P381 Transient periosteal hyperostosis with dysproteinemia (Goldbloom syndrome): two cases report Riccardo Papa, Alessandro Consolaro, Francesca Minoia, Roberta Caorsi, Gianmichele Magnano, Marco Gattorno, Angelo Ravelli, Paolo Picco Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genoa, Italy; Radiologia, Istituto Giannina Gaslini, Genoa, Italy Presenting author: Riccardo Papa Pediatric Rheumatology 2017, 15(Suppl 1):P381

PURPOSE Veliparib, a poly (ADP ribose) polymerase inhibitor, potentiated standard chemotherapy against small-cell lung cancer (SCLC) in preclinical studies. We evaluated the combination of veliparib with cisplatin and etoposide (CE; CE+V) doublet in untreated, extensive-stage SCLC (ES-SCLC). MATERIALS AND METHODS Patients with ES-SCLC, stratified by sex and serum lactate dehydrogenase levels, were randomly assigned to receive four 3-week cycles of CE (75 mg/m2 intravenously on day 1 and 100 mg/m2 on days 1 through 3) along with veliparib (100 mg orally twice per day on days 1 through 7) or placebo (CE+P). The primary end point was progression-free survival (PFS). Using an overall one-sided 0.10-level log-rank test, the study had 88% power to demonstrate a 37.5% reduction in the PFS hazard rate. RESULTS A total of 128 eligible patients received treatment on protocol. The median age was 66 years, 52% of patients were men, and Eastern Cooperative Oncology Group performance status was 0 for 29% of patients and 1 for 71%. The respective median PFS for the CE+V arm versus the CE+P arm was 6.1 versus 5.5 months (unstratified hazard ratio [HR], 0.75 [one-sided P = .06]; stratified HR, 0.63 [one-sided P = .01]), favoring CE+V. The median overall survival was 10.3 versus 8.9 months (stratified HR, 0.83; 80% CI, 0.64 to 1.07; one-sided P = .17) for the CE+V and CE+P arms, respectively. The overall response rate was 71.9% versus 65.6% (two-sided P = .57) for CE+V and CE+P, respectively. There was a significant treatment-by-strata interaction in PFS: Male patients with high lactate dehydrogenase levels derived significant benefit (PFS HR, 0.34; 80% CI, 0.22 to 0.51) but there was no evidence of benefit among patients in other strata (PFS HR, 0.81; 80% CI, 0.60 to 1.09). The following grade ≥ 3 hematology toxicities were more frequent in the CE+V arm than the CE+P arm: CD4 lymphopenia (8% v 0%; P = .06) and neutropenia (49% v 32%; P = .08), but treatment delivery was comparable. CONCLUSION The addition of veliparib to frontline chemotherapy showed signal of efficacy in patients with ES-SCLC and the study met its prespecified end point.

The EU Water Framework Directive aims to ensure restoration of Europe’s water bodies to “good ecological status” by 2027. Many Member States will struggle to meet this target, with around half of EU river catchments currently reporting below standard water quality. Diffuse pollution from agriculture represents a major pressure, affecting over 90% of river basins. Accumulating evidence shows that recent improvements to agricultural practices are benefiting water quality but in many cases will be insufficient to achieve WFD objectives. There is growing support for land use change to help bridge the gap, with a particular focus on targeted tree planting to intercept and reduce the delivery of diffuse pollutants to water. This form of integrated catchment management offers multiple benefits to society but a significant cost to landowners and managers. New economic instruments, in combination with spatial targeting, need to be developed to ensure cost effective solutions – including tree planting for water benefits - are realised. Payments for Ecosystem Services (PES) are flexible, incentive-based mechanisms that could play an important role in promoting land use change to deliver water quality targets. The PESFOR-W COST Action will consolidate learning from existing woodlands for water PES schemes in Europe and help standardize approaches to evaluating the environmental effectiveness and cost-effectiveness of woodland measures. It will also create a European network through which PES schemes can be facilitated, extended and improved, for example by incorporating other ecosystem services linking with aims of the wider forests-carbon policy nexus.

The performed evaluation consisted of two phases: measurement of the illumination levels of (new) LED system and carrying out the public opinion poll on the subjective visual performance of LED in traffic lights. The results of the measured levels of illumination show that deposition of dirt considerably affects its values. The survey results confirm an overall positive impression on LED performances in traffic lights.

segurança do paciente Luciana da Silva Maciel1, Glaycianne de Souza Alves2, Cynthia Djan Alves Costa3, Tamiris Maia Barrocas4. 1Acadêmica de Farmácia pela Universidade Federal do Ceará UFC e estagiária do projeto Proensino Secretaria Estadual de Saúde (SESA) luckmaciel_che@yahoo.com.br 2Acadêmica de Farmácia pela Faculdade Metropolitana da Grande Fortaleza, FAMETRO, e estagiária do Hospital Geral de Fortaleza. 3Farmacêutica Clínica do Hospital Geral de Fortaleza, 3Farmacêutica Clínica do Hospital Geral de Fortaleza 4Acadêmica de Farmácia pela Universidade de Fortaleza, UNIFOR, e estagiária do projeto Proensino Secretaria Estadual de Saúde (SESA).

Device-independent Internet spatial location is needed for many purposes, such as data personalisation and social behaviour analysis. Internet spatial databases provide such locations based the IP address of a device. The free to use databases are natively included into many UNIX and Linux operating systems. These systems are predominantly used for e-shops, social networks, and cloud data storage. Using a constructed ground truth dataset, we comprehensively evaluate these databases for null responses, returned country/region/city, and distance error. The created ground truth dataset differs from others by covering cities with both low and high populations and maintaining only devices that follow the rule of one IP address per ISP (Internet Service Provider) and per city. We define two new performance metrics that show the effect of city population and trustworthiness of the results. We also evaluate the databases against an alternative measurement-based approach. We study the reasons behind the results. The data evaluated comes from Europe. The results may be of use for engineers, developers and researchers that use the knowledge of geographical location for related data processing and analysis, such as marketing.

We deal with quadratic metric-affine gravity (QMAG), which is an alternative theory of gravity and present a new explicit representation of the field equations of this theory. In our previous work we found new explicit vacuum solutions of QMAG, namely generalised pp-waves of parallel Ricci curvature with purely tensor torsion. Here we do not make any assumptions on the properties of torsion and write down our field equations accordingly. We present a review of research done thus far by several authors in finding new solutions of QMAG and different approaches in generalising pp-waves. We present two conjectures on the new types of solutions of QMAG which the ansatz presented in this paper will hopefully enable us to prove.

Background: Physical inactivity and intensive sports activity have been found to be associated with LBP. The aim of this study is the presents the data about the prevalence of LBP in young adults and its associations with vitality, physical activity and emotions. We also studied the impact of low back pain on daily activity. The study sample presented (n=323) students from the Former Yugoslav Republic of Macedonia and Bosnia and Herzegovina in the chronological age of 21.06 ± 1.93 years. The current study assessed the level of LBP amongst students of Faculty of Sport with the level of physical activity in last six months. Methods: We used the questionnaire, which included the Graded Chronic Pain Scale (GCPS) for the evaluation of levels of chronic pain. With a Short Health Survey (SF-36) we tried to measure the health status. Results: A total of (n=323) of all students had pain intensity at some point in last six months. All students reported (n=236, 73.0%) prevalence of LBP. In this study body mass index, level of physical activity were not significant independent predictors of intensity and disability scores. Conclusion: 3/4 of all respondents said to have had any episode LBP. The results of our study can be used by officials in the area of prevention to support efforts to improve health of the student population and to reduce the LBP risk.