se transfuzija trombocita daje samo u slucaju ekstremnog pada njihovog broja u krvi. Heparinom-indukovana trombocitopenije je izuzetak, jer zahteva i lecenje tromboza pomocu direktnih inhibitora trombina.

Imuna trombocitopenija izazvana lekovima (ITIL) nastaje kao posledica destrukcije ili neadekvatne aktivacije trombocita usled dejstva imunog sistema provociranog trenutnim ili pređasnjim prisustvom leka u organizmu. Incidencija ITIL-a je oko 10 slucajeva na 1,000,000 stanovnika tokom jedne godine. Postoje cetiri osnovna mehanizma nastanka ITIL-a: (1) vezivanje antitela zavisnih od lekova za trombocite; (2) blokada vezivanja fibrinogena za glikoproteinske IIb-IIIa receptore; (3) stvaranje autoantitela protiv trombocita koja nisu zavisna od prisustva leka; i (4) stvaranje imunih kompleksa lekova sa antitelima, sto dalje dovodi do aktivacije trombocita i nastanka tromboza. Kod svih oblika imune trombocitopenije izazvane lekovima najvažnije je po utvrđivanju smanjenog broja trombocita sto pre posumnjati da je uzrocnik određeni lek. Kljucni momenat u terapiji je prekid dalje primene leka-uzrocnika, dok se transfuzija trombocita daje samo u slucaju ekstremnog pada njihovog broja u krvi. Heparinom-indukovana trombocitopenije je izuzetak, jer zahteva i lecenje tromboza pomocu direktnih inhibitora trombina.

Young people, according to UN defiiniciji, represent the future of every society and they are the most profitable long-term investmentEach year, approximately 1 million teenage girls become pregnant in the world, and every 67 seconds a baby teenager In the adolescent period a large number of young people start with alcohol, coffee, psychotropic substances and smoking. The reasons are most often the desire to prove, identification, affirmation sekusalnog identity, curiosity for the new and unknown. The aim of the study was to examine the knowledge, attitudes and knowledge of adolescents about the use of psychoactive substances, alcohol and tobacco, as well as to identify ways in which young people use their free time.  The survey was conducted in April 2015, in primary and Secondary School in Foca. The survey included 212 respondents, of different genders and different age groups. Data were collected original survey questionnaire, anonymous character, which contains 14 questions. Both groups of patients in a large percentage stated that they did not try psychoactive substances, as the most common reason for drug use both cited as the main reason for the influence of society. Although sexual activity is still taboo in the RS, alarming data that 19% of ninth grade students sexually active, and to limit entry into sexual relations increasingly lowered. Young in primary and secondary school state that they are sufficiently informed of psychoactive substances, as the most frequent source of information for high school state TV and the Internet, and ninth grade students report that they are parents. In this time of adventure and immature display of defiance social and social norms, young people are very vulnerable group subject to acceptance of various forms of risk behavior.

Conductive atomic force microscopy was used to etch through SiOx resistance switching devices to produce three-dimensional renderings of conductive filaments.

Bosnia and Herzegovina has been lacking the collective political power to address the reforms that were necessary for progress towards EU over the years. The B&H politicians could not agree upon any effective coordination mechanism on EU issues. The lack of coordination mechanism has negatively affected the country’s interaction with the EU. Beside the coordination mechanism the other political issues could not be resolved. The EU Commission intensively facilitated resolution of the Sejdic-Finci ruling of the European Court of Human Rights that B&H has to implement, but without any success. The political actors have also been unable to agree upon countrywide strategy required for Instrument for Pre-Accession Assistance, in sectors, such as: agriculture, energy, transport and environment. These negative developments led to a substantial reduction of funding in these areas. Political disagreements have caused economic stagnation on moving towards European standards. In February 2014, widespread, citizen-led protests have occurred. These protests have underlined the fragility of the socio-economic situation. The EU Commission has launched a New Approach for B&H towards EU aiming to shift the focus towards economic reforms and issues of direct concern to citizens. This included development of a ‘Compact for Growth and Jobs’. The Compact is supposed to be the yardstick for the necessary economic reforms. In this paper we will explain the importance of the New Approach for B&H, as well as what ‘Compact for Growth and Job’ brings to B&H.

The paper presents a research into the use of collocations by B1, B2 and C1 level students of English at the University of Zenica conducted by analysing student's examination papers. Collocations represent an important segment of the knowledge of a foreign language and its vocabulary. They appear in many different forms and learning them might be seen as the most difficult task of L2 learning. Difficulties in using collocations appear even at advanced levels of language learning. A preliminary study into the use of collocations by B2 level students of English showed that the students used proper lexical collocations in about 60% and proper grammatical collocations in about 50% of the cases. In view of those results, a research was conducted among B1, B2 and C1 level students of English at the English Department of the University of Zenica to investigate their use of collocations. Student translations were analysed with a focus on the different types of collocations. The translations were produced as a part of their final examination in the Contemporary English courses 1 through 8 corresponding to the different CEFR levels analysed. We assumed that the results of the students in all four years of the English studies would be consistent with the results of the preliminary study, and that there would be no significant difference between the use of grammatical and lexical collocations.