Considering the escalating global prevalence and the huge therapeutic demand for the treatment of hypertension, there is a persistent need to identify novel target sites for vasodilator action. This study aimed to investigate the role of TRPA1 channels in carvacrol-induced vasodilation and to design novel compounds based on carvacrol structure with improved activities. In an isolated tissue bath experiment, it was shown that 1 µM of the selective TRPA1 antagonist A967079 significantly (p < 0.001) reduced vasodilation induced by 3 mM of carvacrol. A reliable 3D-QSAR model with good statistical parameters was created (R2 = 0.83; Q2 = 0.59 and Rpred2 = 0.84) using 29 TRPA1 agonists. Obtained results from this model were used for the design of novel TRPA1 activators, and to predict their activity against TRPA1. Predicted pEC50 activities of these molecules range between 4.996 to 5.235 compared to experimental pEC50 of 4.77 for carvacrol. Molecular docking studies showed that designed molecules interact with similar amino acid residues of the TRPA1 channel as carvacrol, with eight compounds showing lower binding energies. In conclusion, carvacrol-induced vasodilation is partly mediated by the activation of TRPA1 channels. Combining different in silico approaches pointed out that the molecule D27 (2-[2-(hydroxymethyl)-4-methylphenyl]acetamide) is the best candidate for further synthesis and experimental evaluation in in vitro conditions.

The tendency to abolish, to obtain heat from coal in order to reduce atmospheric pollution, leads to the closure of coal deposits. The alternative for obtaining heat, especially in the category of heating smaller residential buildings, with wood pellets, although acceptable from an ecological point of view, has its drawbacks, if one takes into account the scale of the required amount of energy and the role of the forest in purifying the air. Wood pulp and coal as basic energy carriers have hydrocarbon compounds. So, in both cases COx and NOx gases appear as gaseous products. The difference is in their scale. Unlike wood, coal also contains sulfur compounds, which makes it an environmentally unacceptable fuel. By adding a certain amount of wood pulp and additives to the coal mass, in this work, pyrophyllite shale, the impact on the energy and ecological aspects of heat release of such a complex fuel mixture was investigated. The ecological aspect is accentuated through the release of sulfur from coal. The mixture was subjected to the briquetting process, and the obtained samples were tested with relevant parameters, primarily the obtained lower heat value and sulfur content (SOx) in these products. The obtained results are very optimistic with both parameters mentioned above and can be a guide for further research for this idea. Key words: coal, wood sawdust, briquette, calorific value, sulfur, ecology.

Thermal insulation materials play a vital role in minimising energy loss in building operation and also affect the amount of greenhouse gas emissions associated with heating and cooling. In this context, it is becoming an increasingly important milestone to find suitable thermal insulation materials that not only meet the technical requirements but also minimise their environmental impact. The trend towards the use of eco-friendly materials for thermal insulation reflects the construction industry’s desire to contribute to environmental protection and the transition to more sustainable models of building construction and renovation. For more than 20 years, a number of research teams have been investigating the possibility of replacing synthetically produced materials such as mineral wool and polystyrene foam with natural fibre-based insulation materials. These alternatives include wood as a traditional, easily renewable raw material. This, together with the low energy intensity of processing and manufacturing wood materials, contributes to its low carbon footprint. Compared to traditional synthetic insulation materials, which are often energy intensive to produce, wood is a more environmentally friendly choice. However, with many European countries now facing a potential shortage of higher quality wood, it is necessary to look for alternative sources of wood, including in the field of thermal insulation materials, materials with a lower carbon footprint that can be produced from lower quality wood or from wood waste that would otherwise only have an energy use. The paper is devoted to the study and use of suitable wood waste and secondary raw materials from spruce wood (coarse wood chips, sawdust and wood flour) for the development of modern thermal insulations with the aim of an environmentally friendly and less energy-intensive production process compared to conventional insulants.

BACKGROUND The proliferation of sexting among adolescents around the world today has woven a complex tapestry of sexual expression and exploration. However, its implications extend beyond consensual engagement, occasionally manifesting as a form of cyberviolence. Varied prevalence rates further complicate our understanding of the extent of youth sexting worldwide. Therefore, this study aims to provide a tool to measure sexting in young people from different countries by validating the Sexting Behaviours and Motives Questionnaire (SBM-Q), a comprehensive instrument that captures the diversity of consensual and non-consensual sexting behaviors and motives in different countries. METHOD A total of 4739 students, aged 15 to 25, participated. They were from Spain (1563), Croatia (1598), and Bosnia and Herzegovina (1578). Confirmatory factor analyses and multigroup analyses were conducted. RESULTS The validity of the instrument was confirmed, endorsing its six-factor structure, which includes the dimensions of sending, reasons for sending, victimization by non-consensual forwarding, receiving, forwarding, and reasons for forwarding. Internal consistency across the three countries further underscores the robustness of the SBM-Q. CONCLUSIONS This validated questionnaire provides a reliable measure for understanding sexting behaviors and motives in different countries. Cultural nuances are discussed.

