Zvizdic Z, Milisic E, Jonuzi A, Terzic S, Zvizdic D. The contribution of morphine sulfate to the development of necrotizing enterocolitis in preterm infants: a matched case-control study. Turk J Pediatr 2019; 61: 513-519. The aim of the study was to determine whether morphine sulfate administration is associated with an increased risk of necrotizing enterocolitis (NEC) in preterm infants supported by mechanical ventilation due to respiratory failure. The matched case-control retrospective study was carried out at the Neonatal Intensive Care Unit (NICU) of the University Clinical Center Sarajevo, on 122 preterm infants classified into total NEC group and control group. The total NEC group was further divided into medical NEC and surgical NEC subgroups. The association between the use and duration of morphine sulfate infusion and the development of NEC was evaluated in both unadjusted and adjusted analysis. Preterm infants who developed NEC were on mechanical ventilation more frequently compared to premature infants without signs of NEC (Mann- Whitney U test; p=0.0031). A positive correlation between the frequency of receiving morphine sulfate and the development of NEC was observed (Chi square test of independence; p=0.0001). The risk of NEC in preterm infants was increased by the use of morphine sulfate. Validation of this observation in other populations is warranted.

Paper received: xx.xx.xxxx. Paper accepted: xx.xx.xxxx. Stručni rad REZIME Kranioplastika je hirurška popravka koštanog defekta lobanje koji je ostao nakon ozbiljne povrede ili prethodne operacije. Uobičajna svrha ove intervencije je zaštita moždanog tkiva, smanjenje lokalnog bola i poboljšanje estetike kranijalnog svoda. Kranijalne proteze mogu biti napravljenje od različitih materijala: autologne kosti, titanijuma, keramike i polimera. Njihova proizvodnja je skupa i često zahtijeva kompleksne intraoperativne procese, što ponekad rezultira slabim estetskim rezultatima kod velikih i kompleksnih defekata. Ovaj rad, na konkretnom primjeru, predstavlja metod za izradu implanta po mjeri pacijenta od polimetil metakrilata, uključujući trodimenzionalnu rekonstrukciju baziranu na CT snimcima, tehnologiju 3D printanja i izradu kalupa od zubarskog gipsa.

In this work, both farm milk samples (n=3), as well as samples of milk from Bosnia and Herzegovina market (n=7), were analyzed to quantify the presence of polychlorinated biphenyls. The PCB content (as Aroclor 1254) was determined in the fat extracts using the PCB ELISA kit, according to the procedure provided by the manufacturer. The total PCB concentrations (as Aroclor 1254) in individual milk sample ranged from <LoD to 787.74 μg/kg lipid weight (l.w.). The calculated Ʃ6PCB were ranged from <LoD to 187.72 μg/kg l.w. In one out of ten analyzed samples the presence of PCB higher than maximum limit (ML) was found. However, the absorbance measured for this sample is out of the linear range. In this case the sample can be considered as a suspect and should be analyzed with the quantitative confirmatory method. In other milk samples the concentration of PCB was in the acceptable range, and far below the ML.