Sažetak: Uvod: Jedan od najčešćih malignih tumora glave i vrata jeste karcinom larinksa. Totalna laringektomija dovodi do trajnog gubitka larinksa čime se narušavaju normalni anatomski odnosi u vratu, što izaziva poremećaj komunikacije i socijalne interakcije pacijenta. Cilj: Cilj ovog istraživanja je da se utvrdi koliki uticaj ima radioterapija na kvalitet života laringektomiranih pacijenata nakon vokalne rehabilitacije. Metod rada: U istraživanju je učestvovalo 50 pacijenata nakon totalne laringektomije. Starost ispitanika kretala se od 51 do 83 godine. Jednofaktorskom analizom varijanse (ANOVA) izvršeno je testiranje razlika između prosečnih postignuća na VHI i HNQOL skali pre i posle vokalne rehabilitacije. Ovim skalama možemo doći do informacije o stepenu govorne invalidnosti koju doživljava sam pacijent, zatim zadovoljstvom pacijenta primenjenim lečenjem ili tretmanom i uticaju koji ima vokalna rehabilitacija na kvaliteta njegovog života pre i nakon tretmana. Rezultati: U našoj studiji pacijenti koji su podvrgnuti radikalnoj hirurškoj intervenciji prijavili su bolji kvalitet života u poređenju sa pacijentima koji su bili podvrgnuti drugim kombinovanim modalitetima lečenja. Ustanovljeno je da statistički značajne razlike postoje na svim supskalama obe skale. Statistička značajnost definisana je na nivou verovatnoće nulte hipoteze od p ≤ 0,05 do p < 0,001. Zaključak: Uspešna vokalna rehabilitacija je važan faktor kvalitetnog života pacijenata nakon totalne laringektomije i predstavlja izlaz iz društvene izolacije. Ključne reči: tumori larinksa, laringektomija, vokalna rehabilitacija, kvalitet života, VHI skala, HNQOL skala

Implementation of IMRT offers possibility to escalate radiation therapy dose without increased acute and late toxicity. The aim of this study is to compare acute and late genitourinary and gastrointestinal toxicity in patients treated with IMRT and 3DCRT technique. This study included 35 patients in study group a treated with IMRT technique, and 35 patients in study group B treated with 3DCRT technique. Patients were selected and referred to radical radiotherapy treatment prostate cancer. Acute genitourinary and gastrointestinal toxicity was evaluated during radiotherapy treatment according to recommendation of RTOG group. Late gastrointestinal and genitourinary toxicity was evaluated during regular control exams after radical radiotherapy treatment for six months. Based on the results χ2 test there was no statistical significant difference (p>0,05) between study group a i B in terms of acute gastrointestinal and genitourinary despite escalated radiotherapy dose in study group B treated with IMRT technique. Based on the results χ2 test there was no statistical significant difference (p>0, 05) between study group a i B in terms of late gastrointestinal and genitourinary toxicity. Intensity modulated radiation therapy is optimal technique in the radical treatment prostate cancer. This technique allows clinical benefit compared with 3D conformal radiotherapy-escalation of radiotherapy dose without increased toxicity in patients treated with IMRT technique.

Trivalent chromium is an essential trace element for humans and animals and it is the final product of hexavalent chromium reduction in the cell. It is an integral part of the glucose-tolerance factor, which increases the systemic impact of insulin. The aim of this study was to analyse the effect of trivalent and hexavalent chromium on selected biochemical parameters in Japanese quails. Birds were divided into three groups: group I (control group, n=12), group II (treated with trivalent chromium, n=12) and group III (treated with hexavalent chromium, n=12). During 20 days of follow-up, control and experimental groups of quails had identical diet; chromium was added daily into the food (5 mg/kg) and water (5 mg/L) of the experimental groups. Glucose concentrations were the highest in Group III, while lowest glucose concentrations were obtained in Group I. There were higher differencies regarding blood biochemical parameters between control group and quails treated with Cr(VI). Our results showed that hexavalent chromium had negative effects on biochemical parameters in quails, while treatment with Cr(III) showed minor fluctuations in concentrations or activities of blood biochemical parameters.

Several haematological parameters in Herzegovinian donkeys based on gender and age were analysed in this study. The study included 30 clinically healthy donkeys (12 males and 18 females), between one and twenty years of age. Donkeys were grouped in three age classes: young (1-2 years, n=10), adult (3-6 years, n=12) and old donkeys (7-20 years, n=8). A total of seven haematological parameters were analysed. In both genders and in all age groups, the mean values of MCHC were slightly above the recommended reference intervals for donkeys in general. The mean values of HCT in females and in adult donkeys were lower than the reference intervals. The PLT mean values in female, and in young and old Herzegovinian donkeys were lower than the reference intervals. Gender significantly affected HCT and Hb values (p=0.049; p=0.046, respectively), which were significantly higher in males. Age significantly affected WBC and LYM count, which were lowest in young donkeys.

Integrated intelligent CAD systems (IICAD) can be developed for different purposes. The objective of this article is to emphasize the advantages of the use of IICAD systems in comparison with the classic systems. The article shows a structure of one such developed system, namely the IICADv system. This system is used for automatization of activities undertaken during the realization of certain phases of the process of designing of shafts, especially the synthesis phase. The development of a module for computation of the shaft and integration of the entire system was performed in the C# programming language, while shaping of the shaft was performed in the CATIA system. The interlinking was performed thanks to previously modelled basic 3D models. In such way, utilizing the advanced IICADv system, the computation and shaping of the shaft is done almost instantly. The results of the use of the IICADv systems are generated final 3D models of the shaft, ready for use by numerous other applications.