Abstract Red mud, a voluminous industrial waste produced during the Bayer process in the alumina industry, has numerous application possibilities across various fields. Its potential uses are diverse, ranging from the construction industry and metallurgy to environmental protection and agriculture. There are three main aspects of red mud utilization. First, it can be analyzed from the point of view of resource utilization, where it could be applied as raw material mostly in the construction industry. Second, it could be a useful source of valuable components, such as rare earths and metals, especially iron. Third, red mud could have different environmental applications, in wastewater treatment, soil remediation, etc.The paper summarizes current data on red mud utilization methods and aims to emphasize the potential for red mud utilization in various fields.

Accurate differentiation between Ventricular Tachycardia (VT) and Ventricular Fibrillation (VF) is essential in the field of cardiology. Recent advancements in deep learning have facilitated automated arrhythmia recognition, surpassing traditional electrocardiogram (ECG) methods that depend on manual feature extraction. Building on our previous work, which emphasized the importance of identifying patterns of regularity, we have developed a model that merges Graph Convolutional Networks (GCN) with Long Short-Term Memory (LSTM) networks. This GCN-LSTM model employs a trainable weighted ϵ-neighborhood graph to capture the similarity among time series within ECG segments. This approach has demonstrated substantial improvement in the classification of VT, VF, and non-ventricular rhythms.

The paper explores the evolving role of Artificial Intelligence (AI) in perinatal medicine and hu-man reproduction, highlighting its potential to transform clinical practices. AI technologies are being utilized to improve diagnostic accuracy, personalize treatment, and enhance patient care, particularly in areas like perinatal ultrasound, fetal heart rate monitoring, and fetal neurology. The Kurjak Antenatal Neurodevelopmental Test (KANET) exemplifies how AI can aid early detection of neurodevelopmental disorders. However, the integration of AI presents challenges such as data quality concerns, algorithmic bias, ethical concerns, and the need for robust regulatory frameworks. The authors argue that while AI offers significant opportunities, its implementation must be carefully managed to avoid over-reliance on technology and ensure equitable healthcare access. The paper concludes that the current state of AI in this field marks not an endpoint but a critical phase of growth and development, necessitating a balanced approach that combines innovation with ethical and practical considerations.

This work sets out the methodology and presents the calculation results of the amount of carbon dioxide emitted into the atmosphere of the BelAz dump truck at the Open Pit "Turija" BCM Banovići d.d., based on the fuel consumption monitoring data. Properly determined fuel consumption enables the calculation of the amount of carbon dioxide emitted and preventive measures, as well as the choice of its reduction strategy. Data collection took six months, then the data were analyzed, and thus the results were given for all dump trucks by months. Key words: fuel, open pit mining, BelAz dump truck, maintenance, Coal Mine Banovići, carbon dioxide

Abstract Background During the first epidemic wave, COVID-19 surveillance focused on quantifying the magnitude and the escalation of a growing global health crisis. The scientific community first assessed risk through basic indicators, such as the number of cases or rates of new cases and deaths, and later began using other direct impact indicators to conduct more detailed analyses. We aimed at synthesizing the scientific community’s contribution to assessing the direct impact of the COVID-19 pandemic on population health through indicators reported in research papers. Methods We conducted a rapid scoping review to identify and describe health indicators included in articles published between January 2020 and June 2021, using one strategy to search PubMed, EMBASE and WHO COVID-19 databases. Sixteen experts from European public health institutions screened papers and retrieved indicator characteristics. We also asked in an online survey how the health indicators were added to and used in policy documents in Europe. Results After reviewing 3891 records, we selected a final sample of 67 articles and 233 indicators. We identified 52 (22.3%) morbidity indicators from 33 articles, 105 severity indicators (45.1%, 27 articles) and 68 mortality indicators (29.2%, 51). Respondents from 22 countries completed 31 questionnaires, and the majority reported morbidity indicators (29, 93.5%), followed by mortality indicators (26, 83.9%). Conclusions The indicators collated here might be useful to assess the impact of future pandemics. Therefore, their measurement should be standardized to allow for comparisons between settings, countries and different populations.

The modern period of neurosurgery in Bosnia and Herzegovina began with the first neurosurgical procedure performed by Dr. Karl Bayer in 1891 on 3 patients with depressed skull fractures and epilepsy. In 1956 the Department of Surgery in Sarajevo designated several beds specifically for a neurosurgical unit. A significant milestone in the history of neurosurgery in Bosnia and Herzegovina was the establishment of the Division of Neurosurgery at the Clinical Center University of Sarajevo in 1970. The first neurosurgeon to complete his training in Bosnia and Herzegovina was Dr. Faruk Konjhodžić. The first female neurosurgeon was Dr. Nermina Iblizović. Presently, there are 7 neurosurgical departments in the country, located in Sarajevo, Tuzla, Zenica, Mostar, Banja Luka, Bihać, and Foča. The Association of Neurosurgeons in Bosnia and Herzegovina, founded in 2003, is a member of the European Association of Neurosurgical Societies and the World Federation of Neurosurgical Societies. The aim of this historical paper is to provide a concise chronology of important events and mention key individuals who have contributed to the development of modern neurosurgery in Bosnia and Herzegovina.

Background and Objectives. Distinct pressure curve differences exist between akinetic (A-LVA) and dyskinetic (D-LVA) aneurysms. In D-LVA, left ventricular (LV) ejection pressure decreases relative to the aneurysm size, whereas A-LVA does not impact pressure curves, indicating that the decrease in stroke volume (SV) and cardiac output is proportional to the size of dyskinesia. This study aimed to assess the frequency of A-LVA and D-LVA, determine aneurysm size parameters (volume and surface area), and evaluate predictive parameters using echocardiography in A-LVA and D-LVA. Furthermore, it aimed to compare individual echocardiographic parameters, according to ejection fraction (EF) and SV, with hemodynamic events shown in experimental models of A-LVA and D-LVA and their significance in everyday clinical practice. Materials and Methods. This clinical study included patients with post-infarction left ventricular aneurysm (LVA) admitted to the cardiovascular institute ‘’Dedinje”, Serbia. Echocardiographic volume and surface area of LV and LVA were determined (by the area–length method) along with EF (by Simpson’s method). Results. A-LVA was present in 62.9% of patients, while D-LVA was present in 37.1%. Patients with D-LVA had significantly higher systolic aneurysm volume (LVAVs) (94.07 ± 74.66 vs. 51.54 ± 53.09, p = 0.009), systolic aneurysm surface area (LVAAs) (23.22 ± 11.73 vs. 16.41 ± 8.58, p = 0.018), and end-systolic left ventricular surface areas (LVESA) (50.79 ± 13.33 vs. 42.76 ± 14.11, p = 0.045) compared to patients with A-LVA. The ratio of LVA volume to LV volume was higher in the D-LVA in systole (LVAVs/LVESV). The end-diastolic volume of LV (LVEDV) and end-systolic volume of LV (LVESV) did not significantly differ between D-LVA and A-LVA. EF (21.25 ± 11.92 vs. 28.18 ± 11.91, p = 0.044) was significantly lower among patients with D-LVA. Conclusions. Differentiating between A-LVA and D-LVA using echocardiography is crucial since D-LVA causes greater hemodynamic disturbances in LV function, and thus surgical resection of the aneurysm or LV reconstruction must have a positive effect regardless of myocardial revascularization surgery.

Objectives: To compare carotid endarterectomy patch angioplasty (p-CEA) with eversion carotid endarterectomy (e-CEA) and associated risks of early cardio-cerebrovascular complications. Methods: The study was a prospective randomized single-blind trial, monocentric, clinically applicable, descriptive analytical and comparative. From June 2021 to June 2023, 62 consecutive patients with symptomatic and asymptomatic stenosis of the internal carotid artery, admitted to our department and randomized into two groups: carotid endarterectomy with patch angioplasty and eversion carotid endarterectomy. Follow-up for 30 days after surgery. Results: During surgery e-CEA, 70% patients had an arrhythmia, and 24 hours after 66.7%, seven days after 46.7% and month after 13.3%. During surgery p-CEA, 33.3% patients had an arrhythmia, 24 hours later 33.3%, 7 days after 13.3% and 30 days after 13.3% patients. Statistically significant difference observed during surgery (Fishers p=0.004). One day after the surgery rate of patients with arrhythmia that were treated e-CEA has decreased, but it was still higher than after p-CEA (Fishers p=0.010). Conclusion: The frequency and categorization of postoperative cardiac arrhythmias after eversion carotid endarterectomy, the clinical implications of various postoperative heart rhythm disturbances and their long-term effects on patients need to be further investigate through sufficiently powered randomized controlled studies